JPS5798261A - Manufacture of n-substituted derivatives of 1-desoxynojirimicin - Google Patents
Manufacture of n-substituted derivatives of 1-desoxynojirimicinInfo
- Publication number
- JPS5798261A JPS5798261A JP56162120A JP16212081A JPS5798261A JP S5798261 A JPS5798261 A JP S5798261A JP 56162120 A JP56162120 A JP 56162120A JP 16212081 A JP16212081 A JP 16212081A JP S5798261 A JPS5798261 A JP S5798261A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- aminosorbose
- give
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803038901 DE3038901A1 (de) | 1980-10-15 | 1980-10-15 | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5798261A true JPS5798261A (en) | 1982-06-18 |
JPH039108B2 JPH039108B2 (ja) | 1991-02-07 |
Family
ID=6114418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56162120A Granted JPS5798261A (en) | 1980-10-15 | 1981-10-13 | Manufacture of n-substituted derivatives of 1-desoxynojirimicin |
Country Status (11)
Country | Link |
---|---|
US (1) | US4405714A (ja) |
EP (1) | EP0049858B1 (ja) |
JP (1) | JPS5798261A (ja) |
AT (1) | ATE11913T1 (ja) |
CA (1) | CA1174996A (ja) |
DE (2) | DE3038901A1 (ja) |
ES (1) | ES8206475A1 (ja) |
FI (1) | FI78469C (ja) |
HU (1) | HU188700B (ja) |
IL (1) | IL64034A (ja) |
ZA (1) | ZA817084B (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62242663A (ja) * | 1986-04-09 | 1987-10-23 | バイエル・アクチエンゲゼルシヤフト | 1−デオキシノジリマイシンおよびそれのn−誘導体を製造する方法 |
JP2015172057A (ja) * | 2010-01-25 | 2015-10-01 | ローム アンド ハース エレクトロニック マテリアルズ エルエルシーRohm and Haas Electronic Materials LLC | 窒素含有化合物を含むフォトレジスト |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3507019A1 (de) * | 1985-02-28 | 1986-08-28 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung |
US4999360A (en) * | 1987-12-21 | 1991-03-12 | Monsanto Company | Method of inhibiting virus |
EP0344383A1 (en) * | 1988-06-02 | 1989-12-06 | Merrell Dow Pharmaceuticals Inc. | Novel alpha-Glucosidase inhibitors |
US5329025A (en) * | 1988-09-21 | 1994-07-12 | G. D. Searle & Co. | 3-azido compound |
DE3936295A1 (de) * | 1989-11-01 | 1991-05-02 | Bayer Ag | Verfahren zur herstellung von zwischenprodukten und zur synthese von n-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine |
US5536732A (en) * | 1990-04-27 | 1996-07-16 | Merrell Pharmaceuticals Inc. | N-derivatives of 1-deoxy nojirimycin |
US5252587A (en) * | 1990-04-27 | 1993-10-12 | Merrell Dow Pharmaceuticals, Inc. | N-derivatives of 1-deoxy nojirimycin |
US5151519A (en) * | 1990-05-07 | 1992-09-29 | G. D. Searle & Co. | Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof |
US5504078A (en) * | 1990-06-08 | 1996-04-02 | Merrell Dow Pharmaceuticals Inc. | α-glucosidase inhibitors |
ES2087277T3 (es) * | 1990-09-20 | 1996-07-16 | Monsanto Co | Procedimiento para producir 1-desoxinojirimicina n-sustituida. |
DE4030040A1 (de) * | 1990-09-22 | 1992-03-26 | Bayer Ag | Enzymatische de-acylierung von acyl-aminosorbosen und dessen verwendung bei der herstellung von 1-desoxynojirimicin |
US5401645A (en) * | 1992-03-16 | 1995-03-28 | Monsanto Company | Process for producing n-substituted polyhydroxy nitrogen-containing heterocycles utilizing acetobacteraceae and corynebacterium |
AU1876095A (en) * | 1994-02-25 | 1995-09-11 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
DE19741235A1 (de) | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
US20050032841A1 (en) * | 1999-04-20 | 2005-02-10 | Steven Walkley | Therapeutic compositions and methods of treating glycolipid storage related disorders |
GB9909066D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
ATE382351T1 (de) | 1999-08-10 | 2008-01-15 | Univ Oxford | Langkettige n-alkyl verbindungen und deren oxa- derivate zur verwendung als anitvirale mittel |
DE60211677T2 (de) * | 2001-03-19 | 2006-12-28 | Lonza Ag | Verfahren zur herstellung von 2-hydroxymethyl-pyrolidin-3,4-diolen |
EP3441090A1 (en) | 2005-05-17 | 2019-02-13 | Amicus Therapeutics, Inc. | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
CN1328270C (zh) * | 2005-09-26 | 2007-07-25 | 鲁南制药集团股份有限公司 | 一种工业化生产米格列醇的方法 |
GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
EP2049126A2 (en) * | 2006-08-02 | 2009-04-22 | United Therapeutics Corporation | Liposome treatment of viral infections |
