JPH09221416A - 医薬錠剤およびその製造方法 - Google Patents
医薬錠剤およびその製造方法Info
- Publication number
- JPH09221416A JPH09221416A JP9022465A JP2246597A JPH09221416A JP H09221416 A JPH09221416 A JP H09221416A JP 9022465 A JP9022465 A JP 9022465A JP 2246597 A JP2246597 A JP 2246597A JP H09221416 A JPH09221416 A JP H09221416A
- Authority
- JP
- Japan
- Prior art keywords
- layer
- active substance
- core
- release
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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- 229960003134 mepindolol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 description 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 description 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 1
- 229960004584 methylprednisolone Drugs 0.000 description 1
- 229960002237 metoprolol Drugs 0.000 description 1
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 1
- 229960004255 nadolol Drugs 0.000 description 1
- VWPOSFSPZNDTMJ-UCWKZMIHSA-N nadolol Chemical compound C1[C@@H](O)[C@@H](O)CC2=C1C=CC=C2OCC(O)CNC(C)(C)C VWPOSFSPZNDTMJ-UCWKZMIHSA-N 0.000 description 1
- 229960000210 nalidixic acid Drugs 0.000 description 1
- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 229960003940 naproxen sodium Drugs 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229960001783 nicardipine Drugs 0.000 description 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
- 229960001597 nifedipine Drugs 0.000 description 1
- KJONHKAYOJNZEC-UHFFFAOYSA-N nitrazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1 KJONHKAYOJNZEC-UHFFFAOYSA-N 0.000 description 1
- 229960001454 nitrazepam Drugs 0.000 description 1
- 229960005425 nitrendipine Drugs 0.000 description 1
- 229960000564 nitrofurantoin Drugs 0.000 description 1
- NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 description 1
- 229960004872 nizatidine Drugs 0.000 description 1
- SGXXNSQHWDMGGP-IZZDOVSWSA-N nizatidine Chemical compound [O-][N+](=O)\C=C(/NC)NCCSCC1=CSC(CN(C)C)=N1 SGXXNSQHWDMGGP-IZZDOVSWSA-N 0.000 description 1
- 229960002657 orciprenaline Drugs 0.000 description 1
- 229940082615 organic nitrates used in cardiac disease Drugs 0.000 description 1
- ADIMAYPTOBDMTL-UHFFFAOYSA-N oxazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(O)N=C1C1=CC=CC=C1 ADIMAYPTOBDMTL-UHFFFAOYSA-N 0.000 description 1
- 229960004535 oxazepam Drugs 0.000 description 1
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- GDYUVHBMFVMBAF-LIRRHRJNSA-N oxyfedrine Chemical compound COC1=CC=CC(C(=O)CCN[C@@H](C)[C@H](O)C=2C=CC=CC=2)=C1 GDYUVHBMFVMBAF-LIRRHRJNSA-N 0.000 description 1
- 229960001818 oxyfedrine Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
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- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229960002508 pindolol Drugs 0.000 description 1
- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 description 1
- 229960001732 pipemidic acid Drugs 0.000 description 1
- JOHZPMXAZQZXHR-UHFFFAOYSA-N pipemidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCNCC1 JOHZPMXAZQZXHR-UHFFFAOYSA-N 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 229960000329 ribavirin Drugs 0.000 description 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 1
- 229960003320 roxatidine Drugs 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 229960002370 sotalol Drugs 0.000 description 1
- ZBMZVLHSJCTVON-UHFFFAOYSA-N sotalol Chemical compound CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 ZBMZVLHSJCTVON-UHFFFAOYSA-N 0.000 description 1
- 229960004291 sucralfate Drugs 0.000 description 1
- MNQYNQBOVCBZIQ-JQOFMKNESA-A sucralfate Chemical compound O[Al](O)OS(=O)(=O)O[C@@H]1[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](COS(=O)(=O)O[Al](O)O)O[C@H]1O[C@@]1(COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)O1 MNQYNQBOVCBZIQ-JQOFMKNESA-A 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 229960002044 tolmetin sodium Drugs 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 229960000363 trapidil Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- 229960001722 verapamil Drugs 0.000 description 1
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- 229960000537 xipamide Drugs 0.000 description 1
- MTZBBNMLMNBNJL-UHFFFAOYSA-N xipamide Chemical compound CC1=CC=CC(C)=C1NC(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1O MTZBBNMLMNBNJL-UHFFFAOYSA-N 0.000 description 1
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI000210A IT1282576B1 (it) | 1996-02-06 | 1996-02-06 | Compressa farmaceutica atta a cedere la sostanza attiva in tempi successivi e predeterminabili |
| IT96A000210 | 1996-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH09221416A true JPH09221416A (ja) | 1997-08-26 |
Family
ID=11373151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9022465A Pending JPH09221416A (ja) | 1996-02-06 | 1997-02-05 | 医薬錠剤およびその製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6294200B1 (https=) |
| EP (1) | EP0788790B1 (https=) |
| JP (1) | JPH09221416A (https=) |
| AT (1) | ATE267007T1 (https=) |
| AU (1) | AU720914B2 (https=) |
| CA (1) | CA2196840C (https=) |
| DE (1) | DE69729134T2 (https=) |
| DK (1) | DK0788790T3 (https=) |
| ES (1) | ES2220999T3 (https=) |
| IT (1) | IT1282576B1 (https=) |
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| WO1999059552A1 (en) * | 1998-05-15 | 1999-11-25 | Chugai Seiyaku Kabushiki Kaisha | Regulated release preparations |
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| JP2003523981A (ja) * | 2000-02-24 | 2003-08-12 | セラベル・ファーマスーティカルズ・リミテッド | モルシドミンの放出時間延長を伴う経口投与用新規生薬製剤 |
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1997
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- 1997-02-04 ES ES97101689T patent/ES2220999T3/es not_active Expired - Lifetime
- 1997-02-04 DE DE69729134T patent/DE69729134T2/de not_active Expired - Lifetime
- 1997-02-04 AT AT97101689T patent/ATE267007T1/de active
- 1997-02-04 EP EP97101689A patent/EP0788790B1/en not_active Expired - Lifetime
- 1997-02-04 AU AU12526/97A patent/AU720914B2/en not_active Expired
- 1997-02-04 DK DK97101689T patent/DK0788790T3/da active
- 1997-02-05 CA CA002196840A patent/CA2196840C/en not_active Expired - Lifetime
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| JP5048177B2 (ja) * | 1998-05-15 | 2012-10-17 | 中外製薬株式会社 | 放出制御製剤 |
| WO1999059552A1 (en) * | 1998-05-15 | 1999-11-25 | Chugai Seiyaku Kabushiki Kaisha | Regulated release preparations |
| JP2010070572A (ja) * | 1998-12-04 | 2010-04-02 | Sanofi-Aventis | ゾルピデムまたはその塩からなる制御放出剤形 |
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| JP2003523981A (ja) * | 2000-02-24 | 2003-08-12 | セラベル・ファーマスーティカルズ・リミテッド | モルシドミンの放出時間延長を伴う経口投与用新規生薬製剤 |
| JP4945043B2 (ja) * | 2000-02-24 | 2012-06-06 | セラベル・ファーマスーティカルズ・リミテッド | モルシドミンの放出時間延長を伴う経口投与用新規生薬製剤 |
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| JP2006517514A (ja) * | 2002-09-28 | 2006-07-27 | マクニール−ピーピーシー・インコーポレイテッド | ２つのコアを有する加減放出型投薬形態 |
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| JP2010047607A (ja) * | 2004-09-10 | 2010-03-04 | Nitec Pharma Ag | グルココルチコイドの部位時間制御胃腸放出作用を有する錠剤 |
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| US12102721B2 (en) | 2017-01-26 | 2024-10-01 | Triastek, Inc. | Dosage forms of controlled release at specific gastrointestinal sites |
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| EP4702975A1 (en) * | 2024-09-03 | 2026-03-04 | Biotecnica Di Magagnini Mattia E Malatini Silvia Snc Stp | Nutraceutical composition for the treatment of cystitis |
Also Published As
| Publication number | Publication date |
|---|---|
| IT1282576B1 (it) | 1998-03-31 |
| AU720914B2 (en) | 2000-06-15 |
| EP0788790A2 (en) | 1997-08-13 |
| EP0788790A3 (en) | 1998-11-04 |
| ATE267007T1 (de) | 2004-06-15 |
| AU1252697A (en) | 1997-08-28 |
| DE69729134D1 (de) | 2004-06-24 |
| CA2196840C (en) | 2001-12-04 |
| CA2196840A1 (en) | 1997-08-07 |
| US6294200B1 (en) | 2001-09-25 |
| EP0788790B1 (en) | 2004-05-19 |
| DK0788790T3 (da) | 2004-09-20 |
| ITMI960210A0 (https=) | 1996-02-06 |
| ITMI960210A1 (it) | 1997-08-06 |
| ES2220999T3 (es) | 2004-12-16 |
| DE69729134T2 (de) | 2005-05-12 |
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