JPS54109955A - Stilbene derivative - Google Patents

Stilbene derivative

Info

Publication number
JPS54109955A
JPS54109955A JP15699278A JP15699278A JPS54109955A JP S54109955 A JPS54109955 A JP S54109955A JP 15699278 A JP15699278 A JP 15699278A JP 15699278 A JP15699278 A JP 15699278A JP S54109955 A JPS54109955 A JP S54109955A
Authority
JP
Japan
Prior art keywords
stilbene derivative
stilbene
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15699278A
Other languages
English (en)
Other versions
JPH0146493B2 (ja
Inventor
Peter Loeliger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JPS54109955A publication Critical patent/JPS54109955A/ja
Publication of JPH0146493B2 publication Critical patent/JPH0146493B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C07C1/32—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from compounds containing hetero-atoms other than or in addition to oxygen or halogen
    • C07C1/34—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from compounds containing hetero-atoms other than or in addition to oxygen or halogen reacting phosphines with aldehydes or ketones, e.g. Wittig reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/28—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/47—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with a bicyclo ring system containing ten carbon atoms
    • C07C13/48—Completely or partially hydrogenated naphthalenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/34—Monohydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/164—Unsaturated ethers containing six-membered aromatic rings
    • C07C43/168—Unsaturated ethers containing six-membered aromatic rings containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/548—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings having unsaturation outside the six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/794—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring
    • C07C49/798—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/66—Polycyclic acids with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/12—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5456—Arylalkanephosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
    • C12C11/00—Fermentation processes for beer
    • C12C11/02—Pitching yeast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP15699278A 1977-12-22 1978-12-21 Stilbene derivative Granted JPS54109955A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU78751 1977-12-22
CH1159078 1978-11-10

Publications (2)

Publication Number Publication Date
JPS54109955A true JPS54109955A (en) 1979-08-29
JPH0146493B2 JPH0146493B2 (ja) 1989-10-09

Family

ID=25708596

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15699278A Granted JPS54109955A (en) 1977-12-22 1978-12-21 Stilbene derivative

Country Status (32)

Country Link
EP (1) EP0002742B1 (ja)
JP (1) JPS54109955A (ja)
AR (1) AR224357A1 (ja)
AT (1) AT361459B (ja)
AU (1) AU525419B2 (ja)
BR (1) BR7808470A (ja)
CA (1) CA1123839A (ja)
CS (1) CS208158B2 (ja)
CU (1) CU35002A (ja)
CY (1) CY1277A (ja)
DE (2) DE2854354A1 (ja)
DK (1) DK159967C (ja)
DO (1) DOP1978002760A (ja)
ES (1) ES476224A1 (ja)
FI (1) FI68804C (ja)
FR (1) FR2422620A1 (ja)
GB (1) GB2010836B (ja)
GR (1) GR71656B (ja)
HK (1) HK30185A (ja)
HU (1) HU180786B (ja)
IE (1) IE47617B1 (ja)
IL (1) IL56219A (ja)
IT (1) IT1102753B (ja)
KE (1) KE3504A (ja)
MC (1) MC1230A1 (ja)
MY (1) MY8500248A (ja)
NL (1) NL7812312A (ja)
NO (1) NO146322C (ja)
NZ (1) NZ189203A (ja)
PT (1) PT68965A (ja)
SE (1) SE7813212L (ja)
SG (1) SG5485G (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5921630A (ja) * 1982-07-02 1984-02-03 エフ・ホフマン―ラ　ロシユ　アーゲー 皮脂分泌低下剤
JPS6122046A (ja) * 1984-07-07 1986-01-30 Koichi Shiyudo スチルベン誘導体
JPS6429308A (en) * 1987-07-02 1989-01-31 Richiyaado Soonfueruto Kaaru Treatment of hyperhydrosis, psoriasis and wrinkle
JPH01157934A (ja) * 1987-11-06 1989-06-21 F Hoffmann La Roche Ag 新規なベンゾシクロヘプテン誘導体
JPH0579665U (ja) * 1992-03-27 1993-10-29 株式会社のもと 読取補助シート
JP2007514773A (ja) * 2003-12-17 2007-06-07 アラーガン　インコーポレイテッド 選択的シトクロムｐ４５０ｒａｉ−１または選択的シトクロムｐ４５０ｒａｉ−２阻害活性を有する化合物およびそれを得る方法
JP2010515716A (ja) * 2007-01-15 2010-05-13 チョンシー ユー 非常に高い皮膚浸透率を有するレチノイド及びレチノイド様化合物の正に荷電した水溶性プロドラッグ

