AR004671A1 - Nuevos compuestos en calidad de kappa-opiatagonistas y composiciones farmaceuticas que los contienen - Google Patents
Nuevos compuestos en calidad de kappa-opiatagonistas y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR004671A1 AR004671A1 ARP960103374A AR10337496A AR004671A1 AR 004671 A1 AR004671 A1 AR 004671A1 AR P960103374 A ARP960103374 A AR P960103374A AR 10337496 A AR10337496 A AR 10337496A AR 004671 A1 AR004671 A1 AR 004671A1
- Authority
- AR
- Argentina
- Prior art keywords
- signifies
- hal
- compounds
- treating
- nhcoa
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 208000002193 Pain Diseases 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 201000009053 Neurodermatitis Diseases 0.000 abstract 1
- 208000004550 Postoperative Pain Diseases 0.000 abstract 1
- 208000025747 Rheumatic disease Diseases 0.000 abstract 1
- 206010042496 Sunburn Diseases 0.000 abstract 1
- 230000003187 abdominal effect Effects 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 230000009610 hypersensitivity Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- -1 methylenedioxy Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- GMJSLABTEURMBF-CLSOAGJSSA-N n-[(1s)-2-[(3s)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-n-methyl-2,2-diphenylacetamide;hydrochloride Chemical compound Cl.C([C@@H](N(C)C(=O)C(C=1C=CC=CC=1)C=1C=CC=CC=1)C=1C=CC=CC=1)N1CC[C@H](O)C1 GMJSLABTEURMBF-CLSOAGJSSA-N 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19523502A DE19523502A1 (de) | 1995-06-28 | 1995-06-28 | Kappa-Opiatagonisten für entzündliche Darmerkrankungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR004671A1 true AR004671A1 (es) | 1999-03-10 |
Family
ID=7765475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960103374A AR004671A1 (es) | 1995-06-28 | 1996-06-28 | Nuevos compuestos en calidad de kappa-opiatagonistas y composiciones farmaceuticas que los contienen |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US5776972A (enExample) |
| EP (1) | EP0752246B1 (enExample) |
| JP (2) | JP4415075B2 (enExample) |
| KR (1) | KR100501612B1 (enExample) |
| CN (1) | CN1119147C (enExample) |
| AR (1) | AR004671A1 (enExample) |
| AT (1) | ATE214275T1 (enExample) |
| AU (1) | AU708699B2 (enExample) |
| BR (1) | BR9602915A (enExample) |
| CA (1) | CA2179955C (enExample) |
| CO (1) | CO4700454A1 (enExample) |
| CZ (1) | CZ289805B6 (enExample) |
| DE (2) | DE19523502A1 (enExample) |
| DK (1) | DK0752246T3 (enExample) |
| ES (1) | ES2171577T3 (enExample) |
| HU (1) | HU226976B1 (enExample) |
| NO (1) | NO309674B1 (enExample) |
| PL (1) | PL185537B1 (enExample) |
| PT (1) | PT752246E (enExample) |
| RU (1) | RU2190401C2 (enExample) |
| SI (1) | SI0752246T1 (enExample) |
| SK (1) | SK283497B6 (enExample) |
| TR (1) | TR199600497A2 (enExample) |
| TW (1) | TW430557B (enExample) |
| UA (1) | UA51615C2 (enExample) |
| ZA (1) | ZA965480B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303611B1 (en) * | 1996-03-08 | 2001-10-16 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| EP0948964B1 (en) * | 1996-12-02 | 2003-04-02 | Kyorin Pharmaceutical Co., Ltd. | Novel n-substituted pyrrolidine derivatives and process for preparing the same |
| US6133307A (en) * | 1997-04-30 | 2000-10-17 | Warner-Lambert Company | Certain benzofuranyl-N-[pyrrolidin-1-YL]-N-methyl-acetamide derivatives useful as opioid agonists |
| US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| JP2003526594A (ja) * | 1997-07-14 | 2003-09-09 | アドラー コーポレーション | カッパ・アゴニスト抗掻痒薬学的製剤およびそれにより掻痒を治療する方法 |
| DE19827633A1 (de) * | 1998-04-20 | 1999-10-21 | Merck Patent Gmbh | Verfahren zur Herstellung von enantiomerenreinem N-Methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamid |
| DE10116978A1 (de) * | 2001-04-05 | 2002-10-10 | Merck Patent Gmbh | Kappa-Opiatagonisten für die Behandlung von Erkrankungen der Blase |
| US20050176746A1 (en) * | 2002-05-17 | 2005-08-11 | Frank Weber | Use of compounds that are effective as selective opiate receptor modulators |
| AU2003269399A1 (en) * | 2002-11-01 | 2004-05-25 | Pfizer Products Inc. | Process for the preparation of pyrrolidinyl ethylamine compounds via a copper-mediated aryl amination |
| DE10259245A1 (de) * | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | Derivate des Asimadolins mit kovalent gebundenen Säuren |
