FI813182L - Foerfarande foer framstaellning av n-substituerade 1-desoxinojirimycinderivat - Google Patents

Foerfarande foer framstaellning av n-substituerade 1-desoxinojirimycinderivat

Info

Publication number
FI813182L
FI813182L FI813182A FI813182A FI813182L FI 813182 L FI813182 L FI 813182L FI 813182 A FI813182 A FI 813182A FI 813182 A FI813182 A FI 813182A FI 813182 L FI813182 L FI 813182L
Authority
FI
Finland
Prior art keywords
formula
compound
aminosorbose
give
image
Prior art date
Application number
FI813182A
Other languages
English (en)
Other versions
FI78469C (fi
FI78469B (fi
Inventor
Guenther Kienast
Michael Schedel
Wolfgang Koebernick
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI813182L publication Critical patent/FI813182L/fi
Application granted granted Critical
Publication of FI78469B publication Critical patent/FI78469B/fi
Publication of FI78469C publication Critical patent/FI78469C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Gas Separation By Absorption (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI813182A 1980-10-15 1981-10-13 Foerfarande foer framstaellning av n-substituerade 1-desoxinojirimycinderivat. FI78469C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3038901 1980-10-15
DE19803038901 DE3038901A1 (de) 1980-10-15 1980-10-15 Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins

Publications (3)

Publication Number Publication Date
FI813182L true FI813182L (fi) 1982-04-16
FI78469B FI78469B (fi) 1989-04-28
FI78469C FI78469C (fi) 1989-08-10

Family

ID=6114418

Family Applications (1)

Application Number Title Priority Date Filing Date
FI813182A FI78469C (fi) 1980-10-15 1981-10-13 Foerfarande foer framstaellning av n-substituerade 1-desoxinojirimycinderivat.

Country Status (11)