US20080131398A1 (en) * | 2006-08-21 | 2008-06-05 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
CN101289418B (zh) * | 2007-04-19 | 2011-02-02 | 浙江医药股份有限公司新昌制药厂 | 米格列醇晶体及其制备方法 |
US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
US20090252785A1 (en) * | 2008-03-26 | 2009-10-08 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
CN102655746B (zh) * | 2009-02-23 | 2016-08-03 | 联合治疗公司 | 亚氨基糖以及治疗病毒性疾病的方法 |
JP5951996B2 (ja) * | 2009-02-24 | 2016-07-13 | ユナイテッド セラピューティクス コーポレーション | イミノ糖及びアレナウイルス感染症を治療する方法 |
CA2757026A1 (en) * | 2009-03-27 | 2010-09-30 | The Chancellor, Masters And Scholars Of The University Of Oxford | Cholesterol level lowering liposomes |
CA2765086C (en) * | 2009-06-12 | 2015-12-15 | United Therapeutics Corporation | Iminosugars and methods of treating bunyaviral and togaviral diseases |
KR20120081990A (ko) * | 2009-09-04 | 2012-07-20 | 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 | 이미노당 및 필로바이러스 질환의 치료 방법 |
US20110065753A1 (en) * | 2009-09-04 | 2011-03-17 | United Therapeutics Corporation | Methods of treating poxviral infections |
EP2473482B1 (en) * | 2009-09-04 | 2014-03-05 | United Therapeutics Corporation | Methods of treating orthomyxoviral infections |
CN102740852A (zh) | 2009-12-07 | 2012-10-17 | 牛津大学之校长及学者 | 用于抑制破骨细胞形成和/或破骨细胞活化的n-取代的脱氧野尻霉素化合物 |
CA2924026C (en) | 2013-09-16 | 2021-12-28 | Emergent Virology Llc | Deoxynojirimycin derivatives and methods of their using |
CA2966893C (en) | 2014-11-05 | 2023-10-24 | Emergent Virology Llc | Iminosugars |
EP3318277A1 (en) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases |
CN114516831B (zh) * | 2022-01-21 | 2024-03-08 | 浙江奥翔药业股份有限公司 | 一种米格列醇的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2658563A1 (de) * | 1976-12-23 | 1978-06-29 | Bayer Ag | Inhibitoren fuer glykosid-hydrolasen aus bacillen |
NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
GB2009152B (en) * | 1977-11-10 | 1982-01-06 | Nippon Shinyaku Co Ltd | Method for producing moranoline and n-methylmoranoline |
DE2830469A1 (de) * | 1978-07-11 | 1980-01-24 | Bayer Ag | Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten |
DE2834122A1 (de) * | 1978-08-03 | 1980-02-14 | Bayer Ag | Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose |
DE2839309A1 (de) * | 1978-09-09 | 1980-03-27 | Bayer Ag | 3,4,5-trihydroxypiperidin-derivate |
DE2853573A1 (de) * | 1978-12-12 | 1980-07-03 | Bayer Ag | Herstellung von n-substituierten derivaten des l-desoxynojirimycins |
-
1980
- 1980-10-15 DE DE19803038901 patent/DE3038901A1/de not_active Withdrawn
-
1981
- 1981-09-25 US US06/305,656 patent/US4405714A/en not_active Expired - Lifetime
- 1981-10-07 DE DE8181108007T patent/DE3169076D1/de not_active Expired
- 1981-10-07 AT AT81108007T patent/ATE11913T1/de not_active IP Right Cessation
- 1981-10-07 EP EP81108007A patent/EP0049858B1/de not_active Expired
- 1981-10-12 IL IL64034A patent/IL64034A/xx not_active IP Right Cessation
- 1981-10-13 FI FI813182A patent/FI78469C/fi not_active IP Right Cessation
- 1981-10-13 CA CA000387752A patent/CA1174996A/en not_active Expired
- 1981-10-13 JP JP56162120A patent/JPS5798261A/ja active Granted
- 1981-10-14 ZA ZA817084A patent/ZA817084B/xx unknown
- 1981-10-14 HU HU812966A patent/HU188700B/hu not_active IP Right Cessation
- 1981-10-14 ES ES506237A patent/ES8206475A1/es not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62242663A (ja) * | 1986-04-09 | 1987-10-23 | バイエル・アクチエンゲゼルシヤフト | 1−デオキシノジリマイシンおよびそれのn−誘導体を製造する方法 |
JP2015172057A (ja) * | 2010-01-25 | 2015-10-01 | ローム アンド ハース エレクトロニック マテリアルズ エルエルシーRohm and Haas Electronic Materials LLC | 窒素含有化合物を含むフォトレジスト |
Also Published As
Publication number | Publication date |
---|---|
IL64034A (en) | 1986-03-31 |
HU188700B (en) | 1986-05-28 |
ES506237A0 (es) | 1982-08-16 |
DE3038901A1 (de) | 1982-05-06 |
FI78469C (fi) | 1989-08-10 |
DE3169076D1 (en) | 1985-03-28 |
IL64034A0 (en) | 1982-01-31 |
EP0049858B1 (de) | 1985-02-20 |
ES8206475A1 (es) | 1982-08-16 |
FI813182L (fi) | 1982-04-16 |
EP0049858A2 (de) | 1982-04-21 |
EP0049858A3 (en) | 1982-10-13 |
US4405714A (en) | 1983-09-20 |
FI78469B (fi) | 1989-04-28 |
JPH039108B2 (ja) | 1991-02-07 |
ZA817084B (en) | 1982-09-29 |
CA1174996A (en) | 1984-09-25 |
ATE11913T1 (de) | 1985-03-15 |
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