ES2196167T3 - Composicion farmaceutica que contiene propionato de 3-(2,2,2-trimetilhidrazinio) y gamma-butirobetaina para el tratamiento de enfermedades cardiovasculares. - Google Patents
Composicion farmaceutica que contiene propionato de 3-(2,2,2-trimetilhidrazinio) y gamma-butirobetaina para el tratamiento de enfermedades cardiovasculares.Info
- Publication number
- ES2196167T3 ES2196167T3 ES96927931T ES96927931T ES2196167T3 ES 2196167 T3 ES2196167 T3 ES 2196167T3 ES 96927931 T ES96927931 T ES 96927931T ES 96927931 T ES96927931 T ES 96927931T ES 2196167 T3 ES2196167 T3 ES 2196167T3
- Authority
- ES
- Spain
- Prior art keywords
- gamma
- treatment
- pct
- pharmaceutical composition
- composition containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A COMPOSICIONES FARMACEUTICAS CONTENIENDO GA} PROPIONATO (MILDRONATO) PARA ADMINISTRACION ORAL, PARENTERAL, SUBCUTANEA O RECTAL PARA EL TRATAMIENTO DE ENFERMEDADES CARDIACAS Y SANGUINEAS DE DIVERSOS ORIGENES Y LOCALIZACIONES, TRASTORNOS DE LA CIRCULACION SANGUINEA, ESTENOCARDIA, INFARTO DE MIOCARDIO, ARRITMIA, HIPERTENSION, MIOCARDITIS Y POTENCIA CARDIACA REDUCIDA. ESTA COMPOSICION EN LOS EXPERIMENTOS SOBRE GATOS ANESTESIADOS A UNA DOSIS DE 5 MG / KG DE GA} 5 MG / KG DE MILDRONATO, I.V. AUMENTA EL FLUJO TOTAL DE SANGRE EN UN 18 %, RESULTANDO LA PRESION ARTERIAL Y LA FRECUENCIA CARDIACA PRACTICAMENTE INALTERADAS. LA COMPOSICION INTERRUMPE LOS ESPASMOS EN LOS VASOS SANGUINEOS INDUCIDOS POR ADRENALINA EN OREJA DE CONEJO AISLADA, A UNA CONCENTRACION DE 2,0 MI}M DE GA} ON DE REPERFUSION EN UN 33 %. EL BLOQUEO DE LA NO SMINUYE ESENCIALMENTE EL EFECTO DE LA COMPOSICION SOBRE LOS ESPASMOS EN LOS VASOS SANGUINEOS INDUCIDOS POR ADRENALINA. A UNA DOSIS DE 60 MG / KG DE EN LOS VASOS SANGUINEOS INDUCIDOS POR ADRENALINA + 40 MG / KG DE MILDRONATO, LA COMPOSICION REDUCE EN UN 70 % LA MORTALIDAD EN RATAS POR ARRITMIA INDUCIDA POR CACL SUB,2}. EN LOS REGIMENES PROFILACTICO Y TERAPEUTICO A DOSIS DE 50 MG / KG DE GA} BUTIROBETAINA + 50 MG / KG DE MILDRONATO, LA COMPOSICION EN EXPERIMENTOS EN RATAS PREVIENE DE FORMA EFICAZ LOS FALLOS DE OCLUSION NES VENTRICULARES. EN LOS EXPERIMENTOS COMPARATIVOS, LA COMPOSICION REIVINDICADA DEMUESTRA UN EFECTO MAS POTENTE EN COMPARACION CON LOS EFECTOS DE LAS PREPARACIONES DE MILDRONATO Y GA} BUTIROBETAINA CONOCIDAS SI SE APLICAN POR SEPARADO. LA COMPOSICION ES ADECUADA PARA UNA BAJA TOXICIDAD Y UN AMPLIO INTERVALO DE SEGURIDAD DE ACCION TERAPEUTICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LVP-95-256A LV11728B (en) | 1995-08-21 | 1995-08-21 | Pharmaceutical composition |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2196167T3 true ES2196167T3 (es) | 2003-12-16 |
Family
ID=19736013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96927931T Expired - Lifetime ES2196167T3 (es) | 1995-08-21 | 1996-08-20 | Composicion farmaceutica que contiene propionato de 3-(2,2,2-trimetilhidrazinio) y gamma-butirobetaina para el tratamiento de enfermedades cardiovasculares. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5859056A (es) |
EP (1) | EP0845986B1 (es) |
JP (1) | JP3072858B2 (es) |
AT (1) | ATE235901T1 (es) |
CA (1) | CA2229228C (es) |
DE (1) | DE69627160T2 (es) |
EA (1) | EA000472B1 (es) |
