JPS5569582A - 1,7-phenanthroline-3-carboxylic acid derivative - Google Patents
1,7-phenanthroline-3-carboxylic acid derivativeInfo
- Publication number
- JPS5569582A JPS5569582A JP14178678A JP14178678A JPS5569582A JP S5569582 A JPS5569582 A JP S5569582A JP 14178678 A JP14178678 A JP 14178678A JP 14178678 A JP14178678 A JP 14178678A JP S5569582 A JPS5569582 A JP S5569582A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- solvent
- alkyl group
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 1,7-phenanthroline-3-carboxylic acid derivative Chemical class 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 150000002690 malonic acid derivatives Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formula 1a: (R1 is H or lower alkyl group; R4 is lower alkyl group) or formula 1b, and its salt.
EXAMPLE: 9, 10-Dihydro-4, 8-dioxo-1H, 4H, 7H-1, 7-phenanthroline-3-carboxylic acid.
USE: Antibacterials effective against Gram-positive and Gram-negative bacteria, carcinostatics, and antiviral agents, having low toxicity.
PROCESS: A carbostyril derivative of formula 2 is reacted with a malonic acid derivative of formula 3: (R3 is lower alkyl group) in the presence or absence of a solvent, e.g. methanol, at room temperature to 150°C to give a compound of formula 4, which is then subjected to ring closure in a solvent, e.g. diphenyl ether, at 100W 250°C to form the compound of formula 1a. The resulting compound is then hydrolyzed in a solvent, e.g. methanol, in the presence of a catalyst, e.g. NaOH, at room temperature to 200°C to afford the compound of formula 1b.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP53141786A JPS5854151B2 (en) | 1978-11-16 | 1978-11-16 | 1,7↓-phenanthroline↓-3↓-carboxylic acid derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP53141786A JPS5854151B2 (en) | 1978-11-16 | 1978-11-16 | 1,7↓-phenanthroline↓-3↓-carboxylic acid derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5569582A true JPS5569582A (en) | 1980-05-26 |
| JPS5854151B2 JPS5854151B2 (en) | 1983-12-02 |
Family
ID=15300122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53141786A Expired JPS5854151B2 (en) | 1978-11-16 | 1978-11-16 | 1,7↓-phenanthroline↓-3↓-carboxylic acid derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5854151B2 (en) |
-
1978
- 1978-11-16 JP JP53141786A patent/JPS5854151B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5854151B2 (en) | 1983-12-02 |
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