JPS6163671A - ２，３−ジヒドロベンゾフラン−５−スルホンアミド誘導体および降圧利尿剤 - Google Patents

２，３−ジヒドロベンゾフラン−５−スルホンアミド誘導体および降圧利尿剤

Info

Publication number
JPS6163671A
JPS6163671A JP59186971A JP18697184A JPS6163671A JP S6163671 A JPS6163671 A JP S6163671A JP 59186971 A JP59186971 A JP 59186971A JP 18697184 A JP18697184 A JP 18697184A JP S6163671 A JPS6163671 A JP S6163671A
Authority
JP
Japan
Prior art keywords
compound
lower alkyl
reaction
acid
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59186971A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0354945B2 (https=
Inventor
Hiroshi Harada
紘 原田
Norihiro Matsushita
松下　至博
Masuhisa Nakamura
益久 中村
Yukio Yonetani
米谷　行男
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP59186971A priority Critical patent/JPS6163671A/ja
Priority to US06/764,785 priority patent/US4659709A/en
Priority to CA000488588A priority patent/CA1265800A/en
Priority to AU46215/85A priority patent/AU592060B2/en
Priority to AT85110250T priority patent/ATE70534T1/de
Priority to EP85110250A priority patent/EP0173899B1/en
Priority to DE8585110250T priority patent/DE3584919D1/de
Priority to ZA856277A priority patent/ZA856277B/xx
Priority to NZ213197A priority patent/NZ213197A/xx
Priority to PT81033A priority patent/PT81033B/pt
Priority to NO853441A priority patent/NO169487C/no
Priority to KR1019850006459A priority patent/KR930002100B1/ko
Priority to IE218885A priority patent/IE58911B1/en
Priority to DK403185A priority patent/DK165954C/da
Priority to GB08521967A priority patent/GB2164039B/en
Priority to CN 85107226 priority patent/CN1014148B/zh
Publication of JPS6163671A publication Critical patent/JPS6163671A/ja
Publication of JPH0354945B2 publication Critical patent/JPH0354945B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP59186971A 1984-09-05 1984-09-05 ２，３−ジヒドロベンゾフラン−５−スルホンアミド誘導体および降圧利尿剤 Granted JPS6163671A (ja)

Priority Applications (16)

Application Number Priority Date Filing Date Title
JP59186971A JPS6163671A (ja) 1984-09-05 1984-09-05 ２，３−ジヒドロベンゾフラン−５−スルホンアミド誘導体および降圧利尿剤
US06/764,785 US4659709A (en) 1984-09-05 1985-08-12 2,3-dihydrobenzofuran-5-sulfonamide derivatives useful as antihypertensive diuretic agents
CA000488588A CA1265800A (en) 1984-09-05 1985-08-13 2,3-dihydrobenzofuran-5-sulfonamide derivatives
AU46215/85A AU592060B2 (en) 1984-09-05 1985-08-15 2,3-dihydrobenzofuran-5-sulfonamide derivatives
AT85110250T ATE70534T1 (de) 1984-09-05 1985-08-16 2,3-dihydrobenzofuran-5-sulfonamid-derivate.
EP85110250A EP0173899B1 (en) 1984-09-05 1985-08-16 2,3-dihydrobenzofuran-5-sulfonamide derivatives
DE8585110250T DE3584919D1 (de) 1984-09-05 1985-08-16 2,3-dihydrobenzofuran-5-sulfonamid-derivate.
ZA856277A ZA856277B (en) 1984-09-05 1985-08-19 2,3-dihydrobenzofuran-5-sulfonamide derivatives
NZ213197A NZ213197A (en) 1984-09-05 1985-08-22 2,3-dihydrobenzofuran-5-sulphonamide derivatives and pharmaceutical compositions
PT81033A PT81033B (pt) 1984-09-05 1985-08-27 Processo para a preparacao de derivados de 2,3-di-hidrobenzofurano-5-sulfonamida
NO853441A NO169487C (no) 1984-09-05 1985-09-02 Analogifremgangsmaate for fremstilling av terapeutisk aktive 2,3-dihydrobenzofuran-5-sulfonamider
KR1019850006459A KR930002100B1 (ko) 1984-09-05 1985-09-04 2, 3-디히드로벤조푸란-5-설폰아미드 유도체의 제조방법
IE218885A IE58911B1 (en) 1984-09-05 1985-09-04 2,3-dihydrobenzofuran-5-sulfonamide derivatives
DK403185A DK165954C (da) 1984-09-05 1985-09-04 2,3-dihydrobenzofuran-5-sulfonamidderivater samt antihypertensive og diuretiske midler indeholdende disse
GB08521967A GB2164039B (en) 1984-09-05 1985-09-04 2,3-dihydrobenzofuran-5-sulfonamide derivatives
CN 85107226 CN1014148B (zh) 1984-09-05 1985-09-28 2，3-二氢苯并呋喃-5-磺酰胺衍生物的制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59186971A JPS6163671A (ja) 1984-09-05 1984-09-05 ２，３−ジヒドロベンゾフラン−５−スルホンアミド誘導体および降圧利尿剤

Publications (2)

Publication Number Publication Date
JPS6163671A true JPS6163671A (ja) 1986-04-01
JPH0354945B2 JPH0354945B2 (https=) 1991-08-21

