ZA817084B - Production of n-substituted derivatives of 1-desoxynojirimicin - Google Patents
Production of n-substituted derivatives of 1-desoxynojirimicinInfo
- Publication number
- ZA817084B ZA817084B ZA817084A ZA817084A ZA817084B ZA 817084 B ZA817084 B ZA 817084B ZA 817084 A ZA817084 A ZA 817084A ZA 817084 A ZA817084 A ZA 817084A ZA 817084 B ZA817084 B ZA 817084B
- Authority
- ZA
- South Africa
- Prior art keywords
- formula
- compound
- aminosorbose
- give
- image
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Gas Separation By Absorption (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803038901 DE3038901A1 (de) | 1980-10-15 | 1980-10-15 | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA817084B true ZA817084B (en) | 1982-09-29 |
Family
ID=6114418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA817084A ZA817084B (en) | 1980-10-15 | 1981-10-14 | Production of n-substituted derivatives of 1-desoxynojirimicin |
Country Status (11)
Country | Link |
---|---|
US (1) | US4405714A (ja) |
EP (1) | EP0049858B1 (ja) |
JP (1) | JPS5798261A (ja) |
AT (1) | ATE11913T1 (ja) |
CA (1) | CA1174996A (ja) |
DE (2) | DE3038901A1 (ja) |
ES (1) | ES8206475A1 (ja) |
FI (1) | FI78469C (ja) |
HU (1) | HU188700B (ja) |
IL (1) | IL64034A (ja) |
ZA (1) | ZA817084B (ja) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3507019A1 (de) * | 1985-02-28 | 1986-08-28 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung |
DE3611841A1 (de) * | 1986-04-09 | 1987-10-15 | Bayer Ag | Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten |
US4999360A (en) * | 1987-12-21 | 1991-03-12 | Monsanto Company | Method of inhibiting virus |
EP0344383A1 (en) * | 1988-06-02 | 1989-12-06 | Merrell Dow Pharmaceuticals Inc. | Novel alpha-Glucosidase inhibitors |
US5329025A (en) * | 1988-09-21 | 1994-07-12 | G. D. Searle & Co. | 3-azido compound |
DE3936295A1 (de) * | 1989-11-01 | 1991-05-02 | Bayer Ag | Verfahren zur herstellung von zwischenprodukten und zur synthese von n-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine |
US5252587A (en) * | 1990-04-27 | 1993-10-12 | Merrell Dow Pharmaceuticals, Inc. | N-derivatives of 1-deoxy nojirimycin |
US5536732A (en) * | 1990-04-27 | 1996-07-16 | Merrell Pharmaceuticals Inc. | N-derivatives of 1-deoxy nojirimycin |
US5151519A (en) * | 1990-05-07 | 1992-09-29 | G. D. Searle & Co. | Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof |
US5504078A (en) * | 1990-06-08 | 1996-04-02 | Merrell Dow Pharmaceuticals Inc. | α-glucosidase inhibitors |
JP3162123B2 (ja) * | 1990-09-20 | 2001-04-25 | モンサント カンパニー | N−置換−1−デオキシノジリマイシンの製造方法 |
DE4030040A1 (de) * | 1990-09-22 | 1992-03-26 | Bayer Ag | Enzymatische de-acylierung von acyl-aminosorbosen und dessen verwendung bei der herstellung von 1-desoxynojirimicin |
US5401645A (en) * | 1992-03-16 | 1995-03-28 | Monsanto Company | Process for producing n-substituted polyhydroxy nitrogen-containing heterocycles utilizing acetobacteraceae and corynebacterium |
WO1995022975A1 (en) * | 1994-02-25 | 1995-08-31 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
DE19741235A1 (de) | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
US20050032841A1 (en) * | 1999-04-20 | 2005-02-10 | Steven Walkley | Therapeutic compositions and methods of treating glycolipid storage related disorders |
GB9909066D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
AU1840101A (en) | 1999-08-10 | 2001-03-05 | Chancellor, Masters And Scholars Of The University Of Oxford, The | Long chain n-alkyl compounds and oxo-derivatives thereof |
DE60211677T2 (de) * | 2001-03-19 | 2006-12-28 | Lonza Ag | Verfahren zur herstellung von 2-hydroxymethyl-pyrolidin-3,4-diolen |
EP3782655A1 (en) | 2005-05-17 | 2021-02-24 | Amicus Therapeutics, Inc. | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
CN1328270C (zh) * | 2005-09-26 | 2007-07-25 | 鲁南制药集团股份有限公司 | 一种工业化生产米格列醇的方法 |
GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
KR20090040906A (ko) * | 2006-08-02 | 2009-04-27 | 유나이티드 세러퓨틱스 코오포레이션 | 바이러스 감염의 리포솜 치료 |
JP2010510171A (ja) * | 2006-08-21 | 2010-04-02 | ユナイテッド セラピューティクス コーポレーション | ウイルス感染症の治療のための併用療法 |
CN101289418B (zh) * | 2007-04-19 | 2011-02-02 | 浙江医药股份有限公司新昌制药厂 | 米格列醇晶体及其制备方法 |
US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
WO2009118658A2 (en) * | 2008-03-26 | 2009-10-01 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
KR20120042716A (ko) | 2009-02-23 | 2012-05-03 | 유나이티드 세러퓨틱스 코오포레이션 | 이미노슈가 및 바이러스성 질환을 치료하는 방법 |
CN102625660B (zh) * | 2009-02-24 | 2015-03-11 | 联合治疗公司 | 亚氨基糖以及治疗沙粒病毒感染的方法 |
KR20120059447A (ko) * | 2009-03-27 | 2012-06-08 | 더 챈슬러 마스터즈 앤드 스칼라스 오브 더 유니버시티 오브 옥스포드 | 콜레스테롤 수준 저하 리포좀 |
EP2440205B1 (en) * | 2009-06-12 | 2014-08-27 | United Therapeutics Corporation | Iminosugars for use in the treatment of bunyaviral and togaviral diseases |
KR101459530B1 (ko) * | 2009-09-04 | 2014-11-07 | 유나이티드 세러퓨틱스 코오포레이션 | 폭스바이러스 감염의 치료 방법 |
WO2011028775A1 (en) * | 2009-09-04 | 2011-03-10 | United Therapeutics Corporation | Methods of treating orthomyxoviral infections |
ES2527623T3 (es) | 2009-09-04 | 2015-01-27 | United Therapeutics Corporation | Iminoazúcares para su uso en el tratamiento de enfermedades por filovirus |
CA2783405A1 (en) * | 2009-12-07 | 2011-06-16 | The Chancellor, Masters And Scholars Of The University Of Oxford | N-substituted deoxynojirimycin compounds for use in inhibiting osteoclastogenesis and/or osteoclast activation |
CN102207678B (zh) * | 2010-01-25 | 2015-05-20 | 罗门哈斯电子材料有限公司 | 包含含氮化合物的光致抗蚀剂 |
US10144727B2 (en) | 2013-09-16 | 2018-12-04 | Emergent Virology Llc | Deoxynojirimycin derivatives and methods of their using |
WO2016073652A1 (en) | 2014-11-05 | 2016-05-12 | Unither Virology, Llc | Iminosugars useful for the treatment of viral diseases |
EP3318277A1 (en) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases |
CN114516831B (zh) * | 2022-01-21 | 2024-03-08 | 浙江奥翔药业股份有限公司 | 一种米格列醇的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2658563A1 (de) * | 1976-12-23 | 1978-06-29 | Bayer Ag | Inhibitoren fuer glykosid-hydrolasen aus bacillen |
NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
GB2009152B (en) * | 1977-11-10 | 1982-01-06 | Nippon Shinyaku Co Ltd | Method for producing moranoline and n-methylmoranoline |
DE2830469A1 (de) * | 1978-07-11 | 1980-01-24 | Bayer Ag | Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten |
DE2834122A1 (de) * | 1978-08-03 | 1980-02-14 | Bayer Ag | Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose |
DE2839309A1 (de) * | 1978-09-09 | 1980-03-27 | Bayer Ag | 3,4,5-trihydroxypiperidin-derivate |
DE2853573A1 (de) * | 1978-12-12 | 1980-07-03 | Bayer Ag | Herstellung von n-substituierten derivaten des l-desoxynojirimycins |
-
1980
- 1980-10-15 DE DE19803038901 patent/DE3038901A1/de not_active Withdrawn
-
1981
- 1981-09-25 US US06/305,656 patent/US4405714A/en not_active Expired - Lifetime
- 1981-10-07 AT AT81108007T patent/ATE11913T1/de not_active IP Right Cessation
- 1981-10-07 EP EP81108007A patent/EP0049858B1/de not_active Expired
- 1981-10-07 DE DE8181108007T patent/DE3169076D1/de not_active Expired
- 1981-10-12 IL IL64034A patent/IL64034A/xx not_active IP Right Cessation
- 1981-10-13 CA CA000387752A patent/CA1174996A/en not_active Expired
- 1981-10-13 FI FI813182A patent/FI78469C/fi not_active IP Right Cessation
- 1981-10-13 JP JP56162120A patent/JPS5798261A/ja active Granted
- 1981-10-14 HU HU812966A patent/HU188700B/hu not_active IP Right Cessation
- 1981-10-14 ZA ZA817084A patent/ZA817084B/xx unknown
- 1981-10-14 ES ES506237A patent/ES8206475A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FI813182L (fi) | 1982-04-16 |
HU188700B (en) | 1986-05-28 |
DE3169076D1 (en) | 1985-03-28 |
ATE11913T1 (de) | 1985-03-15 |
CA1174996A (en) | 1984-09-25 |
JPH039108B2 (ja) | 1991-02-07 |
ES506237A0 (es) | 1982-08-16 |
ES8206475A1 (es) | 1982-08-16 |
FI78469B (fi) | 1989-04-28 |
DE3038901A1 (de) | 1982-05-06 |
FI78469C (fi) | 1989-08-10 |
US4405714A (en) | 1983-09-20 |
IL64034A0 (en) | 1982-01-31 |
EP0049858B1 (de) | 1985-02-20 |
IL64034A (en) | 1986-03-31 |
JPS5798261A (en) | 1982-06-18 |
EP0049858A2 (de) | 1982-04-21 |
EP0049858A3 (en) | 1982-10-13 |
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