JPH09505553A - 改良されたニコチン舐剤及び喫煙を中止する療法 - Google Patents
改良されたニコチン舐剤及び喫煙を中止する療法Info
- Publication number
- JPH09505553A JPH09505553A JP7505279A JP50527995A JPH09505553A JP H09505553 A JPH09505553 A JP H09505553A JP 7505279 A JP7505279 A JP 7505279A JP 50527995 A JP50527995 A JP 50527995A JP H09505553 A JPH09505553 A JP H09505553A
- Authority
- JP
- Japan
- Prior art keywords
- nicotine
- lozenge
- lozenges
- minutes
- smoking
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.ニコチン、吸収性賦形剤、及び非栄養性甘味料を含んでいるニコチン舐剤。 2.吸収性賦形剤はマンニトールを含んでいる請求項1のニコチン舐剤。 3.吸収性賦形剤はβ−シクロデキストリンを含んでいる請求項1のニコチン舐 剤。 4.非栄養性甘味料はキシリトールを含んでいる請求項1又は2又は3のニコチ ン舐剤。 5.グリシルリチン酸アンモニウムを含んでいる請求項4のニコチン舐剤。 6.pHは6〜11である請求項1に記載のニコチン舐剤。 7.ニコチン舐剤であって、以下のものを含んでいる: 0.5〜5mgのニコチン; マンニトール及びβ−シクロデキストリンからなる群から選択され、5〜1 5重量%の吸収性賦形剤; キシリトールを含み、80〜90重量%の非栄養性甘味料; 0.1〜5重量%の潤滑剤; 香味料;及び ニコチン舐剤のpHを6〜11に調節するのに十分な量の緩衝剤。 8.グリシルリチン酸アンモニウムを含んでいる請求項7のニコチン舐剤。 9.モノフルオロリン酸ナトリウムまたはフッ化ナトリウムを含んでいる請求項 7のニコチン舐剤。 10.香味料は、シクロデキストリンと精油香味料の包接錯体を含んでいる請求 項7のニコチン舐剤。 11.(省略) 12.(省略) 13.(省略) 14.(省略) 15.(省略) 16.(省略) 17.(省略) 18.(省略) 19.(省略) 20.(省略) 21.(省略) 22.(省略) 23.(省略) 24.(省略) 25.(省略) 26.(省略) 27.(省略) 28.(省略) 29.(省略) 30.(省略) 31.(省略) 32.(省略) 33.(省略) 34.(省略) 35.(省略) 36.(省略) 37.(省略) 38.(省略) 39.(省略) 40.(省略) 41.(省略) 42.(省略) 43.(省略)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/097,962 US5549906A (en) | 1993-07-26 | 1993-07-26 | Nicotine lozenge and therapeutic method for smoking cessation |
US08/097,962 | 1993-07-26 | ||
PCT/US1994/008160 WO1995003050A2 (en) | 1993-07-26 | 1994-07-20 | Improved nicotine lozenge and therapeutic method for smoking cessation |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005167938A Division JP4358787B2 (ja) | 1993-07-26 | 2005-06-08 | 改良されたニコチン舐剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH09505553A true JPH09505553A (ja) | 1997-06-03 |
Family
ID=22265948
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7505279A Pending JPH09505553A (ja) | 1993-07-26 | 1994-07-20 | 改良されたニコチン舐剤及び喫煙を中止する療法 |
JP2005167938A Expired - Lifetime JP4358787B2 (ja) | 1993-07-26 | 2005-06-08 | 改良されたニコチン舐剤 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005167938A Expired - Lifetime JP4358787B2 (ja) | 1993-07-26 | 2005-06-08 | 改良されたニコチン舐剤 |
Country Status (19)
Country | Link |
---|---|
US (3) | US5549906A (ja) |
EP (2) | EP0707478B1 (ja) |
JP (2) | JPH09505553A (ja) |
KR (1) | KR100341340B1 (ja) |
CN (1) | CN1109542C (ja) |
AT (1) | ATE515257T1 (ja) |
AU (1) | AU691826B2 (ja) |
CA (1) | CA2166394C (ja) |
DK (1) | DK0707478T3 (ja) |
ES (1) | ES2369060T3 (ja) |
FI (1) | FI960324A0 (ja) |
HU (1) | HUT74920A (ja) |
NO (1) | NO960313D0 (ja) |
NZ (1) | NZ269670A (ja) |
PL (1) | PL175988B1 (ja) |
