JP2005515976A5 - - Google Patents

Info

Publication number

JP2005515976A5

JP2005515976A5 JP2003542144A JP2003542144A JP2005515976A5 JP 2005515976 A5 JP2005515976 A5 JP 2005515976A5 JP 2003542144 A JP2003542144 A JP 2003542144A JP 2003542144 A JP2003542144 A JP 2003542144A JP 2005515976 A5 JP2005515976 A5 JP 2005515976A5

Authority

JP

Japan

Prior art keywords

alkyl

compound

hydrolyzed

vivo

pharmaceutically acceptable

Prior art date

2002-11-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000000217 alkyl group Chemical group 0.000 claims description 17
• 150000001875 compounds Chemical class 0.000 claims description 17
• 125000003118 aryl group Chemical group 0.000 claims description 7
• 125000003545 alkoxy group Chemical group 0.000 claims description 6
• 229910052736 halogen Inorganic materials 0.000 claims description 6
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 5
• 125000002619 bicyclic group Chemical group 0.000 claims description 5
• 150000002367 halogens Chemical class 0.000 claims description 5
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 5
• 125000006413 ring segment Chemical group 0.000 claims description 5
• 125000001424 substituent group Chemical group 0.000 claims description 5
• 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 4
• 125000002950 monocyclic group Chemical group 0.000 claims description 4
• 150000003839 salts Chemical class 0.000 claims 17
• 238000001727 in vivo Methods 0.000 claims 16
• 150000002148 esters Chemical class 0.000 claims 15
• -1 sulfoxy Chemical group 0.000 claims 7
• 125000001072 heteroaryl group Chemical group 0.000 claims 5
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 5
• DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 4
• 125000000753 cycloalkyl group Chemical group 0.000 claims 3
• 125000006168 tricyclic group Chemical group 0.000 claims 3
• 102000005741 Metalloproteases Human genes 0.000 claims 2
• 108010006035 Metalloproteases Proteins 0.000 claims 2
• ATHHXGZTWNVVOU-UHFFFAOYSA-N N-methylformamide Chemical compound CNC=O ATHHXGZTWNVVOU-UHFFFAOYSA-N 0.000 claims 2
• 150000003857 carboxamides Chemical class 0.000 claims 2
• 125000004093 cyano group Chemical group *C#N 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 125000005843 halogen group Chemical group 0.000 claims 2
• 230000001404 mediated effect Effects 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• CYFLXLSBHQBMFT-UHFFFAOYSA-N sulfamoxole Chemical group O1C(C)=C(C)N=C1NS(=O)(=O)C1=CC=C(N)C=C1 CYFLXLSBHQBMFT-UHFFFAOYSA-N 0.000 claims 2
• 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 1
• 125000006642 (C1-C6) cyanoalkyl group Chemical group 0.000 claims 1
• 125000006582 (C5-C6) heterocycloalkyl group Chemical group 0.000 claims 1
• VFCFMYBQDWJHMB-UHFFFAOYSA-N (diaminoamino)cyanamide Chemical compound NN(N)NC#N VFCFMYBQDWJHMB-UHFFFAOYSA-N 0.000 claims 1
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
• 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims 1
• 125000003342 alkenyl group Chemical group 0.000 claims 1
• 125000004103 aminoalkyl group Chemical group 0.000 claims 1
• 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
• WBJINCZRORDGAQ-UHFFFAOYSA-N formic acid ethyl ester Natural products CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 claims 1
• 125000004404 heteroalkyl group Chemical group 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 125000004964 sulfoalkyl group Chemical group 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1