JPS60502207A - 腸溶フィルム−コ−チング組成物 - Google Patents
腸溶フィルム−コ−チング組成物Info
- Publication number
- JPS60502207A JPS60502207A JP59503482A JP50348284A JPS60502207A JP S60502207 A JPS60502207 A JP S60502207A JP 59503482 A JP59503482 A JP 59503482A JP 50348284 A JP50348284 A JP 50348284A JP S60502207 A JPS60502207 A JP S60502207A
- Authority
- JP
- Japan
- Prior art keywords
- parts
- weight
- enteric
- dry powder
- pvap
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims description 28
- 239000007888 film coating Substances 0.000 title description 6
- 238000009501 film coating Methods 0.000 title description 6
- 238000000576 coating method Methods 0.000 claims description 68
- 239000011248 coating agent Substances 0.000 claims description 65
- 239000000843 powder Substances 0.000 claims description 59
- 239000000725 suspension Substances 0.000 claims description 49
- 238000009505 enteric coating Methods 0.000 claims description 33
- 239000002702 enteric coating Substances 0.000 claims description 33
- 239000002245 particle Substances 0.000 claims description 33
- 239000000049 pigment Substances 0.000 claims description 31
- 229920002744 polyvinyl acetate phthalate Polymers 0.000 claims description 26
- LUJQXGBDWAGQHS-UHFFFAOYSA-N ethenyl acetate;phthalic acid Chemical compound CC(=O)OC=C.OC(=O)C1=CC=CC=C1C(O)=O LUJQXGBDWAGQHS-UHFFFAOYSA-N 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 229920000642 polymer Polymers 0.000 claims description 21
- 239000004014 plasticizer Substances 0.000 claims description 19
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 17
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 17
- 239000000908 ammonium hydroxide Substances 0.000 claims description 14
- 239000004615 ingredient Substances 0.000 claims description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 231100000252 nontoxic Toxicity 0.000 claims description 6
- 230000003000 nontoxic effect Effects 0.000 claims description 6
- 229910021485 fumed silica Inorganic materials 0.000 claims description 5
- 239000004408 titanium dioxide Substances 0.000 claims description 5
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- 239000000454 talc Substances 0.000 claims description 3
- 229910052623 talc Inorganic materials 0.000 claims description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- 235000012754 curcumin Nutrition 0.000 claims description 2
- 239000004148 curcumin Substances 0.000 claims description 2
- 229940109262 curcumin Drugs 0.000 claims description 2
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- -1 Tetsukakamono Chemical compound 0.000 claims 1
- 239000006231 channel black Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 229920002689 polyvinyl acetate Polymers 0.000 claims 1
- 239000011118 polyvinyl acetate Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 description 36
- 239000000243 solution Substances 0.000 description 18
- 239000007921 spray Substances 0.000 description 15
- 235000011114 ammonium hydroxide Nutrition 0.000 description 14
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 10
- 239000000661 sodium alginate Substances 0.000 description 10
- 235000010413 sodium alginate Nutrition 0.000 description 10
- 229940005550 sodium alginate Drugs 0.000 description 10
- 230000015572 biosynthetic process Effects 0.000 description 9
- 239000006185 dispersion Substances 0.000 description 9
- 238000005755 formation reaction Methods 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 8
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 7
- 230000002776 aggregation Effects 0.000 description 6
- 229940072056 alginate Drugs 0.000 description 6
- 235000010443 alginic acid Nutrition 0.000 description 6
- 229920000615 alginic acid Polymers 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 230000002496 gastric effect Effects 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 5
- 229960001138 acetylsalicylic acid Drugs 0.000 description 5
- 238000005054 agglomeration Methods 0.000 description 5
- 210000004051 gastric juice Anatomy 0.000 description 5
- 239000003960 organic solvent Substances 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 4
- 239000000375 suspending agent Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 210000000936 intestine Anatomy 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 229920000609 methyl cellulose Polymers 0.000 description 3
- 239000001923 methylcellulose Substances 0.000 description 3
- 235000010981 methylcellulose Nutrition 0.000 description 3
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 239000007900 aqueous suspension Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000008199 coating composition Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000002662 enteric coated tablet Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000008394 flocculating agent Substances 0.000 description 2
- 238000005189 flocculation Methods 0.000 description 2
- 230000016615 flocculation Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000011253 protective coating Substances 0.000 description 2
- 238000000197 pyrolysis Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 241001330002 Bambuseae Species 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- 101100130497 Drosophila melanogaster Mical gene Proteins 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 101100345589 Mus musculus Mical1 gene Proteins 0.000 description 1
- 229910017974 NH40H Inorganic materials 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002744 anti-aggregatory effect Effects 0.000 description 1
- 239000012914 anti-clumping agent Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical group O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000011363 dried mixture Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000010309 melting process Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940050929 polyethylene glycol 3350 Drugs 0.000 description 1
- 235000020004 porter Nutrition 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- DOKHEARVIDLSFF-UHFFFAOYSA-N prop-1-en-1-ol Chemical group CC=CO DOKHEARVIDLSFF-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Paints Or Removers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US533541 | 1983-09-19 | ||
| US06/533,541 US4556552A (en) | 1983-09-19 | 1983-09-19 | Enteric film-coating compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60502207A true JPS60502207A (ja) | 1985-12-19 |
| JPH0534333B2 JPH0534333B2 (cg-RX-API-DMAC7.html) | 1993-05-21 |
Family
ID=24126414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59503482A Granted JPS60502207A (ja) | 1983-09-19 | 1984-09-07 | 腸溶フィルム−コ−チング組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4556552A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0156852A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPS60502207A (cg-RX-API-DMAC7.html) |
| KR (1) | KR850700009A (cg-RX-API-DMAC7.html) |
| AU (1) | AU3397184A (cg-RX-API-DMAC7.html) |
| IT (1) | IT8448873A0 (cg-RX-API-DMAC7.html) |
| PH (1) | PH21092A (cg-RX-API-DMAC7.html) |
| WO (1) | WO1985001207A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4971791A (en) * | 1985-08-26 | 1990-11-20 | The Procter & Gamble Company | Taste masking compositions |
| US5843445A (en) * | 1987-06-24 | 1998-12-01 | Autoimmune, Inc. | Method of treating rheumatoid arthritis with type II collagen |
| US4857337A (en) * | 1988-05-24 | 1989-08-15 | American Home Products Corp. (Del) | Enteric coated aspirin tablets |
| BR9106114A (pt) | 1990-03-02 | 1993-03-09 | Autoimmune Inc | Metodo para tratar ou prevenir uma doenca auto-imune (ad) e formulacao farmaceutica |
| FR2660317B1 (fr) * | 1990-03-27 | 1994-01-14 | Seppic | Produit filmogene destine a l'enrobage des formes solides; son procede de fabrication et produits revetus de ce produit. |
| IL99699A (en) * | 1990-10-10 | 2002-04-21 | Autoimmune Inc | Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes |
| US5427614A (en) * | 1992-02-14 | 1995-06-27 | Warner-Lambert Company | Starch based formulations |
| US6224911B1 (en) * | 1993-03-16 | 2001-05-01 | Syntex (U.S.A.) Llc | Process for the preparation of enteric coated pharmaceutical dosage forms |
| US5436011A (en) * | 1993-04-16 | 1995-07-25 | Bristol-Myers Squibb Company | Solid pharmaceutical dosage form and a method for reducing abrasion |
| US5800831A (en) * | 1993-07-28 | 1998-09-01 | Pfizer Inc. | Psoriasis treatment with polymer film |
| US6113893A (en) * | 1993-07-28 | 2000-09-05 | Pfizer Inc. | Psoriasis treatment |
| CA2164344C (en) * | 1993-08-30 | 2004-06-29 | Stanley Lech | Tablet coating based on a melt-spun mixture of a saccharide and a polymer |
| DE69522921T2 (de) * | 1994-07-08 | 2002-04-11 | Astrazeneca Ab | Aus mehreren einzeleinheiten zusammengesetzte dosierungsform in tablettenform (i) |
| US5733575A (en) * | 1994-10-07 | 1998-03-31 | Bpsi Holdings, Inc. | Enteric film coating compositions, method of coating therewith, and coated forms |
| US6645943B1 (en) | 1994-10-25 | 2003-11-11 | Hybridon, Inc. | Method of down-regulating gene expression |
| US5591721A (en) * | 1994-10-25 | 1997-01-07 | Hybridon, Inc. | Method of down-regulating gene expression |
| US6608035B1 (en) | 1994-10-25 | 2003-08-19 | Hybridon, Inc. | Method of down-regulating gene expression |
| SE9500422D0 (sv) * | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
| US5683718A (en) * | 1995-04-04 | 1997-11-04 | Time-Cap Labs, Inc. | Enteric coated tablet with raised identification character and method of manufacture |
| US5856446A (en) * | 1995-07-07 | 1999-01-05 | Autoimmune Inc. | Method of treating rheumatoid arthritis with low dose type II collagen |
| US6624293B1 (en) | 1995-08-17 | 2003-09-23 | Hybridon, Inc. | Modified protein kinase A-specific oligonucleotides and methods of their use |
| US7074768B2 (en) | 1995-08-17 | 2006-07-11 | Idera Pharmaceuticals, Inc. | Modified protein kinase A-specific oligonucleotides and methods of their use |
| SE512835C2 (sv) * | 1996-01-08 | 2000-05-22 | Astrazeneca Ab | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
| SE9600071D0 (sv) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral formulation of two active ingredients I |
| SE9600072D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral formulation of two active ingredients II |
| SE9600070D0 (sv) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| US5807580A (en) * | 1996-10-30 | 1998-09-15 | Mcneil-Ppc, Inc. | Film coated tablet compositions having enhanced disintegration characteristics |
| US20070149472A1 (en) * | 1997-08-13 | 2007-06-28 | Mckay Robert | Antisense oligonucleotide compositions and methods for the modulation of jnk proteins |
| US6133246A (en) * | 1997-08-13 | 2000-10-17 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide compositions and methods for the modulation of JNK proteins |
| US5877309A (en) | 1997-08-13 | 1999-03-02 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotides against JNK |
| US6809193B2 (en) | 1997-08-13 | 2004-10-26 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide compositions and methods for the modulation of JNK proteins |
| JP2001514884A (ja) | 1997-08-19 | 2001-09-18 | ハイブリドン・インク | 新規なｈｉｖ特異的合成オリゴヌクレオチド及びその使用方法 |
| EP0901787B1 (en) * | 1997-09-10 | 2003-05-28 | Takeda Chemical Industries, Ltd. | Stabilized pharmaceutical composition |
| US6559158B1 (en) | 1997-11-03 | 2003-05-06 | Ur Labs, Inc. | Use of methylnaltrexone and related compounds to treat chronic opioid use side affects |
| US6274591B1 (en) * | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
| US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
| UA69413C2 (uk) | 1998-05-22 | 2004-09-15 | Брістол-Майерс Сквібб Компані | Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції |
| US7122207B2 (en) * | 1998-05-22 | 2006-10-17 | Bristol-Myers Squibb Company | High drug load acid labile pharmaceutical composition |
| UA73092C2 (uk) | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| US6300320B1 (en) | 1999-01-05 | 2001-10-09 | Isis Pharmaceuticals, Inc. | Modulation of c-jun using inhibitors of protein kinase C |
| US6432448B1 (en) | 1999-02-08 | 2002-08-13 | Fmc Corporation | Edible coating composition |
| US6723342B1 (en) | 1999-02-08 | 2004-04-20 | Fmc Corporation | Edible coating composition |
| US6878749B2 (en) | 1999-09-17 | 2005-04-12 | Novartis Ag | Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes |
| US6559188B1 (en) | 1999-09-17 | 2003-05-06 | Novartis Ag | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes |
| US6812205B2 (en) | 2000-03-15 | 2004-11-02 | The Brigham & Women's Hospital, Inc. | Suppression of vascular disorders by mucosal administration of heat shock protein peptides |
| US7261896B2 (en) | 2000-05-24 | 2007-08-28 | United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health | Methods for preventing strokes by inducing tolerance to e-selectin |
| WO2002040039A2 (en) | 2000-11-20 | 2002-05-23 | Dow Global Technologies Inc. | In vivo use of water absorbent polymers |
| US6932861B2 (en) | 2000-11-28 | 2005-08-23 | Fmc Corporation | Edible PGA coating composition |
| TR200300731T2 (tr) | 2000-11-28 | 2004-08-23 | Fmc Corporation | Yenebilir PGA kaplama bileşimi |
| ATE446751T1 (de) * | 2001-06-05 | 2009-11-15 | Univ Chicago | Verwendung von methylnaltrexon zur behandlung von immunsuppression |
| GB0203296D0 (en) * | 2002-02-12 | 2002-03-27 | Glaxo Group Ltd | Novel composition |
| ATE425744T1 (de) * | 2002-04-29 | 2009-04-15 | Supernus Pharmaceuticals Inc | Pharmazeutische formulierungen mit verbesserter bioverfugbarkeit |
| NZ537885A (en) * | 2002-07-29 | 2007-11-30 | Glaxo Group Ltd | Sustained release formulations comprising a lamotrigine core and an outer coating |
| US8637512B2 (en) * | 2002-07-29 | 2014-01-28 | Glaxo Group Limited | Formulations and method of treatment |
| ES2528669T3 (es) | 2003-04-08 | 2015-02-11 | Progenics Pharmaceuticals, Inc. | Formulaciones farmacéuticas que contienen metilnaltrexona |
| US20040202755A1 (en) * | 2003-04-08 | 2004-10-14 | Myers Gale D. | Speckled confection pieces |
| JP2006522817A (ja) * | 2003-04-08 | 2006-10-05 | プロジェニックス ファーマシューティカルズ，インコーポレーテッド | 過敏性腸症候群を処置するための末梢オピオイドアンタゴニスト、特にメチルナルトレキソンの使用 |
| BRPI0409125A (pt) * | 2003-04-08 | 2006-03-28 | Progenics Pharm Inc | terapia de combinação para constipação compreendendo um laxativo e um antagonista de opióide periférico |
| US7541344B2 (en) | 2003-06-03 | 2009-06-02 | Eli Lilly And Company | Modulation of survivin expression |
| WO2005046663A1 (en) | 2003-11-04 | 2005-05-26 | Shire Laboratories, Inc. | Compositions of quaternary ammonium containing bioavailability enhancers |
| JP5610663B2 (ja) | 2003-11-04 | 2014-10-22 | スパーナス ファーマシューティカルズ インコーポレイテッド | トロスピウムの１日１回剤形 |
| WO2005074908A1 (en) | 2004-02-06 | 2005-08-18 | Borody, Thomas, Julius | Use of aminosalicylates in diarrhoea-predominent irritable bowel syndrome |
| AU2005327506B2 (en) | 2004-10-20 | 2010-07-08 | Antisense Therapeutics Ltd | Antisense modulation of integrin alpha4 expression |
| US8691772B2 (en) | 2005-01-04 | 2014-04-08 | Yeda Research And Development Co. Ltd. | HSP60, HSP60 peptides and T cell vaccines for immunomodulation |
| JP2008528497A (ja) * | 2005-01-20 | 2008-07-31 | プロジェニックス ファーマシューティカルズ，インコーポレーテッド | メチルナルトレキソンおよび関連化合物の術後性胃腸障害のための使用 |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| CA2600350C (en) | 2005-03-07 | 2015-02-10 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| WO2006109312A2 (en) * | 2005-04-15 | 2006-10-19 | Vascular Biogenics Ltd. | Compositions containing beta 2-glycoprotein i-derived peptides for the prevention and/or treatment of vascular disease |
| AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
| US20080194611A1 (en) * | 2005-06-03 | 2008-08-14 | Alverdy John C | Modulation of Cell Barrier Dysfunction |
| US20070098790A1 (en) * | 2005-10-31 | 2007-05-03 | David Jiang | Nutritional supplement for the enhancement of the health of the liver |
| TWI489984B (zh) | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| US7731604B2 (en) * | 2006-10-31 | 2010-06-08 | Taylor Made Golf Company, Inc. | Golf club iron head |
| WO2008080807A1 (en) * | 2007-01-05 | 2008-07-10 | Ciba Holding Inc. | Co-milling organic pigments with fumed silica |
| WO2008121352A2 (en) | 2007-03-29 | 2008-10-09 | Progenics Pharmaceuticals, Inc. | Crystal forms of (r) -n-methylnaltrexone bromide and uses thereof |
| US8338446B2 (en) | 2007-03-29 | 2012-12-25 | Wyeth Llc | Peripheral opioid receptor antagonists and uses thereof |
| TWI553009B (zh) | 2007-03-29 | 2016-10-11 | 普吉尼製藥公司 | 末梢性類鴉片受體拮抗劑及其用途 |
| US9029383B2 (en) * | 2007-05-11 | 2015-05-12 | The Trustees Of The University Of Pennsylvania | Methods of treatment of skin ulcers |
| KR101461659B1 (ko) | 2007-05-11 | 2014-11-17 | 토마스 제퍼슨 유니버시티 | 신경변성 질환 및 장애의 치료 및 예방 방법 |
| JP2011504171A (ja) * | 2007-11-13 | 2011-02-03 | ハーキュリーズ・インコーポレーテッド | 栄養補助食品および医薬品の剤形のための水分散性腸溶性コーティング配合物 |
| HUE041715T2 (hu) * | 2007-12-21 | 2019-05-28 | Dr Willmar Schwabe Gmbh & Co Kg | Ginkgo biloba levél-kivonat alkalmazása |
| EP2240489A1 (en) | 2008-02-06 | 2010-10-20 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone |
| WO2009117669A2 (en) | 2008-03-21 | 2009-09-24 | The University Of Chicago | Treatment with opioid antagonists and mtor inhibitors |
| US20110250278A1 (en) | 2008-07-01 | 2011-10-13 | University Of Chicago | Particles containing an opioid receptor antagonist and methods of use |
| US20100034959A1 (en) * | 2008-08-07 | 2010-02-11 | Vector Corporation | High solids, high molecular weight polymer coating |
| CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
| JP2013545792A (ja) | 2010-12-17 | 2013-12-26 | グラクソ グループ リミテッド | 眼疾患の処置および防止方法 |
| WO2013045352A1 (de) | 2011-09-30 | 2013-04-04 | Basf Se | Verfahren zur herstellung von festen pigmenthaltigen filmüberzugsmitteln in form von granulaten auf basis von magensaftresistenten filmbildnern für pharmazeutische dosierungsformen |
| US9173884B2 (en) | 2011-11-30 | 2015-11-03 | Trustees Of Boston College | Inhibitors of phosphodiesterase 11 (PDE11) |
| CN104203231A (zh) | 2011-12-01 | 2014-12-10 | 葛兰素集团有限公司 | 治疗和预防眼疾病的方法 |
| US8277842B1 (en) * | 2012-01-20 | 2012-10-02 | Dart Neuroscience (Cayman) Ltd. | Enteric-coated HT-2157 compositions and methods of their use |
| CN105378083B (zh) | 2013-03-27 | 2018-09-21 | 伊萨纳治疗有限公司 | 修饰的TGF-β寡核苷酸 |
| JP6686013B2 (ja) | 2014-10-17 | 2020-04-22 | サリックス ファーマスーティカルズ，インコーポレーテッド | 腫瘍の進行を減弱させるためのメチルナルトレキソンの使用 |
| EP3211081A1 (en) | 2016-02-26 | 2017-08-30 | Secarna Pharmaceuticals GmbH & Co. KG | Novel approach for treating inflammatory disorders |
| US10647987B2 (en) | 2016-02-26 | 2020-05-12 | Secama Pharmaceuticals GmbH & Co KG | Approach for treating inflammatory disorders |
| US10883108B2 (en) | 2016-03-31 | 2021-01-05 | The Schepens Eye Research Institute, Inc. | Endomucin inhibitor as an anti-angiogenic agent |
| WO2018065589A1 (en) | 2016-10-07 | 2018-04-12 | Secarna Pharmaceuticals Gmbh & Co. Kg | Novel approach for treating cancer |
| US11229662B2 (en) | 2016-11-15 | 2022-01-25 | The Schepens Eye Research Institute, Inc. | Compositions and methods for the treatment of aberrant angiogenesis |
| WO2019070917A1 (en) | 2017-10-03 | 2019-04-11 | The Schepens Eye Research Institute, Inc. | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE DEGENERATION OF RETINAL PIGMENT EPITHELIUM AND METHODS USING SAME |
| CA3082643A1 (en) | 2017-11-14 | 2019-05-23 | The Schepens Eye Research Institute, Inc. | Runx1 inhibition for treatment of proliferative vitreoretinopathy and conditions associated with epithelial to mesenchymal transition |
| JP2022531415A (ja) | 2019-05-03 | 2022-07-06 | セカルナ・ファーマシューティカルズ・ゲーエムベーハー・ウント・コ・カーゲー | 腫瘍の処置に使用するためのｐｄ－ｌ１アンチセンスオリゴヌクレオチド |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52117415A (en) * | 1976-03-26 | 1977-10-01 | Basf Ag | Coating agent for molded medicine |
