KR20230096026A - Cftr 조절제 화합물, 그의 조성물 및 용도 - Google Patents

Cftr 조절제 화합물, 그의 조성물 및 용도 Download PDF

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Publication number
KR20230096026A
KR20230096026A KR1020237017551A KR20237017551A KR20230096026A KR 20230096026 A KR20230096026 A KR 20230096026A KR 1020237017551 A KR1020237017551 A KR 1020237017551A KR 20237017551 A KR20237017551 A KR 20237017551A KR 20230096026 A KR20230096026 A KR 20230096026A
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South Korea
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optionally substituted
alkyl
compound
aryl
heterocycle
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English (en)
Korean (ko)
Inventor
이명재
오창목
임다미
김경아
이설희
정일지
류재은
이주연
전예린
권진선
손태익
김건희
김정호
윤종민
이진희
윤홍철
이정우
박준태
안경미
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일동제약(주)
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020237017551A 2020-10-23 2021-10-22 Cftr 조절제 화합물, 그의 조성물 및 용도 Pending KR20230096026A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063104979P 2020-10-23 2020-10-23
US63/104,979 2020-10-23
PCT/IB2021/000710 WO2022084741A1 (en) 2020-10-23 2021-10-22 Cftr modulator compounds, compositions, and uses thereof

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Publication Number Publication Date
KR20230096026A true KR20230096026A (ko) 2023-06-29

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US (2) US11827640B2 (enExample)
EP (1) EP4232451A4 (enExample)
JP (1) JP2023547389A (enExample)
KR (1) KR20230096026A (enExample)
CN (1) CN116348468A (enExample)
AR (1) AR123884A1 (enExample)
AU (1) AU2021363703A1 (enExample)
CA (1) CA3196061A1 (enExample)
CL (1) CL2023001139A1 (enExample)
CO (1) CO2023006647A2 (enExample)
IL (1) IL302247A (enExample)
MX (1) MX2023004712A (enExample)
PY (1) PY2193067A (enExample)
TW (1) TW202233620A (enExample)
UY (1) UY39482A (enExample)
WO (1) WO2022084741A1 (enExample)

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CN114380835B (zh) * 2022-01-06 2022-12-27 南京桦冠生物技术有限公司 一种7-(3,4-二甲氧苯基)-2-吡唑[1,5-a]嘧啶羧酸的制备方法
TW202425990A (zh) * 2022-11-02 2024-07-01 南韓商日東製藥股份有限公司 包含ｃｆｔｒ調節劑化合物之點眼用組成物
CN120097921A (zh) * 2024-07-05 2025-06-06 广东省科学院动物研究所 二氟甲氧基苯基类pde4抑制剂及其应用
CN121609673A (zh) * 2026-02-02 2026-03-06 五邑大学 一种pde4抑制剂及其制备方法和应用

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AU651986B2 (en) 1991-04-22 1994-08-11 Otsuka Pharmaceutical Factory, Inc. Pyrazolo{1,5-a}pyrimidine derivative and anti-inflammatory containing the same
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AU2003240488A1 (en) 2002-06-04 2003-12-19 Neogenesis Pharmaceuticals, Inc. Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents
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WO2004087153A2 (en) 2003-03-28 2004-10-14 Chiron Corporation Use of organic compounds for immunopotentiation
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TW202233620A (zh) 2022-09-01
MX2023004712A (es) 2023-05-09
AU2021363703A9 (en) 2025-01-09
US20230080486A1 (en) 2023-03-16
JP2023547389A (ja) 2023-11-10
CN116348468A (zh) 2023-06-27
IL302247A (en) 2023-06-01
UY39482A (es) 2022-05-31
US20240199623A1 (en) 2024-06-20
AR123884A1 (es) 2023-01-18
CA3196061A1 (en) 2022-04-28
PY2193067A (es) 2022-06-20
WO2022084741A1 (en) 2022-04-28
CO2023006647A2 (es) 2023-05-29
EP4232451A1 (en) 2023-08-30
EP4232451A4 (en) 2024-11-06
US11827640B2 (en) 2023-11-28
AU2021363703A1 (en) 2023-06-22
CL2023001139A1 (es) 2023-11-17

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