JPS595188A - １０−ヒドロキシカンプトテシンの製造法 - Google Patents

１０−ヒドロキシカンプトテシンの製造法

Info

Publication number
JPS595188A
JPS595188A JP11159082A JP11159082A JPS595188A JP S595188 A JPS595188 A JP S595188A JP 11159082 A JP11159082 A JP 11159082A JP 11159082 A JP11159082 A JP 11159082A JP S595188 A JPS595188 A JP S595188A
Authority
JP
Japan
Prior art keywords
hydroxycamptothecin
camptothecin
amendment
room temperature
acetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11159082A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6232749B2 (enrdf_load_stackoverflow
Inventor
Sada Miyasaka
宮坂　貞
Seigo Sawada
誠吾 沢田
Kenichiro Nogata
野方　健一郎
Masahiko Mutai
務台　方彦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yakult Honsha Co Ltd
Original Assignee
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Co Ltd filed Critical Yakult Honsha Co Ltd
Priority to JP11159082A priority Critical patent/JPS595188A/ja
Publication of JPS595188A publication Critical patent/JPS595188A/ja
Publication of JPS6232749B2 publication Critical patent/JPS6232749B2/ja
Priority to BR1100882-2A priority patent/BR1100882A/pt
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP11159082A 1982-06-30 1982-06-30 １０−ヒドロキシカンプトテシンの製造法 Granted JPS595188A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP11159082A JPS595188A (ja) 1982-06-30 1982-06-30 １０−ヒドロキシカンプトテシンの製造法
BR1100882-2A BR1100882A (pt) 1982-06-30 1997-05-14 Processo para a preparação de 10-hidroxicamptotecina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11159082A JPS595188A (ja) 1982-06-30 1982-06-30 １０−ヒドロキシカンプトテシンの製造法

Publications (2)

Publication Number Publication Date
JPS595188A true JPS595188A (ja) 1984-01-12
JPS6232749B2 JPS6232749B2 (enrdf_load_stackoverflow) 1987-07-16

Family

ID=14565217

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11159082A Granted JPS595188A (ja) 1982-06-30 1982-06-30 １０−ヒドロキシカンプトテシンの製造法

Country Status (1)

Country Link
JP (1) JPS595188A (enrdf_load_stackoverflow)

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62195384A (ja) * 1986-02-24 1987-08-28 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5049668A (en) * 1989-09-15 1991-09-17 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin analogs
US5053512A (en) * 1987-04-14 1991-10-01 Research Triangle Institute Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
WO1992005785A1 (en) * 1990-09-28 1992-04-16 Smithkline Beecham Corporation Water soluble camptothecin analogues, processes and methods
US5106742A (en) * 1987-03-31 1992-04-21 Wall Monroe E Camptothecin analogs as potent inhibitors of topoisomerase I
US5122606A (en) * 1987-04-14 1992-06-16 Research Triangle Institute 10,11-methylenedioxy camptothecins
US5122526A (en) * 1987-03-31 1992-06-16 Research Triangle Institute Camptothecin and analogs thereof and pharmaceutical compositions and method using them
US5180722A (en) * 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US5225404A (en) * 1989-11-06 1993-07-06 New York University Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
US5227380A (en) * 1987-03-31 1993-07-13 Research Triangle Institute Pharmaceutical compositions and methods employing camptothecins
US5340817A (en) * 1987-04-14 1994-08-23 Research Triangle Institute Method of treating tumors with anti-tumor effective camptothecin compounds
US5364858A (en) * 1987-03-31 1994-11-15 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5447936A (en) * 1993-12-22 1995-09-05 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
US5468754A (en) * 1994-04-19 1995-11-21 Bionumerik Pharmaceuticals, Inc. 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US5646159A (en) * 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
US5883255A (en) * 1990-10-31 1999-03-16 Smithkline Beecham Corporation Substituted indolizino 1,2-b!quinolinones
US5932588A (en) * 1995-11-22 1999-08-03 Research Triangle Institute Camptothecin compounds with combined topoisomerase I inhibition and DNA alkylation properties
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US6486320B2 (en) 2000-09-15 2002-11-26 Aventis Pharma S.A. Preparation of camptothecin and of its derivatives
US6562834B2 (en) 2000-10-27 2003-05-13 Aventis Pharma S. A. Combination comprising camptothecin and a stilbene derivative for the treatment of cancer
US6664242B2 (en) 2000-02-28 2003-12-16 Aventis Pharma S.A. Composition and method comprising CPT-11 and a pyrimidine derivative for the treatment of cancer
WO2004100897A2 (en) 2003-05-12 2004-11-25 Scinopharm Taiwan, Ltd. Process for the preparation of 7-alkyl-10-hydroxy-20(s)-camptothecin
US6872829B2 (en) * 2002-12-16 2005-03-29 Council Of Scientific And Industrial Research Process for the direct preparation of 5-alkoxy and 5-acyloxy analogues of camptothecins or mappicene ketones
US6960596B2 (en) 2000-03-17 2005-11-01 Aventis Pharma S.A. Composition comprising camptothecin or a comptothecin derivative and a platin derivative for the treatment of cancer
WO2005117881A1 (en) * 2004-06-04 2005-12-15 Chatham Biotec Ltd. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
JP2007517778A (ja) * 2003-12-16 2007-07-05 プリヴァ−ラケマ，エー．エス． ７−エチル−１０−ヒドロキシカンプトテシンの製造方法
CZ298934B6 (cs) * 2003-08-26 2008-03-12 Pliva- Lachema A.S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
KR20110010767A (ko) 2008-05-29 2011-02-07 메루샹가부시키가이샤 캠토테신 유도체의 제조 방법

