JPS5649381A - Preparation of cephalosporin analogue - Google Patents

Preparation of cephalosporin analogue

Info

Publication number
JPS5649381A
JPS5649381A JP12488879A JP12488879A JPS5649381A JP S5649381 A JPS5649381 A JP S5649381A JP 12488879 A JP12488879 A JP 12488879A JP 12488879 A JP12488879 A JP 12488879A JP S5649381 A JPS5649381 A JP S5649381A
Authority
JP
Japan
Prior art keywords
salt
cephalosporin
analogue
thiourea
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12488879A
Other languages
Japanese (ja)
Inventor
Tadashi Hirata
Hideo Matsushima
Takehiro Ogasa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP12488879A priority Critical patent/JPS5649381A/en
Publication of JPS5649381A publication Critical patent/JPS5649381A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PURPOSE: To prepare the titled compound useful as a medicine having extremely excellent antibacterial activity, economically, in an industrial scale, by reacting a cephalosporin analogue or its salt with thiourea.
CONSTITUTION: The compound of formula II (R1 is H, etc.; R2 is H, lower alkyl, etc.; R3 is carboxy) is obtained by reacting the cephalosporin analogue of formula I (X is halogen) or its salt with thiourea in a reaction solvent (e.g. water, alcohol, etc.), and if necessary, eliminating the protecting group of R3 by conventional method, and further converting to a proper pharmacologically acceptable salt. The reaction is carried out at room temperature or with heat for 1hr to several days.
EFFECT: The protection and deprotection of the 2-position amino group of the thiazolyl group are not necessary.
COPYRIGHT: (C)1981,JPO&Japio
JP12488879A 1979-09-28 1979-09-28 Preparation of cephalosporin analogue Pending JPS5649381A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12488879A JPS5649381A (en) 1979-09-28 1979-09-28 Preparation of cephalosporin analogue

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12488879A JPS5649381A (en) 1979-09-28 1979-09-28 Preparation of cephalosporin analogue

Publications (1)

Publication Number Publication Date
JPS5649381A true JPS5649381A (en) 1981-05-02

Family

ID=14896571

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12488879A Pending JPS5649381A (en) 1979-09-28 1979-09-28 Preparation of cephalosporin analogue

Country Status (1)

Country Link
JP (1) JPS5649381A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0082501A1 (en) * 1981-12-18 1983-06-29 Kyowa Hakko Kogyo Co., Ltd Beta-lactam compound and a pharmaceutical composition containing the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0082501A1 (en) * 1981-12-18 1983-06-29 Kyowa Hakko Kogyo Co., Ltd Beta-lactam compound and a pharmaceutical composition containing the same

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