JPS6157296B2 - - Google Patents

Info

Publication number

JPS6157296B2

JPS6157296B2 JP4375779A JP4375779A JPS6157296B2 JP S6157296 B2 JPS6157296 B2 JP S6157296B2 JP 4375779 A JP4375779 A JP 4375779A JP 4375779 A JP4375779 A JP 4375779A JP S6157296 B2 JPS6157296 B2 JP S6157296B2

Authority

JP

Japan

Prior art keywords

aluminum salt

acetyl

reaction

acid

aluminum

Prior art date

1979-04-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

• Espacenet
• Global Dossier
• Discuss

• -1 N-acetylamino Chemical group 0.000 claims description 21
• 238000000034 method Methods 0.000 claims description 17
• AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 16
• 239000002253 acid Substances 0.000 claims description 15
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 14
• KPVRRVPOMMDUOB-BBDGQJMTSA-K bis[[(2S)-2-acetamido-5-amino-5-oxopentanoyl]oxy]alumanyl (2S)-2-acetamido-5-amino-5-oxopentanoate Chemical compound [Al+3].CC(=O)N[C@H](C([O-])=O)CCC(N)=O.CC(=O)N[C@H](C([O-])=O)CCC(N)=O.CC(=O)N[C@H](C([O-])=O)CCC(N)=O KPVRRVPOMMDUOB-BBDGQJMTSA-K 0.000 claims description 3
• 238000004519 manufacturing process Methods 0.000 claims description 3
• PYUSRTGWUATZCI-UHFFFAOYSA-K C(C)(=O)NCC(=O)[O-].[Al+3].C(C)(=O)NCC(=O)[O-].C(C)(=O)NCC(=O)[O-] Chemical compound C(C)(=O)NCC(=O)[O-].[Al+3].C(C)(=O)NCC(=O)[O-].C(C)(=O)NCC(=O)[O-] PYUSRTGWUATZCI-UHFFFAOYSA-K 0.000 claims description 2
• 229960004308 acetylcysteine Drugs 0.000 claims description 2
• 239000007864 aqueous solution Substances 0.000 claims description 2
• GCZLOUYULWQRDH-YVLBNVJDSA-H [Al+3].C(C)(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].C(C)(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].C(C)(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Al+3] Chemical compound [Al+3].C(C)(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].C(C)(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].C(C)(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Al+3] GCZLOUYULWQRDH-YVLBNVJDSA-H 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
• 229940024545 aluminum hydroxide Drugs 0.000 description 12
• 239000007788 liquid Substances 0.000 description 9
• 239000000203 mixture Substances 0.000 description 9
• 229910052782 aluminium Inorganic materials 0.000 description 8
• 239000013078 crystal Substances 0.000 description 8
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
• KSMRODHGGIIXDV-YFKPBYRVSA-N N-acetyl-L-glutamine Chemical compound CC(=O)N[C@H](C(O)=O)CCC(N)=O KSMRODHGGIIXDV-YFKPBYRVSA-N 0.000 description 6
• OKJIRPAQVSHGFK-UHFFFAOYSA-N N-acetylglycine Chemical compound CC(=O)NCC(O)=O OKJIRPAQVSHGFK-UHFFFAOYSA-N 0.000 description 6
• 238000000921 elemental analysis Methods 0.000 description 6
• 239000000243 solution Substances 0.000 description 5
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
• 239000000463 material Substances 0.000 description 4
• RFMMMVDNIPUKGG-YFKPBYRVSA-N N-acetyl-L-glutamic acid Chemical compound CC(=O)N[C@H](C(O)=O)CCC(O)=O RFMMMVDNIPUKGG-YFKPBYRVSA-N 0.000 description 3
• 239000002904 solvent Substances 0.000 description 3
• PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 2
• OTCCIMWXFLJLIA-BYPYZUCNSA-N N-acetyl-L-aspartic acid Chemical compound CC(=O)N[C@H](C(O)=O)CC(O)=O OTCCIMWXFLJLIA-BYPYZUCNSA-N 0.000 description 2
• XUYPXLNMDZIRQH-LURJTMIESA-N N-acetyl-L-methionine Chemical compound CSCC[C@@H](C(O)=O)NC(C)=O XUYPXLNMDZIRQH-LURJTMIESA-N 0.000 description 2
• CAHKINHBCWCHCF-JTQLQIEISA-N N-acetyl-L-tyrosine Chemical compound CC(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 CAHKINHBCWCHCF-JTQLQIEISA-N 0.000 description 2
• 239000003957 anion exchange resin Substances 0.000 description 2
• 239000012295 chemical reaction liquid Substances 0.000 description 2
• 238000001816 cooling Methods 0.000 description 2
• 230000000694 effects Effects 0.000 description 2
• 229910052500 inorganic mineral Inorganic materials 0.000 description 2
• 239000003456 ion exchange resin Substances 0.000 description 2
• 229920003303 ion-exchange polymer Polymers 0.000 description 2
• 239000011707 mineral Substances 0.000 description 2
• 229960001682 n-acetyltyrosine Drugs 0.000 description 2
• 239000003960 organic solvent Substances 0.000 description 2
• 238000003756 stirring Methods 0.000 description 2
• 239000000126 substance Substances 0.000 description 2
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
• OTCCIMWXFLJLIA-UHFFFAOYSA-N N-acetyl-DL-aspartic acid Natural products CC(=O)NC(C(O)=O)CC(O)=O OTCCIMWXFLJLIA-UHFFFAOYSA-N 0.000 description 1
• HDVDLQFPDLTOSI-UHFFFAOYSA-L O[AlH]O Chemical compound O[AlH]O HDVDLQFPDLTOSI-UHFFFAOYSA-L 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 150000001370 alpha-amino acid derivatives Chemical class 0.000 description 1
• 235000008206 alpha-amino acids Nutrition 0.000 description 1
• SMZOGRDCAXLAAR-UHFFFAOYSA-N aluminium isopropoxide Chemical compound [Al+3].CC(C)[O-].CC(C)[O-].CC(C)[O-] SMZOGRDCAXLAAR-UHFFFAOYSA-N 0.000 description 1
• 229940024546 aluminum hydroxide gel Drugs 0.000 description 1
• SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 description 1
• 229940024606 amino acid Drugs 0.000 description 1
• 235000001014 amino acid Nutrition 0.000 description 1
• 150000001413 amino acids Chemical class 0.000 description 1
• 229940069428 antacid Drugs 0.000 description 1
• 239000003159 antacid agent Substances 0.000 description 1
• 230000001458 anti-acid effect Effects 0.000 description 1
• 230000000767 anti-ulcer Effects 0.000 description 1
• 239000003125 aqueous solvent Substances 0.000 description 1
• 230000003139 buffering effect Effects 0.000 description 1
• 239000007810 chemical reaction solvent Substances 0.000 description 1
• 150000001875 compounds Chemical class 0.000 description 1
• 238000011109 contamination Methods 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 239000002537 cosmetic Substances 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 229910001410 inorganic ion Inorganic materials 0.000 description 1
• 229940099459 n-acetylmethionine Drugs 0.000 description 1
• 239000002994 raw material Substances 0.000 description 1
• 150000003839 salts Chemical class 0.000 description 1
• 239000002351 wastewater Substances 0.000 description 1