DE2805663B2 - Verfahren zur Herstellung von Antigenen und deren Verwendung zur Herstellung von Antikörpern - Google Patents

Verfahren zur Herstellung von Antigenen und deren Verwendung zur Herstellung von Antikörpern

Info

Publication number
DE2805663B2
DE2805663B2 DE2805663A DE2805663A DE2805663B2 DE 2805663 B2 DE2805663 B2 DE 2805663B2 DE 2805663 A DE2805663 A DE 2805663A DE 2805663 A DE2805663 A DE 2805663A DE 2805663 B2 DE2805663 B2 DE 2805663B2
Authority
DE
Germany
Prior art keywords
glucagon
antibody
antibodies
pancreatic
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE2805663A
Other languages
German (de)
English (en)
Other versions
DE2805663C3 (enExample
DE2805663A1 (de
Inventor
Tomoyoshi Tokushima Nishino (Japan)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of DE2805663A1 publication Critical patent/DE2805663A1/de
Publication of DE2805663B2 publication Critical patent/DE2805663B2/de
Application granted granted Critical
Publication of DE2805663C3 publication Critical patent/DE2805663C3/de
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/817—Steroids or hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE2805663A 1977-02-10 1978-02-10 Verfahren zur Herstellung von Antigenen und deren Verwendung zur Herstellung von Antikörpern Granted DE2805663B2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52013919A JPS5836308B2 (ja) 1977-02-10 1977-02-10 抗体の製造方法

Publications (3)

Publication Number Publication Date
DE2805663A1 DE2805663A1 (de) 1978-08-17
DE2805663B2 true DE2805663B2 (de) 1980-03-13
DE2805663C3 DE2805663C3 (enExample) 1980-11-13

Family

ID=11846569

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2805663A Granted DE2805663B2 (de) 1977-02-10 1978-02-10 Verfahren zur Herstellung von Antigenen und deren Verwendung zur Herstellung von Antikörpern

Country Status (8)

Country Link
US (2) US4221777A (enExample)
JP (1) JPS5836308B2 (enExample)
BE (1) BE863810A (enExample)
DE (1) DE2805663B2 (enExample)
DK (1) DK157340C (enExample)
FR (1) FR2380296A1 (enExample)
GB (1) GB1580582A (enExample)
SE (1) SE427931B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5539702A (en) * 1978-08-30 1980-03-19 Takeda Chem Ind Ltd Method of measuring enzyme immunity of pancreas glucagon
JPS5657753A (en) * 1979-10-16 1981-05-20 Toyo Jozo Co Ltd Novel glucagon fragment, and its use
US4376765A (en) * 1980-03-31 1983-03-15 Institut International De Pathologie Cellulaire Et Moleculaire Medicaments, their preparation and compositions containing same
JPS56163456A (en) * 1980-05-21 1981-12-16 Otsuka Pharmaceut Co Ltd Preparation of antigen
DK283180A (da) * 1980-07-01 1982-01-02 Novo Industri As Polypeptider og derivater deraf
JPS5735551A (en) * 1980-08-08 1982-02-26 Daiichi Rajio Isotope Kenkyusho:Kk Preparation of undecapeptide
US4430326A (en) 1981-12-22 1984-02-07 University Patents, Inc. Method of diminishing glucose levels resulting from endogenous glucagon
FR2525592B1 (enExample) * 1982-04-26 1984-09-14 Pasteur Institut
US4487715A (en) * 1982-07-09 1984-12-11 The Regents Of The University Of California Method of conjugating oligopeptides
US4591552A (en) * 1982-09-29 1986-05-27 New York Blood Center, Inc. Detection of hepatitis B surface antigen (or antibody to same) with labeled synthetic peptide
EP0134868A1 (en) * 1983-08-26 1985-03-27 Anda Biologicals Unicellular organisms activated by glutaraldehyde as solid carriers for sensitizing agents and uses of sensitized unicellular organisms
CA1256795A (en) * 1983-12-28 1989-07-04 Dennis A. Carson Anti-idiotype antibodies induced by synthetic polypeptides
US4666884A (en) * 1984-04-10 1987-05-19 New England Deaconess Hospital Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls
US4617376A (en) * 1985-07-01 1986-10-14 Eli Lilly And Company Process for recovering glucagon from pancreas glands
US4731439A (en) * 1985-11-22 1988-03-15 Oncogen Snake venom growth arresting peptide
US5545618A (en) * 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
US5176227A (en) * 1991-08-01 1993-01-05 Tec Tran Corporation Railway service and parking brake actuator
US5253736A (en) * 1991-08-01 1993-10-19 Tec Tran Corporation Railway brake actuator
US20050009205A1 (en) * 2003-07-11 2005-01-13 Ye Fang Fluorescent ligands for GPCR arrays
BR112017005110A2 (pt) 2014-09-16 2018-01-23 Regeneron Pharma anticorpo monoclonal isolado ou fragmento de ligação ao antígeno do mesmo, molécula isolada de ácido nucleico, composição farmacêutica, e, método para diminuir níveis de glicose no sangue ou para tratar uma condição ou doença.
JP7173962B2 (ja) 2016-08-30 2022-11-16 リジェネロン・ファーマシューティカルズ・インコーポレイテッド グルカゴン受容体シグナル伝達の干渉による重度のインスリン抵抗性の処置方法
US20190248888A1 (en) 2016-10-20 2019-08-15 Regeneron Pharmaceuticals, Inc. Methods of lowering blood glucose levels
CA3071387A1 (en) 2017-08-22 2019-02-28 Regeneron Pharmaceuticals, Inc. Methods of treating urea cycle disorders by interfering with glucagon receptor signaling
CN114410590B (zh) * 2022-01-27 2024-01-09 广州市进德生物科技有限公司 一种分泌胰高血糖素单克隆抗体杂交瘤细胞株及其单克隆抗体与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3553310A (en) * 1967-12-28 1971-01-05 Miles Lab Immunologically reactive particles
CH453269A4 (enExample) * 1968-03-29 1973-01-31
GB1282163A (en) * 1969-08-06 1972-07-19 Beecham Group Ltd Modified allergens and a process for their preparation
US3975342A (en) * 1972-05-15 1976-08-17 Biological Developments, Inc. Tyrosyl-class antigenic conjugates, their preparation and antibodies raised thereto
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4075194A (en) * 1976-12-09 1978-02-21 Yeda Research And Development Co., Ltd. Novel synthetic undecapeptide and clinical assay

Also Published As

Publication number Publication date
SE7801545L (sv) 1978-08-11
DK157340B (da) 1989-12-18
JPS5836308B2 (ja) 1983-08-08
US4221777A (en) 1980-09-09
BE863810A (fr) 1978-05-29
DE2805663C3 (enExample) 1980-11-13
GB1580582A (en) 1980-12-03
FR2380296B1 (enExample) 1981-07-10
DE2805663A1 (de) 1978-08-17
FR2380296A1 (fr) 1978-09-08
JPS5399320A (en) 1978-08-30
DK157340C (da) 1990-05-14
SE427931B (sv) 1983-05-24
US4272433A (en) 1981-06-09
DK59778A (da) 1978-08-11

Similar Documents

Publication Publication Date Title
DE2805663C3 (enExample)
DE69032833T2 (de) Diagnose und behandlung von insulinabhängigem diabetes mellitus
DE69838916T2 (de) Neuartige exendin agonisten
DE69716905T2 (de) Analoge des glucagon ähnlichen peptides -2
DE2743444C3 (de) Immunchemisches Meßverfahren und Reagens zu seiner Durchführung
DE2202441B2 (de) Barbitursäureantigene und spezifische Antikörper hierfür
DE2744983A1 (de) Mehrwertiger antigen-protein-komplex
DE3785038T2 (de) Monoklonale antikoerper gegen nicht reduzierte, nicht enzymatisch glykolysierte proteine.
EP0013930B1 (de) Immunogen, Antikörper für ein Thymus-Hormon, markiertes Thymus-Hormon und Verfahren zur Bestimmung dieses Thymushormons
DE1927209A1 (de) Acyl-substituierte Insuline und Verfahren zu ihrer Herstellung
DE3751316T2 (de) Materialzusammensetzung, welche ein Polypeptid aus Pankreas-Insel-Amyloid und/oder Antikörpern gegen dieses Polypeptid enthält, und Anwendung dieser Zusammensetzung.
DD296933A5 (de) Peptide
DE2219635A1 (de) Insulinprodukt
EP3346273B1 (de) Neue, von d3 abgeleitete d-enantiomere peptide und deren verwendung
DE68917061T2 (de) O-glycosylierter IGF-1.
DE3120312A1 (de) Verfahren zur herstellung von darm-glucagon-antigen
DE60035267T2 (de) Verfahren zur analyse der menge an intraabdominalem fettgewebe
DE60124915T2 (de) Synthetische peptide gegen neurologische krankheiten
EP0124779A2 (de) Radioimmunverfahren für Thymosin beta 4
DE68927283T2 (de) HCG-Peptide zur Verwendung in Antikörper-Reinigungsverfahren
DE2310280A1 (de) Tubocurarin-antigene
DE2604991A1 (de) Bestimmung von antipyrin
DE2364883C2 (de) Des-Lys↑2↑↑9↑-Ala↑3↑↑0↑-Schweine- und -Rinderinsulin, Verfahren zu deren Herstellung und diese Insuline enthaltende injizierbare Präparate
DE3854926T2 (de) Verwendung von antikörper gegen angiogenin: immunotherapeutische mittel
DE2738156A1 (de) Bestimmung von catecholaminen

Legal Events

Date Code Title Description
OAP Request for examination filed
OD Request for examination
C3 Grant after two publication steps (3rd publication)