Cited By (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62195384A (ja) * 1986-02-24 1987-08-28 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US5122526A (en) * 1987-03-31 1992-06-16 Research Triangle Institute Camptothecin and analogs thereof and pharmaceutical compositions and method using them
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5364858A (en) * 1987-03-31 1994-11-15 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5227380A (en) * 1987-03-31 1993-07-13 Research Triangle Institute Pharmaceutical compositions and methods employing camptothecins
US5106742A (en) * 1987-03-31 1992-04-21 Wall Monroe E Camptothecin analogs as potent inhibitors of topoisomerase I
US5180722A (en) * 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US5122606A (en) * 1987-04-14 1992-06-16 Research Triangle Institute 10,11-methylenedioxy camptothecins
US5340817A (en) * 1987-04-14 1994-08-23 Research Triangle Institute Method of treating tumors with anti-tumor effective camptothecin compounds
US5053512A (en) * 1987-04-14 1991-10-01 Research Triangle Institute Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US5049668A (en) * 1989-09-15 1991-09-17 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin analogs
US5652244A (en) * 1989-11-06 1997-07-29 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US5225404A (en) * 1989-11-06 1993-07-06 New York University Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
US6624170B2 (en) 1989-11-06 2003-09-23 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble S-Camptothecin of the closed lactone ring form and derivatives thereof
US6342506B1 (en) 1989-11-06 2002-01-29 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US6166029A (en) * 1989-11-06 2000-12-26 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5889017A (en) * 1989-11-06 1999-03-30 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US5734056A (en) * 1990-09-28 1998-03-31 Smithkline Beecham Corporation Process for the preparation of certain 9-substituted camptothecins
JP2848958B2 (ja) * 1990-09-28 1999-01-20 スミスクライン・ビーチャム・コーポレイション 水溶性カンプトテシン類似体、方法および手段
WO1992005785A1 (en) * 1990-09-28 1992-04-16 Smithkline Beecham Corporation Water soluble camptothecin analogues, processes and methods
US5883255A (en) * 1990-10-31 1999-03-16 Smithkline Beecham Corporation Substituted indolizino 1,2-b!quinolinones
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US5447936A (en) * 1993-12-22 1995-09-05 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
US5633260A (en) * 1994-04-19 1997-05-27 Bionumerik Pharmaceuticals, Inc. 11,7 Substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
US5468754A (en) * 1994-04-19 1995-11-21 Bionumerik Pharmaceuticals, Inc. 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof
US5916896A (en) * 1994-07-20 1999-06-29 Research Triange Institute Water-soluble esters of camptothecin compounds
US5646159A (en) * 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
US6040313A (en) * 1994-07-20 2000-03-21 Research Triangle Institute Water-soluble esters of camptothecin compounds
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds
US5932588A (en) * 1995-11-22 1999-08-03 Research Triangle Institute Camptothecin compounds with combined topoisomerase I inhibition and DNA alkylation properties
US6664242B2 (en) 2000-02-28 2003-12-16 Aventis Pharma S.A. Composition and method comprising CPT-11 and a pyrimidine derivative for the treatment of cancer
US6960596B2 (en) 2000-03-17 2005-11-01 Aventis Pharma S.A. Composition comprising camptothecin or a comptothecin derivative and a platin derivative for the treatment of cancer
US6486320B2 (en) 2000-09-15 2002-11-26 Aventis Pharma S.A. Preparation of camptothecin and of its derivatives
US6562834B2 (en) 2000-10-27 2003-05-13 Aventis Pharma S. A. Combination comprising camptothecin and a stilbene derivative for the treatment of cancer
US6872829B2 (en) * 2002-12-16 2005-03-29 Council Of Scientific And Industrial Research Process for the direct preparation of 5-alkoxy and 5-acyloxy analogues of camptothecins or mappicene ketones
WO2004100897A2 (en) 2003-05-12 2004-11-25 Scinopharm Taiwan, Ltd. Process for the preparation of 7-alkyl-10-hydroxy-20(s)-camptothecin
CZ298934B6 (cs) * 2003-08-26 2008-03-12 Pliva- Lachema A.S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
JP2007517778A (ja) * 2003-12-16 2007-07-05 プリヴァ−ラケマ，エー．エス． ７−エチル−１０−ヒドロキシカンプトテシンの製造方法
WO2005117881A1 (en) * 2004-06-04 2005-12-15 Chatham Biotec Ltd. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
KR20110010767A (ko) 2008-05-29 2011-02-07 메루샹가부시키가이샤 캠토테신 유도체의 제조 방법
US8299251B2 (en) 2008-05-29 2012-10-30 Sichuan Xieli Pharmaceutical Co., Ltd. Method for producing camptothecin derivatives

Also Published As

Publication number Publication date
JPS6232749B2 (enrdf_load_stackoverflow) 1987-07-16

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