JPH10512745A - Dna塩基配列決定およびdna同定の方法および装置 - Google Patents
Dna塩基配列決定およびdna同定の方法および装置Info
- Publication number
- JPH10512745A JPH10512745A JP8517814A JP51781496A JPH10512745A JP H10512745 A JPH10512745 A JP H10512745A JP 8517814 A JP8517814 A JP 8517814A JP 51781496 A JP51781496 A JP 51781496A JP H10512745 A JPH10512745 A JP H10512745A
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- probes
- probe
- sequence
- hybridization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims abstract description 133
- 239000000523 sample Substances 0.000 claims abstract description 372
- 238000009396 hybridization Methods 0.000 claims abstract description 141
- 239000012634 fragment Substances 0.000 claims description 142
- 150000007523 nucleic acids Chemical class 0.000 claims description 110
- 108020004707 nucleic acids Proteins 0.000 claims description 92
- 102000039446 nucleic acids Human genes 0.000 claims description 92
- 238000004458 analytical method Methods 0.000 claims description 46
- 108090000623 proteins and genes Proteins 0.000 claims description 41
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 10
- 238000011534 incubation Methods 0.000 claims description 7
- 238000001514 detection method Methods 0.000 claims description 6
- 230000005684 electric field Effects 0.000 claims description 6
- 230000004888 barrier function Effects 0.000 claims description 5
- 238000002372 labelling Methods 0.000 claims description 5
- 230000002209 hydrophobic effect Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108091008146 restriction endonucleases Proteins 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims 8
- 238000012300 Sequence Analysis Methods 0.000 claims 2
- 230000005012 migration Effects 0.000 claims 2
- 238000013508 migration Methods 0.000 claims 2
- 102000003960 Ligases Human genes 0.000 claims 1
- 108090000364 Ligases Proteins 0.000 claims 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 1
- 108091028664 Ribonucleotide Proteins 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 230000000593 degrading effect Effects 0.000 claims 1
- 239000005547 deoxyribonucleotide Substances 0.000 claims 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 239000002853 nucleic acid probe Substances 0.000 claims 1
- 239000002336 ribonucleotide Substances 0.000 claims 1
- 125000002652 ribonucleotide group Chemical group 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 abstract description 40
- 238000001712 DNA sequencing Methods 0.000 abstract description 3
- 230000036961 partial effect Effects 0.000 abstract description 3
- 108020004414 DNA Proteins 0.000 description 120
- 108091034117 Oligonucleotide Proteins 0.000 description 75
- 230000008569 process Effects 0.000 description 40
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 38
- 238000004422 calculation algorithm Methods 0.000 description 29
- 230000035772 mutation Effects 0.000 description 28
- 238000012360 testing method Methods 0.000 description 26
- 239000012528 membrane Substances 0.000 description 23
- 238000006243 chemical reaction Methods 0.000 description 22
- 238000002474 experimental method Methods 0.000 description 22
- 238000013459 approach Methods 0.000 description 21
- 239000002773 nucleotide Substances 0.000 description 19
- 125000003729 nucleotide group Chemical group 0.000 description 19
- 239000000243 solution Substances 0.000 description 19
- 230000015572 biosynthetic process Effects 0.000 description 16
- 238000003780 insertion Methods 0.000 description 15
- 230000037431 insertion Effects 0.000 description 15
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 12
- 238000004140 cleaning Methods 0.000 description 12
- 239000002751 oligonucleotide probe Substances 0.000 description 12
- 238000003491 array Methods 0.000 description 11
- 230000008859 change Effects 0.000 description 11
- 230000000295 complement effect Effects 0.000 description 11
- 239000000872 buffer Substances 0.000 description 10
- 230000003321 amplification Effects 0.000 description 9
- 238000012217 deletion Methods 0.000 description 9
- 230000037430 deletion Effects 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 238000003199 nucleic acid amplification method Methods 0.000 description 9
- 238000010367 cloning Methods 0.000 description 8
- 238000013507 mapping Methods 0.000 description 8
- 230000003252 repetitive effect Effects 0.000 description 8
- 239000013598 vector Substances 0.000 description 8
- 108700028369 Alleles Proteins 0.000 description 7
- 239000003550 marker Substances 0.000 description 7
- 238000010791 quenching Methods 0.000 description 7
- 230000002829 reductive effect Effects 0.000 description 7
- 208000011317 telomere syndrome Diseases 0.000 description 7
- 238000005406 washing Methods 0.000 description 7
- 241000700605 Viruses Species 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 230000027455 binding Effects 0.000 description 6
- 210000000349 chromosome Anatomy 0.000 description 6
- 238000002844 melting Methods 0.000 description 6
- 230000008018 melting Effects 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- 150000007513 acids Chemical class 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 238000005304 joining Methods 0.000 description 5
- 239000013612 plasmid Substances 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108010050904 Interferons Proteins 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000007850 fluorescent dye Substances 0.000 description 4
- 238000013467 fragmentation Methods 0.000 description 4
- 238000006062 fragmentation reaction Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 125000006850 spacer group Chemical group 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 102000053602 DNA Human genes 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 102000014150 Interferons Human genes 0.000 description 3
- BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 208000024780 Urticaria Diseases 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 239000002299 complementary DNA Substances 0.000 description 3
- 238000007596 consolidation process Methods 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 238000010494 dissociation reaction Methods 0.000 description 3
- 230000005593 dissociations Effects 0.000 description 3
- 230000002068 genetic effect Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000011065 in-situ storage Methods 0.000 description 3
- 229940079322 interferon Drugs 0.000 description 3
- 230000001788 irregular Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000010076 replication Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 108700004121 sarkosyl Proteins 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000026350 Inborn Genetic disease Diseases 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 208000020584 Polyploidy Diseases 0.000 description 2
- 108091081062 Repeated sequence (DNA) Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000000712 assembly Effects 0.000 description 2
- 238000000429 assembly Methods 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000001502 gel electrophoresis Methods 0.000 description 2