ES (1) | ES2196167T3 (es) |
LV (1) | LV11728B (es) |
UA (1) | UA44330C2 (es) |
WO (1) | WO1997006794A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LV12491B (lv) * | 1998-10-29 | 2000-12-20 | Ivars KALVIŅŠ | Farmaceitiska kompozīcija |
FI114538B (fi) * | 2001-01-12 | 2004-11-15 | Finnfeeds Finland Ltd | Glysiinibetaiinin käyttö verenpainetta alentavan tuotteen valmistukseen |
LV12978B (en) * | 2001-09-07 | 2003-05-20 | Ivars Kalvins | Pharmaceutical composition |
LV12979B (en) | 2001-09-07 | 2003-05-20 | Ivars Kalvins | Pharmaceutical composition |
JP4390134B2 (ja) | 2003-11-05 | 2009-12-24 | 日本精工株式会社 | ステアリング装置 |
LV13450B (en) * | 2004-08-24 | 2006-11-20 | Grindeks As | Novel medicinal use of meldonium and pharmaceutical compositions thereof |
WO2010149654A1 (en) * | 2009-06-25 | 2010-12-29 | Grindeks, A Joint Stock Company | Pharmaceutical composition of gamma-butyrobetaine or a pharmaceutically acceptable salt and meldonium or a pharmaceutically acceptable salt |
LV14274B (lv) * | 2009-06-25 | 2011-03-20 | Grindeks, A/S | Meldoniju saturošs kombinēts medicīniskais produkts |
LV14345B (lv) * | 2009-10-22 | 2011-07-20 | Grindeks, A/S | 4-[Etil(dimetil)amonija]butanoāts un tā izmantošana kardiovaskulāro slimību ārstēšanai |
EA201301079A1 (ru) * | 2011-04-27 | 2014-02-28 | Гриндекс, Джоинт Сток Кампани | 4-[(галоидалкил)(диметил)аммоний]бутаноаты и их применение при лечении сердечно-сосудистого заболевания |
BR112013027065B1 (pt) * | 2011-04-27 | 2019-12-03 | Grindeks Jsc | processo para a preparação de sais de 3-carboxi-n-etil-n,n-dimetilpropan-1amínio, compostos e seus usos |
LV14848B (lv) * | 2012-10-25 | 2015-06-20 | Latvijas Organiskās Sintēzes Institūts | Farmaceitiska kompozīcija trimetilamīna-N-oksīda līmeņa pazemināšanai |
GB201315321D0 (en) | 2013-08-28 | 2013-10-09 | Koninklijke Nederlandse Akademie Van Wetenschappen | Transduction Buffer |
CN112180013B (zh) * | 2020-09-29 | 2022-11-15 | 上海脉示生物技术有限公司 | 用于心肌梗死诊断的肠道微生物代谢标志物组合物及其检测方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1198434B (it) * | 1981-01-06 | 1988-12-21 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica comprendente gamma butirrobetaina per il trattamento di sindromi da carenze di carnitina |
IT1210935B (it) * | 1981-09-17 | 1989-09-29 | Inst Orch Sinteza Akademi Nauk | Composizione farmaceutica per il trattamento di malattie cardiovascolari. |
-
1995
- 1995-08-21 LV LVP-95-256A patent/LV11728B/lv unknown
-
1996
- 1996-08-20 WO PCT/LV1996/000002 patent/WO1997006794A1/en active Search and Examination
- 1996-08-20 AT AT96927931T patent/ATE235901T1/de active
- 1996-08-20 US US09/011,380 patent/US5859056A/en not_active Expired - Lifetime
- 1996-08-20 CA CA002229228A patent/CA2229228C/en not_active Expired - Fee Related
- 1996-08-20 ES ES96927931T patent/ES2196167T3/es not_active Expired - Lifetime
- 1996-08-20 UA UA98020919A patent/UA44330C2/uk unknown
- 1996-08-20 EA EA199800160A patent/EA000472B1/ru not_active IP Right Cessation
- 1996-08-20 DE DE69627160T patent/DE69627160T2/de not_active Expired - Lifetime
- 1996-08-20 JP JP09509171A patent/JP3072858B2/ja not_active Expired - Fee Related
- 1996-08-20 EP EP96927931A patent/EP0845986B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EA000472B1 (ru) | 1999-08-26 |
EP0845986A1 (en) | 1998-06-10 |
CA2229228A1 (en) | 1997-02-27 |
DE69627160D1 (de) | 2003-05-08 |
WO1997006794A1 (en) | 1997-02-27 |
EA199800160A1 (ru) | 1998-08-27 |
EP0845986B1 (en) | 2003-04-02 |
UA44330C2 (uk) | 2002-02-15 |
LV11728B (en) | 1997-08-20 |
JPH10512286A (ja) | 1998-11-24 |
CA2229228C (en) | 2008-07-08 |
LV11728A (lv) | 1997-04-20 |
ATE235901T1 (de) | 2003-04-15 |
DE69627160T2 (de) | 2004-02-12 |
JP3072858B2 (ja) | 2000-08-07 |
US5859056A (en) | 1999-01-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2196167T3 (es) | Composicion farmaceutica que contiene propionato de 3-(2,2,2-trimetilhidrazinio) y gamma-butirobetaina para el tratamiento de enfermedades cardiovasculares. | |
DE69523169D1 (de) | Verwendung von Mangiferin oder seinen Derivaten zur kosmetischen Anwendung | |
YU49026B (sh) | UPOTREBA 17 Гџ -(N-TERC-BUTILKARBAMOIL)-4-AZA-5-ALFA-ANDROST-1-3-ON ZA PROIZVODNJU LEKA ZA TRETIRANJE ANDROGENE ALOPECIJE | |
LU90988I2 (fr) | Ebixa-mémantine e ses dérivés pharmaceutiquement acceptables | |
KR870005637A (ko) | 약물 데포 | |
ES2092890T3 (es) | Aplicacion del riluzol en el tratamiento de la enfermedad de parkinson y de los sindromes de parkinson. | |
KR960703009A (ko) | 중추유래의 수면성 무호흡증 및 호흡곤란증의 치료를 위한 모다피닐의 사용 | |
FI971290A (fi) | Multippeliskleroosin (MS) ja muiden myeliinikadosta aiheutuvien sairauksien hoito | |
MY113062A (en) | Amide derivatives and their therapeutic use | |
FI934680A0 (fi) | Arylmorfolin, framstaellning och anvaending | |
ES2090703T3 (es) | Medicamento agudo que contiene flurbiprofeno y su empleo. | |
DK0866711T3 (da) | Anvendelse af 6-methyl-5-oxo-3-thiomorpholinylcarbonyl-L-histidyl-L-prolinamid til fremstilling af et farmaceutisk præparat til modvirkning af sövnapnö | |
KR960703593A (ko) | (R)-암로디핀에 의한 평활근 세포 이동의 억제 (Inhibition of Smooth Muscle Cell Migration by (R)-Amlodipine) | |
FR2700166B1 (fr) | Dérivés de pyrrolidine, leur préparation et les médicaments les contenant. | |
TW330933B (en) | Furanoeremophilane and eremophilanolide sesquiterpenes for treatment of diabetes | |
NO952559D0 (no) | N-acyl-pyrrolidiner og medikamenter for behandling eller prevensjon av cholecystokinin- og gastrin-relaterte mangler | |
NO975790L (no) | Anvendelse av allylaminderivater slik som terbinafin, i fremstillingen av et medikament for behandling av helikobacterpylori-infeksjonsassosierte sykdommer | |
GR3034062T3 (en) | Utilization of efaroxan and derivatives thereof for the preparation of a medicament intended to the treatment of parkinson disease | |
HUP0004647A2 (hu) | Glükóz-amino-glükánok alkalmazása diabétesszel társult szembetegségek kezelésére szolgáló gyógyszerkészítmények előállítására | |
KR920003972A (ko) | 프로스타시클린 화합물을 이용한 백내장 치료 | |
ES2168119T3 (es) | Derivados de quinoxalina para el tratamiento de tinnitus. | |
AR005866A1 (es) | Composicion farmaceutica antioxidante | |
HUP0001499A2 (hu) | 7-Alfa-metil-17-alfa-etinil-ösztrán származékok alkalmazása atherosclerosis kezelésére alkalmas gyógyszerkészítmények előállítására | |
NO307204B1 (no) | Anvendelse av riluzol ved fremstilling av medikamenter ved behandling av stråleskader | |
MX9701528A (es) | Derivados de 1, 1, 2,- trifenilbut-1-eno para tratar la enfermedad de alzheimer. |