| TWI334349B (en) * | 2003-07-04 | 2010-12-11 | Santen Pharmaceutical Co Ltd | Pain threshold reduction depressant |
| US7642274B2 (en) | 2003-07-04 | 2010-01-05 | Santen Pharmaceutical Co., Ltd. | Inhibitor of pain threshold decrease |
| US20080090859A1 (en) * | 2003-10-30 | 2008-04-17 | Tioga Pharmaceuticals, Inc. | Use of Selective Opiate Receptor Modulators In the Treatment Of Neuropathy |
| US7160902B2 (en) * | 2003-11-14 | 2007-01-09 | Adolor Corporation | Amide derivatives and methods of their use |
| PL2136801T3 (pl) * | 2007-03-30 | 2013-01-31 | Tioga Pharmaceuticals Inc | Agoniści kappa-opioidów do leczenia zespołu jelita drażliwego w postaci zmiennej i z dominującą biegunką |
| CN104271552B (zh) * | 2012-03-05 | 2017-08-08 | 雷迪博士实验室有限公司 | 作为kappa阿片样物质受体(kor)激动剂的取代的杂环乙酰胺 |
| WO2015114660A1 (en) * | 2014-01-24 | 2015-08-06 | Cadila Healtchare Limited | Novel heterobicyclic compounds as kappa opioid agonists |
| WO2018119108A1 (en) | 2016-12-21 | 2018-06-28 | Tioga Pharmaceuticals Inc. | Splid pharmaceutical formulations of asimadoline |
| WO2019122361A1 (en) | 2017-12-22 | 2019-06-27 | Dr. August Wolff Gmbh & Co. Kg Arzneimittel | Asimadoline for use in treating pulmonary diseases, vascular diseases, and sepsis |
| EP3932390A1 (en) | 2020-07-02 | 2022-01-05 | Dr. August Wolff GmbH & Co. KG Arzneimittel | Topical gel formulation containing asimadoline |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4663343A (en) * | 1985-07-19 | 1987-05-05 | Warner-Lambert Company | Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds |
| DE4034785A1 (de) * | 1990-11-02 | 1992-05-07 | Merck Patent Gmbh | 1-(2-arylethyl)-pyrrolidine |
| US5232978A (en) * | 1988-12-23 | 1993-08-03 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 1-(2-arylethyl)-pyrrolidines |
| US5232266A (en) * | 1989-07-24 | 1993-08-03 | Mork William J | Upholstered article of furniture with interchangeable seating module |
| DE4215213A1 (de) * | 1992-05-09 | 1993-11-11 | Merck Patent Gmbh | Arylacetamide |
-
1995
- 1995-06-28 DE DE19523502A patent/DE19523502A1/de not_active Withdrawn
-
1996
- 1996-06-12 TR TR96/00497A patent/TR199600497A2/xx unknown
- 1996-06-20 SI SI9630475T patent/SI0752246T1/xx unknown
- 1996-06-20 DE DE59608861T patent/DE59608861D1/de not_active Expired - Lifetime
- 1996-06-20 ES ES96109915T patent/ES2171577T3/es not_active Expired - Lifetime
- 1996-06-20 EP EP96109915A patent/EP0752246B1/de not_active Expired - Lifetime
- 1996-06-20 PT PT96109915T patent/PT752246E/pt unknown
- 1996-06-20 DK DK96109915T patent/DK0752246T3/da active
- 1996-06-20 AT AT96109915T patent/ATE214275T1/de active
- 1996-06-24 AU AU56162/96A patent/AU708699B2/en not_active Ceased
- 1996-06-25 CZ CZ19961866A patent/CZ289805B6/cs not_active IP Right Cessation
- 1996-06-26 CA CA002179955A patent/CA2179955C/en not_active Expired - Fee Related
- 1996-06-26 JP JP16598896A patent/JP4415075B2/ja not_active Expired - Fee Related
- 1996-06-26 RU RU96112771/14A patent/RU2190401C2/ru not_active IP Right Cessation
- 1996-06-27 TW TW085107762A patent/TW430557B/zh not_active IP Right Cessation
- 1996-06-27 SK SK843-96A patent/SK283497B6/sk not_active IP Right Cessation
- 1996-06-27 ZA ZA965480A patent/ZA965480B/xx unknown
- 1996-06-27 CN CN96110142A patent/CN1119147C/zh not_active Expired - Fee Related
- 1996-06-27 UA UA96062557A patent/UA51615C2/uk unknown
- 1996-06-27 KR KR1019960024568A patent/KR100501612B1/ko not_active Expired - Fee Related
- 1996-06-27 BR BR9602915A patent/BR9602915A/pt not_active Application Discontinuation
- 1996-06-27 PL PL96314996A patent/PL185537B1/pl not_active IP Right Cessation
- 1996-06-27 US US08/671,502 patent/US5776972A/en not_active Expired - Lifetime
- 1996-06-27 NO NO962720A patent/NO309674B1/no unknown
- 1996-06-28 AR ARP960103374A patent/AR004671A1/es not_active Application Discontinuation
- 1996-06-28 HU HU9601798A patent/HU226976B1/hu not_active IP Right Cessation
- 1996-06-28 CO CO96034158A patent/CO4700454A1/es unknown
-
1998
- 1998-02-20 US US09/027,228 patent/US5977161A/en not_active Expired - Lifetime
-
2008
- 2008-04-23 JP JP2008112917A patent/JP5308056B2/ja not_active Expired - Lifetime
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |