AU2668101A - Method for producing optically active cyanhydrins - Google Patents

Method for producing optically active cyanhydrins

Info

Publication number
AU2668101A
AU2668101A AU26681/01A AU2668101A AU2668101A AU 2668101 A AU2668101 A AU 2668101A AU 26681/01 A AU26681/01 A AU 26681/01A AU 2668101 A AU2668101 A AU 2668101A AU 2668101 A AU2668101 A AU 2668101A
Authority
AU
Australia
Prior art keywords
enzyme
increased
gel
cyanhydrins
oxynitrilase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU26681/01A
Inventor
Emine Capan
Harald Groger
Klaus-Dieter Vorlop
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
SKW Trostberg AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SKW Trostberg AG filed Critical SKW Trostberg AG
Priority claimed from DE10058342A external-priority patent/DE10058342A1/en
Publication of AU2668101A publication Critical patent/AU2668101A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C12P13/004—Cyanohydrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/084—Polymers containing vinyl alcohol units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/02—Aldehyde-lyases (4.1.2)
    • C12Y401/0201—(R)-Mandelonitrile lyase (4.1.2.10)

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

The invention relates to a method for producing optically active cyanhydrins by reacting oxo compounds, such as for example aldehyde and/or ketone with hydrogen cyanide and/or with a cyanide donor in the presence of an inclusion compound which contains an oxynitrilase with an increased molecular weight. According to said method, an oxynitrilase is used, whose molecular weight is first increased by cross-linkage and which is subsequently converted into a gel inclusion compound and/or a gel complex compound, said conversions occurring substantially in two independent steps. The method which is carried out in particular at temperatures of between - 10 and + 30 DEG C and at pH values of between 3.0 and 6.0, preferably in an aqueous or hydrous system, but also in organic solvents, uses a component which contains enzymes. In said component, the molecular-weight of the enzyme has been increased, in particular by co-cross-linkage or by flocculation and said enzyme is used either in a free form or is enclosed by natural or artificial cells. A deciding factor in this method is the fact that the enzyme is enclosed by or complexed in a gel, which results in negligibly small attrition and leaching losses at a practically constant high level of enzyme activity, rendering the method extremely effective and economic.
AU26681/01A 1999-11-25 2000-11-24 Method for producing optically active cyanhydrins Abandoned AU2668101A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19956864 1999-11-25
DE19956864 1999-11-25
DE10058342 2000-11-24
DE10058342A DE10058342A1 (en) 1999-11-25 2000-11-24 Preparation of optically active cyanhydrites for use in the production of aminoalcohols, comprises reacting oxo compounds with e.g. cyanic acid in the presence of an oxynitrilase composition
PCT/EP2000/011743 WO2001038554A2 (en) 1999-11-25 2000-11-24 Method for producing optically active cyanhydrins

Publications (1)

Publication Number Publication Date
AU2668101A true AU2668101A (en) 2001-06-04

Family

ID=26007769

Family Applications (1)

Application Number Title Priority Date Filing Date
AU26681/01A Abandoned AU2668101A (en) 1999-11-25 2000-11-24 Method for producing optically active cyanhydrins

Country Status (5)

Country Link
EP (1) EP1232277B1 (en)
JP (1) JP2003514567A (en)
AT (1) ATE241700T1 (en)
AU (1) AU2668101A (en)
WO (1) WO2001038554A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4545317B2 (en) 1998-10-28 2010-09-15 ヤフー！ インコーポレイテッド Internet browser interface control method and controllable browser interface
JP5353046B2 (en) * 2008-04-18 2013-11-27 住友化学株式会社 Method for producing optically active cyanohydrin compound
CN113264868B (en) * 2021-05-31 2022-12-02 山东华素制药有限公司 Improved synthesis method of 1-benzyl-3-piperidinol

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177242A (en) * 1991-12-17 1993-01-05 Fmc Corporation Process for preparing optically active cyanohydrins with enzymes

Also Published As

Publication number Publication date
WO2001038554A2 (en) 2001-05-31
WO2001038554A3 (en) 2001-12-27
EP1232277B1 (en) 2003-05-28
ATE241700T1 (en) 2003-06-15
EP1232277A2 (en) 2002-08-21
JP2003514567A (en) 2003-04-22

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase