JPH10501000A - 重合体マトリックス中の作用物質の固溶体の形の作用物質調剤の製法及び該製法により製造された作用物質調剤 - Google Patents
重合体マトリックス中の作用物質の固溶体の形の作用物質調剤の製法及び該製法により製造された作用物質調剤Info
- Publication number
- JPH10501000A JPH10501000A JP8528043A JP52804396A JPH10501000A JP H10501000 A JPH10501000 A JP H10501000A JP 8528043 A JP8528043 A JP 8528043A JP 52804396 A JP52804396 A JP 52804396A JP H10501000 A JPH10501000 A JP H10501000A
- Authority
- JP
- Japan
- Prior art keywords
- active substance
- active ingredient
- preparation
- solid solution
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 229940087562 sodium acetate trihydrate Drugs 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000000176 sodium gluconate Substances 0.000 description 1
- 235000012207 sodium gluconate Nutrition 0.000 description 1
- 229940005574 sodium gluconate Drugs 0.000 description 1
- 229940029258 sodium glycinate Drugs 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- PBDAWQLIMPWEEF-JEDNCBNOSA-M sodium;(2s)-2,6-diaminohexanoate Chemical compound [Na+].NCCCC[C@H](N)C([O-])=O PBDAWQLIMPWEEF-JEDNCBNOSA-M 0.000 description 1
- WTWSHHITWMVLBX-DKWTVANSSA-M sodium;(2s)-2-aminobutanedioate;hydron Chemical compound [Na+].[O-]C(=O)[C@@H](N)CC(O)=O WTWSHHITWMVLBX-DKWTVANSSA-M 0.000 description 1
- WUWHFEHKUQVYLF-UHFFFAOYSA-M sodium;2-aminoacetate Chemical compound [Na+].NCC([O-])=O WUWHFEHKUQVYLF-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/20—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by expressing the material, e.g. through sieves and fragmenting the extruded length
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.重合体マトリックス中の作用物質の固溶体の形の作用物質調剤を製造する方 法において、非イオンの形の作用物質を重合体及び塩とともに溶融押出すること を特徴とする、重合体マトリックス中の作用物質の固溶体の形の作用物質調剤の 製法。 2.重合体として水溶性重合体を使用する、請求項1記載の方法。 3.水溶性重合体としてポリビニルピロリドン、ビニルピロリドン−酢酸ビニル 共重合体又はヒドロキシアルキルセルロースを使用する、請求項2記載の方法。 4.請求項1記載の方法によって製造された、作用物質が重合体マトリックス中 の作用物質の塩の固溶体の形で含有されている作用物質調剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19509807.2 | 1995-03-21 | ||
DE19509807A DE19509807A1 (de) | 1995-03-21 | 1995-03-21 | Verfahren zur Herstellung von Wirkstoffzubereitungen in Form einer festen Lösung des Wirkstoffs in einer Polymermatrix sowie mit diesem Verfahren hergestellte Wirkstoffzubereitungen |
PCT/EP1996/001047 WO1996029061A1 (de) | 1995-03-21 | 1996-03-12 | Verfahren zur herstellung von wirkstoffzubereitungen in form einer festen lösung des wirkstoffs in einer polymermatrix sowie mit diesem verfahren hergestellte wirkstoffzubereitungen |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10501000A true JPH10501000A (ja) | 1998-01-27 |
JP4017661B2 JP4017661B2 (ja) | 2007-12-05 |
Family
ID=7757018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52804396A Expired - Lifetime JP4017661B2 (ja) | 1995-03-21 | 1996-03-12 | 重合体マトリックス中の作用物質の固溶体の形の作用物質調剤の製法及び該製法により製造された作用物質調剤 |
Country Status (18)
Country | Link |
---|---|
US (1) | US5741519A (ja) |
EP (1) | EP0760654B1 (ja) |
JP (1) | JP4017661B2 (ja) |
KR (1) | KR970703133A (ja) |
CN (1) | CN1081458C (ja) |
AT (1) | ATE204162T1 (ja) |
AU (1) | AU5106996A (ja) |
BR (1) | BR9605886A (ja) |
CA (1) | CA2190882C (ja) |
CZ (1) | CZ340596A3 (ja) |
DE (2) | DE19509807A1 (ja) |
ES (1) | ES2163008T3 (ja) |
HU (1) | HUP9603530A3 (ja) |
IL (1) | IL117532A0 (ja) |
MX (1) | MX9605678A (ja) |
NO (1) | NO313485B1 (ja) |
WO (1) | WO1996029061A1 (ja) |
ZA (1) | ZA962243B (ja) |
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AU2015266117A1 (en) | 2014-05-26 | 2016-11-24 | Grunenthal Gmbh | Multiparticles safeguarded against ethanolic dose-dumping |
GB201502077D0 (en) * | 2015-02-09 | 2015-03-25 | Cubic Pharmaceuticals Ltd And Delta Pharmaceuticals Ltd | Improved hme technology |
WO2016128235A1 (en) | 2015-02-11 | 2016-08-18 | Nestec S.A. | Vitamin a composition |
