JPH09501053A - TGF−β−系統群の新規成長−/分化因子 - Google Patents
TGF−β−系統群の新規成長−/分化因子Info
- Publication number
- JPH09501053A JPH09501053A JP7506226A JP50622695A JPH09501053A JP H09501053 A JPH09501053 A JP H09501053A JP 7506226 A JP7506226 A JP 7506226A JP 50622695 A JP50622695 A JP 50622695A JP H09501053 A JPH09501053 A JP H09501053A
- Authority
- JP
- Japan
- Prior art keywords
- protein
- sequence
- tgf
- cells
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.TGF−β−系統群の1つの蛋白質を暗号解読しかつ (a)円熟蛋白質を暗号解読する含分および場合によってはSEQ ID No .1で示されるヌクレオチド配列の他の官能性含分、 (b)遺伝子暗号の退化の範囲内で(a)からの配列に相当するヌクレオチド配 列、 (c)(a)および(b)からの配列の1つの対立遺伝子誘導体に相当するヌク レオチド配列または (d)(a)、(b)または(c)からの配列の1つでハイブリッド化される配 列を含み、この場合(d)に記載のDNA分子は少なくともTGF−β−系統群 の円熟蛋白質を暗号解読する含分を有するという前提条件下にあるDNA分子。 2.請求項1記載のDNA分子の少なくとも1つのコピーを含有するベクター。 3.請求項1記載のDNAまたは請求項2記載のベクターで形質転換されている ホスト細胞。 4.細菌類、真菌類、植物性細胞または動物性細胞である、請求項3記載のホス ト細胞。 5.請求項1記載のDNA配列を暗号解読する、TGF−β−系統群の蛋白質。 6.SEQ ID No.2で示されるアミノ酸配列または場合によってはその 官能性含分を有する、請求項5記載の蛋白質。 7.TGF−β−系統群の蛋白質を製造する方法において、請求項3または4に 記載のホスト細胞を培養し、TGF−β−蛋白質を細胞または/および培養上澄 み液から取得することを特徴とする、TGF−β−系統群の蛋白質の製造法。 8.作用物質としての請求項5または6に記載の少なくとも1つの蛋白質を場合 によっては製薬学的に常用の担持剤、助剤、希釈剤または充填剤と一緒に含有す ることを特徴とする、製薬学的組成物。 9.骨、軟骨、結合組織、皮膚、粘膜、上皮または歯の損傷を治療するかまたは 予防するため、歯のインプラントの際の使用のため、および創傷の治癒プロセス および組織再生のプロセスへの使用のための請求項8記載の製薬学的組成物。 10.請求項5または6に記載の蛋白質に結合されている抗体または抗体断片。
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4326829 | 1993-08-10 | ||
DE4418222 | 1994-05-25 | ||
DE4326829.3 | 1994-06-09 | ||
DE4420157.5 | 1994-06-09 | ||
DE4420157A DE4420157B4 (de) | 1993-08-10 | 1994-06-09 | Neuer Wachstums/Differenzierungsfaktor der TGF-β-Familie |
DE4418222.8 | 1994-06-09 | ||
PCT/EP1994/002630 WO1995004819A1 (de) | 1993-08-10 | 1994-08-09 | NEUER WACHSTUMS-/DIFFERENZIERUNGSFAKTOR DER TGF-β-FAMILIE |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005288456A Division JP4297895B2 (ja) | 1993-08-10 | 2005-09-30 | 皮膚または粘膜の損傷を治療するかまたは予防するための、および創傷の治療プロセスおよび組織再生プロセス用の製薬学的組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09501053A true JPH09501053A (ja) | 1997-02-04 |
JP3795068B2 JP3795068B2 (ja) | 2006-07-12 |
Family
ID=27205438
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50622695A Expired - Fee Related JP3795068B2 (ja) | 1993-08-10 | 1994-08-09 | Mp52蛋白質 |
JP2005288456A Expired - Fee Related JP4297895B2 (ja) | 1993-08-10 | 2005-09-30 | 皮膚または粘膜の損傷を治療するかまたは予防するための、および創傷の治療プロセスおよび組織再生プロセス用の製薬学的組成物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005288456A Expired - Fee Related JP4297895B2 (ja) | 1993-08-10 | 2005-09-30 | 皮膚または粘膜の損傷を治療するかまたは予防するための、および創傷の治療プロセスおよび組織再生プロセス用の製薬学的組成物 |
Country Status (17)
Country | Link |
---|---|
US (1) | US5994094A (ja) |
EP (1) | EP0713529B1 (ja) |
JP (2) | JP3795068B2 (ja) |
CN (1) | CN1185343C (ja) |
AT (1) | ATE189475T1 (ja) |
AU (1) | AU688362B2 (ja) |
CA (1) | CA2169171C (ja) |
CZ (1) | CZ288795B6 (ja) |
DK (1) | DK0713529T3 (ja) |
ES (1) | ES2142953T3 (ja) |
GR (1) | GR3032628T3 (ja) |
HU (1) | HU219504B (ja) |
IL (1) | IL110589A0 (ja) |
NZ (1) | NZ271376A (ja) |
PT (1) | PT713529E (ja) |
TW (1) | TW448183B (ja) |
WO (1) | WO1995004819A1 (ja) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6586388B2 (en) | 1988-04-08 | 2003-07-01 | Stryker Corporation | Method of using recombinant osteogenic protein to repair bone or cartilage defects |
US20070166353A1 (en) * | 1988-04-08 | 2007-07-19 | Stryker Corporation | Osteogenic proteins |
US6171584B1 (en) | 1992-02-12 | 2001-01-09 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Method of treatment with growth/differentiation factors of the TGF-β family |