| JPS5699424A (en) * | 1979-11-29 | 1981-08-10 | Colorcon | Dried edible film coating composition* method and form of film |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2455790A (en) * | 1945-06-09 | 1948-12-07 | Eastman Kodak Co | Enteric coatings |
| CH283585A (de) * | 1950-03-15 | 1952-06-15 | Hoffmann La Roche | Zur Herstellung von Tablettenüberzügen geeignetes Gemisch. |
| US2897122A (en) * | 1956-10-04 | 1959-07-28 | Frosst & Co Charles E | Enteric coated product |
| US2993837A (en) * | 1959-07-13 | 1961-07-25 | Frosst & Co Charles E | Enteric coated tablets |
| US3325365A (en) * | 1963-04-02 | 1967-06-13 | Ciba Geigy Corp | Enteric composition for tablet compression coating |
| US3449489A (en) * | 1965-10-21 | 1969-06-10 | William E Gaunt | Pharmaceutical compositions and their preparation |
| JPS517116A (en) * | 1974-06-11 | 1976-01-21 | Shinetsu Chemical Co | Choyoseihifukuyakuzaino seizohoho |
| DE2966893D1 (en) * | 1978-10-02 | 1984-05-17 | Purdue Research Foundation | Foods and pharmaceutical coating composition, method of preparation and products so coated |
| US4543370A (en) * | 1979-11-29 | 1985-09-24 | Colorcon, Inc. | Dry edible film coating composition, method and coating form |
-
1983
- 1983-09-19 US US06/533,541 patent/US4556552A/en not_active Expired - Lifetime
-
1984
- 1984-09-07 WO PCT/US1984/001424 patent/WO1985001207A1/en not_active Ceased
- 1984-09-07 KR KR1019850700046A patent/KR850700009A/ko not_active Withdrawn
- 1984-09-07 JP JP59503482A patent/JPS60502207A/ja active Granted
- 1984-09-07 EP EP84903508A patent/EP0156852A1/en not_active Withdrawn
- 1984-09-07 AU AU33971/84A patent/AU3397184A/en not_active Abandoned
- 1984-09-17 PH PH31222A patent/PH21092A/en unknown
- 1984-09-18 IT IT8448873A patent/IT8448873A0/it unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52117415A (en) * | 1976-03-26 | 1977-10-01 | Basf Ag | Coating agent for molded medicine |
| JPS5699424A (en) * | 1979-11-29 | 1981-08-10 | Colorcon | Dried edible film coating composition* method and form of film |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0156852A1 (en) | 1985-10-09 |
| AU3397184A (en) | 1985-04-11 |
| IT8448873A0 (it) | 1984-09-18 |
| PH21092A (en) | 1987-07-16 |
| KR850700009A (ko) | 1985-10-21 |
| JPH0534333B2 (cg-RX-API-DMAC7.html) | 1993-05-21 |
| WO1985001207A1 (en) | 1985-03-28 |
| US4556552A (en) | 1985-12-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS60502207A (ja) | 腸溶フィルム−コ−チング組成物 | |
| US4704295A (en) | Enteric film-coating compositions | |
| US5733575A (en) | Enteric film coating compositions, method of coating therewith, and coated forms | |
| US5393333A (en) | Film-forming product for coating solid forms, process for its manufacture and products coated with this film-forming product | |
| US4060598A (en) | Tablets coated with aqueous resin dispersions | |
| US3935326A (en) | Process for coating tablets with aqueous resin dispersions | |
| US6420473B1 (en) | Acrylic enteric coating compositions | |
| US5324351A (en) | Aqueous dispersions of zein and preparation thereof | |
| CA2474934C (en) | Rapidly soluble film covering based on polyvinylalcohol-polyether graft copolymers combined with components containing hydroxyl, amide, or ester functions | |
| WO1996010995A9 (en) | Enteric film coating compositions, method of coating therewith, and coated forms | |
| JPS59193831A (ja) | 腸溶性製剤の製造法 | |
| JPS5855125B2 (ja) | 固形薬剤用腸溶性コ−テイング剤組成物 | |
| CN101137354A (zh) | 聚合物混合物在生产经包衣的药物制剂中的应用和具有混合聚合物包衣的药物制剂 | |
| EP0781549B1 (en) | A method of manufacturing a solid preparation coated with a non-solvent coating | |
| AU782828B2 (en) | Acrylic enteric coating compositions | |
| JP2960482B2 (ja) | 固体医薬品形状物用の被膜形成性水性被覆剤、この製法及び医薬品形状物の被覆法 | |
| JP3417772B2 (ja) | 無溶媒でコーティングされた固形製剤及びその後処理方法 | |
| JPS58157726A (ja) | 固形薬剤用腸溶性コ−テイング剤組成物 |