JPS6089486A - ７‐オキソー１‐アザビシクロ〔３．２．０〕ヘプター２‐エン‐２‐カルボン酸誘導体，その製造法及び用途 - Google Patents

７‐オキソー１‐アザビシクロ〔３．２．０〕ヘプター２‐エン‐２‐カルボン酸誘導体，その製造法及び用途

Info

Publication number
JPS6089486A
JPS6089486A JP59199316A JP19931684A JPS6089486A JP S6089486 A JPS6089486 A JP S6089486A JP 59199316 A JP59199316 A JP 59199316A JP 19931684 A JP19931684 A JP 19931684A JP S6089486 A JPS6089486 A JP S6089486A
Authority
JP
Japan
Prior art keywords
group
compound
reaction
oxo
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59199316A
Other languages
English (en)
Japanese (ja)
Other versions
JPH053471B2 (enrdf_load_stackoverflow
Inventor
Koichi Yoshioka
吉岡　晃一
Norikazu Tamura
典一 田村
Hideaki Natsukari
夏苅　英昭
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to EP84111442A priority Critical patent/EP0137403A3/en
Priority to CA000464131A priority patent/CA1263117A/en
Priority to US06/655,454 priority patent/US4698339A/en
Publication of JPS6089486A publication Critical patent/JPS6089486A/ja
Publication of JPH053471B2 publication Critical patent/JPH053471B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP59199316A 1983-09-28 1984-09-21 ７‐オキソー１‐アザビシクロ〔３．２．０〕ヘプター２‐エン‐２‐カルボン酸誘導体，その製造法及び用途 Granted JPS6089486A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP84111442A EP0137403A3 (en) 1983-09-28 1984-09-26 Carbapenems, their production and use
CA000464131A CA1263117A (en) 1983-09-28 1984-09-27 Carbapenems, their production and use
US06/655,454 US4698339A (en) 1983-09-28 1984-09-28 Carbapenems, their production and use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
WO83/00319 1983-09-28
PCT/JP1983/000319 WO1985001502A1 (en) 1983-09-28 1983-09-28 7-oxo-1-azabicyclo ad3.2.0 bd hept-2-ene-2-carboxylic acid derivatives, process for their preparation, and their use

Publications (2)

Publication Number Publication Date
JPS6089486A true JPS6089486A (ja) 1985-05-20
JPH053471B2 JPH053471B2 (enrdf_load_stackoverflow) 1993-01-14

Family

ID=13790063

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59199316A Granted JPS6089486A (ja) 1983-09-28 1984-09-21 ７‐オキソー１‐アザビシクロ〔３．２．０〕ヘプター２‐エン‐２‐カルボン酸誘導体，その製造法及び用途

Country Status (2)

Country Link
JP (1) JPS6089486A (enrdf_load_stackoverflow)
WO (1) WO1985001502A1 (enrdf_load_stackoverflow)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA792161B (en) * 1978-05-06 1980-05-28 Beecham Group Ltd Alkylcarbopenems,their preparation,use in pharmaceutical compositions and intermediates
EP0005349A1 (en) * 1978-05-06 1979-11-14 Beecham Group Plc Alkylcarbapenems, their preparation, use in pharmaceutical compositions and intermediates
EP0037082B1 (en) * 1980-03-27 1985-03-20 Merck & Co. Inc. Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals

Also Published As

Publication number Publication date
WO1985001502A1 (en) 1985-04-11
JPH053471B2 (enrdf_load_stackoverflow) 1993-01-14

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