JP2023547389A5 - - Google Patents
Info
- Publication number
- JP2023547389A5 JP2023547389A5 JP2023524685A JP2023524685A JP2023547389A5 JP 2023547389 A5 JP2023547389 A5 JP 2023547389A5 JP 2023524685 A JP2023524685 A JP 2023524685A JP 2023524685 A JP2023524685 A JP 2023524685A JP 2023547389 A5 JP2023547389 A5 JP 2023547389A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- compound according
- monocyclic
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063104979P | 2020-10-23 | 2020-10-23 | |
| US63/104,979 | 2020-10-23 | ||
| PCT/IB2021/000710 WO2022084741A1 (en) | 2020-10-23 | 2021-10-22 | Cftr modulator compounds, compositions, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023547389A JP2023547389A (ja) | 2023-11-10 |
| JP2023547389A5 true JP2023547389A5 (enExample) | 2024-10-30 |
Family
ID=81290147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023524685A Pending JP2023547389A (ja) | 2020-10-23 | 2021-10-22 | Ｃｆｔｒ調節剤化合物、その組成物及び用途 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11827640B2 (enExample) |
| EP (1) | EP4232451A4 (enExample) |
| JP (1) | JP2023547389A (enExample) |
| KR (1) | KR20230096026A (enExample) |
| CN (1) | CN116348468A (enExample) |
| AR (1) | AR123884A1 (enExample) |
| AU (1) | AU2021363703A1 (enExample) |
| CA (1) | CA3196061A1 (enExample) |
| CL (1) | CL2023001139A1 (enExample) |
| CO (1) | CO2023006647A2 (enExample) |
| IL (1) | IL302247A (enExample) |
| MX (1) | MX2023004712A (enExample) |
| PY (1) | PY2193067A (enExample) |
| TW (1) | TW202233620A (enExample) |
| UY (1) | UY39482A (enExample) |
| WO (1) | WO2022084741A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114380835B (zh) * | 2022-01-06 | 2022-12-27 | 南京桦冠生物技术有限公司 | 一种7-(3,4-二甲氧苯基)-2-吡唑[1,5-a]嘧啶羧酸的制备方法 |
| TW202425990A (zh) * | 2022-11-02 | 2024-07-01 | 南韓商日東製藥股份有限公司 | 包含ｃｆｔｒ調節劑化合物之點眼用組成物 |
| CN120097921A (zh) * | 2024-07-05 | 2025-06-06 | 广东省科学院动物研究所 | 二氟甲氧基苯基类pde4抑制剂及其应用 |
| CN121609673A (zh) * | 2026-02-02 | 2026-03-06 | 五邑大学 | 一种pde4抑制剂及其制备方法和应用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4178449A (en) | 1978-04-17 | 1979-12-11 | American Cyanamid Company | Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines |
| US4281000A (en) | 1979-07-09 | 1981-07-28 | American Cyanamid Company | Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents |
| AU651986B2 (en) | 1991-04-22 | 1994-08-11 | Otsuka Pharmaceutical Factory, Inc. | Pyrazolo{1,5-a}pyrimidine derivative and anti-inflammatory containing the same |
| CA2465326C (en) * | 2001-11-01 | 2011-03-29 | Icagen, Inc. | Pyrazolopyrimidines for decreasing ion flow through a voltage-dependent sodium channel |
| AU2003240488A1 (en) | 2002-06-04 | 2003-12-19 | Neogenesis Pharmaceuticals, Inc. | Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents |
| US7449488B2 (en) * | 2002-06-04 | 2008-11-11 | Schering Corporation | Pyrazolopyrimidines as protein kinase inhibitors |
| JP2004170323A (ja) | 2002-11-22 | 2004-06-17 | Sumitomo Pharmaceut Co Ltd | 皮膚疾患治療剤のスクリーニング方法 |
| WO2004087153A2 (en) | 2003-03-28 | 2004-10-14 | Chiron Corporation | Use of organic compounds for immunopotentiation |
| WO2004089471A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | NEW PYRAZOLO[1,5-a] PYRIMIDINES DERIVATIVES AND PHARMACEUTICAL USE THEREOF |
| US20070270408A1 (en) | 2003-04-11 | 2007-11-22 | Novo Nordisk A/S | Pharmaceutical use of substituted pyrazolo[1,5-a]pyrimidines |
| WO2004089416A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Combination of an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent |
| WO2005037837A1 (ja) | 2003-10-17 | 2005-04-28 | Nippon Kayaku Kabushiki Kaisha | 置換２−アミノ−[１，２，４]トリアゾロ[１，５−a]ピリミジン誘導体及びその用途 |
| US7498434B2 (en) | 2004-01-14 | 2009-03-03 | Mallinckrodt Inc | Two-phase method for the synthesis of selected pyrazolopyrimidines |
| EP1778685B1 (de) | 2004-08-02 | 2008-03-26 | Schwarz Pharma Ag | Carboxamide des indolizins und seiner aza- und diazaderivate |
| WO2006088246A1 (ja) | 2005-02-18 | 2006-08-24 | Takeda Pharmaceutical Company Limited | Ｇｐｒ３４受容体機能調節剤 |
