JPS60224499A - 安定なウリカ−ゼ製剤 - Google Patents
安定なウリカ−ゼ製剤Info
- Publication number
- JPS60224499A JPS60224499A JP8263084A JP8263084A JPS60224499A JP S60224499 A JPS60224499 A JP S60224499A JP 8263084 A JP8263084 A JP 8263084A JP 8263084 A JP8263084 A JP 8263084A JP S60224499 A JPS60224499 A JP S60224499A
- Authority
- JP
- Japan
- Prior art keywords
- uricase
- solution
- pharmaceutical preparation
- serum albumin
- basic amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010092464 Urate Oxidase Proteins 0.000 title claims abstract description 32
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 3
- 108010071390 Serum Albumin Proteins 0.000 claims abstract description 8
- 102000007562 Serum Albumin Human genes 0.000 claims abstract description 8
- 150000001413 amino acids Chemical class 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims description 11
- 239000002736 nonionic surfactant Substances 0.000 claims description 7
- 239000000243 solution Substances 0.000 abstract description 17
- 239000003381 stabilizer Substances 0.000 abstract description 12
- 238000004108 freeze drying Methods 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 3
- 239000004094 surface-active agent Substances 0.000 abstract description 3
- 239000007853 buffer solution Substances 0.000 abstract description 2
- 238000003745 diagnosis Methods 0.000 abstract description 2
- 239000011259 mixed solution Substances 0.000 abstract description 2
- 238000001694 spray drying Methods 0.000 abstract description 2
- 108090000790 Enzymes Proteins 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 7
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 4
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- -1 polyoxyethylene Polymers 0.000 description 4
- 229940116269 uric acid Drugs 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000005515 coenzyme Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241000124033 Salix Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- GGSUCNLOZRCGPQ-UHFFFAOYSA-N diethylaniline Chemical compound CCN(CC)C1=CC=CC=C1 GGSUCNLOZRCGPQ-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8263084A JPS60224499A (ja) | 1984-04-23 | 1984-04-23 | 安定なウリカ−ゼ製剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8263084A JPS60224499A (ja) | 1984-04-23 | 1984-04-23 | 安定なウリカ−ゼ製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60224499A true JPS60224499A (ja) | 1985-11-08 |
| JPH0243471B2 JPH0243471B2 (enrdf_load_stackoverflow) | 1990-09-28 |
Family
ID=13779763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8263084A Granted JPS60224499A (ja) | 1984-04-23 | 1984-04-23 | 安定なウリカ−ゼ製剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60224499A (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03180181A (ja) * | 1986-08-22 | 1991-08-06 | Cetus Corp | 熱安定性核酸ポリメラーゼ組成物 |
| EP0742013A1 (fr) * | 1995-05-11 | 1996-11-13 | Sanofi | Composition liquide stable contenant de l'urate oxydase et composition lyophilisée pour sa préparation |
| WO1999055850A1 (fr) * | 1998-04-24 | 1999-11-04 | International Reagents Corporation | Methode de stabilisation d'enzymes et compositions enzymatiques |
| JP2003000236A (ja) * | 2001-06-18 | 2003-01-07 | Toyobo Co Ltd | エステラーゼの安定化方法 |
-
1984
- 1984-04-23 JP JP8263084A patent/JPS60224499A/ja active Granted
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03180181A (ja) * | 1986-08-22 | 1991-08-06 | Cetus Corp | 熱安定性核酸ポリメラーゼ組成物 |
| EP0742013A1 (fr) * | 1995-05-11 | 1996-11-13 | Sanofi | Composition liquide stable contenant de l'urate oxydase et composition lyophilisée pour sa préparation |
| FR2733914A1 (fr) * | 1995-05-11 | 1996-11-15 | Sanofi Sa | Composition de liquide stable contenant de l'urate oxydase et composition lyophilisee pour sa preparation |
| CN1090972C (zh) * | 1995-05-11 | 2002-09-18 | 赛诺菲-圣德拉堡股份有限公司 | 含有尿酸氧化酶的稳定液体组合物及用于制备该液体组合物的冻干组合物 |
| WO1999055850A1 (fr) * | 1998-04-24 | 1999-11-04 | International Reagents Corporation | Methode de stabilisation d'enzymes et compositions enzymatiques |
| JP2003000236A (ja) * | 2001-06-18 | 2003-01-07 | Toyobo Co Ltd | エステラーゼの安定化方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0243471B2 (enrdf_load_stackoverflow) | 1990-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |