JPH0832243B2 - 酵素による光学活性シアンヒドリンの製造法 - Google Patents

酵素による光学活性シアンヒドリンの製造法

Info

Publication number
JPH0832243B2
JPH0832243B2 JP5508002A JP50800292A JPH0832243B2 JP H0832243 B2 JPH0832243 B2 JP H0832243B2 JP 5508002 A JP5508002 A JP 5508002A JP 50800292 A JP50800292 A JP 50800292A JP H0832243 B2 JPH0832243 B2 JP H0832243B2
Authority
JP
Japan
Prior art keywords
membrane
enzyme
aldehyde
binder
porous membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP5508002A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06506674A (ja
Inventor
ウォルター アンドラスキイ，ステフェン
ゴールドバーグ，ブルース
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FMC Corp
Original Assignee
FMC Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FMC Corp filed Critical FMC Corp
Publication of JPH06506674A publication Critical patent/JPH06506674A/ja
Publication of JPH0832243B2 publication Critical patent/JPH0832243B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C12P13/004—Cyanohydrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
JP5508002A 1991-12-17 1992-11-13 酵素による光学活性シアンヒドリンの製造法 Expired - Lifetime JPH0832243B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CH1256/91-0 1991-04-26
CH1255/91-8 1991-04-26
CH1997/91-8 1991-07-05
US809,803 1991-12-17
US07/809,803 US5177242A (en) 1991-12-17 1991-12-17 Process for preparing optically active cyanohydrins with enzymes
PCT/US1992/009945 WO1993012072A1 (en) 1991-12-17 1992-11-13 Process for preparing optically active cyanohydrins with enzymes

Publications (2)

Publication Number Publication Date
JPH06506674A JPH06506674A (ja) 1994-07-28
JPH0832243B2 true JPH0832243B2 (ja) 1996-03-29

Family

ID=25202264

Family Applications (2)

Application Number Title Priority Date Filing Date
JP5508002A Expired - Lifetime JPH0832243B2 (ja) 1991-12-17 1992-11-13 酵素による光学活性シアンヒドリンの製造法
JP93508002A Pending JPH05507736A (ja) 1991-12-17 1992-11-13 酵素による光学活性シアンヒドリンの製造法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP93508002A Pending JPH05507736A (ja) 1991-12-17 1992-11-13 酵素による光学活性シアンヒドリンの製造法

Country Status (25)

Country Link
US (1) US5177242A (Direct)
EP (1) EP0590096B1 (Direct)
JP (2) JPH0832243B2 (Direct)
KR (1) KR970009155B1 (Direct)
CN (1) CN1075166A (Direct)
AR (1) AR247921A1 (Direct)
AT (1) ATE135047T1 (Direct)
AU (1) AU647982B2 (Direct)
BG (1) BG61277B1 (Direct)
BR (1) BR9205413A (Direct)
CA (1) CA2093826C (Direct)
CZ (1) CZ280422B6 (Direct)
DE (2) DE69208878T2 (Direct)
FI (1) FI931583A7 (Direct)
HU (1) HUT71308A (Direct)
IL (1) IL104046A0 (Direct)
MW (1) MW4993A1 (Direct)
MX (1) MX9206954A (Direct)
OA (1) OA09873A (Direct)
PL (1) PL170490B1 (Direct)
RO (1) RO112765B1 (Direct)
RU (1) RU2092558C1 (Direct)
SK (1) SK36293A3 (Direct)
TW (1) TW242166B (Direct)
WO (1) WO1993012072A1 (Direct)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT396252B (de) * 1991-10-31 1993-07-26 Chemie Linz Gmbh Enzymatisches verfahren zur enantioselektiven herstellung optisch aktiver cyanhydrine
GB9222253D0 (en) * 1992-10-23 1992-12-09 Celltech Ltd Chemical compounds
AT400035B (de) * 1993-06-01 1995-09-25 Chemie Linz Gmbh Enzymatisches verfahren zur herstellung aliphatischer s-cyanhydrine
DE4322064A1 (de) * 1993-07-02 1995-01-12 Chemie Linz Deutschland Enzymatisches Verfahren zur Herstellung aliphatischer S-Cyanhydrine
DE19529116A1 (de) * 1995-08-08 1997-03-06 Chemie Linz Deutschland Gmbh I (S)-Hydroxynitrillyase aus Hevea brasiliensis
DK0799894T3 (da) * 1996-02-09 2004-08-09 Degussa Fremgangsmåde til fremstilling af (S)-cyanhydriner
CN1093531C (zh) * 1998-05-04 2002-10-30 中国科学院上海有机化学研究所 氰醇裂解酶催化合成光学活性氰醇化合物
CN1083009C (zh) * 1999-07-16 2002-04-17 中国科学院上海有机化学研究所 一种新酶源的醇腈裂解酶催化合成光学活性氰醇化合物的方法
AU2668101A (en) * 1999-11-25 2001-06-04 Skw Trostberg Aktiengesellschaft Method for producing optically active cyanhydrins
JP3709317B2 (ja) * 2000-01-12 2005-10-26 株式会社日本触媒 光学活性シアノヒドリンの合成方法
US7078225B2 (en) * 2000-06-02 2006-07-18 Nippon Shokubai Co., Ltd. Method for enzymatically producing an optically active cyanohydrin
WO2007026623A1 (ja) * 2005-08-30 2007-03-08 Sumitomo Chemical Company, Limited ３−アミノ−６−クロロピリダジンの製造方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4102746A (en) 1975-08-29 1978-07-25 Amerace Corporation Immobilized proteins
US4859784A (en) 1987-01-20 1989-08-22 Degussa Aktiengesellschaft Process for the production of optically active cyanohydrins

