JPS59122428A - コレステロ−ル低下活性蛋白質 - Google Patents
コレステロ−ル低下活性蛋白質Info
- Publication number
- JPS59122428A JPS59122428A JP57227395A JP22739582A JPS59122428A JP S59122428 A JPS59122428 A JP S59122428A JP 57227395 A JP57227395 A JP 57227395A JP 22739582 A JP22739582 A JP 22739582A JP S59122428 A JPS59122428 A JP S59122428A
- Authority
- JP
- Japan
- Prior art keywords
- protein
- crp
- cholesterol
- electrophoresis
- protein crp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 239000012488 sample solution Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229940115921 streptococcus equinus Drugs 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 1
- 235000011046 triammonium citrate Nutrition 0.000 description 1
- 239000001393 triammonium citrate Substances 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/885—Streptococcus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57227395A JPS59122428A (ja) | 1982-12-28 | 1982-12-28 | コレステロ−ル低下活性蛋白質 |
| AU22242/83A AU568521B2 (en) | 1982-12-28 | 1983-12-09 | Hypocholesterolemically active protein |
| MX83101938U MX7656E (es) | 1982-12-28 | 1983-12-15 | Procedimiento para producir una proteina capaz de reducir el contenido de colesterol en la sangre |
| DE8383307760T DE3377654D1 (en) | 1982-12-28 | 1983-12-20 | Hypocholesterolemically active protein |
| EP83307760A EP0115157B1 (en) | 1982-12-28 | 1983-12-20 | Hypocholesterolemically active protein |
| CA000443863A CA1225957A (en) | 1982-12-28 | 1983-12-21 | Hypocholesterolemically active protein |
| SU833682599A SU1423002A3 (ru) | 1982-12-28 | 1983-12-27 | Способ получени белка,понижающего содержание холестерина в крови млекопитающих животных |
| HU834484A HU191746B (en) | 1982-12-28 | 1983-12-27 | Process for producing new proteins for diminishing level of cholesterol in the blood and pharmaceutical compositions containing them |
| DD83258777A DD215580A5 (de) | 1982-12-28 | 1983-12-28 | Hypocholesterolaemisch aktives protein |
| ES528497A ES8506806A1 (es) | 1982-12-28 | 1983-12-28 | Procedimiento para la preparacion de una proteina hipocolesterolemicamente activa |
| PL1983245380A PL140807B1 (en) | 1982-12-28 | 1983-12-28 | Method of obtaining a protein capable of lovering cholesterol level in blood |
| US06/827,500 US4812441A (en) | 1982-12-28 | 1986-02-07 | Hypocholesterolemically active protein derived from streptococcus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57227395A JPS59122428A (ja) | 1982-12-28 | 1982-12-28 | コレステロ−ル低下活性蛋白質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59122428A true JPS59122428A (ja) | 1984-07-14 |
| JPH0142280B2 JPH0142280B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1989-09-11 |
Family
ID=16860146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57227395A Granted JPS59122428A (ja) | 1982-12-28 | 1982-12-28 | コレステロ−ル低下活性蛋白質 |
Country Status (12)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5753268A (en) * | 1982-06-03 | 1998-05-19 | Dcv Biologics, L.P. | Anti-cholesterolemic egg, vaccine and method for production, and use |
| US5932250A (en) * | 1982-06-03 | 1999-08-03 | Dcv, Inc. | Anti-cholesterolemic egg, vaccine and method for production, and use |
| JPS5927833A (ja) * | 1982-08-06 | 1984-02-14 | Advance Res & Dev Co Ltd | コレステロール乃至トリグリセリド低下剤 |
| JPS59122428A (ja) * | 1982-12-28 | 1984-07-14 | Advance Res & Dev Co Ltd | コレステロ−ル低下活性蛋白質 |
| JPS61151128A (ja) * | 1984-12-24 | 1986-07-09 | Advance Res & Dev Co Ltd | コレステロ−ル低下活性ｒｎａ画分 |
| JPS625991A (ja) * | 1985-07-03 | 1987-01-12 | Advance Res & Dev Co Ltd | コレステロ−ル乃至トリグリセリド低下活性ｒｎａ画分 |
| US5248688A (en) * | 1986-09-10 | 1993-09-28 | Dudrick Medical Research Fund I, Ltd. | Method and substrate composition for treating atherosclerosis |
| US4945157A (en) * | 1988-05-27 | 1990-07-31 | University Of Florida | Novel Extraction procedure for protein G |
| US5006472A (en) * | 1988-06-03 | 1991-04-09 | Miles Inc. | Enzymatic purification process |
| US5449679A (en) * | 1994-07-29 | 1995-09-12 | Leonard; Robert J. | Process and products for reducing biological fluid levels of a lipid soluble waste |
| US5674488A (en) * | 1994-10-07 | 1997-10-07 | Reich; John J. | Method for prevention and treatment of hyperchlolesterolemia by in vivo hydrogenation of cholesterol |
| WO1997045530A1 (fr) * | 1996-05-27 | 1997-12-04 | UZILOVA, Irina Semenovna, Heiress of UZILOV | Utilisation de souches de streptococcus faecium et composition a base de ces souches |
| CN1111512C (zh) * | 1999-12-03 | 2003-06-18 | 华南农业大学 | 味精废水絮凝下沉物的脱水与制造饲料蛋白方法 |
| EP1176208A1 (en) * | 2000-07-28 | 2002-01-30 | Société des Produits Nestlé S.A. | Koji molds and use thereof for preparing cholesterol-lowering products |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB930107A (en) * | 1960-01-11 | 1963-07-03 | Giuseppe Carlo Sigurta | Therapeutic oral preparation of micro-organisms |
| FR3626M (fr) * | 1963-11-13 | 1965-10-18 | Lucien Nouvel | Médicament pour affections intestinales. |
| DE2106154C3 (de) * | 1971-02-10 | 1974-10-31 | Morishita Pharmaceutical Co. Ltd., Osaka (Japan) | Verfahren zur Herstellung eines Milchsäurebakterien-Präparates |
| FR2405301A1 (fr) * | 1977-10-04 | 1979-05-04 | Api Labor | Substrats et procede permettant l'identification rapide de bacteries du genre streptococcus |
| ZA794413B (en) * | 1978-09-01 | 1980-08-27 | Us Government | Protection against dental caries |
| US4268434A (en) * | 1979-01-09 | 1981-05-19 | Higerd Thomas B | Immunosuppressive extracellular product from oral bacteria |
| JPS5946491B2 (ja) * | 1979-03-14 | 1984-11-13 | 極東脂肪酸株式会社 | 喘息治療剤 |
| JPS5946492B2 (ja) * | 1979-07-12 | 1984-11-13 | 極東脂肪酸株式会社 | 脂質酸化抑制剤 |
| JPS5943929B2 (ja) * | 1979-08-13 | 1984-10-25 | サッポロビール株式会社 | 多糖体ｒｂｓ物質，その製法およびそれを有効成分とする抗腫瘍性剤 |
| GB2077101B (en) * | 1980-05-12 | 1984-08-08 | Kyokuto Fatty Acid Corp | Antiallergic composition containing streptococci |
| JPS58131917A (ja) * | 1982-02-01 | 1983-08-06 | Advance Res & Dev Co Ltd | 抗動脈硬化剤 |
| DE3305047A1 (de) * | 1982-02-19 | 1983-09-22 | Terumo Kabushiki Kaisha trading as Terumo Corp., Tokyo | Polysaccharide, ihre herstellung und diese enthaltende therapeutische zusammensetzungen |
| JPS5927833A (ja) * | 1982-08-06 | 1984-02-14 | Advance Res & Dev Co Ltd | コレステロール乃至トリグリセリド低下剤 |
| JPS59122428A (ja) * | 1982-12-28 | 1984-07-14 | Advance Res & Dev Co Ltd | コレステロ−ル低下活性蛋白質 |
| JPS6028401A (ja) * | 1983-07-27 | 1985-02-13 | Advance Res & Dev Co Ltd | トリグリセリド低下活性多糖類 |
-
1982
- 1982-12-28 JP JP57227395A patent/JPS59122428A/ja active Granted
-
1983
- 1983-12-09 AU AU22242/83A patent/AU568521B2/en not_active Ceased
- 1983-12-15 MX MX83101938U patent/MX7656E/es unknown
- 1983-12-20 DE DE8383307760T patent/DE3377654D1/de not_active Expired
- 1983-12-20 EP EP83307760A patent/EP0115157B1/en not_active Expired
- 1983-12-21 CA CA000443863A patent/CA1225957A/en not_active Expired
- 1983-12-27 HU HU834484A patent/HU191746B/hu not_active IP Right Cessation
- 1983-12-27 SU SU833682599A patent/SU1423002A3/ru active
- 1983-12-28 DD DD83258777A patent/DD215580A5/de not_active IP Right Cessation
- 1983-12-28 PL PL1983245380A patent/PL140807B1/pl unknown
- 1983-12-28 ES ES528497A patent/ES8506806A1/es not_active Expired
-
1986
- 1986-02-07 US US06/827,500 patent/US4812441A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES528497A0 (es) | 1985-08-01 |
| JPH0142280B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1989-09-11 |
| AU568521B2 (en) | 1988-01-07 |
| AU2224283A (en) | 1984-07-05 |
| EP0115157A2 (en) | 1984-08-08 |
| US4812441A (en) | 1989-03-14 |
| PL245380A1 (en) | 1984-10-22 |
| HU191746B (en) | 1987-04-28 |
| ES8506806A1 (es) | 1985-08-01 |
| DE3377654D1 (en) | 1988-09-15 |
| MX7656E (es) | 1990-06-11 |
| EP0115157A3 (en) | 1985-08-07 |
| SU1423002A3 (ru) | 1988-09-07 |
| EP0115157B1 (en) | 1988-08-10 |
| CA1225957A (en) | 1987-08-25 |
| PL140807B1 (en) | 1987-05-30 |
| DD215580A5 (de) | 1984-11-14 |
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