PT (1) | PT707478E (ja) |
RU (2) | RU2153338C2 (ja) |
UA (1) | UA41369C2 (ja) |
WO (1) | WO1995003050A2 (ja) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002530335A (ja) * | 1998-11-23 | 2002-09-17 | フアーマシア アクチエボラグ | 急速経粘膜吸収を与えるニコチン含有医薬組成物 |
JP2005500296A (ja) * | 2001-06-20 | 2005-01-06 | ファイザー・ヘルス・アクチボラグ | コーティングしたニコチン含有チューインガム、その製造および使用 |
JP2005504094A (ja) * | 2001-09-27 | 2005-02-10 | ファーマシア アクティエボラーグ | 新規の配合物及びその使用 |
JP2006503046A (ja) * | 2002-09-16 | 2006-01-26 | スミスクライン ビーチャム コーポレーション | 放出が改変された経口製剤 |
JP2006511566A (ja) * | 2002-12-20 | 2006-04-06 | ニコノヴァム エービー | 物理的および化学的に安定なニコチン−含有粒状物質 |
JP2007515950A (ja) * | 2003-11-07 | 2007-06-21 | ユーエス スモークレス タバコ カンパニー | タバコ組成物 |
JP2008541727A (ja) * | 2005-05-25 | 2008-11-27 | ユー エス スモークレス タバコ コンパニー | タバコ組成物 |
JP2011142926A (ja) * | 2004-06-29 | 2011-07-28 | Fertin Pharma As | タバコアルカロイド放出チューインガム |
JP2013121363A (ja) * | 2003-03-14 | 2013-06-20 | Kraft Foods Global Brands Llc | 吸熱剤を含有するチューインガムおよび菓子組成物 |
US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
JP2015503581A (ja) * | 2012-01-05 | 2015-02-02 | マクニール・アーベーMcNeilAB | 感覚刺激性撹乱の低減された固体ニコチン含有剤形 |
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US5889028A (en) * | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
ES2206709T3 (es) | 1996-05-13 | 2004-05-16 | Novartis Consumer Health S.A. | Sistema de suministro bucal. |
FR2758459B1 (fr) * | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
US6166032A (en) * | 1997-02-07 | 2000-12-26 | Synapse Pharmaceuticals International, Inc. | Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use |
US5760049A (en) * | 1997-02-21 | 1998-06-02 | Synapse Pharmaceuticals International, Inc. | Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use |
JP3236249B2 (ja) | 1997-09-03 | 2001-12-10 | 廣次 野原 | 油水エマルジョン燃料 |
US6908631B1 (en) | 1997-12-01 | 2005-06-21 | Nicogen, Inc. | Therapeutic and diagnostic methods dependent on CYP2A enzymes |
US6211194B1 (en) * | 1998-04-30 | 2001-04-03 | Duke University | Solution containing nicotine |
US6268386B1 (en) * | 1998-06-25 | 2001-07-31 | Marshall Anlauf Thompson | Nicotine beverage |
US6358060B2 (en) * | 1998-09-03 | 2002-03-19 | Jsr Llc | Two-stage transmucosal medicine delivery system for symptom relief |
US6344222B1 (en) | 1998-09-03 | 2002-02-05 | Jsr Llc | Medicated chewing gum delivery system for nicotine |
US6224897B1 (en) | 1998-09-29 | 2001-05-01 | Novartis Consumer Health S.A. | Methods to abate the use of tobacco by humans |
US6242473B1 (en) * | 1999-01-08 | 2001-06-05 | Maxim Pharmaceuticals, Inc. | Treatment and prevention of reactive oxygen metabolite-mediated cellular damage |
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