IL64034A - Production of n-substituted derivatives of 1-desoxy-nojirimicin - Google Patents
Production of n-substituted derivatives of 1-desoxy-nojirimicinInfo
- Publication number
- IL64034A IL64034A IL64034A IL6403481A IL64034A IL 64034 A IL64034 A IL 64034A IL 64034 A IL64034 A IL 64034A IL 6403481 A IL6403481 A IL 6403481A IL 64034 A IL64034 A IL 64034A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- compound
- aminosorbose
- give
- image
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Gas Separation By Absorption (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803038901 DE3038901A1 (de) | 1980-10-15 | 1980-10-15 | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
Publications (2)
Publication Number | Publication Date |
---|---|
IL64034A0 IL64034A0 (en) | 1982-01-31 |
IL64034A true IL64034A (en) | 1986-03-31 |
Family
ID=6114418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL64034A IL64034A (en) | 1980-10-15 | 1981-10-12 | Production of n-substituted derivatives of 1-desoxy-nojirimicin |
Country Status (11)
Country | Link |
---|---|
US (1) | US4405714A (ja) |
EP (1) | EP0049858B1 (ja) |
JP (1) | JPS5798261A (ja) |
AT (1) | ATE11913T1 (ja) |
CA (1) | CA1174996A (ja) |
DE (2) | DE3038901A1 (ja) |
ES (1) | ES506237A0 (ja) |
FI (1) | FI78469C (ja) |
HU (1) | HU188700B (ja) |
IL (1) | IL64034A (ja) |
ZA (1) | ZA817084B (ja) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3507019A1 (de) * | 1985-02-28 | 1986-08-28 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung |
DE3611841A1 (de) * | 1986-04-09 | 1987-10-15 | Bayer Ag | Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten |
US4999360A (en) * | 1987-12-21 | 1991-03-12 | Monsanto Company | Method of inhibiting virus |
EP0344383A1 (en) * | 1988-06-02 | 1989-12-06 | Merrell Dow Pharmaceuticals Inc. | Novel alpha-Glucosidase inhibitors |
US5329025A (en) * | 1988-09-21 | 1994-07-12 | G. D. Searle & Co. | 3-azido compound |
DE3936295A1 (de) * | 1989-11-01 | 1991-05-02 | Bayer Ag | Verfahren zur herstellung von zwischenprodukten und zur synthese von n-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine |
US5536732A (en) * | 1990-04-27 | 1996-07-16 | Merrell Pharmaceuticals Inc. | N-derivatives of 1-deoxy nojirimycin |
US5252587A (en) * | 1990-04-27 | 1993-10-12 | Merrell Dow Pharmaceuticals, Inc. | N-derivatives of 1-deoxy nojirimycin |
US5151519A (en) * | 1990-05-07 | 1992-09-29 | G. D. Searle & Co. | Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof |
US5504078A (en) * | 1990-06-08 | 1996-04-02 | Merrell Dow Pharmaceuticals Inc. | α-glucosidase inhibitors |
JP3162123B2 (ja) | 1990-09-20 | 2001-04-25 | モンサント カンパニー | N−置換−1−デオキシノジリマイシンの製造方法 |
DE4030040A1 (de) * | 1990-09-22 | 1992-03-26 | Bayer Ag | Enzymatische de-acylierung von acyl-aminosorbosen und dessen verwendung bei der herstellung von 1-desoxynojirimicin |
US5401645A (en) * | 1992-03-16 | 1995-03-28 | Monsanto Company | Process for producing n-substituted polyhydroxy nitrogen-containing heterocycles utilizing acetobacteraceae and corynebacterium |
WO1995022975A1 (en) * | 1994-02-25 | 1995-08-31 | G.D. Searle & Co. | Use of 1-deoxynojirimycin and its derivatives for treating mammals infected with respiratory syncytial virus |
DE19741235A1 (de) | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
GB9909066D0 (en) * | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
US20050032841A1 (en) * | 1999-04-20 | 2005-02-10 | Steven Walkley | Therapeutic compositions and methods of treating glycolipid storage related disorders |
US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
JP2003506406A (ja) * | 1999-08-10 | 2003-02-18 | ザ・チャンセラー・マスターズ・アンド・スカラーズ・オブ・ザ・ユニバーシティ・オブ・オックスフォード | 長鎖n−アルキル化合物およびそのオキサ誘導体 |
DE60211677T2 (de) * | 2001-03-19 | 2006-12-28 | Lonza Ag | Verfahren zur herstellung von 2-hydroxymethyl-pyrolidin-3,4-diolen |
EP3441090A1 (en) | 2005-05-17 | 2019-02-13 | Amicus Therapeutics, Inc. | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
CN1328270C (zh) * | 2005-09-26 | 2007-07-25 | 鲁南制药集团股份有限公司 | 一种工业化生产米格列醇的方法 |
GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
JP2009545621A (ja) | 2006-08-02 | 2009-12-24 | ユナイテッド セラピューティクス コーポレーション | ウィルス感染症のリポソーム処置 |
CA2666814A1 (en) * | 2006-08-21 | 2008-05-29 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