- 208000016361 genetic disease Diseases 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000006317 isomerization reaction Methods 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000013600 plasmid vector Substances 0.000 description 2
- 238000011176 pooling Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 2
- 238000002416 scanning tunnelling spectroscopy Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 101150064522 60 gene Proteins 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 101100096502 Danio rerio spring gene Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 108700024394 Exon Proteins 0.000 description 1
- 108060002716 Exonuclease Proteins 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical class O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
- 108090000467 Interferon-beta Proteins 0.000 description 1
- 108020005196 Mitochondrial DNA Proteins 0.000 description 1
- 101100096504 Mus musculus Spring1 gene Proteins 0.000 description 1
- 108020004485 Nonsense Codon Proteins 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 101100426090 Rattus norvegicus Trim9 gene Proteins 0.000 description 1
- 241000231739 Rutilus rutilus Species 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 101100096505 Xenopus laevis spring1 gene Proteins 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 238000000376 autoradiography Methods 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000000078 claw Anatomy 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 238000004624 confocal microscopy Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- ZAMACTJOCIFTPJ-UHFFFAOYSA-N ethyl dibunate Chemical compound CC(C)(C)C1=CC=C2C(S(=O)(=O)OCC)=CC(C(C)(C)C)=CC2=C1 ZAMACTJOCIFTPJ-UHFFFAOYSA-N 0.000 description 1
- 229950001503 ethyl dibunate Drugs 0.000 description 1
- 102000013165 exonuclease Human genes 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000009191 jumping Effects 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 238000000329 molecular dynamics simulation Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000003471 mutagenic agent Substances 0.000 description 1
- 231100000707 mutagenic chemical Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000037434 nonsense mutation Effects 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 238000003203 nucleic acid sequencing method Methods 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 238000007645 offset printing Methods 0.000 description 1
- 238000011369 optimal treatment Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical group OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 208000030683 polygenic disease Diseases 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 108700022487 rRNA Genes Proteins 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000000163 radioactive labelling Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 229940043230 sarcosine Drugs 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AEEZIRBYGITPDN-UHFFFAOYSA-M sodium;dodecanoyl sulfate Chemical compound [Na+].CCCCCCCCCCCC(=O)OS([O-])(=O)=O AEEZIRBYGITPDN-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00364—Pipettes
- B01J2219/00367—Pipettes capillary
- B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00378—Piezoelectric or ink jet dispensers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00387—Applications using probes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00504—Pins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00513—Essentially linear supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. ハイブリダイゼーション法によって核酸を分析する方法であって、 基質の第1のセクタ上に第1の複数の核酸セグメントを配列する配列ステップ と、 前記基質の第2のセクタ上に第2の複数の核酸セグメントを配置する配置ステ ップと、 完全な相補性と一塩基の不整合とを弁別する条件下で、第1の複数の核酸セグ メントを、前記第1のセクタにあり、かつ前記第1の複数の核酸セグメントの一 つよりも短い第1のハイブリダイゼーションプローブに作用させる作用ステップ と、 完全な相補性と一塩基の不整合とを弁別する条件下で、前記第2のセクタにあ り、また前記第2の複数の核酸セグメントの一つのセグメントよりも短く、かつ 前記第1のハイブリッド・プローブとは異なる配列を持つ第2のハイブリダイゼ ーションプローブをインキュベートするインキュベーション・ステップと、 核酸セグメントに対するハイブリダイゼーションプローブのハイブリダイゼー ションを検出する検出ステップと、 結果を分析する分析ステップとを有することを特徴とする核酸分析方法。 2.請求項1に記載の方法であって、 さらに、前記配置ステップに先だって、核酸の移動に対する障壁を導入する導 入ステップを有することを特徴とする核酸分析方法。 3.請求項1に記載の方法であって、 前記配列ステップおよび前記配置ステップの後であり、また前記インキュベー ション・ステップに先だって、核酸の移動に対する障壁を導入する導入ステップ を有することを特徴とする核酸分析方法。 4.請求項3に記載の方法であって、 前記導入ステップは、前記基質に対して物理的障壁を押しつけることを特徴と する核酸分析方法。 5.請求項2に記載の方法であって、 前記導入ステップは、前記セクタ間のプローブの混合を防ぐために前記支持体 に対して垂直な方向切り換え電界を印加することを特徴とする核酸分析方法。 6.請求項3に記載の方法であって、 前記導入ステップは、前記セクタ間のプローブの混合を防ぐために前記支持体 に対して垂直な方向切り換え電界を印加することを特徴とする核酸分析方法。 7.請求項1に記載の方法であって、 前記配列ステップは、ピン配列の手段によって核酸試料をスポッティングする スポッティングステップを含むことを特徴とする核酸分析方法。 8.請求項1に記載の方法であって、 前記配列ステップは、管の配列によって核酸を分配する分配ステップを含むこ とを特徴とする核酸分析方法。 9.請求項1に記載の方法であって、 核酸試料をジェット印刷する印刷ステップを含むことを特徴とする核酸分析方 法。 10.請求項1に記載の方法であって、 前記作用ステップは、複数の連続的にハイブリダイズするプローブを適 用する適用ステップを有することを特徴とする核酸分析方法。 11.請求項1に記載の方法であって、 前記インキュベーション・ステップは、複数の連続的にハイブリダイズするプ ローブを適用するステップを有することを特徴とする核酸分析方法。 12.請求項10に記載の方法であって、 少なくとも2つの前記連続的にハイブリダイズするプローブをリゲートするリ ゲーションステップを有することを特徴とする核酸分析方法。 13.請求項11に記載の方法であって、 少なくとも2つの前記連続的にハイブリダイズするプローブをリゲートするリ ゲーションステップを有することを特徴とする核酸分析方法。 14.請求項1に記載の方法であって、 前記作用ステップは、重なり合った核酸配列を持つ複数の拮抗的にハイブリダ イズするプローブを適用するステップを有することを特徴とする核酸分析方法。 15.請求項1に記載の方法であって、 前記インキュベーション・ステップは、重なり合った核酸配列を持つ複数の拮 抗的にハイブリダイズするプローブを適用するステップを有することを特徴とす る核酸分析方法。 16.請求項1に記載の方法であって、 少なくとも2つの前記第1の複数の核酸セグメントは混合物として配列される ことを特徴とする核酸分析方法。 17.請求項1に記載の方法であって、 少なくとも2つの前記第2の複数の核酸セグメントは混合物として配列される ことを特徴とする核酸分析方法。 18.請求項1に記載の方法であって、 HgI型制限酵素による消化によって試料を調製し、得られた制限フラグメン トにアンカーをリゲーションするステップをさらに有することを特徴とする核酸 分析方法。 19.請求項1に記載の方法であって、 所定の長さのプローブの普遍的セットからプローブを選択するステップをさら に有することを特徴とする核酸分析方法。 20.請求項1に記載の方法であって、 所定の長さのプローブの普遍的セットからプローブを選択するステップをさら に有することを特徴とする核酸分析方法。 21.請求項1に記載の方法であって、 デオキシリボヌクレオチド・プローブを選択するステップをさらに有すること を特徴とする核酸分析方法。 22.請求項1に記載の方法であって、 リボヌクレオチド・プローブを選択するステップをさらに有することを特徴と する核酸分析方法。 23.請求項1に記載の方法であって、 タンパク質核酸プローブと塩基類似体含有プローブとからなる群から選択され る核酸類自体を選択するステップをさらに有することを特徴とする核酸分析方法 。 24.請求項1に記載の方法であって、 プローブを多重標識するステップをさらに有することを特徴とする核酸分析方 法。 25.請求項1に記載の方法であって、 ハイブリダイゼーションしていないプローブ上の標識を劣化させるステップを 含むことを特徴とする核酸分析方法。 26.請求項19に記載の方法であって、 前記作用ステップまたは前記インキュベーション・ステップは、普遍的プロー ブを長さが6,7,8,9,または10塩基であるセットに集合させるステップ を含むことを特徴とする核酸分析方法。 27.請求項19に記載の方法であって、 前記作用ステップまたは前記インキュベーション・ステップは、遍的プローブ のセットを長さが6,7,8,9,または10塩基に集合させるステップを含む ことを特徴とする核酸分析方法。 28.請求項20に記載の方法であって、 前記作用ステップまたは前記インキュベーション・ステップは、プローブのセ ットを長さが5,6,7,8,9,10,11,12,13,14,15,16 ,17,18,19,20,21,22,23,24,25,26,27,28 ,29,または30塩基に集合させるステップを含むことを特徴とする核酸分析 方法。 29.ハイブリダイゼーションによって核酸を分析する装置であって、 核酸フラグメントを付着する点を持つ基質を備え、該基質は疎水性領域によっ てセグメント化されることを特徴とする核酸分析装置。 30.請求項20に記載の方法であって、 前記配置ステップは、プローブのセットを長さが5,6,7,8,9,10, 11,12,13,14,15,16,17,18,19,20,21,22, 23,24,25,26,27,28,29,または30塩基に集合させるステ ップを含むことを特徴とする核酸分析方法。 31.請求項1に記載の方法であって、 前記少なくとも2つの塩基を含む重なり合った核酸シークエンスを有する2つ 以上のプローブのハイブリダイゼーションを検知することによって、セグメント の少なくとも2つの塩基の相対的順序を確認するステップをさらに有することを 特徴とする核酸分析方法。 32.核酸の配列を分析する方法であって、 プローブの配列に試料を導入するステップと、 試料分子の主な部分が所定の時間でリゲーションしたプローブによって解離す る温度に設定するステップと、 混合物に標識されたプローブを添加するステップと、 混合物をリガーゼとインキュベーションするステップと、 遊離のプローブを除去するステップと、 リゲーション産物を検出するステップとを有することを特徴とする核酸配列分 析方法。 33.請求項1に記載の方法であって、所望の結果を改善するために追加のプロ ーブを定めるステップと、前記作用ステップ、前記インキュベーション・ステッ プ、前記検知および分析ステップを繰り返すステップとをさらに有することを特 徴とする核酸配列分析方法。 34.請求項1に記載の方法であって、前記複数の核酸配列を再利用するために プローブから基質を取り除くステップをさらに有することを特徴と する核酸配列分析方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/353,554 US6270961B1 (en) | 1987-04-01 | 1994-12-09 | Methods and apparatus for DNA sequencing and DNA identification |
