RU2190401C2 - Средство для лечения воспалительных заболеваний кишечника - Google Patents

Средство для лечения воспалительных заболеваний кишечника Download PDF

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Publication number
RU2190401C2
RU2190401C2 RU96112771/14A RU96112771A RU2190401C2 RU 2190401 C2 RU2190401 C2 RU 2190401C2 RU 96112771/14 A RU96112771/14 A RU 96112771/14A RU 96112771 A RU96112771 A RU 96112771A RU 2190401 C2 RU2190401 C2 RU 2190401C2
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RU
Russia
Prior art keywords
compounds
formula
pain
phenyl
treatment
Prior art date
Application number
RU96112771/14A
Other languages
English (en)
Russian (ru)
Other versions
RU96112771A (ru
Inventor
Эндрю БАРБЕР (DE)
Эндрю БАРБЕР
Кристоф ЗЕЙФРИД (DE)
Кристоф Зейфрид
Герд БАРТОШИК (DE)
Герд Бартошик
Рудольф ГОТТШЛИХ (DE)
Рудольф ГОТТШЛИХ
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of RU96112771A publication Critical patent/RU96112771A/ru
Application granted granted Critical
Publication of RU2190401C2 publication Critical patent/RU2190401C2/ru

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
RU96112771/14A 1995-06-28 1996-06-26 Средство для лечения воспалительных заболеваний кишечника RU2190401C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19523502A DE19523502A1 (de) 1995-06-28 1995-06-28 Kappa-Opiatagonisten für entzündliche Darmerkrankungen
DE19523502.9 1995-06-28

Publications (2)

Publication Number Publication Date
RU96112771A RU96112771A (ru) 1998-09-27
RU2190401C2 true RU2190401C2 (ru) 2002-10-10

Family

ID=7765475

Family Applications (1)

Application Number Title Priority Date Filing Date
RU96112771/14A RU2190401C2 (ru) 1995-06-28 1996-06-26 Средство для лечения воспалительных заболеваний кишечника

Country Status (26)

Country Link
US (2) US5776972A (enExample)
EP (1) EP0752246B1 (enExample)
JP (2) JP4415075B2 (enExample)
KR (1) KR100501612B1 (enExample)
CN (1) CN1119147C (enExample)
AR (1) AR004671A1 (enExample)
AT (1) ATE214275T1 (enExample)
AU (1) AU708699B2 (enExample)
BR (1) BR9602915A (enExample)
CA (1) CA2179955C (enExample)
CO (1) CO4700454A1 (enExample)
CZ (1) CZ289805B6 (enExample)
DE (2) DE19523502A1 (enExample)
DK (1) DK0752246T3 (enExample)
ES (1) ES2171577T3 (enExample)
HU (1) HU226976B1 (enExample)
NO (1) NO309674B1 (enExample)
PL (1) PL185537B1 (enExample)
PT (1) PT752246E (enExample)
RU (1) RU2190401C2 (enExample)
SI (1) SI0752246T1 (enExample)
SK (1) SK283497B6 (enExample)
TR (1) TR199600497A2 (enExample)
TW (1) TW430557B (enExample)
UA (1) UA51615C2 (enExample)
ZA (1) ZA965480B (enExample)

Families Citing this family (22)

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Publication number Priority date Publication date Assignee Title
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6303611B1 (en) * 1996-03-08 2001-10-16 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
KR100483221B1 (ko) * 1996-12-02 2005-04-15 교린 세이야꾸 가부시키 가이샤 N-치환된 피롤리딘 유도체 및 이의 제조방법
US6133307A (en) * 1997-04-30 2000-10-17 Warner-Lambert Company Certain benzofuranyl-N-[pyrrolidin-1-YL]-N-methyl-acetamide derivatives useful as opioid agonists
NZ500438A (en) * 1997-07-14 2001-11-30 Adolor Corp Compositions containing a compound having kappa opioid agonist activity for treatment of pruritis (itchiness)
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
DE19827633A1 (de) * 1998-04-20 1999-10-21 Merck Patent Gmbh Verfahren zur Herstellung von enantiomerenreinem N-Methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamid
DE10116978A1 (de) * 2001-04-05 2002-10-10 Merck Patent Gmbh Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase
CA2486000A1 (en) * 2002-05-17 2003-11-27 Merck Patent Gesellschaft Mit Beschraenkter Haftung Use of compounds that are effective as selective opiate receptor modulators
WO2004039785A1 (en) * 2002-11-01 2004-05-13 Pfizer Products Inc. Process for the preparation of pyrrolidinyl ethylamine compounds via a copper-mediated aryl amination
DE10259245A1 (de) * 2002-12-17 2004-07-01 Merck Patent Gmbh Derivate des Asimadolins mit kovalent gebundenen Säuren
US7642274B2 (en) 2003-07-04 2010-01-05 Santen Pharmaceutical Co., Ltd. Inhibitor of pain threshold decrease
WO2005002622A1 (ja) * 2003-07-04 2005-01-13 Santen Pharmaceutical Co., Ltd. 疼痛閾値低下抑制剤
JP2007509865A (ja) * 2003-10-30 2007-04-19 ティオガ ファーマシュウティカルズ,インコーポレイテッド 神経障害の治療における選択的オピエート受容体調節物質の使用
US7160902B2 (en) * 2003-11-14 2007-01-09 Adolor Corporation Amide derivatives and methods of their use
EP2136801B1 (en) * 2007-03-30 2012-08-29 Tioga Pharmaceuticals, Inc. Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome
JP6138169B2 (ja) * 2012-03-05 2017-05-31 ドクター レディズ ラボラトリーズ リミテッド κオピオイド受容体(KOR)アゴニストとしての置換複素環式アセトアミド
EA201691489A1 (ru) * 2014-01-24 2016-12-30 Кадила Хелзкэр Лимитед Новые гетероциклические соединения в качестве агонистов каппа-опиодиов
EP3558300B1 (en) 2016-12-21 2021-11-24 Tioga Pharmaceuticals, Inc. Solid pharmaceutical formulations of asimadoline
WO2019122361A1 (en) 2017-12-22 2019-06-27 Dr. August Wolff Gmbh & Co. Kg Arzneimittel Asimadoline for use in treating pulmonary diseases, vascular diseases, and sepsis
EP3932390A1 (en) 2020-07-02 2022-01-05 Dr. August Wolff GmbH & Co. KG Arzneimittel Topical gel formulation containing asimadoline

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4215213A1 (de) * 1992-05-09 1993-11-11 Merck Patent Gmbh Arylacetamide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663343A (en) * 1985-07-19 1987-05-05 Warner-Lambert Company Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds
DE4034785A1 (de) * 1990-11-02 1992-05-07 Merck Patent Gmbh 1-(2-arylethyl)-pyrrolidine
US5232978A (en) * 1988-12-23 1993-08-03 Merck Patent Gesellschaft Mit Beschrankter Haftung 1-(2-arylethyl)-pyrrolidines
US5232266A (en) * 1989-07-24 1993-08-03 Mork William J Upholstered article of furniture with interchangeable seating module

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4215213A1 (de) * 1992-05-09 1993-11-11 Merck Patent Gmbh Arylacetamide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Болезни органов пищеварения и системы крови. - М.: Медицина, 1992, т.3, с.182. Реферат из АБД Medline: Junien-JL et al. Review article: the hypertensive gut - peripheral kappa agonists as a new pharmacological approach. Aliment-Pharmacol-Ther. 1995, Apr; 9(2), р.117-26. *

Also Published As

Publication number Publication date
HU226976B1 (en) 2010-04-28
PL185537B1 (pl) 2003-05-30
NO309674B1 (no) 2001-03-12
ATE214275T1 (de) 2002-03-15
PT752246E (pt) 2002-09-30
US5776972A (en) 1998-07-07
BR9602915A (pt) 1998-04-22
JP5308056B2 (ja) 2013-10-09
NO962720D0 (no) 1996-06-27
JP2008201794A (ja) 2008-09-04
CA2179955A1 (en) 1996-12-29
AU708699B2 (en) 1999-08-12
CN1119147C (zh) 2003-08-27
AR004671A1 (es) 1999-03-10
TR199600497A2 (tr) 1997-01-21
TW430557B (en) 2001-04-21
SK283497B6 (sk) 2003-08-05
ES2171577T3 (es) 2002-09-16
UA51615C2 (uk) 2002-12-16
DK0752246T3 (da) 2002-05-13
KR100501612B1 (ko) 2005-10-12
JPH0920659A (ja) 1997-01-21
DE19523502A1 (de) 1997-01-02
KR970000230A (ko) 1997-01-21
JP4415075B2 (ja) 2010-02-17
EP0752246A2 (de) 1997-01-08
NO962720L (no) 1996-12-30
CA2179955C (en) 2008-10-07
CZ186696A3 (en) 1997-01-15
SK84396A3 (en) 1997-04-09
PL314996A1 (en) 1997-01-06
CN1145781A (zh) 1997-03-26
EP0752246B1 (de) 2002-03-13
CZ289805B6 (cs) 2002-04-17
US5977161A (en) 1999-11-02
EP0752246A3 (de) 1997-02-26
ZA965480B (en) 1997-01-27
SI0752246T1 (en) 2002-10-31
CO4700454A1 (es) 1998-12-29
AU5616296A (en) 1997-01-09
DE59608861D1 (de) 2002-04-18
HUP9601798A1 (hu) 1998-03-30

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Legal Events

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RH4A Copy of patent granted that was duplicated for the russian federation

Effective date: 20070605

PC4A Invention patent assignment

Effective date: 20070903

MM4A The patent is invalid due to non-payment of fees

Effective date: 20090627