JPS61194034A - 経鼻投与用粉末状組成物 - Google Patents
経鼻投与用粉末状組成物Info
- Publication number
- JPS61194034A JPS61194034A JP60034581A JP3458185A JPS61194034A JP S61194034 A JPS61194034 A JP S61194034A JP 60034581 A JP60034581 A JP 60034581A JP 3458185 A JP3458185 A JP 3458185A JP S61194034 A JPS61194034 A JP S61194034A
- Authority
- JP
- Japan
- Prior art keywords
- cellulose
- alkyl ether
- nasal administration
- lower alkyl
- powder composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP60034581A JPS61194034A (ja) | 1985-02-25 | 1985-02-25 | 経鼻投与用粉末状組成物 |
DE8686301317T DE3676515D1 (de) | 1985-02-25 | 1986-02-24 | Intranasal applizierbare pharmazeutische puder. |
EP86301317A EP0193372B1 (en) | 1985-02-25 | 1986-02-24 | Intranasally applicable powdery pharmaceutical composition |
MYPI87000102A MY102422A (en) | 1985-02-25 | 1987-02-05 | Intranasally applicable powdery pharmaceutical composition. |
US07/132,447 US4985242A (en) | 1985-02-25 | 1987-12-14 | Intranasally applicable powdery pharmaceutical composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP60034581A JPS61194034A (ja) | 1985-02-25 | 1985-02-25 | 経鼻投与用粉末状組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS61194034A true JPS61194034A (ja) | 1986-08-28 |
JPH0430926B2 JPH0430926B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-05-25 |
Family
ID=12418284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP60034581A Granted JPS61194034A (ja) | 1985-02-25 | 1985-02-25 | 経鼻投与用粉末状組成物 |
Country Status (5)
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5989619A (ja) * | 1982-10-05 | 1984-05-23 | サンド・アクチエンゲゼルシヤフト | カルシトニン組成物およびその用途 |
JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3169095A (en) * | 1962-10-30 | 1965-02-09 | Rexall Drug Chemical | Self-propelling powder-dispensing compositions |
CA986441A (en) * | 1971-10-22 | 1976-03-30 | Aslam Khwaja | Enzyme treatment |
JPS6034925B2 (ja) * | 1979-07-31 | 1985-08-12 | 帝人株式会社 | 持続性鼻腔用製剤およびその製造法 |
JPS58189118A (ja) * | 1982-04-30 | 1983-11-04 | Takeda Chem Ind Ltd | 経鼻投与製剤 |
GB2127689B (en) * | 1982-10-05 | 1986-07-09 | Sandoz Ltd | Calcitonin inhalation compositions |
IL70489A0 (en) * | 1982-12-29 | 1984-03-30 | Armour Pharma | Pharmaceutical compositions containing calcitonin |
-
1985
- 1985-02-25 JP JP60034581A patent/JPS61194034A/ja active Granted
-
1986
- 1986-02-24 DE DE8686301317T patent/DE3676515D1/de not_active Expired - Lifetime
- 1986-02-24 EP EP86301317A patent/EP0193372B1/en not_active Expired - Lifetime
-
1987
- 1987-02-05 MY MYPI87000102A patent/MY102422A/en unknown
- 1987-12-14 US US07/132,447 patent/US4985242A/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5989619A (ja) * | 1982-10-05 | 1984-05-23 | サンド・アクチエンゲゼルシヤフト | カルシトニン組成物およびその用途 |
JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62178524A (ja) * | 1986-01-23 | 1987-08-05 | ベ−リングヴエルケ・アクチエンゲゼルシヤフト | 鼻内投与用製剤およびその製造法 |
JPH01132532A (ja) * | 1987-10-15 | 1989-05-25 | Syntex Usa Inc | 粉末形態ポリプペチド類の経鼻投与 |
JP2008515870A (ja) * | 2004-10-11 | 2008-05-15 | ナサリーズ・ピーピーエム・リミテッド | 経鼻投与用組成物 |
JP2007084508A (ja) * | 2005-09-26 | 2007-04-05 | Shiseido Co Ltd | 新規血管内皮増殖因子発現阻害剤 |
Also Published As
Publication number | Publication date |
---|---|
US4985242A (en) | 1991-01-15 |
MY102422A (en) | 1992-06-30 |
DE3676515D1 (de) | 1991-02-07 |
EP0193372A2 (en) | 1986-09-03 |
JPH0430926B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-05-25 |
EP0193372B1 (en) | 1990-12-27 |
EP0193372A3 (en) | 1987-07-01 |
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Legal Events
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EXPY | Cancellation because of completion of term |