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862030A (en) * 1972-12-13 1975-01-21 Amerace Esna Corp Microporous sub-micron filter media
IL46178A (en) * 1974-12-03 1978-10-31 Rehovot Res Prod Method for the performance of enzymatic reactions
US4169014A (en) * 1976-08-16 1979-09-25 Amerace Corporation Method of immobilizing proteinaceous substances
US4795704A (en) * 1985-10-11 1989-01-03 Sepracor, Inc. Multiphase asymmetric membrane reactor systems
US4959467A (en) * 1985-11-27 1990-09-25 Allied-Signal Inc. Control of product selectivity in the addition of HCN to arabinose
US4900667A (en) * 1985-12-19 1990-02-13 Allied-Signal Inc. One carbon homologation of carbohydrates by transcyanohydrination
US4800162A (en) * 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
DE3823864A1 (de) * 1988-01-29 1989-08-10 Kernforschungsanlage Juelich Enymatisches verfahren zur herstellung von optisch aktiven cyanhydrinen
DE3917374A1 (de) * 1988-07-14 1990-12-06 Forschungszentrum Juelich Gmbh Verfahren zur herstellung von s-cyanhydrinen
DK0446826T3 (da) * 1990-03-16 1996-02-12 Forschungszentrum Juelich Gmbh Fremgangsmåde til enzymatisk fremstilling af optisk aktive cyanhydriner
AT396252B (de) * 1991-10-31 1993-07-26 Chemie Linz Gmbh Enzymatisches verfahren zur enantioselektiven herstellung optisch aktiver cyanhydrine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4102746A (en) 1975-08-29 1978-07-25 Amerace Corporation Immobilized proteins
US4859784A (en) 1987-01-20 1989-08-22 Degussa Aktiengesellschaft Process for the production of optically active cyanohydrins

Also Published As

Publication number Publication date
DE69208878T2 (de) 1996-10-31
FI931583L (fi) 1993-06-18
HU9301020D0 (en) 1993-11-29
SK36293A3 (en) 1993-10-06
AU3141493A (en) 1993-07-19
KR970009155B1 (ko) 1997-06-07
JPH05507736A (ja) 1993-11-04
TW242166B (Direct) 1995-03-01
MW4993A1 (en) 1994-10-12
DE590096T1 (de) 1994-07-28
CA2093826A1 (en) 1993-06-18
JPH06506674A (ja) 1994-07-28
WO1993012072A1 (en) 1993-06-24
RU2092558C1 (ru) 1997-10-10
MX9206954A (es) 1993-06-01
OA09873A (en) 1994-09-15
EP0590096A1 (en) 1994-04-06
CZ65193A3 (en) 1994-04-13
DE69208878D1 (de) 1996-04-11
PL170490B1 (pl) 1996-12-31
CZ280422B6 (cs) 1996-01-17
BR9205413A (pt) 1994-05-31
BG61277B1 (en) 1997-04-30
CN1075166A (zh) 1993-08-11
IL104046A0 (en) 1993-05-13
CA2093826C (en) 1995-08-29
RO112765B1 (ro) 1997-12-30
FI931583A0 (fi) 1993-04-07
EP0590096B1 (en) 1996-03-06
ATE135047T1 (de) 1996-03-15
AU647982B2 (en) 1994-03-31
FI931583A7 (fi) 1993-06-18
EP0590096A4 (en) 1994-02-18
US5177242A (en) 1993-01-05
AR247921A1 (es) 1995-04-28
HUT71308A (en) 1995-11-28
BG97619A (bg) 1994-03-31

Similar Documents

Publication Publication Date Title
US4102746A (en) Immobilized proteins
US3983053A (en) Coated adsorbent materials
RU2089283C1 (ru) Био-, гемосовместимые сорбенты на основе сверхсшитых полимеров стирола с модифицированной поверхностью, способ их получения (варианты) и способ получения матрицы сорбента
US4169014A (en) Method of immobilizing proteinaceous substances
JPH0832243B2 (ja) 酵素による光学活性シアンヒドリンの製造法
CA2121747C (en) Hydrophilic polymer coated perfluorocarbon polymer-based matrices, their preparation and use in bioaffinity
US5155144A (en) Polysaccharide-based porous sheets
JPH08252579A (ja) 多孔質イオン交換体および脱イオン水の製造方法
CN113861600A (zh) 一种生物基多孔材料及其制备方法和应用
US7112620B2 (en) Hemocompatible polymer systems & related methods
US7201962B2 (en) Hemocompatible coated polymer and related one-step methods
CN109942768A (zh) 球形多孔三聚氰胺-甲醛-硫脲聚合物树脂及其制备方法
US7629049B2 (en) Hemocompatible polymer systems and related devices
JPH037068B2 (Direct)
JPS61171506A (ja) 液中に溶存する尿素の分解吸着剤
JPS5876142A (ja) 炭素を主成分とする多孔質吸着剤の製造方法
WO2010063725A2 (en) Structuring particles into useful structures and their use in life science
JPS6211614B2 (Direct)
JPS5950312B2 (ja) 酵素もしくは微生物菌体の固定化法
Pişkin Structural and transport properties of polymeric carriers for bioagents and immobilization techniques and their applications
JPH0435742A (ja) β↓２―ミクログロブリン用吸着剤
JPS62111687A (ja) 不溶化ｌ−フエニルアラニンアンモニアリア−ゼ剤