ES2087277T3 - Procedimiento para producir 1-desoxinojirimicina n-sustituida. - Google Patents
Procedimiento para producir 1-desoxinojirimicina n-sustituida.Info
- Publication number
- ES2087277T3 ES2087277T3 ES91870145T ES91870145T ES2087277T3 ES 2087277 T3 ES2087277 T3 ES 2087277T3 ES 91870145 T ES91870145 T ES 91870145T ES 91870145 T ES91870145 T ES 91870145T ES 2087277 T3 ES2087277 T3 ES 2087277T3
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- procedure
- produce
- deoxynojirimycin
- oxidizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Catalysts (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
LA INVENCION ES UN PROCESO PARA LA PRODUCCION DE GLUCAMINAS SUSTITUIDAS-N , UN PROCESO PARA OXIDAR UNA GLUCAMINA SUSTITUIDA-N CON UN MICROBIO OXIDANTE O UN EXTRACTO DEL MISMO, Y UN PROCESO PARA OXIDAR UNA GLUCAMINA SUSTITUIDA-N CON UN MICROBIO OXIDANTE O UN EXTRACTO DEL MISMO Y REDUCIR LA GLUCAMINA SUSTITUIDA-N OXIDADA A N-SUSTITUIDA-1-DEOXINOJIRIMICINA. ADEMAS, SE EXPONE EL PROCESO DE UNA SOLA MARMITA PARA LA PRODUCCION DE N-SUSTITUIDA-1-DEOXINOJIRIMICINA DE LA GLUCOSA-D.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58558890A | 1990-09-20 | 1990-09-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2087277T3 true ES2087277T3 (es) | 1996-07-16 |
Family
ID=24342101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91870145T Expired - Lifetime ES2087277T3 (es) | 1990-09-20 | 1991-09-19 | Procedimiento para producir 1-desoxinojirimicina n-sustituida. |
Country Status (9)
Country | Link |
---|---|
US (4) | US5610039A (es) |
EP (1) | EP0477160B1 (es) |
JP (2) | JP3162123B2 (es) |
AT (1) | ATE137266T1 (es) |
CA (1) | CA2051855C (es) |
DE (1) | DE69119010T2 (es) |
DK (1) | DK0477160T3 (es) |
ES (1) | ES2087277T3 (es) |
GR (1) | GR3020532T3 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5401645A (en) * | 1992-03-16 | 1995-03-28 | Monsanto Company | Process for producing n-substituted polyhydroxy nitrogen-containing heterocycles utilizing acetobacteraceae and corynebacterium |
US6177447B1 (en) * | 1996-07-15 | 2001-01-23 | Universiteit Van Amsterdam | Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors |
US20030100532A1 (en) | 1997-02-14 | 2003-05-29 | Gary S. Jacob | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections |
AU753336B2 (en) | 1997-11-10 | 2002-10-17 | G.D. Searle & Co. | Use of alkylated iminosugars to treat multidrug resistance |
US6689759B1 (en) | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
TR200002323T2 (tr) | 1998-02-12 | 2000-12-21 | G.D. Searle & Co. | Hepatit virüs enfeksiyonlarının tedavi edilmesi için N-ikameli-1,5-dideoksi 1,5-imino-D-glusitol bileşiklerinin kullanımı |
EP1165080A2 (en) | 1999-02-12 | 2002-01-02 | G.D. SEARLE & CO. | Use of substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections |
JP2003505501A (ja) | 1999-02-12 | 2003-02-12 | ジー・ディー・サール・アンド・カンパニー | 肝炎ウィルス感染の処置のためのグルカミン化合物 |
US6462197B2 (en) | 2000-03-31 | 2002-10-08 | Board Of Trustees Of Michigan State University | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines |
JP2004506365A (ja) * | 2000-08-09 | 2004-02-26 | スカイビッツ,インコーポレイテッド | Cordic位相ロテーターを用いた周波数変換装置 |
CN1300098C (zh) * | 2003-10-28 | 2007-02-14 | 浙江医药股份有限公司新昌制药厂 | N-丁基-葡糖胺的合成方法 |
JP3916166B2 (ja) * | 2004-09-27 | 2007-05-16 | 学校法人慶應義塾 | 化合物ライブラリーの作製方法、並びに、スクリーニング方法 |
CN1328270C (zh) * | 2005-09-26 | 2007-07-25 | 鲁南制药集团股份有限公司 | 一种工业化生产米格列醇的方法 |
CA2666814A1 (en) * | 2006-08-21 | 2008-05-29 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
EP1903034A1 (en) * | 2006-09-19 | 2008-03-26 | Technische Universität Graz | Iminosugar glycoconjugates |
CN101289418B (zh) * | 2007-04-19 | 2011-02-02 | 浙江医药股份有限公司新昌制药厂 | 米格列醇晶体及其制备方法 |
