ES2171577T3 - Kappa-opiaceos para enfermedades intestinales inflamatorias. - Google Patents

Kappa-opiaceos para enfermedades intestinales inflamatorias.

Info

Publication number
ES2171577T3
ES2171577T3 ES96109915T ES96109915T ES2171577T3 ES 2171577 T3 ES2171577 T3 ES 2171577T3 ES 96109915 T ES96109915 T ES 96109915T ES 96109915 T ES96109915 T ES 96109915T ES 2171577 T3 ES2171577 T3 ES 2171577T3
Authority
ES
Spain
Prior art keywords
sub
sup
hal
nhcoa
nha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96109915T
Other languages
English (en)
Spanish (es)
Inventor
Andrew Dr Barber
Christoph Dr Seyfried
Gerd Bartoszyk
Rudolf Dr Gottschlich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2171577T3 publication Critical patent/ES2171577T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
ES96109915T 1995-06-28 1996-06-20 Kappa-opiaceos para enfermedades intestinales inflamatorias. Expired - Lifetime ES2171577T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19523502A DE19523502A1 (de) 1995-06-28 1995-06-28 Kappa-Opiatagonisten für entzündliche Darmerkrankungen

Publications (1)

Publication Number Publication Date
ES2171577T3 true ES2171577T3 (es) 2002-09-16

Family

ID=7765475

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96109915T Expired - Lifetime ES2171577T3 (es) 1995-06-28 1996-06-20 Kappa-opiaceos para enfermedades intestinales inflamatorias.

Country Status (26)

Country Link
US (2) US5776972A (enExample)
EP (1) EP0752246B1 (enExample)
JP (2) JP4415075B2 (enExample)
KR (1) KR100501612B1 (enExample)
CN (1) CN1119147C (enExample)
AR (1) AR004671A1 (enExample)
AT (1) ATE214275T1 (enExample)
AU (1) AU708699B2 (enExample)
BR (1) BR9602915A (enExample)
CA (1) CA2179955C (enExample)
CO (1) CO4700454A1 (enExample)
CZ (1) CZ289805B6 (enExample)
DE (2) DE19523502A1 (enExample)
DK (1) DK0752246T3 (enExample)
ES (1) ES2171577T3 (enExample)
HU (1) HU226976B1 (enExample)
NO (1) NO309674B1 (enExample)
PL (1) PL185537B1 (enExample)
PT (1) PT752246E (enExample)
RU (1) RU2190401C2 (enExample)
SI (1) SI0752246T1 (enExample)
SK (1) SK283497B6 (enExample)
TR (1) TR199600497A2 (enExample)
TW (1) TW430557B (enExample)
UA (1) UA51615C2 (enExample)
ZA (1) ZA965480B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6303611B1 (en) * 1996-03-08 2001-10-16 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
KR100483221B1 (ko) * 1996-12-02 2005-04-15 교린 세이야꾸 가부시키 가이샤 Ｎ-치환된 피롤리딘 유도체 및 이의 제조방법
US6133307A (en) * 1997-04-30 2000-10-17 Warner-Lambert Company Certain benzofuranyl-N-[pyrrolidin-1-YL]-N-methyl-acetamide derivatives useful as opioid agonists
NZ500438A (en) * 1997-07-14 2001-11-30 Adolor Corp Compositions containing a compound having kappa opioid agonist activity for treatment of pruritis (itchiness)
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
DE19827633A1 (de) * 1998-04-20 1999-10-21 Merck Patent Gmbh Verfahren zur Herstellung von enantiomerenreinem N-Methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamid
DE10116978A1 (de) * 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
CA2486000A1 (en) * 2002-05-17 2003-11-27 Merck Patent Gesellschaft Mit Beschraenkter Haftung Use of compounds that are effective as selective opiate receptor modulators
WO2004039785A1 (en) * 2002-11-01 2004-05-13 Pfizer Products Inc. Process for the preparation of pyrrolidinyl ethylamine compounds via a copper-mediated aryl amination
DE10259245A1 (de) * 2002-12-17 2004-07-01 Merck Patent Gmbh Derivate des Asimadolins mit kovalent gebundenen Säuren
US7642274B2 (en) 2003-07-04 2010-01-05 Santen Pharmaceutical Co., Ltd. Inhibitor of pain threshold decrease
WO2005002622A1 (ja) * 2003-07-04 2005-01-13 Santen Pharmaceutical Co., Ltd. 疼痛閾値低下抑制剤
JP2007509865A (ja) * 2003-10-30 2007-04-19 ティオガ ファーマシュウティカルズ，インコーポレイテッド 神経障害の治療における選択的オピエート受容体調節物質の使用
US7160902B2 (en) * 2003-11-14 2007-01-09 Adolor Corporation Amide derivatives and methods of their use
EP2136801B1 (en) * 2007-03-30 2012-08-29 Tioga Pharmaceuticals, Inc. Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome
JP6138169B2 (ja) * 2012-03-05 2017-05-31 ドクター レディズ ラボラトリーズ リミテッド κオピオイド受容体（ＫＯＲ）アゴニストとしての置換複素環式アセトアミド
EA201691489A1 (ru) * 2014-01-24 2016-12-30 Кадила Хелзкэр Лимитед Новые гетероциклические соединения в качестве агонистов каппа-опиодиов
EP3558300B1 (en) 2016-12-21 2021-11-24 Tioga Pharmaceuticals, Inc. Solid pharmaceutical formulations of asimadoline
WO2019122361A1 (en) 2017-12-22 2019-06-27 Dr. August Wolff Gmbh & Co. Kg Arzneimittel Asimadoline for use in treating pulmonary diseases, vascular diseases, and sepsis
EP3932390A1 (en) 2020-07-02 2022-01-05 Dr. August Wolff GmbH & Co. KG Arzneimittel Topical gel formulation containing asimadoline

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663343A (en) * 1985-07-19 1987-05-05 Warner-Lambert Company Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds
DE4034785A1 (de) * 1990-11-02 1992-05-07 Merck Patent Gmbh 1-(2-arylethyl)-pyrrolidine
US5232978A (en) * 1988-12-23 1993-08-03 Merck Patent Gesellschaft Mit Beschrankter Haftung 1-(2-arylethyl)-pyrrolidines
US5232266A (en) * 1989-07-24 1993-08-03 Mork William J Upholstered article of furniture with interchangeable seating module
DE4215213A1 (de) * 1992-05-09 1993-11-11 Merck Patent Gmbh Arylacetamide

Also Published As

Publication number Publication date
HU226976B1 (en) 2010-04-28
PL185537B1 (pl) 2003-05-30
NO309674B1 (no) 2001-03-12
ATE214275T1 (de) 2002-03-15
PT752246E (pt) 2002-09-30
US5776972A (en) 1998-07-07
BR9602915A (pt) 1998-04-22
JP5308056B2 (ja) 2013-10-09
NO962720D0 (no) 1996-06-27
JP2008201794A (ja) 2008-09-04
CA2179955A1 (en) 1996-12-29
AU708699B2 (en) 1999-08-12
CN1119147C (zh) 2003-08-27
AR004671A1 (es) 1999-03-10
TR199600497A2 (tr) 1997-01-21
TW430557B (en) 2001-04-21
SK283497B6 (sk) 2003-08-05
UA51615C2 (uk) 2002-12-16
DK0752246T3 (da) 2002-05-13
KR100501612B1 (ko) 2005-10-12
JPH0920659A (ja) 1997-01-21
DE19523502A1 (de) 1997-01-02
KR970000230A (ko) 1997-01-21
JP4415075B2 (ja) 2010-02-17
EP0752246A2 (de) 1997-01-08
NO962720L (no) 1996-12-30
CA2179955C (en) 2008-10-07
CZ186696A3 (en) 1997-01-15
SK84396A3 (en) 1997-04-09
PL314996A1 (en) 1997-01-06
CN1145781A (zh) 1997-03-26
EP0752246B1 (de) 2002-03-13
CZ289805B6 (cs) 2002-04-17
US5977161A (en) 1999-11-02
EP0752246A3 (de) 1997-02-26
ZA965480B (en) 1997-01-27
SI0752246T1 (en) 2002-10-31
CO4700454A1 (es) 1998-12-29
RU2190401C2 (ru) 2002-10-10
AU5616296A (en) 1997-01-09
DE59608861D1 (de) 2002-04-18
HUP9601798A1 (hu) 1998-03-30

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