DE19525416A1 (de) | 1995-07-12 | 1997-01-16 | Bioph Biotech Entw Pharm Gmbh | Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems |
US7025959B1 (en) | 1992-02-12 | 2006-04-11 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | MP121, a growth/differentiation factor of the TGF-β family |
US7067637B1 (en) * | 1992-02-12 | 2006-06-27 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Antibody or antibody fragments specific for a protein of the TGF-β family |
US20080233170A1 (en) * | 1992-02-21 | 2008-09-25 | Stryker Corporation | Osteogenic Proteins |
US6027919A (en) * | 1993-12-07 | 2000-02-22 | Genetics Institute, Inc. | BMP-12 and BMP-13 proteins and DNA encoding them |
US20010011131A1 (en) * | 1997-07-28 | 2001-08-02 | Luyten Frank P. | DNA molecules encoding cartilage-derived morphogenetic proteins |
AU1120295A (en) | 1994-11-07 | 1996-05-31 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Cartilage-derived morphogenetic proteins |
PL186518B1 (pl) | 1995-04-19 | 2004-01-30 | Bioph Biotech Entw Pharm Gmbh | Białko, kompozycja farmaceutyczna i sposób wytwarzania białka |
AP856A (en) * | 1995-04-19 | 2000-07-12 | Biopharm Gmbh | A novel homodimer protein used in pharmaceutical preparation for treating cartlage and bone diseases. |
JPH0931098A (ja) * | 1995-07-24 | 1997-02-04 | Hoechst Japan Ltd | 新規なタンパク質hmwヒトmp52 |
ZA966489B (en) * | 1995-08-03 | 1997-02-26 | Bioph Biotech Entw Pharm Gmbh | New protein human MP52 Arg. |
JPH09143093A (ja) * | 1995-11-17 | 1997-06-03 | Hoechst Japan Ltd | 軟骨・骨誘導性修復用材料 |
JPH09295945A (ja) * | 1996-04-30 | 1997-11-18 | Hoechst Yakuhin Kogyo Kk | 成熟型骨誘導因子の製造方法 |
DE19647853A1 (de) | 1996-11-19 | 1998-05-20 | Bioph Biotech Entw Pharm Gmbh | Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender Aktivität |
EP1074620A1 (en) | 1999-08-06 | 2001-02-07 | HyGene AG | Monomeric protein of the TGF-beta family |
JP2000004882A (ja) * | 1998-06-18 | 2000-01-11 | Hoechst Marion Roussel Kk | ヒトmp52遺伝子プロモーターおよびこれを用いた有用物質の探索法 |
US6992066B2 (en) * | 1998-10-16 | 2006-01-31 | Zimmer Orthobiologics, Inc. | Povidone-containing carriers for polypeptide growth factors |
US7087577B2 (en) * | 1998-10-16 | 2006-08-08 | Zimmer Orthobiologies, Inc. | Method of promoting natural bypass |
DE19906096A1 (de) | 1999-02-13 | 2000-08-17 | Walter Sebald | Protein mit einem Heparin-bindenden Epitop |
US20030059806A1 (en) * | 2001-01-05 | 2003-03-27 | Science & Technology Corporation @ Unm | Probes for the detection of human papillomavirus |
US7232802B2 (en) * | 2001-12-21 | 2007-06-19 | Zimmer Orthobiologics, Inc. | Compositions and methods for promoting myocardial and peripheral angiogenesis |
CN1653179B (zh) * | 2002-03-12 | 2012-07-25 | 组织基因股份有限公司 | 使用软骨细胞和TGF-β的软骨再生 |
US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
AU2004252570C1 (en) | 2003-06-27 | 2012-03-01 | Ethicon, Incorporated | Soft tissue repair and regeneration using postpartum-derived cells |
US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
US8491883B2 (en) | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
US8518390B2 (en) | 2003-06-27 | 2013-08-27 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells |
US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
WO2005116052A2 (en) | 2004-04-27 | 2005-12-08 | Research Development Foundation | ANTAGONISM OF TGF-β SUPERFAMILY RECEPTOR SIGNALING |
US20060069008A1 (en) | 2004-09-28 | 2006-03-30 | Sanjay Mistry | Treatment of neurological deficits in the striatum or substanta nigra pars compacta |