US08/353,554 | 1994-12-09 | ||
PCT/US1995/016154 WO1996017957A1 (en) | 1994-12-09 | 1995-12-08 | Methods and apparatus for dna sequencing and dna identification |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH10512745A true JPH10512745A (ja) | 1998-12-08 |
Family
ID=23389627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8517814A Ceased JPH10512745A (ja) | 1994-12-09 | 1995-12-08 | Dna塩基配列決定およびdna同定の方法および装置 |
Country Status (10)
Country | Link |
---|---|
US (4) | US6270961B1 (ja) |
EP (1) | EP0797683A4 (ja) |
JP (1) | JPH10512745A (ja) |
KR (1) | KR980700433A (ja) |
CN (1) | CN1175283A (ja) |
AU (1) | AU715506B2 (ja) |
CA (1) | CA2206815A1 (ja) |
FI (1) | FI972429A (ja) |
NO (1) | NO972535L (ja) |
WO (1) | WO1996017957A1 (ja) |
Families Citing this family (228)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6270961B1 (en) * | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
US6040138A (en) * | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
US6551784B2 (en) | 1989-06-07 | 2003-04-22 | Affymetrix Inc | Method of comparing nucleic acid sequences |
US6416952B1 (en) | 1989-06-07 | 2002-07-09 | Affymetrix, Inc. | Photolithographic and other means for manufacturing arrays |
US5925525A (en) * | 1989-06-07 | 1999-07-20 | Affymetrix, Inc. | Method of identifying nucleotide differences |
US5744101A (en) * | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US6919211B1 (en) * | 1989-06-07 | 2005-07-19 | Affymetrix, Inc. | Polypeptide arrays |
US6955915B2 (en) * | 1989-06-07 | 2005-10-18 | Affymetrix, Inc. | Apparatus comprising polymers |
US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US6346413B1 (en) | 1989-06-07 | 2002-02-12 | Affymetrix, Inc. | Polymer arrays |
US5547839A (en) * | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US6506558B1 (en) | 1990-03-07 | 2003-01-14 | Affymetrix Inc. | Very large scale immobilized polymer synthesis |
DE69132843T2 (de) * | 1990-12-06 | 2002-09-12 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Identifizierung von Nukleinsäuren in Proben |
US6468740B1 (en) | 1992-11-05 | 2002-10-22 | Affymetrix, Inc. | Cyclic and substituted immobilized molecular synthesis |
US6401267B1 (en) * | 1993-09-27 | 2002-06-11 | Radoje Drmanac | Methods and compositions for efficient nucleic acid sequencing |
US6287850B1 (en) * | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
US8236493B2 (en) * | 1994-10-21 | 2012-08-07 | Affymetrix, Inc. | Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA |
US5795716A (en) * | 1994-10-21 | 1998-08-18 | Chee; Mark S. | Computer-aided visualization and analysis system for sequence evaluation |
US6312894B1 (en) | 1995-04-03 | 2001-11-06 | Epoch Pharmaceuticals, Inc. | Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders |
US5801155A (en) | 1995-04-03 | 1998-09-01 | Epoch Pharmaceuticals, Inc. | Covalently linked oligonucleotide minor grove binder conjugates |
US6720149B1 (en) * | 1995-06-07 | 2004-04-13 | Affymetrix, Inc. | Methods for concurrently processing multiple biological chip assays |
US6660233B1 (en) * | 1996-01-16 | 2003-12-09 | Beckman Coulter, Inc. | Analytical biochemistry system with robotically carried bioarray |
EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
AU4495497A (en) | 1996-09-19 | 1998-04-14 | Affymetrix, Inc. | Identification of molecular sequence signatures and methods involving the same |
US6391550B1 (en) * | 1996-09-19 | 2002-05-21 | Affymetrix, Inc. | Identification of molecular sequence signatures and methods involving the same |
US20020042048A1 (en) * | 1997-01-16 | 2002-04-11 | Radoje Drmanac | Methods and compositions for detection or quantification of nucleic acid species |
US6297006B1 (en) * | 1997-01-16 | 2001-10-02 | Hyseq, Inc. | Methods for sequencing repetitive sequences and for determining the order of sequence subfragments |
EP0972078B1 (en) | 1997-03-20 | 2005-06-01 | Affymetrix, Inc. (a California Corporation) | Iterative resequencing |
US20030036084A1 (en) * | 1997-10-09 | 2003-02-20 | Brian Hauser | Nucleic acid detection method employing oligonucleotide probes affixed to particles and related compositions |
US6322968B1 (en) | 1997-11-21 | 2001-11-27 | Orchid Biosciences, Inc. | De novo or “universal” sequencing array |
US7715989B2 (en) | 1998-04-03 | 2010-05-11 | Elitech Holding B.V. | Systems and methods for predicting oligonucleotide melting temperature (TmS) |
US6127121A (en) | 1998-04-03 | 2000-10-03 | Epoch Pharmaceuticals, Inc. | Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination |
US6683173B2 (en) | 1998-04-03 | 2004-01-27 | Epoch Biosciences, Inc. | Tm leveling methods |
US6949367B1 (en) | 1998-04-03 | 2005-09-27 | Epoch Pharmaceuticals, Inc. | Modified oligonucleotides for mismatch discrimination |
US7045610B2 (en) | 1998-04-03 | 2006-05-16 | Epoch Biosciences, Inc. | Modified oligonucleotides for mismatch discrimination |
US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
US6872521B1 (en) | 1998-06-16 | 2005-03-29 | Beckman Coulter, Inc. | Polymerase signaling assay |
US6703228B1 (en) | 1998-09-25 | 2004-03-09 | Massachusetts Institute Of Technology | Methods and products related to genotyping and DNA analysis |
EP1001037A3 (en) * | 1998-09-28 | 2003-10-01 | Whitehead Institute For Biomedical Research | Pre-selection and isolation of single nucleotide polymorphisms |
US7034143B1 (en) | 1998-10-13 | 2006-04-25 | Brown University Research Foundation | Systems and methods for sequencing by hybridization |
WO2000022171A2 (en) * | 1998-10-13 | 2000-04-20 | Brown University Research Foundation | Systems and methods for sequencing by hybridization |
US7071324B2 (en) | 1998-10-13 | 2006-07-04 | Brown University Research Foundation | Systems and methods for sequencing by hybridization |
US6545264B1 (en) | 1998-10-30 | 2003-04-08 | Affymetrix, Inc. | Systems and methods for high performance scanning |
ATE440148T1 (de) * | 1999-01-06 | 2009-09-15 | Callida Genomics Inc | Verbesserte sequenzierung mittels hybridisierung durch verwendung von sondengemischen |
US6635470B1 (en) | 1999-01-08 | 2003-10-21 | Applera Corporation | Fiber array and methods for using and making same |
US7595189B2 (en) | 1999-01-08 | 2009-09-29 | Applied Biosystems, Llc | Integrated optics fiber array |
JP2003527075A (ja) * | 1999-03-25 | 2003-09-16 | ハイセック,インコーポレーテッド | ハイブリダイゼーションによる配列分析のための、溶液ベースの方法 |
US6516276B1 (en) * | 1999-06-18 | 2003-02-04 | Eos Biotechnology, Inc. | Method and apparatus for analysis of data from biomolecular arrays |
US6818395B1 (en) * | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
US7501245B2 (en) * | 1999-06-28 | 2009-03-10 | Helicos Biosciences Corp. | Methods and apparatuses for analyzing polynucleotide sequences |
US6339147B1 (en) | 1999-07-29 | 2002-01-15 | Epoch Biosciences, Inc. | Attachment of oligonucleotides to solid supports through Schiff base type linkages for capture and detection of nucleic acids |
CA2386791A1 (en) | 1999-10-08 | 2001-04-19 | Protogene Laboratories, Inc. | Method and apparatus for performing large numbers of reactions using array assembly |
JP3668075B2 (ja) * | 1999-10-12 | 2005-07-06 | 光夫 板倉 | 遺伝物質シーケンス決定用懸濁系、その懸濁系を用いた遺伝物質シーケンス決定方法およびその懸濁系を用いたSNPs高速スコアリング方法 |
US7668658B2 (en) * | 1999-10-13 | 2010-02-23 | Sequenom, Inc. | Methods for generating databases and databases for identifying polymorphic genetic markers |
US6660845B1 (en) | 1999-11-23 | 2003-12-09 | Epoch Biosciences, Inc. | Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof |
US20040081959A9 (en) | 1999-12-08 | 2004-04-29 | Epoch Biosciences, Inc. | Fluorescent quenching detection reagents and methods |
US7205105B2 (en) | 1999-12-08 | 2007-04-17 | Epoch Biosciences, Inc. | Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis |
US6727356B1 (en) | 1999-12-08 | 2004-04-27 | Epoch Pharmaceuticals, Inc. | Fluorescent quenching detection reagents and methods |
JP2003519495A (ja) * | 2000-01-11 | 2003-06-24 | マキシジェン, インコーポレイテッド | 多様性生成およびスクリーニングのための一体化されたシステムおよび方法 |
EP1944310A3 (en) | 2000-03-01 | 2008-08-06 | Epoch Biosciences, Inc. | Modified oligonucleotides for mismatch discrimination |
WO2001064958A2 (en) | 2000-03-01 | 2001-09-07 | Epoch Bioscienecs, Inc. | Modified oligonucleotides for mismatch discrimination |
JP3502803B2 (ja) * | 2000-03-06 | 2004-03-02 | 日立ソフトウエアエンジニアリング株式会社 | マイクロアレイ、マイクロアレイ作製方法及びマイクロアレイにおけるピン間スポット量誤差補正方法 |
AU2001265121A1 (en) * | 2000-05-30 | 2001-12-11 | Applera Corporation | Methods for detecting target nucleic acids using coupled ligation and amplification |
ES2334639T3 (es) | 2000-06-14 | 2010-03-15 | Vistagen, Inc. | Tipificacion de toxicidad empleando celulas madre hepaticas. |
US7846733B2 (en) | 2000-06-26 | 2010-12-07 | Nugen Technologies, Inc. | Methods and compositions for transcription-based nucleic acid amplification |
US6913879B1 (en) * | 2000-07-10 | 2005-07-05 | Telechem International Inc. | Microarray method of genotyping multiple samples at multiple LOCI |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
US6681186B1 (en) | 2000-09-08 | 2004-01-20 | Paracel, Inc. | System and method for improving the accuracy of DNA sequencing and error probability estimation through application of a mathematical model to the analysis of electropherograms |
EP1427847B1 (en) | 2000-12-13 | 2010-07-28 | Nugen Technologies, Inc. | Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof |
CA2433419A1 (en) * | 2001-01-02 | 2002-07-25 | Stemron, Inc. | A method for producing a population of homozygous stem cells having a pre-selected immunotype and/or genotype, cells suitable for transplant derived therefrom, and materials and methods using same |
WO2003012147A1 (en) * | 2001-02-20 | 2003-02-13 | Datascope Investment Corp. | Method for reusing standard blots and microarrays utilizing dna dendrimer technology |
KR20030082535A (ko) | 2001-03-09 | 2003-10-22 | 뉴젠 테크놀로지스 인코포레이티드 | Rna 서열의 증폭을 위한 방법 및 조성물 |
CA2440754A1 (en) * | 2001-03-12 | 2002-09-19 | Stephen Quake | Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension |
DE10120798B4 (de) * | 2001-04-27 | 2005-12-29 | Genovoxx Gmbh | Verfahren zur Bestimmung der Genexpression |
US7138506B2 (en) * | 2001-05-09 | 2006-11-21 | Genetic Id, Na, Inc. | Universal microarray system |
US20030036073A1 (en) * | 2001-06-07 | 2003-02-20 | Saba James Anthony | Matrix Sequencing: a novel method of polynucleotide analysis utilizing probes containing universal nucleotides |
US6767731B2 (en) * | 2001-08-27 | 2004-07-27 | Intel Corporation | Electron induced fluorescent method for nucleic acid sequencing |
AU2002331777A1 (en) * | 2001-08-30 | 2003-03-18 | Spectral Genomics, Inc. | Arrays comprising pre-labeled biological molecules and methods for making and using these arrays |
EP1436424A4 (en) * | 2001-09-18 | 2005-11-16 | Us Genomics Inc | DIFFERENTIAL MARKING OF POLYMERS FOR HIGH RESOLUTION LINEAR ANALYSIS |
AU2002364945A1 (en) * | 2001-10-25 | 2003-07-09 | Neurogenetics, Inc. | Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases |
US20030170678A1 (en) * | 2001-10-25 | 2003-09-11 | Neurogenetics, Inc. | Genetic markers for Alzheimer's disease and methods using the same |
US20030224380A1 (en) * | 2001-10-25 | 2003-12-04 | The General Hospital Corporation | Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases |
GB0202462D0 (en) * | 2002-02-04 | 2002-03-20 | Tepnel Medical Ltd | Nucleic acid analysis |
WO2003093296A2 (en) * | 2002-05-03 | 2003-11-13 | Sequenom, Inc. | Kinase anchor protein muteins, peptides thereof, and related methods |
EP1573056A4 (en) * | 2002-05-17 | 2007-11-28 | Nugen Technologies Inc | METHODS FOR FRAGMENTATION, LABELING AND IMMOBILIZATION OF NUCLEIC ACIDS |
DE10224824A1 (de) * | 2002-06-05 | 2003-12-24 | Eppendorf Ag | Verfahren zur Analyse von Target-Nukleinsäuresequenzen |
AU2003257110A1 (en) | 2002-07-31 | 2004-02-16 | University Of Southern California | Polymorphisms for predicting disease and treatment outcome |
US20040235005A1 (en) * | 2002-10-23 | 2004-11-25 | Ernest Friedlander | Methods and composition for detecting targets |
US6641899B1 (en) * | 2002-11-05 | 2003-11-04 | International Business Machines Corporation | Nonlithographic method to produce masks by selective reaction, articles produced, and composition for same |
WO2004076683A2 (en) * | 2003-02-26 | 2004-09-10 | Callida Genomics, Inc. | Random array dna analysis by hybridization |
US20070141570A1 (en) * | 2003-03-07 | 2007-06-21 | Sequenom, Inc. | Association of polymorphic kinase anchor proteins with cardiac phenotypes and related methods |
FR2852317B1 (fr) | 2003-03-13 | 2006-08-04 | Biopuces a sondes et leurs methodes d'utilisation | |
CA2519362A1 (en) | 2003-03-19 | 2004-09-30 | The University Of British Columbia | Plasminogen activator inhibitor-1 (pai-1) haplotypes useful as indicators of patient outcome |
KR100877129B1 (ko) * | 2003-03-26 | 2009-01-07 | 신에쯔 한도타이 가부시키가이샤 | 열처리용 웨이퍼 지지구 및 열처리 장치 |
US7402386B2 (en) * | 2003-04-14 | 2008-07-22 | Nugen Technologies, Inc. | Global amplification using random priming by a composite primer |
US8652774B2 (en) * | 2003-04-16 | 2014-02-18 | Affymetrix, Inc. | Automated method of manufacturing polyer arrays |
US7425700B2 (en) | 2003-05-22 | 2008-09-16 | Stults John T | Systems and methods for discovery and analysis of markers |
US20050239089A1 (en) * | 2003-06-06 | 2005-10-27 | Johnson Martin D | Mobility cassettes |
US20050170367A1 (en) * | 2003-06-10 | 2005-08-04 | Quake Stephen R. | Fluorescently labeled nucleoside triphosphates and analogs thereof for sequencing nucleic acids |
JP4067463B2 (ja) * | 2003-07-18 | 2008-03-26 | トヨタ自動車株式会社 | ハイブリッド車輌の制御装置 |
US20050038776A1 (en) * | 2003-08-15 | 2005-02-17 | Ramin Cyrus | Information system for biological and life sciences research |
US7348146B2 (en) | 2003-10-02 | 2008-03-25 | Epoch Biosciences, Inc. | Single nucleotide polymorphism analysis of highly polymorphic target sequences |
PT1687609E (pt) | 2003-10-28 | 2015-03-02 | Epoch Biosciences Inc | Sondas fluorescentes para a detecção de adn por hibridação com uma maior sensibilidade e menor ruído de fundo |
US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
US7439341B2 (en) | 2003-11-14 | 2008-10-21 | Integrated Dna Technologies, Inc. | Fluorescence quenching azo dyes, their methods of preparation and use |
US7276338B2 (en) * | 2003-11-17 | 2007-10-02 | Jacobson Joseph M | Nucleotide sequencing via repetitive single molecule hybridization |
