JPS59159795A - 微生物変換による抱合型ウルソデオキシコ−ル酸の製造方法 - Google Patents

微生物変換による抱合型ウルソデオキシコ−ル酸の製造方法

Info

Publication number
JPS59159795A
JPS59159795A JP58035554A JP3555483A JPS59159795A JP S59159795 A JPS59159795 A JP S59159795A JP 58035554 A JP58035554 A JP 58035554A JP 3555483 A JP3555483 A JP 3555483A JP S59159795 A JPS59159795 A JP S59159795A
Authority
JP
Japan
Prior art keywords
acid
type
ursodeoxycholic acid
mold
conjugated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58035554A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0529438B2 (enrdf_load_html_response
Inventor
Haruji Sawada
沢田　治司
Masaaki Watanuki
綿貫　雅章
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yakult Honsha Co Ltd
Original Assignee
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Co Ltd filed Critical Yakult Honsha Co Ltd
Priority to JP58035554A priority Critical patent/JPS59159795A/ja
Priority to US06/583,426 priority patent/US4604353A/en
Priority to AT84301378T priority patent/ATE27464T1/de
Priority to EP84301378A priority patent/EP0119040B1/en
Priority to DE8484301378T priority patent/DE3463946D1/de
Publication of JPS59159795A publication Critical patent/JPS59159795A/ja
Publication of JPH0529438B2 publication Critical patent/JPH0529438B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
JP58035554A 1983-03-04 1983-03-04 微生物変換による抱合型ウルソデオキシコ−ル酸の製造方法 Granted JPS59159795A (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP58035554A JPS59159795A (ja) 1983-03-04 1983-03-04 微生物変換による抱合型ウルソデオキシコ−ル酸の製造方法
US06/583,426 US4604353A (en) 1983-03-04 1984-02-24 Method for producing conjugated ursodeoxycholic acids by means of microbial transformation
AT84301378T ATE27464T1 (de) 1983-03-04 1984-03-02 Herstellung von ursodeoxycholsaeurekonjugaten.
EP84301378A EP0119040B1 (en) 1983-03-04 1984-03-02 Producing conjugated ursodeoxycholic acids
DE8484301378T DE3463946D1 (en) 1983-03-04 1984-03-02 Producing conjugated ursodeoxycholic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58035554A JPS59159795A (ja) 1983-03-04 1983-03-04 微生物変換による抱合型ウルソデオキシコ−ル酸の製造方法

Publications (2)

Publication Number Publication Date
JPS59159795A true JPS59159795A (ja) 1984-09-10
JPH0529438B2 JPH0529438B2 (enrdf_load_html_response) 1993-04-30

Family

ID=12444939

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58035554A Granted JPS59159795A (ja) 1983-03-04 1983-03-04 微生物変換による抱合型ウルソデオキシコ−ル酸の製造方法

Country Status (5)

Country Link
US (1) US4604353A (enrdf_load_html_response)
EP (1) EP0119040B1 (enrdf_load_html_response)
JP (1) JPS59159795A (enrdf_load_html_response)
AT (1) ATE27464T1 (enrdf_load_html_response)
DE (1) DE3463946D1 (enrdf_load_html_response)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH021193A (ja) * 1988-03-03 1990-01-05 Fanuc Ltd レーザ発振装置
JPH0317096A (ja) * 1989-05-30 1991-01-25 Prod Chim & Alimentari Spa タウロウルソデオキシコール酸二水塩の製造方法
JPH06156869A (ja) * 1992-11-09 1994-06-03 Idai Kagi Kofun Yugenkoshi 自動給紙紙折り機
KR20230107360A (ko) 2020-11-27 2023-07-14 가부시키가이샤 에바라 세이사꾸쇼 유로 전환 장치 및 잠몰식 펌프의 공전을 방지하기 위한 방법
KR20250011678A (ko) 2022-05-26 2025-01-21 가부시키가이샤 에바라 세이사꾸쇼 펌프 장치의 드라이 업 방법, 쿨다운 방법, 및 핫 업 방법
KR20250011670A (ko) 2022-05-26 2025-01-21 가부시키가이샤 에바라 세이사꾸쇼 직렬로 연결된 펌프 장치의 시동 방법 및 정지 방법

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH674369A5 (enrdf_load_html_response) * 1986-11-26 1990-05-31 Jago Res Ag
EP0905230A1 (en) * 1996-03-29 1999-03-31 Tokyo Tanabe Company Limited Novel bile acid converting microorganism and process for preparing bile acid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2962423A (en) * 1959-01-02 1960-11-29 American Cyanamid Co Process for the 1-hydroxylation of steroids by mortierella
US3060101A (en) * 1961-02-13 1962-10-23 American Cyanamid Co Process for the 6beta-hydroxylation of steroids with mortierella
US3401180A (en) * 1966-02-15 1968-09-10 Squibb & Sons Inc 7beta-hydroxy-estranes and intermediates in their microbiological production
US4301246A (en) * 1979-04-12 1981-11-17 Hoffmann-La Roche Inc. Process for chenodeoxycholic acid production
JPS58155098A (ja) * 1982-03-09 1983-09-14 Yakult Honsha Co Ltd 微生物によるウルソデオキシコ−ル酸の製造法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH021193A (ja) * 1988-03-03 1990-01-05 Fanuc Ltd レーザ発振装置
JPH0317096A (ja) * 1989-05-30 1991-01-25 Prod Chim & Alimentari Spa タウロウルソデオキシコール酸二水塩の製造方法
JPH06156869A (ja) * 1992-11-09 1994-06-03 Idai Kagi Kofun Yugenkoshi 自動給紙紙折り機
KR20230107360A (ko) 2020-11-27 2023-07-14 가부시키가이샤 에바라 세이사꾸쇼 유로 전환 장치 및 잠몰식 펌프의 공전을 방지하기 위한 방법
KR20250011678A (ko) 2022-05-26 2025-01-21 가부시키가이샤 에바라 세이사꾸쇼 펌프 장치의 드라이 업 방법, 쿨다운 방법, 및 핫 업 방법
KR20250011670A (ko) 2022-05-26 2025-01-21 가부시키가이샤 에바라 세이사꾸쇼 직렬로 연결된 펌프 장치의 시동 방법 및 정지 방법

Also Published As

Publication number Publication date
JPH0529438B2 (enrdf_load_html_response) 1993-04-30
EP0119040A1 (en) 1984-09-19
ATE27464T1 (de) 1987-06-15
EP0119040B1 (en) 1987-05-27
US4604353A (en) 1986-08-05
DE3463946D1 (en) 1987-07-02

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