JPS5663993A - Novel preparation of tobramycin - Google Patents
Novel preparation of tobramycinInfo
- Publication number
- JPS5663993A JPS5663993A JP13926279A JP13926279A JPS5663993A JP S5663993 A JPS5663993 A JP S5663993A JP 13926279 A JP13926279 A JP 13926279A JP 13926279 A JP13926279 A JP 13926279A JP S5663993 A JPS5663993 A JP S5663993A
- Authority
- JP
- Japan
- Prior art keywords
- protecting group
- formula
- eliminating
- acts
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 title abstract 2
- 229960000707 tobramycin Drugs 0.000 title 1
- 229960001192 bekanamycin Drugs 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 229930182824 kanamycin B Natural products 0.000 abstract 2
- SKKLOUVUUNMCJE-FQSMHNGLSA-N kanamycin B Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SKKLOUVUUNMCJE-FQSMHNGLSA-N 0.000 abstract 2
- 229910001507 metal halide Inorganic materials 0.000 abstract 2
- 150000005309 metal halides Chemical class 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13926279A JPS5663993A (en) | 1979-10-30 | 1979-10-30 | Novel preparation of tobramycin |
| US06/196,586 US4349666A (en) | 1979-10-30 | 1980-10-14 | Process for the production of kanomycin B derivatives and products obtained therefrom |
| GB8034764A GB2061942B (en) | 1979-10-30 | 1980-10-29 | Process for the production of tobramycin and novel 3'-halo intermediates thereof |
| DE3040611A DE3040611C2 (de) | 1979-10-30 | 1980-10-29 | Verfahren zur Herstellung von 3'-Desoxykanamycin B (Tobramycin) |
| FR8023421A FR2468616B1 (fr) | 1979-10-30 | 1980-10-29 | Nouveau procede de production de la tobramycine ou 3'-desoxy-kanamycine b a partir d'un derive protege de kanamycine b, et produits intermediaires obtenus au cours de ce procede |
| CA000363650A CA1151161A (en) | 1979-10-30 | 1980-10-30 | Process for the production of tobramycin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13926279A JPS5663993A (en) | 1979-10-30 | 1979-10-30 | Novel preparation of tobramycin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5663993A true JPS5663993A (en) | 1981-05-30 |
| JPS631952B2 JPS631952B2 (ja) | 1988-01-14 |
Family
ID=15241184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13926279A Granted JPS5663993A (en) | 1979-10-30 | 1979-10-30 | Novel preparation of tobramycin |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4349666A (ja) |
| JP (1) | JPS5663993A (ja) |
| CA (1) | CA1151161A (ja) |
| DE (1) | DE3040611C2 (ja) |
| FR (1) | FR2468616B1 (ja) |
| GB (1) | GB2061942B (ja) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5815994A (ja) * | 1981-07-22 | 1983-01-29 | Microbial Chem Res Found | ２′位修飾カナマイシン誘導体およびその製造法 |
| JPS6140297A (ja) * | 1984-08-02 | 1986-02-26 | Microbial Chem Res Found | ３′−フルオロ−３′−デオキシカナマイシンａ |
| JPS6251694A (ja) * | 1985-08-29 | 1987-03-06 | Microbial Chem Res Found | ３′，４′−ジデオキシ−３′−フルオロカナマイシンｂおよびその製造法 |
| DE3727648A1 (de) * | 1987-08-19 | 1989-03-02 | Bayer Ag | Neue avermectin derivate, verfahren zu ihrer herstellung und ihre verwendung |
| JPH02122257U (ja) * | 1989-03-20 | 1990-10-05 | ||
| JP5382852B2 (ja) | 2009-02-06 | 2014-01-08 | 株式会社オンチップ・バイオテクノロジーズ | 使い捨てチップ型フローセルとそれを用いたフローサイトメーター |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3929762A (en) * | 1972-08-23 | 1975-12-30 | Microbial Chem Res Found | 3{40 -Deoxy derivatives of neamine and its related aminoglycosidic antibiotics, and the production thereof |
| JPS57876B2 (ja) * | 1972-12-08 | 1982-01-08 | ||
| JPS5821918B2 (ja) * | 1975-04-24 | 1983-05-04 | ザイダンホウジン ビセイブツカガクケンキユウカイ | １−Ｎ−（α−置換−ω−アミノアシル）−３′−デオキシリ ボスタマイシンの新規な製造 |
| US4195170A (en) * | 1975-12-09 | 1980-03-25 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | 3',4'-Episulfido kanamycin B compounds |
| JPS6029720B2 (ja) * | 1975-12-11 | 1985-07-12 | 財団法人微生物化学研究会 | ３′，４′‐ジデオキシカナマイシンｂの新規な製造法 |
| LU76689A1 (ja) * | 1977-02-02 | 1977-08-18 |
-
1979
- 1979-10-30 JP JP13926279A patent/JPS5663993A/ja active Granted
-
1980
- 1980-10-14 US US06/196,586 patent/US4349666A/en not_active Expired - Lifetime
- 1980-10-29 FR FR8023421A patent/FR2468616B1/fr not_active Expired
- 1980-10-29 GB GB8034764A patent/GB2061942B/en not_active Expired
- 1980-10-29 DE DE3040611A patent/DE3040611C2/de not_active Expired
- 1980-10-30 CA CA000363650A patent/CA1151161A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3040611C2 (de) | 1985-04-18 |
| GB2061942A (en) | 1981-05-20 |
| GB2061942B (en) | 1983-09-28 |
| FR2468616A1 (fr) | 1981-05-08 |
| FR2468616B1 (fr) | 1985-06-28 |
| US4349666A (en) | 1982-09-14 |
| DE3040611A1 (de) | 1981-05-14 |
| JPS631952B2 (ja) | 1988-01-14 |
| CA1151161A (en) | 1983-08-02 |
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