| AR056876A1 (es) | 2005-10-21 | 2007-10-31 | Tanabe Seiyaku Co | Compuestos de pirazolo[1-5-a]pirimidina, antagonistas de receptores canabinoides cb1, composiciones farmaceuticas que los contienen y usos en el tratamiento de enfermedades del sistema nervioso central, tales como trastornos psicoticos, neurologicos y similares |
| AR061793A1 (es) | 2006-07-05 | 2008-09-24 | Mitsubishi Tanabe Pharma Corp | Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica |
| WO2008045664A2 (en) | 2006-10-06 | 2008-04-17 | Kalypsys, Inc. | Heterocyclic pde4 inhibitors as antiinflammatory agents |
| WO2008056176A1 (en) | 2006-11-10 | 2008-05-15 | Scottish Biomedical Limited | Pyrazolopyrimidines as phosphodiesterase inhibitors |
| CA2705303A1 (en) * | 2007-11-07 | 2009-05-14 | Foldrx Pharmaceuticals, Inc. | Modulation of protein trafficking |
| JP5637859B2 (ja) * | 2007-12-13 | 2014-12-10 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 嚢胞性線維症膜コンダクタンスレギュレーターのモジュレーター |
| WO2010063487A1 (en) | 2008-12-05 | 2010-06-10 | Merz Pharma Gmbh & Co. Kgaa | Pyrazolopyrimidines, a process for their preparation and their use as medicine |
| JP5578490B2 (ja) | 2008-12-26 | 2014-08-27 | 味の素株式会社 | ピラゾロピリミジン化合物 |
| WO2010086040A1 (en) | 2009-01-29 | 2010-08-05 | Biomarin Iga, Ltd. | Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy |
| WO2011050245A1 (en) | 2009-10-23 | 2011-04-28 | Yangbo Feng | Bicyclic heteroaryls as kinase inhibitors |
| EP2588105A1 (en) | 2010-07-01 | 2013-05-08 | Cellzome Limited | Triazolopyridines as tyk2 inhibitors |
| US8883789B2 (en) * | 2011-12-14 | 2014-11-11 | Boehringer Ingelheim International Gmbh | Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors |
| EP2831074B1 (en) | 2012-03-29 | 2016-09-14 | Boehringer Ingelheim International GmbH | Novel pyrazolopyrimidines as metabotropic glutamate 5 receptor antagonists for the treatment of psychiatric diseases |
| WO2014144455A1 (en) | 2013-03-15 | 2014-09-18 | Epizyme, Inc. | 1 -phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof |
| CN103923105B (zh) | 2014-04-17 | 2016-08-24 | 北京大学 | 2-中氮茚甲酰胺类化合物及其制备和用途 |
| WO2016012896A1 (en) * | 2014-07-24 | 2016-01-28 | Pfizer Inc. | Pyrazolopyrimidine compounds |
| JP2018076234A (ja) | 2015-03-16 | 2018-05-17 | 大正製薬株式会社 | ピラゾロ［１，５−ａ］ピリミジン化合物 |
| JP6894902B2 (ja) | 2015-12-24 | 2021-06-30 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ｃｆｔｒ制御因子及びこの使用方法 |
| CN107286156A (zh) | 2016-04-05 | 2017-10-24 | 江苏新元素医药科技有限公司 | 新型urat1抑制剂及其在医药上的应用 |
| WO2018078005A1 (en) | 2016-10-29 | 2018-05-03 | Bayer Pharma Aktiengesellschaft | Amido-substituted azaspiro derivatives as tankyrase inhibitors |
| JP2020514323A (ja) | 2017-02-06 | 2020-05-21 | ケース ウエスタン リザーブ ユニバーシティ | 短鎖デヒドロゲナーゼ活性を調節する組成物と方法 |
| WO2018226150A1 (en) | 2017-06-05 | 2018-12-13 | Medivir Aktiebolag | Pyrazolopyrimidine as malt-1 inhibitors |
-
2021
- 2021-10-22 AU AU2021363703A patent/AU2021363703A1/en active Pending
- 2021-10-22 IL IL302247A patent/IL302247A/en unknown
- 2021-10-22 AR ARP210102922A patent/AR123884A1/es not_active Application Discontinuation
- 2021-10-22 CN CN202180072298.5A patent/CN116348468A/zh active Pending
- 2021-10-22 EP EP21882228.6A patent/EP4232451A4/en active Pending
- 2021-10-22 TW TW110139341A patent/TW202233620A/zh unknown
- 2021-10-22 MX MX2023004712A patent/MX2023004712A/es unknown
- 2021-10-22 JP JP2023524685A patent/JP2023547389A/ja active Pending
- 2021-10-22 WO PCT/IB2021/000710 patent/WO2022084741A1/en not_active Ceased
- 2021-10-22 CA CA3196061A patent/CA3196061A1/en active Pending
- 2021-10-22 PY PY202102193067A patent/PY2193067A/es unknown
- 2021-10-22 KR KR1020237017551A patent/KR20230096026A/ko active Pending
- 2021-10-22 US US17/508,198 patent/US11827640B2/en active Active
- 2021-10-22 UY UY0001039482A patent/UY39482A/es unknown
-
2023
- 2023-04-20 CL CL2023001139A patent/CL2023001139A1/es unknown
- 2023-05-19 CO CONC2023/0006647A patent/CO2023006647A2/es unknown
- 2023-10-17 US US18/488,925 patent/US20240199623A1/en not_active Abandoned
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