JPS5836308B2 - 抗体の製造方法 - Google Patents

抗体の製造方法

Info

Publication number
JPS5836308B2
JPS5836308B2 JP52013919A JP1391977A JPS5836308B2 JP S5836308 B2 JPS5836308 B2 JP S5836308B2 JP 52013919 A JP52013919 A JP 52013919A JP 1391977 A JP1391977 A JP 1391977A JP S5836308 B2 JPS5836308 B2 JP S5836308B2
Authority
JP
Japan
Prior art keywords
glucagon
antibody
pancreatic
antigen
gctr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP52013919A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5399320A (en
Inventor
友善 西野
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP52013919A priority Critical patent/JPS5836308B2/ja
Priority to SE7801545A priority patent/SE427931B/sv
Priority to BE185040A priority patent/BE863810A/xx
Priority to DK059778A priority patent/DK157340C/da
Priority to GB5388/78A priority patent/GB1580582A/en
Priority to FR7803905A priority patent/FR2380296A1/fr
Priority to DE2805663A priority patent/DE2805663B2/de
Priority to US05/924,319 priority patent/US4221777A/en
Publication of JPS5399320A publication Critical patent/JPS5399320A/ja
Priority to US06/077,221 priority patent/US4272433A/en
Publication of JPS5836308B2 publication Critical patent/JPS5836308B2/ja
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/817—Steroids or hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP52013919A 1977-02-10 1977-02-10 抗体の製造方法 Expired JPS5836308B2 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP52013919A JPS5836308B2 (ja) 1977-02-10 1977-02-10 抗体の製造方法
SE7801545A SE427931B (sv) 1977-02-10 1978-02-09 Forfarande for framstellning av en pankreatisk glukagonspecifik antikropp
BE185040A BE863810A (fr) 1977-02-10 1978-02-09 Procede de preparation d'un antigene et d'un anticorps
DK059778A DK157340C (da) 1977-02-10 1978-02-09 Fremgangsmaade til fremstilling af et pancreatisk glucagonspecifikt antistof
FR7803905A FR2380296A1 (fr) 1977-02-10 1978-02-10 Procede pour preparer un antigene et un anticorps
GB5388/78A GB1580582A (en) 1977-02-10 1978-02-10 Peptide protein antigen complex and processes for the production thereof and the antibody thereto
DE2805663A DE2805663B2 (de) 1977-02-10 1978-02-10 Verfahren zur Herstellung von Antigenen und deren Verwendung zur Herstellung von Antikörpern
US05/924,319 US4221777A (en) 1977-02-10 1978-07-13 Method for preparing a pancreatic glucagon specific antibody
US06/077,221 US4272433A (en) 1977-02-10 1979-09-20 Method for preparing antigen and antibody

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52013919A JPS5836308B2 (ja) 1977-02-10 1977-02-10 抗体の製造方法

Publications (2)

Publication Number Publication Date
JPS5399320A JPS5399320A (en) 1978-08-30
JPS5836308B2 true JPS5836308B2 (ja) 1983-08-08

Family

ID=11846569

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52013919A Expired JPS5836308B2 (ja) 1977-02-10 1977-02-10 抗体の製造方法

Country Status (8)

Country Link
US (2) US4221777A (enExample)
JP (1) JPS5836308B2 (enExample)
BE (1) BE863810A (enExample)
DE (1) DE2805663B2 (enExample)
DK (1) DK157340C (enExample)
FR (1) FR2380296A1 (enExample)
GB (1) GB1580582A (enExample)
SE (1) SE427931B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5539702A (en) * 1978-08-30 1980-03-19 Takeda Chem Ind Ltd Method of measuring enzyme immunity of pancreas glucagon
JPS5657753A (en) * 1979-10-16 1981-05-20 Toyo Jozo Co Ltd Novel glucagon fragment, and its use
US4376765A (en) * 1980-03-31 1983-03-15 Institut International De Pathologie Cellulaire Et Moleculaire Medicaments, their preparation and compositions containing same
JPS56163456A (en) * 1980-05-21 1981-12-16 Otsuka Pharmaceut Co Ltd Preparation of antigen
DK283180A (da) * 1980-07-01 1982-01-02 Novo Industri As Polypeptider og derivater deraf
JPS5735551A (en) * 1980-08-08 1982-02-26 Daiichi Rajio Isotope Kenkyusho:Kk Preparation of undecapeptide
US4430326A (en) 1981-12-22 1984-02-07 University Patents, Inc. Method of diminishing glucose levels resulting from endogenous glucagon
FR2525592B1 (enExample) * 1982-04-26 1984-09-14 Pasteur Institut
US4487715A (en) * 1982-07-09 1984-12-11 The Regents Of The University Of California Method of conjugating oligopeptides
US4591552A (en) * 1982-09-29 1986-05-27 New York Blood Center, Inc. Detection of hepatitis B surface antigen (or antibody to same) with labeled synthetic peptide
EP0134868A1 (en) * 1983-08-26 1985-03-27 Anda Biologicals Unicellular organisms activated by glutaraldehyde as solid carriers for sensitizing agents and uses of sensitized unicellular organisms
CA1256795A (en) * 1983-12-28 1989-07-04 Dennis A. Carson Anti-idiotype antibodies induced by synthetic polypeptides
US4666884A (en) * 1984-04-10 1987-05-19 New England Deaconess Hospital Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls
US4617376A (en) * 1985-07-01 1986-10-14 Eli Lilly And Company Process for recovering glucagon from pancreas glands
US4731439A (en) * 1985-11-22 1988-03-15 Oncogen Snake venom growth arresting peptide
US5545618A (en) * 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
US5176227A (en) * 1991-08-01 1993-01-05 Tec Tran Corporation Railway service and parking brake actuator
US5253736A (en) * 1991-08-01 1993-10-19 Tec Tran Corporation Railway brake actuator
US20050009205A1 (en) * 2003-07-11 2005-01-13 Ye Fang Fluorescent ligands for GPCR arrays
BR112017005110A2 (pt) 2014-09-16 2018-01-23 Regeneron Pharma anticorpo monoclonal isolado ou fragmento de ligação ao antígeno do mesmo, molécula isolada de ácido nucleico, composição farmacêutica, e, método para diminuir níveis de glicose no sangue ou para tratar uma condição ou doença.
JP7173962B2 (ja) 2016-08-30 2022-11-16 リジェネロン・ファーマシューティカルズ・インコーポレイテッド グルカゴン受容体シグナル伝達の干渉による重度のインスリン抵抗性の処置方法
US20190248888A1 (en) 2016-10-20 2019-08-15 Regeneron Pharmaceuticals, Inc. Methods of lowering blood glucose levels
CA3071387A1 (en) 2017-08-22 2019-02-28 Regeneron Pharmaceuticals, Inc. Methods of treating urea cycle disorders by interfering with glucagon receptor signaling
CN114410590B (zh) * 2022-01-27 2024-01-09 广州市进德生物科技有限公司 一种分泌胰高血糖素单克隆抗体杂交瘤细胞株及其单克隆抗体与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3553310A (en) * 1967-12-28 1971-01-05 Miles Lab Immunologically reactive particles
CH453269A4 (enExample) * 1968-03-29 1973-01-31
GB1282163A (en) * 1969-08-06 1972-07-19 Beecham Group Ltd Modified allergens and a process for their preparation
US3975342A (en) * 1972-05-15 1976-08-17 Biological Developments, Inc. Tyrosyl-class antigenic conjugates, their preparation and antibodies raised thereto
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4075194A (en) * 1976-12-09 1978-02-21 Yeda Research And Development Co., Ltd. Novel synthetic undecapeptide and clinical assay

Also Published As

Publication number Publication date
SE7801545L (sv) 1978-08-11
DK157340B (da) 1989-12-18
US4221777A (en) 1980-09-09
BE863810A (fr) 1978-05-29
DE2805663C3 (enExample) 1980-11-13
GB1580582A (en) 1980-12-03
FR2380296B1 (enExample) 1981-07-10
DE2805663A1 (de) 1978-08-17
FR2380296A1 (fr) 1978-09-08
JPS5399320A (en) 1978-08-30
DK157340C (da) 1990-05-14
SE427931B (sv) 1983-05-24
US4272433A (en) 1981-06-09
DE2805663B2 (de) 1980-03-13
DK59778A (da) 1978-08-11

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