JPH10512286A - 3−(2,2,2−トリメチルヒドラジニウム)プロピオネートとガンマ−ブチロベタインを含有する心臓血管疾患の治療のための医薬組成物 - Google Patents
3−(2,2,2−トリメチルヒドラジニウム)プロピオネートとガンマ−ブチロベタインを含有する心臓血管疾患の治療のための医薬組成物Info
- Publication number
- JPH10512286A JPH10512286A JP9509171A JP50917197A JPH10512286A JP H10512286 A JPH10512286 A JP H10512286A JP 9509171 A JP9509171 A JP 9509171A JP 50917197 A JP50917197 A JP 50917197A JP H10512286 A JPH10512286 A JP H10512286A
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- butyrobetaine
- pharmaceutically acceptable
- acceptable carrier
- propionate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.心臓血管疾患の治療のための医薬組成物であって、活性素として 0.5〜95 重量%の、3−(2,2,2−トリメチルヒドラジニウム)プロピオネートとγ −ブチロベタイン化合物、並びに医薬として許容される担体を含有する医薬組成 物。 2.前記組成物中の前記物質の比が、1:10、好ましくは、1:3〜3:1で ある、請求項1に記載の医薬組成物。 3.経口又は舌下投与を意図され、そして(カバーを伴うか又は伴わない)錠 剤、カプセル、キャップレット(Caplets)、糖衣剤、粒剤、粉剤又は溶液の形態 にあり、各錠剤、カプセル、糖衣剤、粒剤又は粉剤の投薬中0.01〜0.5 gの、又 は経口投与のための 0.5〜40重量%の溶液又はシロップとして、活性素を含有す る、請求項1又は2に記載の医薬組成物。 4.前記の許容される担体が、ステアリン酸及びその塩、ラクトース、グルコ ース、サッカロース、デンプン、タルク、植物油、ポリエチレン・グリコール、 微晶性セルロース、エアロジル、芳香剤、調味料、着色料、エチル・アルコール 及び水であって別々に又は組合せて使用されるものから成る物質群から選ばれた 、請求項3に記載の医薬組成物。 5.非経口投与を意図され、そして注射のための溶液中にあり、0.5〜40重量 %の活性素及び医薬として許容される担体を含有する、請求項1又は2に記載の 医薬組成物。 6.医薬として許容される溶媒が、蒸留水、等張溶液、緩衝溶液又はグルコー ス溶液であって別々に又は組合せて使用されるものを含む溶媒から選ばれた、請 求項5に記載の医薬組成物。 7.前記活性素の経皮投与を意図され、そして軟膏、溶液又は硬 膏の形態にあり、かつ、0.5〜40重量%の活性素及び医薬として許容される担体 を含有する、請求項1又は2に記載の医薬組成物。 8.前記医薬として許容される担体が、水、ポリエチレン・グリコール 400, 1500及び4000、植物油、脂肪、グリセリン、保存料、エマルゲーター(emulgato rs)、安定剤、細孔性ポリマー材料、ジメチルスルホキシド、アルコール及び水 であって別々に又は組合せて使用されるものから成る群から選ばれた、請求項7 に記載の医薬組成物。 9.座剤又はマイクロ浣腸の形態での前記活性素の直腸投与を意図され、かつ 、0.5〜40重量%の活性素及び医薬として許容される担体を含有する、請求項1 又は2に記載の医薬組成物。 10.前記の医薬として許容される担体が、水、ポリエチレン・グリコール 400 ,1500及び4000、植物油、脂肪、グリセリン、保存料、エマルゲーター及び安定 剤であって別々に又は組合せて使用されるものから成る群から選ばれた、請求項 9に記載の医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LV95-256 | 1995-08-21 | ||
LVP-95-256A LV11728B (en) | 1995-08-21 | 1995-08-21 | Pharmaceutical composition |
PCT/LV1996/000002 WO1997006794A1 (en) | 1995-08-21 | 1996-08-20 | Pharmaceutical composition for treating cardiovascular diseases containing 3-(2,2,2-trimethylhydrazinium) propionate and gamma-butyrobetaine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10512286A true JPH10512286A (ja) | 1998-11-24 |
JP3072858B2 JP3072858B2 (ja) | 2000-08-07 |
Family
ID=19736013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP09509171A Expired - Fee Related JP3072858B2 (ja) | 1995-08-21 | 1996-08-20 | 3−(2,2,2−トリメチルヒドラジニウム)プロピオネートとガンマ−ブチロベタインを含有する心臓血管疾患の治療のための医薬組成物 |
Country Status (11)
Country | Link |
---|---|
US (1) | US5859056A (ja) |
EP (1) | EP0845986B1 (ja) |
JP (1) | JP3072858B2 (ja) |
AT (1) | ATE235901T1 (ja) |
CA (1) | CA2229228C (ja) |
DE (1) | DE69627160T2 (ja) |
EA (1) | EA000472B1 (ja) |
ES (1) | ES2196167T3 (ja) |
LV (1) | LV11728B (ja) |
UA (1) | UA44330C2 (ja) |
WO (1) | WO1997006794A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7354069B2 (en) | 2003-11-05 | 2008-04-08 | Nsk Ltd. | Steering apparatus |
JP2013508342A (ja) * | 2009-10-22 | 2013-03-07 | グリンデクス,ア ジョイント ストック カンパニー | 4−[エチル(ジメチル)アンモニオ]ブタノアートの、心血管疾患の治療における利用方法 |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LV12491B (lv) * | 1998-10-29 | 2000-12-20 | Ivars KALVIŅŠ | Farmaceitiska kompozīcija |
FI114538B (fi) * | 2001-01-12 | 2004-11-15 | Finnfeeds Finland Ltd | Glysiinibetaiinin käyttö verenpainetta alentavan tuotteen valmistukseen |
LV12978B (en) * | 2001-09-07 | 2003-05-20 | Ivars Kalvins | Pharmaceutical composition |
LV12979B (en) | 2001-09-07 | 2003-05-20 | Ivars Kalvins | Pharmaceutical composition |
LV13450B (en) * | 2004-08-24 | 2006-11-20 | Grindeks As | Novel medicinal use of meldonium and pharmaceutical compositions thereof |
WO2010149654A1 (en) * | 2009-06-25 | 2010-12-29 | Grindeks, A Joint Stock Company | Pharmaceutical composition of gamma-butyrobetaine or a pharmaceutically acceptable salt and meldonium or a pharmaceutically acceptable salt |
LV14274B (lv) * | 2009-06-25 | 2011-03-20 | Grindeks, A/S | Meldoniju saturošs kombinēts medicīniskais produkts |
EA201301079A1 (ru) * | 2011-04-27 | 2014-02-28 | Гриндекс, Джоинт Сток Кампани | 4-[(галоидалкил)(диметил)аммоний]бутаноаты и их применение при лечении сердечно-сосудистого заболевания |
BR112013027065B1 (pt) * | 2011-04-27 | 2019-12-03 | Grindeks Jsc | processo para a preparação de sais de 3-carboxi-n-etil-n,n-dimetilpropan-1amínio, compostos e seus usos |
LV14848B (lv) * | 2012-10-25 | 2015-06-20 | Latvijas Organiskās Sintēzes Institūts | Farmaceitiska kompozīcija trimetilamīna-N-oksīda līmeņa pazemināšanai |
GB201315321D0 (en) | 2013-08-28 | 2013-10-09 | Koninklijke Nederlandse Akademie Van Wetenschappen | Transduction Buffer |
CN112180013B (zh) * | 2020-09-29 | 2022-11-15 | 上海脉示生物技术有限公司 | 用于心肌梗死诊断的肠道微生物代谢标志物组合物及其检测方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1198434B (it) * | 1981-01-06 | 1988-12-21 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica comprendente gamma butirrobetaina per il trattamento di sindromi da carenze di carnitina |
IT1210935B (it) * | 1981-09-17 | 1989-09-29 | Inst Orch Sinteza Akademi Nauk | Composizione farmaceutica per il trattamento di malattie cardiovascolari. |
-
1995
- 1995-08-21 LV LVP-95-256A patent/LV11728B/lv unknown
-
1996
- 1996-08-20 WO PCT/LV1996/000002 patent/WO1997006794A1/en active Search and Examination
- 1996-08-20 AT AT96927931T patent/ATE235901T1/de active
- 1996-08-20 US US09/011,380 patent/US5859056A/en not_active Expired - Lifetime
- 1996-08-20 CA CA002229228A patent/CA2229228C/en not_active Expired - Fee Related
- 1996-08-20 ES ES96927931T patent/ES2196167T3/es not_active Expired - Lifetime
- 1996-08-20 UA UA98020919A patent/UA44330C2/uk unknown
- 1996-08-20 EA EA199800160A patent/EA000472B1/ru not_active IP Right Cessation
- 1996-08-20 DE DE69627160T patent/DE69627160T2/de not_active Expired - Lifetime
- 1996-08-20 JP JP09509171A patent/JP3072858B2/ja not_active Expired - Fee Related
- 1996-08-20 EP EP96927931A patent/EP0845986B1/en not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7354069B2 (en) | 2003-11-05 | 2008-04-08 | Nsk Ltd. | Steering apparatus |
JP2013508342A (ja) * | 2009-10-22 | 2013-03-07 | グリンデクス,ア ジョイント ストック カンパニー | 4−[エチル(ジメチル)アンモニオ]ブタノアートの、心血管疾患の治療における利用方法 |
Also Published As
Publication number | Publication date |
---|---|
EA000472B1 (ru) | 1999-08-26 |
EP0845986A1 (en) | 1998-06-10 |
CA2229228A1 (en) | 1997-02-27 |
DE69627160D1 (de) | 2003-05-08 |
WO1997006794A1 (en) | 1997-02-27 |
EA199800160A1 (ru) | 1998-08-27 |
EP0845986B1 (en) | 2003-04-02 |
UA44330C2 (uk) | 2002-02-15 |
LV11728B (en) | 1997-08-20 |
CA2229228C (en) | 2008-07-08 |
LV11728A (lv) | 1997-04-20 |
ATE235901T1 (de) | 2003-04-15 |
DE69627160T2 (de) | 2004-02-12 |
JP3072858B2 (ja) | 2000-08-07 |
ES2196167T3 (es) | 2003-12-16 |
US5859056A (en) | 1999-01-12 |
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