PL1831356T3 (pl) | 2004-12-23 | 2017-07-31 | DePuy Synthes Products, Inc. | Komórki poporodowe pochodzące z tkanki pępowinowej i sposoby ich wytwarzania i stosowania |
EP1833496B1 (en) | 2004-12-23 | 2013-07-31 | Ethicon, Incorporated | Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells |
EP1698691A1 (en) | 2005-03-04 | 2006-09-06 | Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH | Growth factor mutants with improved biological activity |
ES2382464T3 (es) | 2005-11-18 | 2012-06-08 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Mutantes de factor del crecimiento de actividad elevada |
CN101374946B (zh) | 2005-12-16 | 2017-07-18 | 伊西康公司 | 用于在组织相容性不匹配的移植中抑制有害的免疫反应的组合物和方法 |
JP5179376B2 (ja) | 2005-12-19 | 2013-04-10 | エシコン・インコーポレイテッド | ローラーボトルでの分娩後取り出し細胞の体外増殖 |
US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
CA2671437A1 (en) * | 2006-10-31 | 2008-05-29 | University Of Rochester | Targeted delivery of therapeutic agents with lyophilized matrices |
AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
US20100047299A1 (en) * | 2007-01-25 | 2010-02-25 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Use of gdf-5 for the improvement or maintenance of dermal appearance |
US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
US8058237B2 (en) | 2007-08-07 | 2011-11-15 | Advanced Technologies & Regenerative Medicine, LLC | Stable composition of GDF-5 and method of storage |
AU2008308531B2 (en) | 2007-10-05 | 2014-04-24 | Ethicon, Incorporated | Repair and regeneration of renal tissue using human umbilical cord tissue-derived cells |
US8236538B2 (en) | 2007-12-20 | 2012-08-07 | Advanced Technologies And Regenerative Medicine, Llc | Methods for sterilizing materials containing biologically active agents |
CN102026619A (zh) | 2008-04-14 | 2011-04-20 | 先进科技及再生医学有限责任公司 | 液体缓冲的gdf-5制剂 |
US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
BRPI0923068B1 (pt) | 2008-12-19 | 2021-05-25 | Advanced Technologies And Regenerative Medicine, Llc | Uso de células derivadas de tecido de cordão umbilical para tratar um paciente tendo uma doença, distúrbio ou injúria pulmonar |
CN102498204B (zh) | 2009-03-26 | 2015-02-04 | 德普伊新特斯产品有限责任公司 | 人脐带组织细胞作为用于阿尔茨海默病的疗法 |
US20110002897A1 (en) | 2009-06-11 | 2011-01-06 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
DE202009017772U1 (de) | 2009-12-10 | 2011-04-21 | Orthogen Ag | Kombinationspräparate mit Cytokin-Antagonist und Corticosteroid |
US20130122066A1 (en) | 2010-07-30 | 2013-05-16 | Biopham Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Drug delivery devices and growth factor formulations for accelerated wound healing |
US9688735B2 (en) | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
BR112013003587B1 (pt) | 2010-08-20 | 2022-11-08 | Wyeth Llc | Proteínas osteogênicas projetadas, seus usos, seu método de produção e molécula de ácido nucleico isolada |
EP2537538A1 (en) | 2011-06-22 | 2012-12-26 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | Bioresorbable Wound Dressing |
EP2602264A1 (en) | 2011-12-05 | 2013-06-12 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | GDF-5 mutant for inducing cartilage formation |
US9611513B2 (en) | 2011-12-23 | 2017-04-04 | DePuy Synthes Products, Inc. | Detection of human umbilical cord tissue derived cells |
UY35384A (es) | 2013-03-11 | 2014-10-31 | Genzyme Corp | Anticuerpos y fragmentos de unión a antígeno diseñados para unirse al factor de crecimiento transformante ß (TGFß). |
KR101800200B1 (ko) | 2017-05-26 | 2017-11-23 | (주)넥스젠바이오텍 | 항산화 활성 및 피부 세포 증식 효과가 증가한 성장 분화 인자 11과 상피세포 성장인자의 융합단백질 및 이를 유효성분으로 함유하는 피부 주름 개선용 화장료 조성물 |