EA035434B1 (ru) | 2015-04-24 | 2020-06-15 | Грюненталь Гмбх | Защищенная от применения не по назначению лекарственная форма с немедленным высвобождением и устойчивостью к экстракции растворителями |
JP2018526414A (ja) | 2015-09-10 | 2018-09-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1766546C3 (de) * | 1968-06-11 | 1974-11-28 | Karl Gunnar Lidingoe Eriksson | Verfahren zum Herstellen von festen dragee- oder tablettenförmigen Arzneimittelzubereitungen |
DE3612211A1 (de) * | 1986-04-11 | 1987-10-15 | Basf Ag | Kontinuierliches verfahren zum tablettieren |
DE3830353A1 (de) * | 1988-09-07 | 1990-03-15 | Basf Ag | Verfahren zur kontinuierlichen herstellung von festen pharmazeutischen formen |
AU1537292A (en) * | 1991-04-16 | 1992-11-17 | Nippon Shinyaku Co. Ltd. | Method of manufacturing solid dispersion |
DK0661045T3 (da) * | 1992-09-18 | 2002-10-28 | Yamanouchi Pharma Co Ltd | Hydrogelpræparat med forsinket frigivelse |
-
1995
- 1995-03-21 DE DE19509807A patent/DE19509807A1/de not_active Withdrawn
-
1996
- 1996-03-12 EP EP96907439A patent/EP0760654B1/de not_active Expired - Lifetime
- 1996-03-12 WO PCT/EP1996/001047 patent/WO1996029061A1/de active IP Right Grant
- 1996-03-12 ES ES96907439T patent/ES2163008T3/es not_active Expired - Lifetime
- 1996-03-12 AU AU51069/96A patent/AU5106996A/en not_active Abandoned
- 1996-03-12 CA CA002190882A patent/CA2190882C/en not_active Expired - Lifetime
- 1996-03-12 AT AT96907439T patent/ATE204162T1/de not_active IP Right Cessation
- 1996-03-12 CZ CZ963405A patent/CZ340596A3/cs unknown
- 1996-03-12 MX MX9605678A patent/MX9605678A/es not_active IP Right Cessation
- 1996-03-12 DE DE59607490T patent/DE59607490D1/de not_active Expired - Lifetime
- 1996-03-12 US US08/737,745 patent/US5741519A/en not_active Expired - Lifetime
- 1996-03-12 CN CN96190364A patent/CN1081458C/zh not_active Expired - Lifetime
- 1996-03-12 KR KR1019960706601A patent/KR970703133A/ko not_active Application Discontinuation
- 1996-03-12 BR BR9605886A patent/BR9605886A/pt not_active Application Discontinuation
- 1996-03-12 HU HU9603530A patent/HUP9603530A3/hu unknown
- 1996-03-12 JP JP52804396A patent/JP4017661B2/ja not_active Expired - Lifetime
- 1996-03-18 IL IL11753296A patent/IL117532A0/xx unknown
- 1996-03-20 ZA ZA9602243A patent/ZA962243B/xx unknown
- 1996-11-20 NO NO19964939A patent/NO313485B1/no not_active IP Right Cessation
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003510264A (ja) * | 1999-09-24 | 2003-03-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗ウイルス組成物 |
JP2003518012A (ja) * | 1999-09-24 | 2003-06-03 | アボット ゲーエムベーハー ウント カンパニー カーゲー | 放出速度制御型粒子 |
JP2008519067A (ja) * | 2004-11-04 | 2008-06-05 | エスケー ケミカルズ カンパニー リミテッド | 向上された生体利用効率を備えるプランルカスト固体分散体組成物およびその固体分散体の製造方法 |
JP2017511313A (ja) * | 2014-03-26 | 2017-04-20 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | 汎rafキナーゼ阻害剤の薬学的製剤、その調製プロセス、及び使用方法 |
Also Published As
Publication number | Publication date |
---|---|
HU9603530D0 (en) | 1997-02-28 |
CN1150757A (zh) | 1997-05-28 |
JP4017661B2 (ja) | 2007-12-05 |
WO1996029061A1 (de) | 1996-09-26 |
US5741519A (en) | 1998-04-21 |
CN1081458C (zh) | 2002-03-27 |
DE19509807A1 (de) | 1996-09-26 |
AU5106996A (en) | 1996-10-08 |
NO964939L (no) | 1997-01-17 |
ZA962243B (en) | 1997-09-22 |
CA2190882C (en) | 2007-01-16 |
MX9605678A (es) | 1998-04-30 |
EP0760654B1 (de) | 2001-08-16 |
EP0760654A1 (de) | 1997-03-12 |
ES2163008T3 (es) | 2002-01-16 |
HUP9603530A3 (en) | 2001-12-28 |
BR9605886A (pt) | 1997-09-16 |
CZ340596A3 (en) | 1997-06-11 |
NO964939D0 (no) | 1996-11-20 |
CA2190882A1 (en) | 1996-09-26 |
ATE204162T1 (de) | 2001-09-15 |
NO313485B1 (no) | 2002-10-14 |
HU76547A2 (en) | 1997-09-29 |
KR970703133A (ko) | 1997-07-03 |
DE59607490D1 (de) | 2001-09-20 |
IL117532A0 (en) | 1996-07-23 |
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