JPS525777A - 1,4-dihydroxypyridine derivatives - Google Patents
1,4-dihydroxypyridine derivativesInfo
- Publication number
- JPS525777A JPS525777A JP51079413A JP7941376A JPS525777A JP S525777 A JPS525777 A JP S525777A JP 51079413 A JP51079413 A JP 51079413A JP 7941376 A JP7941376 A JP 7941376A JP S525777 A JPS525777 A JP S525777A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- cyano
- formula
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HFFBRLXQWQCDEX-UHFFFAOYSA-N 1-hydroxy-2h-pyridin-4-ol Chemical class ON1CC=C(O)C=C1 HFFBRLXQWQCDEX-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 abstract 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB27945/75A GB1552911A (en) | 1975-07-02 | 1975-07-02 | 1,4 dihydropyridine derivatives and the preparation thereof |
GB3985475 | 1975-09-29 | ||
GB5152475 | 1975-12-16 | ||
GB1376176 | 1976-04-05 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP59091231A Division JPS6012324B2 (ja) | 1975-07-02 | 1984-05-07 | 1,4―ジヒドロピリジン誘導体を含有する血管拡張剤および血圧降下剤 |
JP59091232A Division JPS601154A (ja) | 1975-07-02 | 1984-05-07 | 1,4−ジヒドロピリジン誘導体中間体 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS525777A true JPS525777A (en) | 1977-01-17 |
JPS5948827B2 JPS5948827B2 (ja) | 1984-11-29 |
Family
ID=27448211
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51079413A Expired JPS5948827B2 (ja) | 1975-07-02 | 1976-07-02 | 1,4−ジヒドロピリジン誘導体 |
Country Status (19)
Country | Link |
---|---|
US (1) | US4145432A (ja) |
JP (1) | JPS5948827B2 (ja) |
AR (2) | AR213097A1 (ja) |
AU (1) | AU510353B2 (ja) |
CH (3) | CH629778A5 (ja) |
DD (1) | DD126722A5 (ja) |
DE (1) | DE2629892A1 (ja) |
DK (1) | DK298176A (ja) |
FI (1) | FI61696C (ja) |
FR (1) | FR2315930A1 (ja) |
GB (1) | GB1552911A (ja) |
GR (1) | GR60422B (ja) |
IE (1) | IE43408B1 (ja) |
IT (1) | IT1068561B (ja) |
MX (1) | MX3591E (ja) |
NL (1) | NL190812C (ja) |
PH (1) | PH13772A (ja) |
SE (1) | SE434049B (ja) |
YU (2) | YU41562B (ja) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5395977A (en) * | 1976-12-17 | 1978-08-22 | Fujisawa Pharmaceut Co Ltd | 1,4-dihydropyrimidine compounds and process for their preparation |
JPS5826872A (ja) * | 1981-07-30 | 1983-02-17 | バイエル・アクチエンゲゼルシヤフト | 心臓収縮性増進剤 |
JPS58185821U (ja) * | 1982-06-02 | 1983-12-10 | 日産自動車株式会社 | ウインドシ−ルド |
JPS5927871A (ja) * | 1982-08-06 | 1984-02-14 | Banyu Pharmaceut Co Ltd | 2−カルバモイルオキシアルキル−1,4−ジヒドロピリジン誘導体の新規な製造法 |
JPS6157578A (ja) * | 1984-08-17 | 1986-03-24 | ジヨン・ワイス・アンド・ブラザー・リミテツド | 複素環式化合物 |
JPS62145064A (ja) * | 1985-12-13 | 1987-06-29 | バイエル・アクチエンゲゼルシヤフト | 新規なフツ素含有1,4−ジヒドロピリジン類 |
JPS62155280A (ja) * | 1985-12-18 | 1987-07-10 | バイエル・アクチエンゲゼルシヤフト | 4−チエニル−ジヒドロピリジン類 |
JPS62190187A (ja) * | 1986-01-11 | 1987-08-20 | バイエル・アクチエンゲゼルシヤフト | 4−アミノアリ−ルジヒドロピリジンラクトン類 |
JPS62292757A (ja) * | 1986-06-12 | 1987-12-19 | Taisho Pharmaceut Co Ltd | 1,4−ジヒドロピリジン誘導体 |
JPS63211266A (ja) * | 1978-09-08 | 1988-09-02 | Fujisawa Pharmaceut Co Ltd | ジヒドロピリジン誘導体の中間体 |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4370334A (en) * | 1975-07-02 | 1983-01-25 | Fujisawa Pharmaceutical Co., Ltd. | 1,4-Dihydro-pyridine derivatives and methods of using same |
DE2639257A1 (de) * | 1976-09-01 | 1978-03-02 | Bayer Ag | Aminoalkylidenamino-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2658183A1 (de) * | 1976-12-22 | 1978-07-06 | Bayer Ag | In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4466972A (en) * | 1977-06-20 | 1984-08-21 | Sandoz Ltd. | Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compositions containing them |
FI64938C (fi) * | 1977-06-20 | 1984-02-10 | Sandoz Ag | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara bensoxa- och bensotiadiazolyl-1,4-dihydropyridinderivat |
DE2738153A1 (de) * | 1977-08-24 | 1979-03-08 | Bayer Ag | 2-pyridyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2747513A1 (de) * | 1977-10-22 | 1979-05-03 | Bayer Ag | Dihydropyridine mit schwefelhaltigen estergruppierungen |
SE429652B (sv) * | 1978-06-30 | 1983-09-19 | Haessle Ab | 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester |
DE2841667A1 (de) * | 1978-09-25 | 1980-04-10 | Bayer Ag | Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
CA1117117A (en) * | 1978-10-10 | 1982-01-26 | Fujisawa Pharmaceutical Co., Ltd. | 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same |
DE2935451A1 (de) * | 1979-09-01 | 1981-03-19 | Bayer Ag, 5090 Leverkusen | Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel |
DE3022030A1 (de) * | 1980-06-12 | 1981-12-17 | Bayer Ag, 5090 Leverkusen | 4-thiazol- bzw. 4-imidazol-substituierte, 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel |
CS228917B2 (en) | 1981-03-14 | 1984-05-14 | Pfizer | Method of preparing substituted derivatives of 1,4-dihydropyridine |
JPS57171968A (en) * | 1981-04-17 | 1982-10-22 | Kyowa Hakko Kogyo Co Ltd | 1,4-dihydropyridine derivative |
JPS57175164A (en) * | 1981-04-18 | 1982-10-28 | Banyu Pharmaceut Co Ltd | 1,4-dihydropyridine derivative and its preparation |
JPS57175166A (en) | 1981-04-23 | 1982-10-28 | Banyu Pharmaceut Co Ltd | Carbamoyloxyalkyl-1,4-dihydropyridine derivative and its preparation |
DE3130041A1 (de) * | 1981-07-30 | 1983-02-17 | Bayer Ag, 5090 Leverkusen | Dihydropyridine mit positiv inotroper wirkung, neue verbindungen, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung |
EP0080220B1 (en) * | 1981-11-17 | 1986-02-19 | FISONS plc | Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals |
US4497808A (en) * | 1981-12-30 | 1985-02-05 | Ciba-Geigy Corporation | N-Oxide compounds useful in the treatment of cardiovascular ailments |
ZA83959B (en) * | 1982-03-10 | 1984-09-26 | Sandoz Ltd | 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them |
DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
DE3209276A1 (de) * | 1982-03-13 | 1983-09-15 | Bayer Ag, 5090 Leverkusen | Arzneimittel mit antihypoxischer und ischaemie-protektiver wirkung |
DE3209274A1 (de) * | 1982-03-13 | 1983-09-15 | Bayer Ag, 5090 Leverkusen | Pyridincarbonsaeureester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
JPS58208271A (ja) * | 1982-04-30 | 1983-12-03 | Kyowa Hakko Kogyo Co Ltd | 1,4−ジヒドロピリジン誘導体 |
IL68604A0 (en) * | 1982-05-21 | 1983-09-30 | Haessle Ab | Processes for preparing therapeutically active dihydropyridines and intermediates for the processes |
DE3379107D1 (en) * | 1982-06-03 | 1989-03-09 | Pierrel Spa | Hydroxyimino and alkoxyimino derivatives of 1,4-dihydropyridine, process for the preparation thereof and pharmaceutical composition therefrom |
DE3363743D1 (en) * | 1982-07-22 | 1986-07-03 | Pfizer Ltd | Dihydropyridine anti-ischaemic and antihypertensive agents |
HU192166B (en) * | 1982-08-06 | 1987-05-28 | Banyu Pharma Co Ltd | Process for producing 2-carbamoyl-oxy-alkyl-1,4-dihydro-pyridine derivatives |
EP0107293A3 (en) * | 1982-09-04 | 1984-06-06 | Pfizer Limited | Dihydropyridines |
PH19166A (en) * | 1982-09-04 | 1986-01-16 | Pfizer | Dihydropyridined,pharmaceutical compositions and method of use |
EP0111455A3 (de) * | 1982-12-10 | 1984-07-25 | Ciba-Geigy Ag | Ungesättigte Lactone |
DE3247118A1 (de) * | 1982-12-20 | 1984-06-20 | Cassella Ag, 6000 Frankfurt | Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US4515799A (en) * | 1983-02-02 | 1985-05-07 | Pfizer Inc. | Dihydropyridine anti-ischaemic and antihypertensive agents |
EP0125803A3 (en) * | 1983-04-27 | 1987-01-21 | FISONS plc | Pharmaceutically active dihydropyridines |
US4686217A (en) * | 1983-04-27 | 1987-08-11 | Fisons Plc | Calcium antagonist 2-fluoroalkyl-1,4-dihydropyridines |
DE3319956A1 (de) * | 1983-06-01 | 1984-12-06 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
AU561213B2 (en) * | 1983-06-02 | 1987-04-30 | Teijin Limited | 1, 4-dihydropyridine derivative |
DE3343658A1 (de) * | 1983-12-02 | 1985-06-13 | Bayer Ag, 5090 Leverkusen | Hydroxy-tetrahydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
JPS60156671A (ja) * | 1984-01-25 | 1985-08-16 | Yamanouchi Pharmaceut Co Ltd | ジヒドロピリジン誘導体およびその製造法 |
DE3410645A1 (de) * | 1984-03-23 | 1985-09-26 | Bayer Ag, 5090 Leverkusen | L-alkylsubstituierte 1,4-dihydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
JPS6127711A (ja) * | 1984-07-06 | 1986-02-07 | Sumitomo Rubber Ind Ltd | タイヤ識別用バーコード付きタイヤ及びタイヤの自動識別方法 |
GB8421039D0 (en) * | 1984-08-17 | 1984-09-19 | Wyeth John & Brother Ltd | Heterocyclic compounds |
US4975440A (en) * | 1984-09-28 | 1990-12-04 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Optically-active 1,4-dihydropyridine |
NO854021L (no) * | 1984-10-26 | 1986-04-28 | Bayer Ag | 1,4-dihydropyridin-hydroksyaminer og fremgangsmaate til fremstilling derav. |
DE3443179A1 (de) * | 1984-11-27 | 1986-05-28 | Cassella Ag, 6000 Frankfurt | 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung |
GB8503428D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Nitrogen-containing compounds |
GB8503429D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Chemical compounds |
US4652573A (en) * | 1985-03-14 | 1987-03-24 | Nelson Research & Development Co. | Calcium antagonist N-hetero ester 1,4-dihydropyridines |
JPS625958A (ja) * | 1985-07-03 | 1987-01-12 | Suntory Ltd | 1,4−ジヒドロピリジン誘導体、その製造法および循環系疾患治療剤 |
IT1215298B (it) * | 1985-08-06 | 1990-01-31 | Boehringer Biochemia Srl | 2-(eteroalchil)-1,4-diidropiridine ed un processo per la loro produzione. |
EP0226271B1 (en) * | 1985-08-21 | 1990-11-22 | GLAXO S.p.A. | 1,4-dihydropyridine compounds and their preparation and pharmaceutical formulation |
US4849436A (en) * | 1986-03-11 | 1989-07-18 | Nelson Research & Development Co. | 1,4-dihydropyridines |
JPS63115890A (ja) * | 1986-10-31 | 1988-05-20 | Nippon Shinyaku Co Ltd | 2位置換1,4−ジヒドロピリジン誘導体 |
DE3706204A1 (de) * | 1987-02-26 | 1988-09-08 | Bayer Ag | Benzylaminoaryl-dihydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
EP0343193A1 (de) * | 1987-03-27 | 1989-11-29 | Byk Gulden Lomberg Chemische Fabrik Gmbh | 1,4-dihydropyridine-enantiomere |
GB8710493D0 (en) * | 1987-05-02 | 1987-06-03 | Pfizer Ltd | Dihydropyridines |
IT1229118B (it) * | 1988-07-29 | 1991-07-22 | Simes | Composti attivi sul sistema cardiovascolare che presentano sia la struttura dei beta-bloccanti sia una porzione calcio-antagonista |
US5571827A (en) * | 1990-03-13 | 1996-11-05 | Sepracor Inc. | Methods and compositions for treating hypertension, angina and other disorders using optically pure s(-) nitrendipine |
US5254692A (en) * | 1990-04-06 | 1993-10-19 | Bayer Aktiengesellschaft | 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines |
DE4134760A1 (de) * | 1991-10-22 | 1993-07-08 | Bayer Ag | Aryl-chinolyl-substituierte 1,4-dihydropyridin-dicarbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
DE4202526A1 (de) * | 1992-01-30 | 1993-08-05 | Bayer Ag | Neue 4-cinnolinyl- und 4-naphthyridinyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
JPH08502263A (ja) * | 1992-10-06 | 1996-03-12 | セプラコア,インコーポレーテッド | 光学的に純粋なs(−)ニトレンジピンを用いる高血圧、狭心症、その他の疾患の治療方法および組成物 |
DE4313690A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | Kondensierte Chinolyl-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
DE4313691A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 2,6-Disubstituierte 4-Chinolyl-dihydropyridine |
DE4313697A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | Chinolyl-dihydropyridinester, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
DE4313692A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 3-Chinolyl substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
US6653481B2 (en) * | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3946027A (en) * | 1972-09-30 | 1976-03-23 | Bayer Aktiengesellschaft | 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives |
GB1409865A (en) * | 1973-02-13 | 1975-10-15 | Science Union & Cie | Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them |
DE2310747A1 (de) * | 1973-03-03 | 1974-09-12 | Bayer Ag | Verfahren zur herstellung von neuen amino-3,4-dihydropyridinen und ihre verwendung als arzneimittel |
DE2335466A1 (de) * | 1973-07-12 | 1975-01-30 | Bayer Ag | Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
CH607848A5 (ja) * | 1974-06-04 | 1978-11-30 | Bayer Ag |
-
1975
- 1975-07-02 GB GB27945/75A patent/GB1552911A/en not_active Expired
-
1976
- 1976-06-30 IT IT24866/76A patent/IT1068561B/it active
- 1976-06-30 CH CH837776A patent/CH629778A5/de not_active IP Right Cessation
- 1976-07-01 US US05/701,994 patent/US4145432A/en not_active Expired - Lifetime
- 1976-07-01 DK DK298176A patent/DK298176A/da not_active Application Discontinuation
- 1976-07-01 SE SE7607566A patent/SE434049B/xx not_active IP Right Cessation
- 1976-07-01 MX MX76912U patent/MX3591E/es unknown
- 1976-07-01 FI FI761912A patent/FI61696C/fi not_active IP Right Cessation
- 1976-07-02 NL NL7607338A patent/NL190812C/xx not_active IP Right Cessation
- 1976-07-02 JP JP51079413A patent/JPS5948827B2/ja not_active Expired
- 1976-07-02 DE DE19762629892 patent/DE2629892A1/de not_active Ceased
- 1976-07-02 GR GR51170A patent/GR60422B/el unknown
- 1976-07-02 IE IE1456/76A patent/IE43408B1/en unknown
- 1976-07-02 DD DD193705A patent/DD126722A5/xx unknown
- 1976-07-02 PH PH18646A patent/PH13772A/en unknown
- 1976-07-02 AU AU15547/76A patent/AU510353B2/en not_active Expired
- 1976-07-02 AR AR263837A patent/AR213097A1/es active
- 1976-07-02 YU YU1633/76A patent/YU41562B/xx unknown
- 1976-07-02 FR FR7620392A patent/FR2315930A1/fr active Granted
-
1977
- 1977-03-16 AR AR266869A patent/AR217321A1/es active
-
1982
- 1982-03-23 CH CH177982A patent/CH637938A5/de not_active IP Right Cessation
- 1982-03-23 CH CH178082A patent/CH634052A5/de not_active IP Right Cessation
- 1982-08-19 YU YU01794/82A patent/YU179482A/xx unknown
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5948828B2 (ja) * | 1976-12-17 | 1984-11-29 | 藤沢薬品工業株式会社 | 1.4↓−ジヒドロピリジン化合物およびその製造法 |
JPS5395977A (en) * | 1976-12-17 | 1978-08-22 | Fujisawa Pharmaceut Co Ltd | 1,4-dihydropyrimidine compounds and process for their preparation |
JPH0121827B2 (ja) * | 1978-09-08 | 1989-04-24 | Fujisawa Pharmaceutical Co | |
JPS63211266A (ja) * | 1978-09-08 | 1988-09-02 | Fujisawa Pharmaceut Co Ltd | ジヒドロピリジン誘導体の中間体 |
JPS5826872A (ja) * | 1981-07-30 | 1983-02-17 | バイエル・アクチエンゲゼルシヤフト | 心臓収縮性増進剤 |
JPH066535B2 (ja) * | 1981-07-30 | 1994-01-26 | バイエル・アクチエンゲゼルシヤフト | 心臓収縮性増進剤 |
JPH05271078A (ja) * | 1981-07-30 | 1993-10-19 | Bayer Ag | ジヒドロピリジン類 |
JPS58185821U (ja) * | 1982-06-02 | 1983-12-10 | 日産自動車株式会社 | ウインドシ−ルド |
JPS5927871A (ja) * | 1982-08-06 | 1984-02-14 | Banyu Pharmaceut Co Ltd | 2−カルバモイルオキシアルキル−1,4−ジヒドロピリジン誘導体の新規な製造法 |
JPH0348180B2 (ja) * | 1982-08-06 | 1991-07-23 | Banyu Pharma Co Ltd | |
JPS6157578A (ja) * | 1984-08-17 | 1986-03-24 | ジヨン・ワイス・アンド・ブラザー・リミテツド | 複素環式化合物 |
JPS62145064A (ja) * | 1985-12-13 | 1987-06-29 | バイエル・アクチエンゲゼルシヤフト | 新規なフツ素含有1,4−ジヒドロピリジン類 |
JPS62155280A (ja) * | 1985-12-18 | 1987-07-10 | バイエル・アクチエンゲゼルシヤフト | 4−チエニル−ジヒドロピリジン類 |
JPS62190187A (ja) * | 1986-01-11 | 1987-08-20 | バイエル・アクチエンゲゼルシヤフト | 4−アミノアリ−ルジヒドロピリジンラクトン類 |
JPS62292757A (ja) * | 1986-06-12 | 1987-12-19 | Taisho Pharmaceut Co Ltd | 1,4−ジヒドロピリジン誘導体 |
Also Published As
Publication number | Publication date |
---|---|
AU1554776A (en) | 1978-01-05 |
US4145432A (en) | 1979-03-20 |
AR217321A1 (es) | 1980-03-14 |
YU163376A (en) | 1983-01-21 |
DE2629892A1 (de) | 1977-01-27 |
CH629778A5 (de) | 1982-05-14 |
FI61696B (fi) | 1982-05-31 |
IE43408B1 (en) | 1981-02-25 |
AU510353B2 (en) | 1980-06-19 |
YU41562B (en) | 1987-10-31 |
JPS5948827B2 (ja) | 1984-11-29 |
NL190812C (nl) | 1994-09-01 |
FR2315930A1 (fr) | 1977-01-28 |
IT1068561B (it) | 1985-03-21 |
DK298176A (da) | 1977-01-03 |
NL7607338A (nl) | 1977-01-04 |
NL190812B (nl) | 1994-04-05 |
FR2315930B1 (ja) | 1978-11-17 |
IE43408L (en) | 1977-01-02 |
PH13772A (en) | 1980-09-23 |
GR60422B (en) | 1978-05-25 |
MX3591E (es) | 1981-03-24 |
GB1552911A (en) | 1979-09-19 |
SE7607566L (sv) | 1977-01-03 |
CH637938A5 (de) | 1983-08-31 |
AR213097A1 (es) | 1978-12-15 |
FI761912A (ja) | 1977-01-03 |
CH634052A5 (de) | 1983-01-14 |
FI61696C (fi) | 1982-09-10 |
DD126722A5 (ja) | 1977-08-10 |
SE434049B (sv) | 1984-07-02 |
YU179482A (en) | 1983-02-28 |
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