Family

ID=16197928

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59186971A Granted JPS6163671A (ja) 1984-09-05 1984-09-05 ２，３−ジヒドロベンゾフラン−５−スルホンアミド誘導体および降圧利尿剤

Country Status (15)

Country Link
US (1) US4659709A (https=)
EP (1) EP0173899B1 (https=)
JP (1) JPS6163671A (https=)
KR (1) KR930002100B1 (https=)
AT (1) ATE70534T1 (https=)
AU (1) AU592060B2 (https=)
CA (1) CA1265800A (https=)
DE (1) DE3584919D1 (https=)
DK (1) DK165954C (https=)
GB (1) GB2164039B (https=)
IE (1) IE58911B1 (https=)
NO (1) NO169487C (https=)
NZ (1) NZ213197A (https=)
PT (1) PT81033B (https=)
ZA (1) ZA856277B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009513679A (ja) * 2005-10-25 2009-04-02 カリプシス・インコーポレーテッド Ｐｐａｒ調節剤の塩および代謝障害の治療方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116874A (en) * 1985-09-23 1992-05-26 Eli Lilly And Company Anti-tumor method and compounds
JPH01100164A (ja) * 1987-10-12 1989-04-18 Shionogi & Co Ltd スルファモイル−２−ベンゾフランカルボン酸誘導体
DE3861963D1 (de) * 1987-12-24 1991-04-11 Boehringer Mannheim Gmbh Heterocyclisch substituierte alkylsulfonamide, verfahren zu ihrer herstellung sowie arzneimittel.
GB9110636D0 (en) * 1991-05-16 1991-07-03 Glaxo Group Ltd Chemical compounds
US5254582A (en) * 1992-02-05 1993-10-19 Eli Lilly And Company Antitumor compositions and methods
US5387681A (en) * 1992-08-19 1995-02-07 Eli Lilly And Company Synthesis of bicyclic aromatic sulfonic acids sulfonyl chlorides and sulfonamides
US6150402A (en) * 1994-08-15 2000-11-21 Loma Linda University Medical Center Natriuretic compounds
DE10135499A1 (de) * 2001-07-20 2003-01-30 Merck Patent Gmbh Indanverbindungen mit negativem Delta-epsilon
WO2005037223A2 (en) * 2003-10-15 2005-04-28 Brigham And Women's Hospital, Inc. Methods and compositions for immunomodulation
MX2007005205A (es) 2004-10-29 2007-05-11 Kalypsys Inc Compuestos biciclicos sulfonilo-sustituidos como moduladores de receptores activados por el proliferador de la peroxisoma.
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6004073A (en) * 1972-09-09 1975-03-06 Basf Ag Fluorescent benzofuran compounds
US4401669A (en) * 1978-01-27 1983-08-30 Merck & Co., Inc. 2,3-Dihydro-substituted-5-benzoyl benzofuran-2-carboxylic acids and their use in treating hypertension
CA1145758A (en) * 1979-05-16 1983-05-03 Shell Canada Limited 2,3-dihydro-2-benzofurancarboxamide derivatives
US4237130A (en) * 1979-06-21 1980-12-02 Merck & Co., Inc. 2,3-Dihydro-6,7-disubstituted-5-(substituted sulfonyl)benzofuran-2-carboxylic acids
DE3317884A1 (de) * 1983-05-17 1984-11-22 Hoechst Ag, 6230 Frankfurt 5-(4-chlor-3-sulfamoylbenzoyl)-2,3-dihydro-2-benzofurancarbonsaeuren und verfahren zu ihrer herstellung
US4544667A (en) * 1984-02-09 1985-10-01 Merck & Co., Inc. 2-Sulfamoylbenzo[b]furan derivatives for the treatment of elevated intraocular pressure

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009513679A (ja) * 2005-10-25 2009-04-02 カリプシス・インコーポレーテッド Ｐｐａｒ調節剤の塩および代謝障害の治療方法

Also Published As

Publication number Publication date
GB8521967D0 (en) 1985-10-09
DE3584919D1 (de) 1992-01-30
NO169487C (no) 1992-07-01
GB2164039B (en) 1988-05-18
EP0173899B1 (en) 1991-12-18
ZA856277B (en) 1986-04-30
DK403185A (da) 1986-03-06
NZ213197A (en) 1989-01-06
DK165954B (da) 1993-02-15
IE58911B1 (en) 1993-12-01
KR860002490A (ko) 1986-04-26
AU4621585A (en) 1986-03-13
JPH0354945B2 (https=) 1991-08-21
AU592060B2 (en) 1990-01-04
EP0173899A2 (en) 1986-03-12
IE852188L (en) 1986-03-05
NO853441L (no) 1986-03-06
GB2164039A (en) 1986-03-12
DK165954C (da) 1993-07-05
CA1265800A (en) 1990-02-13
NO169487B (no) 1992-03-23
US4659709A (en) 1987-04-21
DK403185D0 (da) 1985-09-04
ATE70534T1 (de) 1992-01-15
KR930002100B1 (ko) 1993-03-26
PT81033A (en) 1985-09-01
PT81033B (pt) 1987-09-18
EP0173899A3 (en) 1988-07-20

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