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI67386C (fi) * 1979-06-21 1985-03-11 Hoffmann La Roche Foerfarande foer framstaellning av nya terapeutiskt anvaendbara sockerderivat
EP0084667B1 (de) * 1982-01-23 1985-09-18 BASF Aktiengesellschaft Phenylethylen-Derivate, ihre Herstellung und Verwendung als Arzneimittel
DK158947C (da) * 1982-07-06 1991-01-21 Hoffmann La Roche Tetrahydronaphthalin-,benzofuran- og benzothiophenderivater, fremstilling og anvendelse deraf samt rodenticid indeholdende saadanne derivater
US4808597A (en) * 1983-07-05 1989-02-28 Pfizer Inc. Method for inhibiting the degradation of cartilage
EP0155940A1 (en) * 1983-08-08 1985-10-02 Sri International Benzonorbornenyl, benzopyranyl and benzothiopyranyl retinoic acid analogues
FR2555571B1 (fr) * 1983-11-28 1986-11-28 Interna Rech Dermatolo Centre Derives du naphtalene, leur procede de preparation et leur application dans le domaine therapeutique
FR2562539B1 (fr) * 1984-04-06 1987-04-17 Chauvin Blache Lab Nouveaux derives de l'acide vinyl-4 benzoique, leur procede de preparation et leurs applications en therapeutique et comme ligands
DE3580134D1 (de) * 1984-07-07 1990-11-22 Shudo Koichi Prof Dr Chem Benzoesaeurederivate.
DE3434948A1 (de) * 1984-09-22 1986-04-03 Basf Ag, 6700 Ludwigshafen Vinyltetrazolylphenyl-derivate, ihre herstellung und verwendung
DE3434942A1 (de) * 1984-09-22 1986-04-03 Basf Ag, 6700 Ludwigshafen Tetralin-derivate, ihre herstellung und verwendung
DE3438386A1 (de) * 1984-09-22 1986-04-03 Basf Ag, 6700 Ludwigshafen Phosphorsaeurevinylbenzylester, ihre herstellung und verwendung
DE3434946A1 (de) 1984-09-22 1986-04-03 Basf Ag, 6700 Ludwigshafen Diarylacetylene, ihre herstellung und verwendung
DE3434944A1 (de) * 1984-09-22 1986-04-03 Basf Ag, 6700 Ludwigshafen L-substituierte tetralinderivate, ihre herstellung und verwendung
LU85558A1 (fr) * 1984-09-28 1986-04-03 Oreal Nouveaux derives naphtaleniques a action retinoique,leurs procedes de preparation et compositions medicamenteuse et cosmetique les contenant
LU85726A1 (fr) * 1985-01-10 1986-08-04 Cird Nouveaux derives naphtaleniques du benzonorbornene,leur procede de preparation et compositions medicamenteuse et cosmetique les contenant
CA1268125A (en) * 1985-06-28 1990-04-24 F. Hoffmann-La Roche Ag Use of a retinoid
ZW7487A1 (en) * 1986-05-23 1987-12-16 Hoffmann La Roche Tetrahydronaphthaline and indane derivatives
DE3726806A1 (de) * 1987-08-12 1989-02-23 Basf Ag Arylphosphorderivate, ihre herstellung und verwendung
US5250562A (en) * 1988-02-24 1993-10-05 Hoffmann-La Roche Inc. Stilbene derivatives
AU618590B2 (en) * 1988-04-11 1992-01-02 Allergan, Inc. Tetralin esters of phenols or benzoic acids having retinoid like activity
US5196532A (en) * 1989-02-08 1993-03-23 Basf Aktiengesellschaft Diaryl-substituted heterocyclic compounds, their preparation and drugs and cosmetics obtained therefrom
DE3903993A1 (de) * 1989-02-10 1990-08-16 Basf Ag Diarylsubstituierte heterocyclische verbindungen, ihre herstellung und arzneimittel daraus
DE3903989A1 (de) * 1989-02-10 1990-09-20 Basf Ag Diphenylheteroalkylderivate, ihre herstellung und daraus hergestellte arzneimittel und kosmetika
DE3926148A1 (de) * 1989-08-08 1991-02-28 Basf Ag Diarylacetylene, ihre herstellung und verwendung
CA2129773C (en) 1993-09-02 2007-05-01 Michael Klaus Aromatic carboxylic acid derivatives
FR2743560B1 (fr) 1996-01-17 1998-04-03 Europ De Bioprospective Centre Derives polycycliques aromatiques de type retinoide, leur procede de preparation et leur utilisation pour la fabrication de compositions pharmaceutiques et cosmetiques
WO2017174999A1 (en) * 2016-04-07 2017-10-12 High Force Research Limited Synthetic retinoids for use in rar mediated conditions
CN115667190A (zh) * 2020-06-17 2023-01-31 贝达药业股份有限公司 双环类化合物及其应用

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5921630A (ja) * 1982-07-02 1984-02-03 エフ・ホフマン―ラ　ロシユ　アーゲー 皮脂分泌低下剤
JPS6122046A (ja) * 1984-07-07 1986-01-30 Koichi Shiyudo スチルベン誘導体
JPS6429308A (en) * 1987-07-02 1989-01-31 Richiyaado Soonfueruto Kaaru Treatment of hyperhydrosis, psoriasis and wrinkle
JP2608762B2 (ja) * 1987-07-02 1997-05-14 セレジー ファーマシューティカルズ，インク． 多汗症の治療剤
JPH01157934A (ja) * 1987-11-06 1989-06-21 F Hoffmann La Roche Ag 新規なベンゾシクロヘプテン誘導体
JPH0579665U (ja) * 1992-03-27 1993-10-29 株式会社のもと 読取補助シート
JP2007514773A (ja) * 2003-12-17 2007-06-07 アラーガン　インコーポレイテッド 選択的シトクロムｐ４５０ｒａｉ−１または選択的シトクロムｐ４５０ｒａｉ−２阻害活性を有する化合物およびそれを得る方法
JP2010515716A (ja) * 2007-01-15 2010-05-13 チョンシー ユー 非常に高い皮膚浸透率を有するレチノイド及びレチノイド様化合物の正に荷電した水溶性プロドラッグ

Also Published As

Publication number Publication date
FR2422620B1 (ja) 1981-09-18
AU4286178A (en) 1979-06-28
DE2861748D1 (en) 1982-05-27
DE2854354A1 (de) 1979-07-05
CU35002A (en) 1982-08-24
HK30185A (en) 1985-04-26
IL56219A (en) 1983-05-15
MY8500248A (en) 1985-12-31
CS208158B2 (en) 1981-08-31
DK159967B (da) 1991-01-07
IT7831277A0 (it) 1978-12-22
ES476224A1 (es) 1979-11-16
ATA917578A (de) 1980-08-15
GR71656B (ja) 1983-06-20
IT1102753B (it) 1985-10-07
SG5485G (en) 1985-06-14
NO146322B (no) 1982-06-01
NO146322C (no) 1982-09-15
FI68804B (fi) 1985-07-31
DK536178A (da) 1979-06-23
EP0002742B1 (de) 1982-04-14
GB2010836A (en) 1979-07-04
EP0002742A1 (de) 1979-07-11
PT68965A (en) 1979-01-01
DOP1978002760A (es) 1990-05-28
IL56219A0 (en) 1979-03-12
AR224357A1 (es) 1981-11-30
KE3504A (en) 1985-03-08
FI68804C (fi) 1985-11-11
NO784329L (no) 1979-06-25
IE47617B1 (en) 1984-05-02
JPH0146493B2 (ja) 1989-10-09
MC1230A1 (fr) 1979-10-26
NZ189203A (en) 1984-07-06
IE782472L (en) 1979-06-22
SE7813212L (sv) 1979-06-23
CA1123839A (en) 1982-05-18
AT361459B (de) 1981-03-10
NL7812312A (nl) 1979-06-26
DK159967C (da) 1991-06-03
BR7808470A (pt) 1979-08-21
FR2422620A1 (fr) 1979-11-09
AU525419B2 (en) 1982-11-04
CY1277A (en) 1985-07-05
HU180786B (en) 1983-04-29
FI783863A (fi) 1979-06-23
GB2010836B (en) 1982-08-04

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