WO2005054441A2 (en) * | 2003-12-01 | 2005-06-16 | California Institute Of Technology | Device for immobilizing chemical and biomedical species and methods of using same |
CA2552007A1 (en) | 2003-12-29 | 2005-07-21 | Nugen Technologies, Inc. | Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids |
US7981604B2 (en) | 2004-02-19 | 2011-07-19 | California Institute Of Technology | Methods and kits for analyzing polynucleotide sequences |
US20060046258A1 (en) * | 2004-02-27 | 2006-03-02 | Lapidus Stanley N | Applications of single molecule sequencing |
JP2007525980A (ja) | 2004-03-04 | 2007-09-13 | ザ ユニバーシティ オブ ブリティッシュ コロンビア | 患者結果を予測するトロンボモジュリン(thbd)ハプロタイプ |
GB2413796B (en) * | 2004-03-25 | 2006-03-29 | Global Genomics Ab | Methods and means for nucleic acid sequencing |
US20050239085A1 (en) * | 2004-04-23 | 2005-10-27 | Buzby Philip R | Methods for nucleic acid sequence determination |
US20050260609A1 (en) * | 2004-05-24 | 2005-11-24 | Lapidus Stanley N | Methods and devices for sequencing nucleic acids |
US20070117104A1 (en) * | 2005-11-22 | 2007-05-24 | Buzby Philip R | Nucleotide analogs |
US7635562B2 (en) * | 2004-05-25 | 2009-12-22 | Helicos Biosciences Corporation | Methods and devices for nucleic acid sequence determination |
US20070117103A1 (en) * | 2005-11-22 | 2007-05-24 | Buzby Philip R | Nucleotide analogs |
US7476734B2 (en) * | 2005-12-06 | 2009-01-13 | Helicos Biosciences Corporation | Nucleotide analogs |
US20060024678A1 (en) * | 2004-07-28 | 2006-02-02 | Helicos Biosciences Corporation | Use of single-stranded nucleic acid binding proteins in sequencing |
WO2006035443A2 (en) * | 2004-09-29 | 2006-04-06 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Monitoring of convection enhanced drug delivery |
US20060118754A1 (en) * | 2004-12-08 | 2006-06-08 | Lapen Daniel C | Stabilizing a polyelectrolyte multilayer |
US20060172328A1 (en) * | 2005-01-05 | 2006-08-03 | Buzby Philip R | Methods and compositions for correcting misincorporation in a nucleic acid synthesis reaction |
US7482120B2 (en) * | 2005-01-28 | 2009-01-27 | Helicos Biosciences Corporation | Methods and compositions for improving fidelity in a nucleic acid synthesis reaction |
EP1869077A2 (en) * | 2005-02-18 | 2007-12-26 | Abraxis BioScience, Inc. | Q3 sparc deletion mutant and uses thereof |
WO2006127507A2 (en) | 2005-05-20 | 2006-11-30 | Integrated Dna Technologies, Inc. | Compounds and methods for labeling oligonucleotides |
US20060263790A1 (en) * | 2005-05-20 | 2006-11-23 | Timothy Harris | Methods for improving fidelity in a nucleic acid synthesis reaction |
US8445194B2 (en) | 2005-06-15 | 2013-05-21 | Callida Genomics, Inc. | Single molecule arrays for genetic and chemical analysis |
US20090264299A1 (en) * | 2006-02-24 | 2009-10-22 | Complete Genomics, Inc. | High throughput genome sequencing on DNA arrays |
WO2006136033A1 (en) * | 2005-06-23 | 2006-12-28 | The University Of British Columbia | Coagulation factor iii polymorphisms associated with prediction of subject outcome and response to therapy |
US7666593B2 (en) | 2005-08-26 | 2010-02-23 | Helicos Biosciences Corporation | Single molecule sequencing of captured nucleic acids |
EP1929046B1 (en) | 2005-09-07 | 2012-07-11 | Nugen Technologies, Inc. | Improved nucleic acid amplification procedure |
US7960104B2 (en) * | 2005-10-07 | 2011-06-14 | Callida Genomics, Inc. | Self-assembled single molecule arrays and uses thereof |
US20070117102A1 (en) * | 2005-11-22 | 2007-05-24 | Buzby Philip R | Nucleotide analogs |
US20070128610A1 (en) * | 2005-12-02 | 2007-06-07 | Buzby Philip R | Sample preparation method and apparatus for nucleic acid sequencing |
DK1987159T4 (da) | 2006-02-08 | 2020-11-16 | Illumina Cambridge Ltd | Fremgangsmåde til sekventering af en polynukleotidtemplate |
EP1994180A4 (en) * | 2006-02-24 | 2009-11-25 | Callida Genomics Inc | GENOME SEQUENCING ON DNA ARRAYS WITH HIGH THROUGHPUT |
CA2656315A1 (en) * | 2006-06-30 | 2008-01-10 | Nugen Technologies, Inc. | Methods for fragmentation and labeling of nucleic acids |
GB0618514D0 (en) * | 2006-09-20 | 2006-11-01 | Univ Nottingham Trent | Method of detecting interactions on a microarray using nuclear magnetic resonance |
WO2008039071A2 (en) * | 2006-09-29 | 2008-04-03 | Agendia B.V. | High-throughput diagnostic testing using arrays |
WO2008070352A2 (en) | 2006-10-27 | 2008-06-12 | Complete Genomics, Inc. | Efficient arrays of amplified polynucleotides |
US20090105961A1 (en) * | 2006-11-09 | 2009-04-23 | Complete Genomics, Inc. | Methods of nucleic acid identification in large-scale sequencing |
US20090111705A1 (en) * | 2006-11-09 | 2009-04-30 | Complete Genomics, Inc. | Selection of dna adaptor orientation by hybrid capture |
AU2007321678B2 (en) | 2006-11-15 | 2014-03-20 | The University Of British Columbia | Polymorphisms predictive of anthracycline-induced cardiotoxicity |
CA2675362A1 (en) | 2007-01-18 | 2008-07-24 | University Of Southern California | Polymorphisms in the egfr pathway as markers for cancer treatment |
US8435752B2 (en) * | 2007-01-18 | 2013-05-07 | University Of Southern California | Gene polymorphisms predictive for dual TKI therapy |
US7881933B2 (en) * | 2007-03-23 | 2011-02-01 | Verizon Patent And Licensing Inc. | Age determination using speech |
US7572990B2 (en) * | 2007-03-30 | 2009-08-11 | Intermec Ip Corp. | Keypad overlay membrane |
DK3078743T3 (da) | 2007-09-28 | 2020-08-10 | Portola Pharm Inc | Antidoter til faktor xa-inhibitorer og fremgangsmåder til anvendelse af disse |
WO2009046094A1 (en) | 2007-10-01 | 2009-04-09 | Nabsys, Inc. | Biopolymer sequencing by hybridization of probes to form ternary complexes and variable range alignment |
WO2009052214A2 (en) * | 2007-10-15 | 2009-04-23 | Complete Genomics, Inc. | Sequence analysis using decorated nucleic acids |
US8298768B2 (en) * | 2007-11-29 | 2012-10-30 | Complete Genomics, Inc. | Efficient shotgun sequencing methods |
US7897344B2 (en) * | 2007-11-06 | 2011-03-01 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs |
US8518640B2 (en) * | 2007-10-29 | 2013-08-27 | Complete Genomics, Inc. | Nucleic acid sequencing and process |
US8415099B2 (en) | 2007-11-05 | 2013-04-09 | Complete Genomics, Inc. | Efficient base determination in sequencing reactions |
US8617811B2 (en) * | 2008-01-28 | 2013-12-31 | Complete Genomics, Inc. | Methods and compositions for efficient base calling in sequencing reactions |
US7901890B2 (en) * | 2007-11-05 | 2011-03-08 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation |
CA2705213C (en) * | 2007-11-07 | 2016-10-04 | The University Of British Columbia | Microfluidic device and method of using same |
CN102016579B (zh) | 2007-11-30 | 2015-04-08 | 健泰科生物技术公司 | Vegf多态性和抗血管发生疗法 |
US8592150B2 (en) | 2007-12-05 | 2013-11-26 | Complete Genomics, Inc. | Methods and compositions for long fragment read sequencing |
WO2009094583A1 (en) * | 2008-01-23 | 2009-07-30 | Complete Genomics, Inc. | Methods and compositions for preventing bias in amplification and sequencing reactions |
US20090203531A1 (en) | 2008-02-12 | 2009-08-13 | Nurith Kurn | Method for Archiving and Clonal Expansion |
GB2470672B (en) | 2008-03-21 | 2012-09-12 | Nugen Technologies Inc | Methods of RNA amplification in the presence of DNA |
US20090270273A1 (en) * | 2008-04-21 | 2009-10-29 | Complete Genomics, Inc. | Array structures for nucleic acid detection |
JP4667490B2 (ja) * | 2008-07-09 | 2011-04-13 | 三菱電機株式会社 | 加熱調理器 |
CN102186989B (zh) | 2008-09-03 | 2021-06-29 | 纳伯塞斯2.0有限责任公司 | 用于流体通道中生物分子和其它分析物的电压感测的纵向移位纳米级电极的使用 |
US8262879B2 (en) | 2008-09-03 | 2012-09-11 | Nabsys, Inc. | Devices and methods for determining the length of biopolymers and distances between probes bound thereto |
US9650668B2 (en) | 2008-09-03 | 2017-05-16 | Nabsys 2.0 Llc | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels |
JP2012501658A (ja) * | 2008-09-05 | 2012-01-26 | ライフ テクノロジーズ コーポレーション | 核酸配列決定の検証、較正、および標準化のための方法およびシステム |
EP2356250A2 (en) | 2008-11-05 | 2011-08-17 | Genentech, Inc. | Genetic polymorphisms in age-related macular degeneration |
WO2010096696A2 (en) * | 2009-02-20 | 2010-08-26 | Cold Spring Harbor Laboratory | Harnessing high throughput sequencing for multiplexed specimen analysis |
WO2010111522A2 (en) | 2009-03-26 | 2010-09-30 | The Regents Of The University Of California | Mesenchymal stem cells producing inhibitory rna for disease modification |
EP3604510A1 (en) | 2009-03-30 | 2020-02-05 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same |
WO2010123626A1 (en) | 2009-04-24 | 2010-10-28 | University Of Southern California | Cd133 polymorphisms and expression predict clinical outcome in patients with cancer |
US9524369B2 (en) | 2009-06-15 | 2016-12-20 | Complete Genomics, Inc. | Processing and analysis of complex nucleic acid sequence data |
WO2011005598A1 (en) | 2009-06-24 | 2011-01-13 | University Of Southern California | Compositions and methods for the rapid biosynthesis and in vivo screening of biologically relevant peptides |
PT2453910T (pt) | 2009-07-15 | 2016-12-07 | Portola Pharm Inc | Formulação de dose unitária de antídoto contra inibidores de fator xa para uso na prevenção de sangramento |
RU2546008C2 (ru) | 2009-10-21 | 2015-04-10 | Дженентек, Инк. | Генетические полиморфизмы при возрастной дегенерации желтого пятна |
WO2011084757A1 (en) | 2009-12-21 | 2011-07-14 | University Of Southern California | Germline polymorphisms in the sparc gene associated with clinical outcome in gastric cancer |
WO2011085334A1 (en) | 2010-01-11 | 2011-07-14 | University Of Southern California | Cd44 polymorphisms predict clinical outcome in patients with gastric cancer |
EP2848704B1 (en) | 2010-01-19 | 2018-08-29 | Verinata Health, Inc | Sequencing methods for prenatal diagnoses |
US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
US20120100548A1 (en) | 2010-10-26 | 2012-04-26 | Verinata Health, Inc. | Method for determining copy number variations |
US9260745B2 (en) | 2010-01-19 | 2016-02-16 | Verinata Health, Inc. | Detecting and classifying copy number variation |
US9323888B2 (en) | 2010-01-19 | 2016-04-26 | Verinata Health, Inc. | Detecting and classifying copy number variation |
EP2526415B1 (en) | 2010-01-19 | 2017-05-03 | Verinata Health, Inc | Partition defined detection methods |
WO2011103467A2 (en) | 2010-02-19 | 2011-08-25 | Life Technologies Corporation | Methods and systems for nucleic acid sequencing validation, calibration and normalization |
WO2011120049A1 (en) | 2010-03-26 | 2011-09-29 | Integrated Dna Technologies, Inc. | Methods for enhancing nucleic acid hybridization |
US9506057B2 (en) | 2010-03-26 | 2016-11-29 | Integrated Dna Technologies, Inc. | Modifications for antisense compounds |
AU2011299233B2 (en) | 2010-09-07 | 2016-09-15 | Integrated Dna Technologies, Inc. | Modifications for antisense compounds |
WO2012037456A1 (en) | 2010-09-17 | 2012-03-22 | President And Fellows Of Harvard College | Functional genomics assay for characterizing pluripotent stem cell utility and safety |
US8715933B2 (en) | 2010-09-27 | 2014-05-06 | Nabsys, Inc. | Assay methods using nicking endonucleases |
WO2012067911A1 (en) | 2010-11-16 | 2012-05-24 | Nabsys, Inc. | Methods for sequencing a biomolecule by detecting relative positions of hybridized probes |
WO2012068519A2 (en) | 2010-11-19 | 2012-05-24 | Sirius Genomics Inc. | Markers associated with response to activated protein c administration, and uses thereof |
WO2012109574A2 (en) | 2011-02-11 | 2012-08-16 | Nabsys, Inc. | Assay methods using dna binding proteins |
WO2012129547A1 (en) | 2011-03-23 | 2012-09-27 | Elitech Holding B.V. | Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use |
US8969003B2 (en) | 2011-03-23 | 2015-03-03 | Elitech Holding B.V. | Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use |
DK2697392T3 (en) | 2011-04-12 | 2016-03-29 | Verinata Health Inc | SOLUTION OF GENOME FRACTIONS USING Polymorphism COUNTS |
US9411937B2 (en) | 2011-04-15 | 2016-08-09 | Verinata Health, Inc. | Detecting and classifying copy number variation |
EP2701722A4 (en) | 2011-04-28 | 2014-12-31 | Univ Southern California | CANCEROUS MARKERS OF HUMAN SUPPRESSIVE MYELOID CELLS |
ES2537189T3 (es) | 2011-05-24 | 2015-06-03 | Elitech Holding B.V. | Detección de estafilococos áureos resistentes a la meticilina |
SG10201510189WA (en) | 2011-10-19 | 2016-01-28 | Nugen Technologies Inc | Compositions And Methods For Directional Nucleic Acid Amplification And Sequencing |
MX354547B (es) | 2011-11-14 | 2018-03-09 | Alfasigma Spa | Ensayos y métodos para seleccionar un regimen de tratamiento para un sujeto con depresión. |
WO2013112923A1 (en) | 2012-01-26 | 2013-08-01 | Nugen Technologies, Inc. | Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation |
WO2013119923A1 (en) | 2012-02-09 | 2013-08-15 | The Regents Of The University Of Michigan | Different states of cancer stem cells |
EP2861787B1 (en) | 2012-06-18 | 2017-09-20 | Nugen Technologies, Inc. | Compositions and methods for negative selection of non-desired nucleic acid sequences |
US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
GB201220924D0 (en) | 2012-11-21 | 2013-01-02 | Cancer Res Inst Royal | Materials and methods for determining susceptibility or predisposition to cancer |
US9914966B1 (en) | 2012-12-20 | 2018-03-13 | Nabsys 2.0 Llc | Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation |
US10294516B2 (en) | 2013-01-18 | 2019-05-21 | Nabsys 2.0 Llc | Enhanced probe binding |
WO2014159063A1 (en) | 2013-03-14 | 2014-10-02 | Elitech Holding B.V. | Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use |
EP2971130A4 (en) | 2013-03-15 | 2016-10-05 | Nugen Technologies Inc | SEQUENTIAL SEQUENCING |
US20160186263A1 (en) | 2013-05-09 | 2016-06-30 | Trustees Of Boston University | Using plexin-a4 as a biomarker and therapeutic target for alzheimer's disease |
EP3008229B1 (en) | 2013-06-10 | 2020-05-27 | President and Fellows of Harvard College | Early developmental genomic assay for characterizing pluripotent stem cell utility and safety |
US20160230231A1 (en) | 2013-10-18 | 2016-08-11 | Institut De Cardiologie De Montreal | Genotyping tests and methods for evaluating plasma creatine kinase levels |
JP6525473B2 (ja) | 2013-11-13 | 2019-06-05 | ニューゲン テクノロジーズ, インコーポレイテッド | 複製物配列決定リードを同定するための組成物および方法 |
WO2015131107A1 (en) | 2014-02-28 | 2015-09-03 | Nugen Technologies, Inc. | Reduced representation bisulfite sequencing with diversity adaptors |
