JPH0920659A5 - - Google Patents

Info

Publication number
JPH0920659A5
JPH0920659A5 JP1996165988A JP16598896A JPH0920659A5 JP H0920659 A5 JPH0920659 A5 JP H0920659A5 JP 1996165988 A JP1996165988 A JP 1996165988A JP 16598896 A JP16598896 A JP 16598896A JP H0920659 A5 JPH0920659 A5 JP H0920659A5
Authority
JP
Japan
Prior art keywords
phenyl
pharmaceutical
methyl
general formula
hal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1996165988A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0920659A (ja
JP4415075B2 (ja
Filing date
Publication date
Priority claimed from DE19523502A external-priority patent/DE19523502A1/de
Application filed filed Critical
Publication of JPH0920659A publication Critical patent/JPH0920659A/ja
Publication of JPH0920659A5 publication Critical patent/JPH0920659A5/ja
Application granted granted Critical
Publication of JP4415075B2 publication Critical patent/JP4415075B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP16598896A 1995-06-28 1996-06-26 炎症性腸疾患のためのカッパーアヘン製剤作働薬 Expired - Fee Related JP4415075B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19523502-9 1995-06-28
DE19523502A DE19523502A1 (de) 1995-06-28 1995-06-28 Kappa-Opiatagonisten für entzündliche Darmerkrankungen

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008112917A Division JP5308056B2 (ja) 1995-06-28 2008-04-23 炎症性腹部疾患のためのカッパ−アヘン製剤作働薬

Publications (3)

Publication Number Publication Date
JPH0920659A JPH0920659A (ja) 1997-01-21
JPH0920659A5 true JPH0920659A5 (enExample) 2004-07-15
JP4415075B2 JP4415075B2 (ja) 2010-02-17

Family

ID=7765475

Family Applications (2)

Application Number Title Priority Date Filing Date
JP16598896A Expired - Fee Related JP4415075B2 (ja) 1995-06-28 1996-06-26 炎症性腸疾患のためのカッパーアヘン製剤作働薬
JP2008112917A Expired - Lifetime JP5308056B2 (ja) 1995-06-28 2008-04-23 炎症性腹部疾患のためのカッパ−アヘン製剤作働薬

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008112917A Expired - Lifetime JP5308056B2 (ja) 1995-06-28 2008-04-23 炎症性腹部疾患のためのカッパ−アヘン製剤作働薬

Country Status (26)

Country Link
US (2) US5776972A (enExample)
EP (1) EP0752246B1 (enExample)
JP (2) JP4415075B2 (enExample)
KR (1) KR100501612B1 (enExample)
CN (1) CN1119147C (enExample)
AR (1) AR004671A1 (enExample)
AT (1) ATE214275T1 (enExample)
AU (1) AU708699B2 (enExample)
BR (1) BR9602915A (enExample)
CA (1) CA2179955C (enExample)
CO (1) CO4700454A1 (enExample)
CZ (1) CZ289805B6 (enExample)
DE (2) DE19523502A1 (enExample)
DK (1) DK0752246T3 (enExample)
ES (1) ES2171577T3 (enExample)
HU (1) HU226976B1 (enExample)
NO (1) NO309674B1 (enExample)
PL (1) PL185537B1 (enExample)
PT (1) PT752246E (enExample)
RU (1) RU2190401C2 (enExample)
SI (1) SI0752246T1 (enExample)
SK (1) SK283497B6 (enExample)
TR (1) TR199600497A2 (enExample)
TW (1) TW430557B (enExample)
UA (1) UA51615C2 (enExample)
ZA (1) ZA965480B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6303611B1 (en) * 1996-03-08 2001-10-16 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
KR100483221B1 (ko) * 1996-12-02 2005-04-15 교린 세이야꾸 가부시키 가이샤 Ｎ-치환된 피롤리딘 유도체 및 이의 제조방법
US6133307A (en) * 1997-04-30 2000-10-17 Warner-Lambert Company Certain benzofuranyl-N-[pyrrolidin-1-YL]-N-methyl-acetamide derivatives useful as opioid agonists
NZ500438A (en) * 1997-07-14 2001-11-30 Adolor Corp Compositions containing a compound having kappa opioid agonist activity for treatment of pruritis (itchiness)
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
DE19827633A1 (de) * 1998-04-20 1999-10-21 Merck Patent Gmbh Verfahren zur Herstellung von enantiomerenreinem N-Methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamid
DE10116978A1 (de) * 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
CA2486000A1 (en) * 2002-05-17 2003-11-27 Merck Patent Gesellschaft Mit Beschraenkter Haftung Use of compounds that are effective as selective opiate receptor modulators
WO2004039785A1 (en) * 2002-11-01 2004-05-13 Pfizer Products Inc. Process for the preparation of pyrrolidinyl ethylamine compounds via a copper-mediated aryl amination
DE10259245A1 (de) * 2002-12-17 2004-07-01 Merck Patent Gmbh Derivate des Asimadolins mit kovalent gebundenen Säuren
US7642274B2 (en) 2003-07-04 2010-01-05 Santen Pharmaceutical Co., Ltd. Inhibitor of pain threshold decrease
WO2005002622A1 (ja) * 2003-07-04 2005-01-13 Santen Pharmaceutical Co., Ltd. 疼痛閾値低下抑制剤
JP2007509865A (ja) * 2003-10-30 2007-04-19 ティオガ ファーマシュウティカルズ，インコーポレイテッド 神経障害の治療における選択的オピエート受容体調節物質の使用
US7160902B2 (en) * 2003-11-14 2007-01-09 Adolor Corporation Amide derivatives and methods of their use
EP2136801B1 (en) * 2007-03-30 2012-08-29 Tioga Pharmaceuticals, Inc. Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome
JP6138169B2 (ja) * 2012-03-05 2017-05-31 ドクター レディズ ラボラトリーズ リミテッド κオピオイド受容体（ＫＯＲ）アゴニストとしての置換複素環式アセトアミド
EA201691489A1 (ru) * 2014-01-24 2016-12-30 Кадила Хелзкэр Лимитед Новые гетероциклические соединения в качестве агонистов каппа-опиодиов
EP3558300B1 (en) 2016-12-21 2021-11-24 Tioga Pharmaceuticals, Inc. Solid pharmaceutical formulations of asimadoline
WO2019122361A1 (en) 2017-12-22 2019-06-27 Dr. August Wolff Gmbh & Co. Kg Arzneimittel Asimadoline for use in treating pulmonary diseases, vascular diseases, and sepsis
EP3932390A1 (en) 2020-07-02 2022-01-05 Dr. August Wolff GmbH & Co. KG Arzneimittel Topical gel formulation containing asimadoline

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663343A (en) * 1985-07-19 1987-05-05 Warner-Lambert Company Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds
DE4034785A1 (de) * 1990-11-02 1992-05-07 Merck Patent Gmbh 1-(2-arylethyl)-pyrrolidine
US5232978A (en) * 1988-12-23 1993-08-03 Merck Patent Gesellschaft Mit Beschrankter Haftung 1-(2-arylethyl)-pyrrolidines
US5232266A (en) * 1989-07-24 1993-08-03 Mork William J Upholstered article of furniture with interchangeable seating module
DE4215213A1 (de) * 1992-05-09 1993-11-11 Merck Patent Gmbh Arylacetamide

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