JPH11508591A5 - - Google Patents

Info

Publication number
JPH11508591A5
JPH11508591A5 JP1997505071A JP50507197A JPH11508591A5 JP H11508591 A5 JPH11508591 A5 JP H11508591A5 JP 1997505071 A JP1997505071 A JP 1997505071A JP 50507197 A JP50507197 A JP 50507197A JP H11508591 A5 JPH11508591 A5 JP H11508591A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1997505071A
Other languages
English (en)
Japanese (ja)
Other versions
JP4107682B2 (ja
JPH11508591A (ja
Filing date
Publication date
Priority claimed from SE9502487A external-priority patent/SE9502487D0/xx
Priority claimed from SE9502504A external-priority patent/SE9502504D0/xx
Priority claimed from SE9502505A external-priority patent/SE9502505D0/xx
Priority claimed from SE9503923A external-priority patent/SE9503923D0/xx
Priority claimed from SE9504349A external-priority patent/SE9504349D0/xx
Priority claimed from GBGB9526411.5A external-priority patent/GB9526411D0/en
Application filed filed Critical
Priority claimed from PCT/SE1996/000878 external-priority patent/WO1997002284A1/en
Publication of JPH11508591A publication Critical patent/JPH11508591A/ja
Publication of JPH11508591A5 publication Critical patent/JPH11508591A5/ja
Publication of JP4107682B2 publication Critical patent/JP4107682B2/ja
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP50507197A 1995-07-06 1996-07-02 新規なトロンビン阻害剤、それらの製造および使用 Expired - Fee Related JP4107682B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
SE9502487A SE9502487D0 (sv) 1995-07-06 1995-07-06 New amino acid derivatives
SE9502505A SE9502505D0 (sv) 1995-07-07 1995-07-07 New amino acid derivatives
SE9502504A SE9502504D0 (sv) 1995-07-07 1995-07-07 New amino acid derivatives
SE9503923A SE9503923D0 (sv) 1995-11-07 1995-11-07 New amino acid derivatives
SE9504349A SE9504349D0 (sv) 1995-12-05 1995-12-05 New amino acid derivatives
GB9526411.5 1995-12-22
GB9502504-5 1995-12-22
GB9504349-3 1995-12-22
GB9502505-2 1995-12-22
GB9502487-3 1995-12-22
GB9503923-6 1995-12-22
GBGB9526411.5A GB9526411D0 (en) 1995-12-22 1995-12-22 Compounds
PCT/SE1996/000878 WO1997002284A1 (en) 1995-07-06 1996-07-02 New thrombin inhibitors, their preparation and use

Publications (3)

Publication Number Publication Date
JPH11508591A JPH11508591A (ja) 1999-07-27
JPH11508591A5 true JPH11508591A5 (enExample) 2004-08-19
JP4107682B2 JP4107682B2 (ja) 2008-06-25

Family

ID=27547251

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50507197A Expired - Fee Related JP4107682B2 (ja) 1995-07-06 1996-07-02 新規なトロンビン阻害剤、それらの製造および使用

Country Status (30)

Country Link
US (4) US6051568A (enExample)
EP (1) EP0836615B1 (enExample)
JP (1) JP4107682B2 (enExample)
KR (1) KR100435008B1 (enExample)
CN (1) CN1147504C (enExample)
AR (1) AR003440A1 (enExample)
AT (1) ATE238342T1 (enExample)
AU (1) AU709710B2 (enExample)
BR (1) BR9609447A (enExample)
CA (1) CA2226256C (enExample)
CZ (1) CZ298487B6 (enExample)
DE (1) DE69627659T2 (enExample)
DK (1) DK0836615T3 (enExample)
EE (1) EE04500B1 (enExample)
ES (1) ES2197240T3 (enExample)
HU (1) HUP9802315A3 (enExample)
IL (1) IL122813A0 (enExample)
IS (1) IS2081B (enExample)
MX (1) MX9800146A (enExample)
MY (1) MY116539A (enExample)
NO (1) NO324092B1 (enExample)
NZ (2) NZ509474A (enExample)
PL (1) PL185606B1 (enExample)
PT (1) PT836615E (enExample)
RU (1) RU2176645C2 (enExample)
SA (1) SA96170106A (enExample)
SI (1) SI0836615T1 (enExample)
SK (1) SK284695B6 (enExample)
TR (1) TR199800009T1 (enExample)
WO (1) WO1997002284A1 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SA96170106A (ar) * 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
US6200967B1 (en) 1996-06-25 2001-03-13 Eli Lilly And Company Anticoagulant agents
WO1997049404A1 (en) * 1996-06-25 1997-12-31 Eli Lilly And Company Anticoagulant agents
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) * 1997-12-05 1997-12-05 Astra Ab New compounds
US6417161B1 (en) 1998-04-24 2002-07-09 3-Dimensional Pharmaceuticals, Inc. Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors
SE9802938D0 (sv) 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions
AU1185400A (en) * 1998-11-20 2000-06-13 Banyu Pharmaceutical Co., Ltd. 1-acylazetidine derivatives
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
KR20000047461A (ko) * 1998-12-29 2000-07-25 성재갑 트롬빈 억제제
TR200102037T2 (tr) * 1999-01-13 2001-10-22 Astrazeneca Ab Yeni amidinobenzilamin türevleri ve trombin engelleyiciler olarak kullanılmaları.
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
JP2004506039A (ja) * 2000-08-16 2004-02-26 アストラゼネカ　アクチボラグ 新規なアミジノ誘導体と、トロンビン阻害剤としてのそれらの使用
US6433186B1 (en) * 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
SE0102921D0 (sv) * 2001-08-30 2001-08-30 Astrazeneca Ab Pharmaceutically useful compounds
RU2300521C2 (ru) * 2000-12-01 2007-06-10 Астразенека Аб Новые производные миндальной кислоты и их применение в качестве ингибиторов тромбина
US7129233B2 (en) * 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
US6528503B2 (en) * 2000-12-18 2003-03-04 Merck & Co., Inc. Thrombin inhibitors
CA2436176A1 (en) * 2001-02-09 2002-08-22 Merck & Co., Inc. Thrombin inhibitors
SE0101762D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab New use
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
UA78195C2 (uk) * 2001-08-30 2007-03-15 Astrazeneca Ab Похідні мигдалевої кислоти та їх застосування як інгібіторів тромбіну, фармацевтична композиція на їх основі
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
SE0201658D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Immediate release pharmaceutical formulation
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7524354B2 (en) * 2005-07-07 2009-04-28 Research Foundation Of State University Of New York Controlled synthesis of highly monodispersed gold nanoparticles
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178398B (en) * 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
EP0168342B1 (de) * 1984-06-14 1991-07-03 Ciba-Geigy Ag Verfahren zur Herstellung von Thrombin-Inhibitoren
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
IL77748A (en) * 1985-02-04 1991-11-21 Merrell Dow Pharma Amino acid and peptide derivatives as peptidase inhibitors
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
ZA883953B (en) * 1987-06-05 1990-02-28 Du Pont Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (en) * 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV protease inhibitors
ZA897514B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
CA2024697A1 (en) * 1989-09-07 1991-03-08 George P. Vlasuk Protein having anticoagulant properties
TW201303B (enExample) * 1990-07-05 1993-03-01 Hoffmann La Roche
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
SE9102462D0 (sv) * 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
RU2048719C1 (ru) * 1991-11-06 1995-11-27 Гкн Вальтершайд Гмбх Устройство для соединения сельскохозяйственного орудия с трактором
US5416093A (en) * 1991-11-12 1995-05-16 Eli Lilly And Company Antithrombotic agents
ZA928581B (en) * 1991-11-12 1994-05-06 Lilly Co Eli Antithrombotic agents
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
EP0629212B1 (en) * 1992-03-04 1997-10-08 Gyogyszerkutato Intezet Kft. New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof
TW223629B (enExample) 1992-03-06 1994-05-11 Hoffmann La Roche
FR2695562B1 (fr) * 1992-09-11 1994-10-14 Synthelabo Utilisation d'un inhibiteur direct de la thrombine pour la fabrication d'un médicament à activité thrombolytique.
US5519193A (en) 1992-10-27 1996-05-21 International Business Machines Corporation Method and apparatus for stressing, burning in and reducing leakage current of electronic devices using microwave radiation
US5583146A (en) * 1992-12-02 1996-12-10 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US5780631A (en) * 1993-06-03 1998-07-14 Astra Aktiebolag Starting materials in the synthesis of thrombin and kininogenase inhibitors
DE4321444A1 (de) * 1993-06-28 1995-01-05 Bernd Prof Dr Clement Pharmazeutische Zubereitung
EP0648780A1 (en) * 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
TW394760B (en) * 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
AU1025795A (en) * 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
IL112795A (en) * 1994-03-04 2001-01-28 Astrazeneca Ab Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them
US5561146A (en) * 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) * 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
EP0794777A1 (en) * 1994-11-24 1997-09-17 Janssen Pharmaceutica N.V. Lubeluzole intravenous solutions
SK104697A3 (en) * 1995-02-17 1998-11-04 Basf Ag Novel dipeptide amidines as thrombin inhibitors
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5629324A (en) * 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
SA96170106A (ar) * 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
SE9602263D0 (sv) * 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives

Similar Documents

Publication Publication Date Title
JP2000500445A5 (enExample)
JP2000500228A5 (enExample)
JP2000500440A5 (enExample)
JP2000500479A5 (enExample)
JP2000500327A5 (enExample)
JPH11513305A5 (enExample)
JPH11509608A5 (enExample)
JP2000500406A5 (enExample)
JP2000500115A5 (enExample)
JP2000500322A5 (enExample)
JPH11511378A5 (enExample)
JP2000500258A5 (enExample)
JP2000500342A5 (enExample)
JP2000500192A5 (enExample)
JPH11507381A5 (enExample)
JP2000500112A5 (enExample)
JPH10510699A5 (enExample)
JP2000500226A5 (enExample)
JP2000500051A5 (enExample)
JP2000500407A5 (enExample)
JP2000500397A5 (enExample)
JP2000500166A5 (enExample)
JPH11508591A5 (enExample)
JP2000500125A5 (enExample)
JP2000500044A5 (enExample)