JPH09509057A - メニスカスの移動により高分子を整列させる方法およびその使用 - Google Patents
メニスカスの移動により高分子を整列させる方法およびその使用Info
- Publication number
- JPH09509057A JPH09509057A JP7521021A JP52102195A JPH09509057A JP H09509057 A JPH09509057 A JP H09509057A JP 7521021 A JP7521021 A JP 7521021A JP 52102195 A JP52102195 A JP 52102195A JP H09509057 A JPH09509057 A JP H09509057A
- Authority
- JP
- Japan
- Prior art keywords
- dna
- gene
- meniscus
- molecules
- macromolecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 溶媒Aおよび表面Sおよび媒体B間の接触から生ずるトリプルラインS /A/B(メニスカス)が上記表面S上で動かされ、高分子が一部、特に一端を 表面S上につなぎとめて、他の部分、特に他端、が溶媒Aの溶液中にあることを 特徴とする、支持体の表面S上で高分子を整列させるための方法。 2. メニスカスの移動が溶媒Aの蒸発による行われる、請求項1に記載の方 法。 3. メニスカスの移動が表面Sに対するA/B界面の相対的移動による行わ れる、請求項1に記載の方法。 4. メニスカスを移動させるために、表面Sが溶媒Aから除去されるか、ま たは溶媒Aが表面Sから除去される、請求項3に記載の方法。 5. メニスカスが水/空気メニスカスである、請求項1〜4のいずれか一項 に記載の方法。 6. 支持体が、少くとも表面で、有機または無機ポリマー、金属、酸化また は硫化金属、ケイ素のような半導体元素または半導体元素の酸化物、あるいはそ れら組合せの1つからなる、請求項1〜5のいずれか一項に記載の方法。 7. 支持体が、少くとも表面で、ガラス、表面酸化ケイ素、金、グラファイ ト、硫化モリブデンまたは雲母からなる、請求項1〜6のいずれか一項に記載の 方法。 8. 支持体がプレート、ビーズ、繊維または粒子系の形である、請求項1〜 7のいずれか一項に記載の方法。 9. 整列される高分子が溶液中にある溶媒Aが2つの支持体間におかれ、そ のうち少くとも一方が表面Sの上記支持体に相当し、メニスカスが蒸発により移 動される、請求項1〜8のいずれか一項に記載の方法。 10. 高分子の固定が物理化学的相互作用により、特に吸着または共有結合 により、表面と高分子とで直接、あるいは表面と上記高分子を認識しおよび/ま たはそれと相互作用する他の分子とで間接的に行われる、請求項1〜9のいずれ か一項に記載の方法。 11. 高分子またはその高分子を認識できる生物活性を有する分子に親和性 を有する露出反応基を表面に有した支持体が用いられる、請求項1〜10のいず れか一項に記載の方法。 12. 表面がビニル、アミン、カルボキシル、アルデヒドまたはヒドロキシ ル基から選択される基でコートされる、請求項1〜11のいずれか一項に記載の 方法。 13. 表面が ‐支持体上に、少くとも ・支持体に親和性を有する結合基、および ・結合条件下で上記支持体および上記結合基に親和性をほとんどまたは全く有 しないが、結合に続く化学的修飾後に高分子または生物活性を有する分子と場合 により親和性を有する露出基 を有する長い構造の有機化合物の実質的に単分子の層 を有する、請求項10または12に記載の方法。 14. 高分子の一部の固定が、表面で吸着により、媒体の既定領域のpHま たはイオン含有率で上記高分子を上記表面と接触させることにより、あるいは既 定電圧を固定表面に適用することにより行われる、請求項1〜13のいずれか一 項に記載の方法。 15. 固定を行うためのpHが、完全吸着の状態に有利なpHと、吸着の不 存在に有利なpHとの間の範囲で選択される、請求項1〜14のいずれか一項に 記載の方法。 16. 核酸またはタンパク質の固定が、媒体の既定領域のpHまたはイオン 含有率で核酸またはタンパク質を表面と接触させることにより、エチレン性二重 結合をもつ基またはアミン基を有した表面への吸着により行われる、請求項1〜 15のいずれか一項に記載の方法。 