CN101302549B (zh) * | 2007-05-09 | 2013-06-05 | 浙江医药股份有限公司新昌制药厂 | 高纯度米格列醇的生产方法 |
US8225824B2 (en) * | 2007-11-16 | 2012-07-24 | Intelligent Hospital Systems, Ltd. | Method and apparatus for automated fluid transfer operations |
CN101195602B (zh) * | 2007-12-25 | 2011-03-23 | 郑州大学 | 1-脱氧野尻毒素衍生物、其制备方法及其应用 |
KR101698436B1 (ko) * | 2010-08-11 | 2017-01-20 | (주)아모레퍼시픽 | 데아닌 유도체, 이의 제조방법 및 이를 함유하는 항여드름용 피부 외용제 조성물 |
CN105968042B (zh) * | 2016-07-15 | 2019-06-07 | 四川维奥制药有限公司 | 一种米格列醇的制备方法 |
CN107935865A (zh) * | 2017-10-31 | 2018-04-20 | 浙江工业大学 | 米格列醇中间体1‑脱氧‑1‑(2‑羟乙基氨基)‑d‑葡萄糖醇的制备方法 |
CN107746385A (zh) * | 2017-10-31 | 2018-03-02 | 浙江工业大学 | 一种米格列醇的制备方法 |
WO2019144920A1 (zh) * | 2018-01-26 | 2019-08-01 | 浙江工业大学 | 一种促进氧化葡糖杆菌合成山梨醇脱氢酶及辅酶吡咯喹啉醌的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3920664A (en) * | 1972-07-21 | 1975-11-18 | Lilly Co Eli | D-2-halo-6-alkyl-8-substituted ergolines and related compounds |
JPS5317677B2 (es) * | 1973-09-25 | 1978-06-09 | ||
US3919316A (en) * | 1974-08-05 | 1975-11-11 | Lilly Co Eli | 2-Aminodichlorotetralins |
DE2834122A1 (de) * | 1978-08-03 | 1980-02-14 | Bayer Ag | Verfahren zur herstellung von 6-amino-6-desoxy-l-sorbose |
DE2853573A1 (de) * | 1978-12-12 | 1980-07-03 | Bayer Ag | Herstellung von n-substituierten derivaten des l-desoxynojirimycins |
DE2907190A1 (de) * | 1979-02-23 | 1980-08-28 | Bayer Ag | 1-desoxynojirimycin-herstellung |
DE3038901A1 (de) * | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
DE3049446A1 (de) * | 1980-12-30 | 1982-07-29 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 1,5-didesoxy-1,5-imino-d-glucitol und dessen n-derivaten |
DE3611841A1 (de) * | 1986-04-09 | 1987-10-15 | Bayer Ag | Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten |
DE3814549A1 (de) * | 1987-10-30 | 1989-05-18 | Bayer Ag | N-substituierte derivate von 1-desoxynojirimycin und 1-desoxymannonojirimycin, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
US5151519A (en) * | 1990-05-07 | 1992-09-29 | G. D. Searle & Co. | Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof |
-
1991
- 1991-09-19 ES ES91870145T patent/ES2087277T3/es not_active Expired - Lifetime
- 1991-09-19 CA CA002051855A patent/CA2051855C/en not_active Expired - Lifetime
- 1991-09-19 DE DE69119010T patent/DE69119010T2/de not_active Expired - Lifetime
- 1991-09-19 DK DK91870145.9T patent/DK0477160T3/da active
- 1991-09-19 AT AT91870145T patent/ATE137266T1/de not_active IP Right Cessation
- 1991-09-19 JP JP23968091A patent/JP3162123B2/ja not_active Expired - Lifetime
- 1991-09-19 EP EP91870145A patent/EP0477160B1/en not_active Expired - Lifetime
-
1995
- 1995-05-19 US US08/444,505 patent/US5610039A/en not_active Expired - Lifetime
- 1995-05-19 US US08/444,636 patent/US5602013A/en not_active Expired - Lifetime
-
1996
- 1996-07-12 GR GR960401895T patent/GR3020532T3/el unknown
- 1996-12-27 US US08/775,069 patent/US5916784A/en not_active Expired - Fee Related
-
1999
- 1999-04-14 US US09/291,005 patent/US6552176B2/en not_active Expired - Fee Related
-
2000
- 2000-06-13 JP JP2000176476A patent/JP2001058975A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2051855A1 (en) | 1992-03-21 |
US5602013A (en) | 1997-02-11 |
US20010019837A1 (en) | 2001-09-06 |
EP0477160A1 (en) | 1992-03-25 |
US5916784A (en) | 1999-06-29 |
DE69119010T2 (de) | 1996-11-28 |
US5610039A (en) | 1997-03-11 |
EP0477160B1 (en) | 1996-04-24 |
US6552176B2 (en) | 2003-04-22 |
ATE137266T1 (de) | 1996-05-15 |
GR3020532T3 (en) | 1996-10-31 |
CA2051855C (en) | 2002-11-26 |
DE69119010D1 (de) | 1996-05-30 |
DK0477160T3 (da) | 1996-05-20 |
JPH04342567A (ja) | 1992-11-30 |
JP2001058975A (ja) | 2001-03-06 |
JP3162123B2 (ja) | 2001-04-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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