KR102456013B1 (ko) | 2014-07-30 | 2022-10-18 | 에프. 호프만-라 로슈 아게 | 고밀도 지질단백질(hdl)-상승 제제 또는 hdl-모방 제제에 의한 치료법에 대한 반응성을 예측하기 위한 유전 표지 |
US9789087B2 (en) | 2015-08-03 | 2017-10-17 | Thomas Jefferson University | PAR4 inhibitor therapy for patients with PAR4 polymorphism |
WO2018226602A1 (en) | 2017-06-05 | 2018-12-13 | Research Institute At Nationwide Children's Hospital | Enhanced modified viral capsid proteins |
WO2019010410A1 (en) * | 2017-07-07 | 2019-01-10 | Massachusetts Institute Of Technology | SYSTEMS AND METHODS OF GENETIC IDENTIFICATION AND ANALYSIS |
US11099202B2 (en) | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
BR112021012570A2 (pt) * | 2019-01-07 | 2021-09-14 | Personal Genome Diagnostics Inc. | Quantificação de instrumentos e reagentes de sequenciamento para uso em métodos de diagnóstico molecular |
CN109801679B (zh) * | 2019-01-15 | 2021-02-02 | 广州柿宝生物科技有限公司 | 一种用于长链分子的数学序列重建方法 |
IL303893A (en) | 2019-08-05 | 2023-08-01 | Seer Inc | Systems and methods for sample preparation, data generation and corona protein analysis |
CN113275053A (zh) | 2020-02-03 | 2021-08-20 | 帝肯基因组学公司 | 试剂存储系统 |
EP4430199A2 (en) | 2021-11-24 | 2024-09-18 | Research Institute at Nationwide Children's Hospital | Chimeric hsv expressing hil21 to boost anti-tumor immune activity |
Family Cites Families (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4302204A (en) * | 1979-07-02 | 1981-11-24 | The Board Of Trustees Of Leland Stanford Junior University | Transfer and detection of nucleic acids |
US4562159A (en) * | 1981-03-31 | 1985-12-31 | Albert Einstein College Of Medicine, A Division Of Yeshiva Univ. | Diagnostic test for hepatitis B virus |
CA1180647A (en) * | 1981-07-17 | 1985-01-08 | Cavit Akin | Light-emitting polynucleotide hybridization diagnostic method |
FI63596C (fi) * | 1981-10-16 | 1983-07-11 | Orion Yhtymae Oy | Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser |
US4591567A (en) | 1982-04-21 | 1986-05-27 | California Institute Of Technology | Recombinant DNA screening system including fixed array replicator and support |
JPS5927900A (ja) * | 1982-08-09 | 1984-02-14 | Wakunaga Seiyaku Kk | 固定化オリゴヌクレオチド |
EP0756010B1 (en) * | 1983-01-10 | 2001-07-04 | Gen-Probe Incorporated | Method for detecting, identifying, and quantitating organisms and viruses |
JPS6010174A (ja) * | 1983-06-29 | 1985-01-19 | Fuji Photo Film Co Ltd | オ−トラジオグラフイ−による遺伝子のスクリ−ニング方法 |
CA1222680A (en) * | 1983-07-05 | 1987-06-09 | Nanibhushan Dattagupta | Testing dna samples for particular nucleotide sequences |
US4677054A (en) * | 1983-08-08 | 1987-06-30 | Sloan-Kettering Institute For Cancer Research | Method for simple analysis of relative nucleic acid levels in multiple small samples by cytoplasmic dot hybridization |
WO1985001051A1 (en) * | 1983-09-02 | 1985-03-14 | Molecular Biosystems, Inc. | Oligonucleotide polymeric support system |
US4613566A (en) * | 1984-01-23 | 1986-09-23 | President And Fellows Of Harvard College | Hybridization assay and kit therefor |
FI71768C (fi) * | 1984-02-17 | 1987-02-09 | Orion Yhtymae Oy | Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning. |
CA1223222A (en) | 1984-02-22 | 1987-06-23 | Nanibhushan Dattagupta | Immobilized nucleic acid-containing probes |
US4766062A (en) * | 1984-05-07 | 1988-08-23 | Allied Corporation | Displacement polynucleotide assay method and polynucleotide complex reagent therefor |
US4883750A (en) | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
US5242794A (en) | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
GB8432118D0 (en) * | 1984-12-19 | 1985-01-30 | Malcolm A D B | Sandwich hybridisation technique |
DE3506703C1 (de) * | 1985-02-26 | 1986-04-30 | Sagax Instrument AB, Sundbyberg | Verfahren zur Sequenzanalyse von Nucleinsaeuren,insbesondere der Desoxyribonucleinsaeure (DNA) und der Ribonucleinsaeure (RNA),sowie Traeger zur Durchfuehrung des Verfahrens und Verfahren zur Herstellung des Traegers |
GB8509880D0 (en) * | 1985-04-17 | 1985-05-22 | Ici Plc | Testing device |
EP0200113A3 (en) * | 1985-04-30 | 1987-03-18 | Pandex Laboratories, Inc. | A method of solid phase nucleic acid hybridization assay incorporating a luminescent label |
AU558846B2 (en) * | 1985-06-21 | 1987-02-12 | Miles Laboratories Inc. | Solid-phase hydridization assay using anti-hybrid antibodies |
US4794073A (en) * | 1985-07-10 | 1988-12-27 | Molecular Diagnostics, Inc. | Detection of nucleic acid hybrids by prolonged chemiluminescence |
US4775631A (en) * | 1985-07-26 | 1988-10-04 | Janssen Pharmaceuitica, N.V. | Method of localizing nucleic acids bound to polyamide supports |
US4806631A (en) * | 1985-09-30 | 1989-02-21 | Miles Inc. | Immobilization of nucleic acids on solvolyzed nylon supports |
US4806546A (en) * | 1985-09-30 | 1989-02-21 | Miles Inc. | Immobilization of nucleic acids on derivatized nylon supports |
TW203120B (ja) * | 1985-10-04 | 1993-04-01 | Abbott Lab | |
US4770992A (en) * | 1985-11-27 | 1988-09-13 | Den Engh Gerrit J Van | Detection of specific DNA sequences by flow cytometry |
US4882269A (en) * | 1985-12-13 | 1989-11-21 | Princeton University | Amplified hybridization assay |
EP0228075B1 (en) * | 1986-01-03 | 1991-04-03 | Molecular Diagnostics, Inc. | Eucaryotic genomic dna dot-blot hybridization method |
EP0231010A3 (en) * | 1986-01-27 | 1990-10-17 | INCSTAR Corporation | A method of solid phase enzyme immunoassay and nucleic acid hybridization assay and dip-stick design and stabilized chromogenic substrate |
NO870613L (no) * | 1986-03-05 | 1987-09-07 | Molecular Diagnostics Inc | Deteksjon av mikroorganismer i en prve inneholdende nukleinsyre. |
US5348855A (en) * | 1986-03-05 | 1994-09-20 | Miles Inc. | Assay for nucleic acid sequences in an unpurified sample |
CA1284931C (en) * | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
US5310893A (en) * | 1986-03-31 | 1994-05-10 | Hoffmann-La Roche Inc. | Method for HLA DP typing |
AU7015287A (en) * | 1986-03-19 | 1987-09-24 | Cetus Corporation | Detection of nucleic acid sequence using liquid hybridization method |
US4981783A (en) * | 1986-04-16 | 1991-01-01 | Montefiore Medical Center | Method for detecting pathological conditions |
EP0245206A1 (en) * | 1986-05-05 | 1987-11-11 | IntraCel Corporation | Analytical method for detecting and measuring specifically sequenced nucleic acid |
DE3785658T2 (de) * | 1986-08-11 | 1993-08-12 | Siska Diagnostics Inc | Methoden und zusammensetzungen fuer tests mit nukleinsaeuresonden. |
US4885250A (en) * | 1987-03-02 | 1989-12-05 | E. I. Du Pont De Nemours And Company | Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports |
KR960000479B1 (ko) * | 1987-03-02 | 1996-01-08 | 젠-프로우브 인코오퍼레이티드 | 핵산 정제,분리 및 혼성체 형성용 다가양이온성 지지체 |
AU601021B2 (en) * | 1987-03-11 | 1990-08-30 | Molecular Diagnostics, Inc. | Assay for necleic acid sequences in a sample |
US5525464A (en) * | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
US6270961B1 (en) * | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
IL85551A0 (en) * | 1987-04-01 | 1988-08-31 | Miles Inc | Rapid hybridization assay and reagent system used therein |
US4849334A (en) * | 1987-06-09 | 1989-07-18 | Life Technologies, Inc. | Human papillomavirus 43 nucleic acid hybridization probes and methods for employing the same |