Country Link
US (1) US4405714A (fi)
EP (1) EP0049858B1 (fi)
JP (1) JPS5798261A (fi)
AT (1) ATE11913T1 (fi)
CA (1) CA1174996A (fi)
DE (2) DE3038901A1 (fi)
ES (1) ES506237A0 (fi)
FI (1) FI78469C (fi)
HU (1) HU188700B (fi)
IL (1) IL64034A (fi)
ZA (1) ZA817084B (fi)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3507019A1 (de) * 1985-02-28 1986-08-28 Bayer Ag, 5090 Leverkusen Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung
DE3611841A1 (de) * 1986-04-09 1987-10-15 Bayer Ag Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten
US4999360A (en) * 1987-12-21 1991-03-12 Monsanto Company Method of inhibiting virus
EP0344383A1 (en) * 1988-06-02 1989-12-06 Merrell Dow Pharmaceuticals Inc. Novel alpha-Glucosidase inhibitors
US5329025A (en) * 1988-09-21 1994-07-12 G. D. Searle & Co. 3-azido compound
DE3936295A1 (de) * 1989-11-01 1991-05-02 Bayer Ag Verfahren zur herstellung von zwischenprodukten und zur synthese von n-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine
US5536732A (en) * 1990-04-27 1996-07-16 Merrell Pharmaceuticals Inc. N-derivatives of 1-deoxy nojirimycin
US5252587A (en) * 1990-04-27 1993-10-12 Merrell Dow Pharmaceuticals, Inc. N-derivatives of 1-deoxy nojirimycin
US5151519A (en) * 1990-05-07 1992-09-29 G. D. Searle & Co. Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof
US5504078A (en) * 1990-06-08 1996-04-02 Merrell Dow Pharmaceuticals Inc. α-glucosidase inhibitors
JP3162123B2 (ja) 1990-09-20 2001-04-25 モンサント カンパニー Ｎ−置換−１−デオキシノジリマイシンの製造方法
DE4030040A1 (de) * 1990-09-22 1992-03-26 Bayer Ag Enzymatische de-acylierung von acyl-aminosorbosen und dessen verwendung bei der herstellung von 1-desoxynojirimicin
US5401645A (en) * 1992-03-16 1995-03-28 Monsanto Company Process for producing n-substituted polyhydroxy nitrogen-containing heterocycles utilizing acetobacteraceae and corynebacterium
WO1995022975A1 (en) * 1994-02-25 1995-08-31 G.D. Searle & Co. Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US6465488B1 (en) 1997-12-11 2002-10-15 Chancellor, Masters & Scholars Of The University Of Oxford Inhibition of glycolipid biosynthesis
GB9909066D0 (en) * 1999-04-20 1999-06-16 Oxford Glycosciences Uk Ltd Therapies
US20050032841A1 (en) * 1999-04-20 2005-02-10 Steven Walkley Therapeutic compositions and methods of treating glycolipid storage related disorders
US7256005B2 (en) 1999-08-10 2007-08-14 The Chancellor, Masters And Scholars Of The University Of Oxford Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
JP2003506406A (ja) * 1999-08-10 2003-02-18 ザ・チャンセラー・マスターズ・アンド・スカラーズ・オブ・ザ・ユニバーシティ・オブ・オックスフォード 長鎖ｎ−アルキル化合物およびそのオキサ誘導体
DE60211677T2 (de) * 2001-03-19 2006-12-28 Lonza Ag Verfahren zur herstellung von 2-hydroxymethyl-pyrolidin-3,4-diolen
EP3441090A1 (en) 2005-05-17 2019-02-13 Amicus Therapeutics, Inc. A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives
CN1328270C (zh) * 2005-09-26 2007-07-25 鲁南制药集团股份有限公司 一种工业化生产米格列醇的方法
GB0614947D0 (en) * 2006-07-27 2006-09-06 Isis Innovation Epitope reduction therapy
JP2009545621A (ja) 2006-08-02 2009-12-24 ユナイテッド セラピューティクス コーポレーション ウィルス感染症のリポソーム処置
CA2666814A1 (en) * 2006-08-21 2008-05-29 United Therapeutics Corporation Combination therapy for treatment of viral infections
CN101289418B (zh) * 2007-04-19 2011-02-02 浙江医药股份有限公司新昌制药厂 米格列醇晶体及其制备方法
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
EP2282723A2 (en) * 2008-03-26 2011-02-16 University of Oxford Endoplasmic reticulum targeting liposomes
CN106420740A (zh) * 2009-02-23 2017-02-22 伊莫根特病毒学有限责任公司 亚氨基糖以及治疗病毒性疾病的方法
EP2400843B1 (en) * 2009-02-24 2015-11-11 United Therapeutics Corporation Iminosugars and methods of treating arenaviral infections
US8703744B2 (en) * 2009-03-27 2014-04-22 The Chancellor, Masters And Scholars Of The University Of Oxford Cholesterol level lowering liposomes
CA2765086C (en) 2009-06-12 2015-12-15 United Therapeutics Corporation Iminosugars and methods of treating bunyaviral and togaviral diseases
ES2527623T3 (es) * 2009-09-04 2015-01-27 United Therapeutics Corporation Iminoazúcares para su uso en el tratamiento de enfermedades por filovirus
ES2485623T3 (es) * 2009-09-04 2014-08-13 United Therapeutics Corporation Procedimiento para el tratamiento de infecciones por poxvirus
CA2772875A1 (en) * 2009-09-04 2011-03-10 United Therapeutics Corporation Methods of treating orthomyxoviral infections
EP2509598A1 (en) 2009-12-07 2012-10-17 The Chancellor, Masters And Scholars Of The University Of Oxford N-substituted deoxynojirimycin compounds for use in inhibiting osteoclastogenesis and/or osteoclast activation
US8927190B2 (en) * 2010-01-25 2015-01-06 Rohm And Haas Electronic Materials Llc Photoresist comprising nitrogen-containing compound
KR20160055916A (ko) 2013-09-16 2016-05-18 이머전트 바이롤로지 엘엘씨 데옥시노지리마이신 유도체 및 그의 이용 방법
EP3215499B1 (en) 2014-11-05 2021-01-20 Emergent Virology LLC Iminosugars useful for the treatment of viral diseases
EP3318277A1 (en) 2016-11-04 2018-05-09 Institut du Cerveau et de la Moelle Epiniere-ICM Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases
CN114516831B (zh) * 2022-01-21 2024-03-08 浙江奥翔药业股份有限公司 一种米格列醇的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2658563A1 (de) * 1976-12-23 1978-06-29 Bayer Ag Inhibitoren fuer glykosid-hydrolasen aus bacillen
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
GB2009152B (en) * 1977-11-10 1982-01-06 Nippon Shinyaku Co Ltd Method for producing moranoline and n-methylmoranoline
DE2830469A1 (de) * 1978-07-11 1980-01-24 Bayer Ag Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten
DE2834122A1 (de) * 1978-08-03 1980-02-14 Bayer Ag Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose
DE2839309A1 (de) * 1978-09-09 1980-03-27 Bayer Ag 3,4,5-trihydroxypiperidin-derivate
DE2853573A1 (de) * 1978-12-12 1980-07-03 Bayer Ag Herstellung von n-substituierten derivaten des l-desoxynojirimycins

Also Published As

Publication number Publication date
US4405714A (en) 1983-09-20
CA1174996A (en) 1984-09-25
FI78469C (fi) 1989-08-10
HU188700B (en) 1986-05-28
IL64034A (en) 1986-03-31
IL64034A0 (en) 1982-01-31
EP0049858A3 (en) 1982-10-13
FI78469B (fi) 1989-04-28
JPH039108B2 (fi) 1991-02-07
ES8206475A1 (es) 1982-08-16
ES506237A0 (es) 1982-08-16
DE3038901A1 (de) 1982-05-06
DE3169076D1 (en) 1985-03-28
EP0049858B1 (de) 1985-02-20
ATE11913T1 (de) 1985-03-15
ZA817084B (en) 1982-09-29
EP0049858A2 (de) 1982-04-21
JPS5798261A (en) 1982-06-18

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Legal Events

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MM Patent lapsed

Owner name: BAYER AKTIENGESELLSCHAFT