17. 非官能化DNAの固定がビニルまたはアミン基で終わる分子でコート された表面への吸着により行われる、請求項16に記載の方法。 18. DNAの固定が、8以下のpHでDNAを表面と接触させることによ り、エチレン性二重結合を有する基を有する表面においてその末端により行われ る、請求項17に記載の方法。 19. 反応が5〜6のpHで行われ、その後pH8で停止される、請求項1 8に記載の方法。 20. DNAの固定がポリリジンまたはアミン基で終わるシラン基でコート された表面でその末端により行われる、請求項17に記載の方法。 21. DNAの固定が、8〜10のpHでDNAを表面と接触させることに より、アミン基でコートされた表面でその末端により行われる、請求項17に記 載の方法。 22. DNAの固定が、5〜8のpHでDNAを表面と接触させることによ り、酸浴中で予め処理されたガラス表面でその末端により行われる、請求項17 に記載の方法。 23. 請求項1〜22のいずれか一項に記載された方法により得られた整列 高分子を有する表面。 24. 請求項1〜23のいずれか一項に記載された整列方法が用いられ、そ の場合にサンプル高分子を認識できる生物活性を有する分子が表面Sと結合する ようになり、検出、分離またはアッセイが結合分子または上記高分子の存在を検 出する試薬、蛍光またはその他を用いて行われることを特徴とする、サンプル中 における高分子の検出、分離および/またはアッセイ方法。 25. 生物活性を有する高分子および分子がタンパク質、核酸、脂質、多糖 およびそれらの誘導体から選択される、請求項1〜24のいずれか一項に記載の 方法。 26. 生物活性を有する高分子および分子が抗体、抗原、DNA、RNA、 リガンドまたはそれらのレセプターと、その誘導体から選択される、請求項24 に記載の方法。 27. 結合DNAが、サンプルから単離されるDNA配列と相補的な配列を 含む、請求項24〜26のいずれか一項に記載の方法。 28. 結合タンパク質が、サンプルから単離されるタンパク質を特異的に認 識して結合することができる、請求項24〜26のいずれか一項に記載の方法。 29. 生物活性を有する分子がビオチン、アビジン、ストレプトアビジン、 それらの誘導体または抗原‐抗体系から選択される、請求項24〜26のいずれ か一項に記載の方法。 30. 表面が低蛍光を示し、試薬が蛍光性である、請求項24〜26のいず れか一項に記載の方法。 31. 試薬がビーズからなる、請求項24〜26のいずれか一項に記載の方 法。 32. 検出が光学または近視野顕微鏡測定により行われる、請求項24〜2 6のいずれか一項に記載の方法。 33. 生物活性を有する分子とサンプルの高分子との反応産物が検出前にミ スマッチを壊すためにストレスに付される、請求項24〜26のいずれか一項に 記載の方法。 34. ‐高分子が溶液中にある溶媒Aに相当するサンプルが、DNA/DN A、DNA/RNAハイブリッドを形成するかまたはタンパク質/タンパク質反 応産物を形成させるための条件下で支持体の表面と接触させられ、 ‐ハイブリッド、またはハイブリッドまたは反応産物を標識するための高分子 が一部分で固定され、残りが溶液中にあり、それがハイブリッドまたは上記標識 高分子を配向させるために溶媒と表面との接触で作られるメニスカスの移動によ り伸長され、こうして配向されたハイブリッドまたは上記標識高分子の測定また は観察が行われる、 ことを特徴とする、請求項24〜33のいずれか一項に記載のサンプル中におけ るDNA配列またはタンパク質からなる高分子の検出方法。 35. 結合DNAおよびサンプルDNAが別々に“着色”され、伸長後にサ ンプルDNAの末端に対する相補的配列の位置が測定される、請求項24〜34 のいずれか一項に記載の方法。 36. ELISAまたはFISH検出法が用いられる、請求項24〜35の いずれか一項に記載の方法。 37. サンプルが核酸の酵素増幅の産物または基質である、請求項24〜3 6のいずれか一項に記載の方法。 38. 1以上の既定DNA配列の位置またはサイズを調べるために、DNA が伸長され、その後変性され、そして特異的プローブとハイブリッド形成される 、請求項24〜37のいずれか一項に記載の方法。 39. DNAが請求項1〜38のいずれか一項に記載された方法により整列 および/または検出される、ゲノムDNA上における遺伝子の物理的マッピング 方法。 40. ゲノムDNA上における望ましい遺伝子の位置またはサイズが、マッ ピングされる上記遺伝子に特異的なプローブとのハイブリッド形成により調べら れる、請求項39に記載の方法。 41. ‐参照宿主からの全ゲノムDNA ‐DNAの固定および整列を行える表面を有した支持体 ‐マッピングされる遺伝子に特異的なプローブ、および ‐DNAのハイブリッド形成および検出用の試薬 を含む、請求項39または40に記載された方法を行う上で有用なキット。 42. 1以上の所定DNA配列の存在または不存在を調べるために、DNA が伸長され、その後変性され、そして特異的プローブとハイブリッド形成される 、請求項34〜37のいずれか一項に記載の方法。 43. 請求項42に記載された方法が用いられる、病状に特異的な所定DN A配列の存在または不存在に関連した病状の診断方法。 44. ‐表面が患者DNAの固定および整列を行える支持体 ‐調査病状に関与する遺伝子に特異的なプローブ、および ‐DNAのハイブリッド形成および検出用の試薬 を含む、請求項43に記載された診断方法を行う上で有用なキット。 45. ‐表面が望ましい病状に関与する遺伝子に特異的なプローブを有して いる支持体(上記プローブは表面上につなぎとめおよび整列されている) ‐DNA、特に患者DNA、を標識するための試薬 ‐DNAのハイブリッド形成および検出用の試薬 を含む、請求項43に記載された診断方法を行う上で有用なキット。 46. 請求項1〜27のいずれか一項に記載された方法により整列されたゲ ノムDNA上における遺伝子の位置がその遺伝子に特異的なプローブにより同定 され、上記遺伝子の配列および/またはそのフランキング配列の酵素増幅が行わ れ、増幅産物が単離されることを特徴とする、ゲノムDNAからの遺伝子の作製 方法。 47. 場合により同種または異種調節配列を結合した、請求項46に記載さ れた方法により作製された遺伝子を含むDNA構築物。 48. 外来遺伝子の標的挿入により真核細胞のゲノム中で遺伝子を置き換え る方法に有用なDNA構築物を作製し、上記外来遺伝子は請求項46に記載され た方法により得られる、請求項46に記載された方法により得られた遺伝子の使 用。 49. 外来遺伝子が請求項46に記載された方法により作製されることを特 徴とする、外来遺伝子の標的挿入により真核細胞のゲノムで遺伝子を置き換える ための方法に有用なベクター。
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FR9407444A FR2716263B1 (fr) | 1994-02-11 | 1994-06-17 | Procédé d'alignement de macromolécules par passage d'un ménisque et applications dans un procédé de mise en évidence, séparation et/ou dosage d'une macromolécule dans un échantillon. |
PCT/FR1995/000165 WO1995021939A1 (fr) | 1994-02-11 | 1995-02-10 | Procede d'alignement de macromolecules par passage d'un menisque et applications |
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JP2006501485A (ja) * | 2002-09-20 | 2006-01-12 | インテル・コーポレーション | 走査型プローブ顕微鏡検査(spm)読取用の特定の情報をエンコードするナノバーコードの制御された整列 |
JP2006503297A (ja) * | 2002-10-17 | 2006-01-26 | インテル・コーポレーション | 分子構造を検出および同定するための走査型プローブ顕微鏡像のモデルを用いた融合 |
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