JPH02503983A (ja) * | 1987-06-26 | 1990-11-22 | イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー | 捕捉ビーズを用いる組み換えクローン化naからの混入配列のアフイニテイ除去 |
US5120643A (en) * | 1987-07-13 | 1992-06-09 | Abbott Laboratories | Process for immunochromatography with colloidal particles |
US4921805A (en) * | 1987-07-29 | 1990-05-01 | Life Technologies, Inc. | Nucleic acid capture method |
US4942124A (en) * | 1987-08-11 | 1990-07-17 | President And Fellows Of Harvard College | Multiplex sequencing |
EP0305145A3 (en) * | 1987-08-24 | 1990-05-02 | Ortho Diagnostic Systems Inc. | Methods and probes for detecting nucleic acids |
DE3888653T2 (de) * | 1987-12-21 | 1994-07-07 | Applied Biosystems | Verfahren und Testsatz zum Nachweis einer Nukleinsäure-Sequenz. |
US5354657A (en) * | 1988-01-12 | 1994-10-11 | Boehringer Mannheim Gmbh | Process for the highly specific detection of nucleic acids in solid |
GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
US4988617A (en) * | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
US5002867A (en) * | 1988-04-25 | 1991-03-26 | Macevicz Stephen C | Nucleic acid sequence determination by multiple mixed oligonucleotide probes |
ATE173508T1 (de) * | 1988-05-20 | 1998-12-15 | Hoffmann La Roche | Befestigung von sequenzspezifischen proben |
US5094939A (en) * | 1988-07-19 | 1992-03-10 | Fujirebio, Inc. | Chemiluminescence assays using stabilized dioxetane derivatives |
GB8822228D0 (en) * | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
EP0392546A3 (en) * | 1989-04-14 | 1991-09-11 | Ro Institut Za Molekularnu Genetiku I Geneticko Inzenjerstvo | Process for determination of a complete or a partial contents of very short sequences in the samples of nucleic acids connected to the discrete particles of microscopic size by hybridization with oligonucleotide probes |
US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
WO1992007093A1 (en) * | 1990-10-17 | 1992-04-30 | Jack Love | Identification and paternity determination by detecting presence or absence of multiple nucleic acid sequences |
DE69132843T2 (de) * | 1990-12-06 | 2002-09-12 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Identifizierung von Nukleinsäuren in Proben |
AU1999092A (en) * | 1991-05-24 | 1992-12-30 | Walter Gilbert | Method and apparatus for rapid nucleic acid sequencing |
US5672472A (en) * | 1991-08-23 | 1997-09-30 | Isis Pharmaceuticals, Inc. | Synthetic unrandomization of oligomer fragments |
US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US6017696A (en) | 1993-11-01 | 2000-01-25 | Nanogen, Inc. | Methods for electronic stringency control for molecular biological analysis and diagnostics |
US5503980A (en) * | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
ATE257861T1 (de) * | 1993-09-27 | 2004-01-15 | Arch Dev Corp | Methoden und zusammensetzungen zur effizienten nukleinsaeuresequenzierung |
BR9507343A (pt) * | 1994-04-04 | 1997-09-16 | Ciba Corning Diagnostics Corp | Testes de hibridização - ligação para a detecção de sequências de ácido nucléico específicas |
GB9507238D0 (en) * | 1995-04-07 | 1995-05-31 | Isis Innovation | Detecting dna sequence variations |
US5545531A (en) * | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
JP2000504575A (ja) * | 1996-02-08 | 2000-04-18 | アフィメトリックス,インコーポレイテッド | 微生物のチップベースの種分化および表現型特徴付け |
-
1994
- 1994-12-09 US US08/353,554 patent/US6270961B1/en not_active Expired - Fee Related
-
1995
- 1995-12-08 EP EP95943413A patent/EP0797683A4/en not_active Withdrawn
- 1995-12-08 AU AU44687/96A patent/AU715506B2/en not_active Ceased
- 1995-12-08 CN CN95197574A patent/CN1175283A/zh active Pending
- 1995-12-08 JP JP8517814A patent/JPH10512745A/ja not_active Ceased
- 1995-12-08 CA CA002206815A patent/CA2206815A1/en not_active Abandoned
- 1995-12-08 KR KR1019970703847A patent/KR980700433A/ko not_active Application Discontinuation
- 1995-12-08 WO PCT/US1995/016154 patent/WO1996017957A1/en active Search and Examination
-
1997
- 1997-06-04 NO NO972535A patent/NO972535L/no not_active Application Discontinuation
- 1997-06-06 FI FI972429A patent/FI972429A/fi unknown
- 1997-08-28 US US08/920,295 patent/US6025136A/en not_active Expired - Fee Related
-
2000
- 2000-02-14 US US09/503,442 patent/US6403315B1/en not_active Expired - Fee Related
-
2002
- 2002-04-25 US US10/133,888 patent/US20020192691A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6270961B1 (en) | 2001-08-07 |
WO1996017957A1 (en) | 1996-06-13 |
CN1175283A (zh) | 1998-03-04 |
NO972535L (no) | 1997-08-06 |
US20020192691A1 (en) | 2002-12-19 |
CA2206815A1 (en) | 1996-06-13 |
KR980700433A (ko) | 1998-03-30 |
FI972429A (fi) | 1997-08-06 |
EP0797683A1 (en) | 1997-10-01 |
FI972429A0 (fi) | 1997-06-06 |
NO972535D0 (no) | 1997-06-04 |
EP0797683A4 (en) | 1999-03-03 |
AU4468796A (en) | 1996-06-26 |
US6025136A (en) | 2000-02-15 |
AU715506B2 (en) | 2000-02-03 |
US6403315B1 (en) | 2002-06-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPH10512745A (ja) | Dna塩基配列決定およびdna同定の方法および装置 | |
US6297006B1 (en) | Methods for sequencing repetitive sequences and for determining the order of sequence subfragments | |
Chetverin et al. | Oligonucleotide arrays: New concepts and possibilities | |
US6309824B1 (en) | Methods for analyzing a target nucleic acid using immobilized heterogeneous mixtures of oligonucleotide probes | |
Southern | DNA chips: analysing sequence by hybridization to oligonucleotides on a large scale | |
US6383742B1 (en) | Three dimensional arrays for detection or quantification of nucleic acid species | |
CA3141255A1 (en) | Method of signal encoding of analytes in a sample | |
US20220205028A1 (en) | Multiplex method for detecting different analytes in a sample | |
US20020034737A1 (en) | Methods and compositions for detection or quantification of nucleic acid species | |
US20060073506A1 (en) | Methods for identifying biological samples | |
US20030087232A1 (en) | Methods for screening polypeptides | |
US20110039731A1 (en) | Enhanced Sequencing by Hybridization Using Pools of Probes | |
JP2001514906A (ja) | 核酸種を検出または定量するための方法および組成物 | |
JP2004105189A (ja) | 核酸配列のハイブリダイゼーションと配列決定 | |
Carter et al. | Chipping away at complex behavior: transcriptome/phenotype correlations in the mouse brain | |
CN114875118B (zh) | 确定细胞谱系的方法、试剂盒和装置 | |
CN110272994B (zh) | 诊断cvm的基因突变及其应用 | |
WO2000079007A9 (en) | Improved methods of sequence assembly in sequencing by hybridization | |
CN118389706B (zh) | 一种用于鳜鱼基因分型的标记组合及应用其的全基因组液相芯片 | |
KR102102107B1 (ko) | 이동성 유전인자 SINE 선택적 발굴을 위한 HiSeq 시퀀서 기반의 DNA 라이브러리 제작 방법 | |
US20050176007A1 (en) | Discriminative analysis of clone signature | |
Gupta et al. | Microarray: an emerging diagnostic tool in dentistry | |
JP3783315B2 (ja) | 核酸分析方法 | |
CN117625763A (zh) | 准确地平行定量变体核酸的高灵敏度方法 | |
CZ254699A3 (cs) | Způsoby a kompozice vhodné pro detekci nebo kvantifikaci druhů nukleových kyselin |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20060404 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20060704 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20060821 |
|
A313 | Final decision of rejection without a dissenting response from the applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A313 Effective date: 20061127 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20070116 |