US11287191B2 (en) | 2019-03-19 | 2022-03-29 | Baltimore Aircoil Company, Inc. | Heat exchanger having plume abatement assembly bypass |
BR112022010740A2 (pt) | 2019-12-11 | 2022-08-23 | Baltimore Aircoil Co Inc | Sistema de trocador de calor com otimização baseada em aprendizagem de máquina |
AU2020403846A1 (en) | 2019-12-18 | 2022-08-11 | Merck Patent Gmbh | Use of the GDF-5 mutant for the treatment of pain and cartilage destruction |
US11976882B2 (en) | 2020-11-23 | 2024-05-07 | Baltimore Aircoil Company, Inc. | Heat rejection apparatus, plume abatement system, and method |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5266683A (en) * | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
EP0429570B1 (en) * | 1989-03-28 | 1998-01-14 | Genetics Institute, Inc. | Osteoinductive compositions |
ATE167486T1 (de) * | 1989-10-17 | 1998-07-15 | Stryker Corp | Osteogene vorrichtungen |
CZ287715B6 (en) * | 1992-02-12 | 2001-01-17 | Bioph Biotech Entw Pharm Gmbh | DNA sequence, recombinant DNA molecule containing thereof, process for preparing protein from the group of TGF-beta substances, pharmaceutical preparation containing such protein, antibody or fragment thereof and its use |
EP1439190A1 (en) * | 1993-01-12 | 2004-07-21 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-5 |
-
1994
- 1994-08-08 IL IL11058994A patent/IL110589A0/xx not_active IP Right Cessation
- 1994-08-09 ES ES94924856T patent/ES2142953T3/es not_active Expired - Lifetime
- 1994-08-09 AT AT94924856T patent/ATE189475T1/de active
- 1994-08-09 PT PT94924856T patent/PT713529E/pt unknown
- 1994-08-09 DK DK94924856T patent/DK0713529T3/da active
- 1994-08-09 AU AU74986/94A patent/AU688362B2/en not_active Ceased
- 1994-08-09 CN CNB941930270A patent/CN1185343C/zh not_active Expired - Fee Related
- 1994-08-09 JP JP50622695A patent/JP3795068B2/ja not_active Expired - Fee Related
- 1994-08-09 HU HU9503853A patent/HU219504B/hu not_active IP Right Cessation
- 1994-08-09 EP EP94924856A patent/EP0713529B1/de not_active Expired - Lifetime
- 1994-08-09 CZ CZ1996357A patent/CZ288795B6/cs not_active IP Right Cessation
- 1994-08-09 CA CA002169171A patent/CA2169171C/en not_active Expired - Fee Related
- 1994-08-09 NZ NZ271376A patent/NZ271376A/en not_active IP Right Cessation
- 1994-08-09 WO PCT/EP1994/002630 patent/WO1995004819A1/de active IP Right Grant
- 1994-08-10 US US08/288,508 patent/US5994094A/en not_active Expired - Lifetime
- 1994-09-09 TW TW083108337A patent/TW448183B/zh not_active IP Right Cessation
-
2000
- 2000-02-10 GR GR20000400326T patent/GR3032628T3/el unknown
-
2005
- 2005-09-30 JP JP2005288456A patent/JP4297895B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2169171A1 (en) | 1995-02-16 |
EP0713529B1 (de) | 2000-02-02 |
IL110589A0 (en) | 1994-11-11 |
DK0713529T3 (da) | 2000-06-19 |
CZ35796A3 (en) | 1996-07-17 |
CZ288795B6 (cs) | 2001-09-12 |
JP4297895B2 (ja) | 2009-07-15 |
US5994094A (en) | 1999-11-30 |
GR3032628T3 (en) | 2000-05-31 |
CN1129013A (zh) | 1996-08-14 |
CN1185343C (zh) | 2005-01-19 |
ATE189475T1 (de) | 2000-02-15 |
AU7498694A (en) | 1995-02-28 |
WO1995004819A1 (de) | 1995-02-16 |
HUT74271A (en) | 1996-11-28 |
CA2169171C (en) | 2008-04-08 |
HU219504B (hu) | 2001-04-28 |
MX9406061A (es) | 2002-03-14 |
PT713529E (pt) | 2000-06-30 |
AU688362B2 (en) | 1998-03-12 |
ES2142953T3 (es) | 2000-05-01 |
NZ271376A (en) | 1997-04-24 |
TW448183B (en) | 2001-08-01 |
JP3795068B2 (ja) | 2006-07-12 |
HU9503853D0 (en) | 1996-02-28 |
EP0713529A1 (de) | 1996-05-29 |
JP2006083178A (ja) | 2006-03-30 |
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