CN101289418B (zh) * | 2007-04-19 | 2011-02-02 | 浙江医药股份有限公司新昌制药厂 | 米格列醇晶体及其制备方法 |
US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
EP2282723A2 (en) * | 2008-03-26 | 2011-02-16 | University of Oxford | Endoplasmic reticulum targeting liposomes |
CN106420740A (zh) * | 2009-02-23 | 2017-02-22 | 伊莫根特病毒学有限责任公司 | 亚氨基糖以及治疗病毒性疾病的方法 |
EP2400843B1 (en) * | 2009-02-24 | 2015-11-11 | United Therapeutics Corporation | Iminosugars and methods of treating arenaviral infections |
US8703744B2 (en) * | 2009-03-27 | 2014-04-22 | The Chancellor, Masters And Scholars Of The University Of Oxford | Cholesterol level lowering liposomes |
CA2765086C (en) | 2009-06-12 | 2015-12-15 | United Therapeutics Corporation | Iminosugars and methods of treating bunyaviral and togaviral diseases |
ES2527623T3 (es) * | 2009-09-04 | 2015-01-27 | United Therapeutics Corporation | Iminoazúcares para su uso en el tratamiento de enfermedades por filovirus |
ES2485623T3 (es) * | 2009-09-04 | 2014-08-13 | United Therapeutics Corporation | Procedimiento para el tratamiento de infecciones por poxvirus |
CA2772875A1 (en) * | 2009-09-04 | 2011-03-10 | United Therapeutics Corporation | Methods of treating orthomyxoviral infections |
EP2509598A1 (en) | 2009-12-07 | 2012-10-17 | The Chancellor, Masters And Scholars Of The University Of Oxford | N-substituted deoxynojirimycin compounds for use in inhibiting osteoclastogenesis and/or osteoclast activation |
US8927190B2 (en) * | 2010-01-25 | 2015-01-06 | Rohm And Haas Electronic Materials Llc | Photoresist comprising nitrogen-containing compound |
KR20160055916A (ko) | 2013-09-16 | 2016-05-18 | 이머전트 바이롤로지 엘엘씨 | 데옥시노지리마이신 유도체 및 그의 이용 방법 |
EP3215499B1 (en) | 2014-11-05 | 2021-01-20 | Emergent Virology LLC | Iminosugars useful for the treatment of viral diseases |
EP3318277A1 (en) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases |
CN114516831B (zh) * | 2022-01-21 | 2024-03-08 | 浙江奥翔药业股份有限公司 | 一种米格列醇的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2658563A1 (de) * | 1976-12-23 | 1978-06-29 | Bayer Ag | Inhibitoren fuer glykosid-hydrolasen aus bacillen |
NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
GB2009152B (en) * | 1977-11-10 | 1982-01-06 | Nippon Shinyaku Co Ltd | Method for producing moranoline and n-methylmoranoline |
DE2830469A1 (de) * | 1978-07-11 | 1980-01-24 | Bayer Ag | Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten |
DE2834122A1 (de) * | 1978-08-03 | 1980-02-14 | Bayer Ag | Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose |
DE2839309A1 (de) * | 1978-09-09 | 1980-03-27 | Bayer Ag | 3,4,5-trihydroxypiperidin-derivate |
DE2853573A1 (de) * | 1978-12-12 | 1980-07-03 | Bayer Ag | Herstellung von n-substituierten derivaten des l-desoxynojirimycins |
-
1980
- 1980-10-15 DE DE19803038901 patent/DE3038901A1/de not_active Withdrawn
-
1981
- 1981-09-25 US US06/305,656 patent/US4405714A/en not_active Expired - Lifetime
- 1981-10-07 AT AT81108007T patent/ATE11913T1/de not_active IP Right Cessation
- 1981-10-07 EP EP81108007A patent/EP0049858B1/de not_active Expired
- 1981-10-07 DE DE8181108007T patent/DE3169076D1/de not_active Expired
- 1981-10-12 IL IL64034A patent/IL64034A/xx not_active IP Right Cessation
- 1981-10-13 JP JP56162120A patent/JPS5798261A/ja active Granted
- 1981-10-13 CA CA000387752A patent/CA1174996A/en not_active Expired
- 1981-10-13 FI FI813182A patent/FI78469C/fi not_active IP Right Cessation
- 1981-10-14 HU HU812966A patent/HU188700B/hu not_active IP Right Cessation
- 1981-10-14 ES ES506237A patent/ES506237A0/es active Granted
- 1981-10-14 ZA ZA817084A patent/ZA817084B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US4405714A (en) | 1983-09-20 |
CA1174996A (en) | 1984-09-25 |
FI78469C (fi) | 1989-08-10 |
HU188700B (en) | 1986-05-28 |
IL64034A0 (en) | 1982-01-31 |
EP0049858A3 (en) | 1982-10-13 |
FI78469B (fi) | 1989-04-28 |
JPH039108B2 (ja) | 1991-02-07 |
ES8206475A1 (es) | 1982-08-16 |
ES506237A0 (es) | 1982-08-16 |
DE3038901A1 (de) | 1982-05-06 |
DE3169076D1 (en) | 1985-03-28 |
EP0049858B1 (de) | 1985-02-20 |
FI813182L (fi) | 1982-04-16 |
ATE11913T1 (de) | 1985-03-15 |
ZA817084B (en) | 1982-09-29 |
EP0049858A2 (de) | 1982-04-21 |
JPS5798261A (en) | 1982-06-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
EXP | Patent expired |