JPH0753370A - ワートマンニンおよびその類縁体によるホスファチジルイノシトール３−キナーゼの阻害 - Google Patents

ワートマンニンおよびその類縁体によるホスファチジルイノシトール３−キナーゼの阻害

Info

Publication number
JPH0753370A
JPH0753370A JP6165068A JP16506894A JPH0753370A JP H0753370 A JPH0753370 A JP H0753370A JP 6165068 A JP6165068 A JP 6165068A JP 16506894 A JP16506894 A JP 16506894A JP H0753370 A JPH0753370 A JP H0753370A
Authority
JP
Japan
Prior art keywords
kinase
phosphatidylinositol
wortmannin
active ingredient
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6165068A
Other languages
English (en)
Japanese (ja)
Inventor
Rosanne Bonjouklian
ロザンヌ・ボンジョウクリアン
Powis Garth
ガース・ポウィス
Chris J Vlahos
クリス・ジョン・ブラホス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
University of Arizona Foundation
University of Arizona
Original Assignee
Eli Lilly and Co
University of Arizona Foundation
University of Arizona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co, University of Arizona Foundation, University of Arizona filed Critical Eli Lilly and Co
Publication of JPH0753370A publication Critical patent/JPH0753370A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
JP6165068A 1993-07-19 1994-07-18 ワートマンニンおよびその類縁体によるホスファチジルイノシトール３−キナーゼの阻害 Pending JPH0753370A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/094,279 US5378725A (en) 1993-07-19 1993-07-19 Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof
US094279 1993-07-19

Publications (1)

Publication Number Publication Date
JPH0753370A true JPH0753370A (ja) 1995-02-28

Family

ID=22244209

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6165068A Pending JPH0753370A (ja) 1993-07-19 1994-07-18 ワートマンニンおよびその類縁体によるホスファチジルイノシトール３−キナーゼの阻害

Country Status (16)

Country Link
US (1) US5378725A (member.php)
EP (1) EP0635268A1 (member.php)
JP (1) JPH0753370A (member.php)
KR (1) KR950002755A (member.php)
CN (1) CN1111127A (member.php)
AU (1) AU678831B2 (member.php)
CA (1) CA2128046A1 (member.php)
CZ (1) CZ283806B6 (member.php)
HU (1) HUT67667A (member.php)
IL (1) IL110325A0 (member.php)
NO (1) NO942641L (member.php)
PH (1) PH30794A (member.php)
PL (1) PL304317A1 (member.php)
RU (1) RU94026082A (member.php)
TW (1) TW287102B (member.php)
ZA (1) ZA945103B (member.php)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004077063A3 (en) * 2003-02-28 2004-10-07 Proxara Biotechnology Ltd Method involving plasma membrane localisation of oxysterol biding proteins
JP2005509635A (ja) * 2001-10-19 2005-04-14 アイコス コーポレイション 人間のホスファチジルイノシトール３−キナーゼデルタの阻害
WO2007026928A1 (ja) * 2005-08-31 2007-03-08 Japan Science And Technology Agency 神経因性疼痛治療剤
JP2008545670A (ja) * 2005-05-27 2008-12-18 バイエル・ヘルスケア・アクチェンゲゼルシャフト 疾患を処置するためのジアリールウレア類を含む組合せ治療

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504103A (en) * 1993-08-25 1996-04-02 Eli Lilly And Company Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof
US5468773A (en) * 1993-08-25 1995-11-21 Eli Lilly And Company Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs
US7863429B2 (en) * 1995-12-21 2011-01-04 Qlt Inc. Treatment of inflammatory diseases including psoriasis
US5910417A (en) * 1996-05-31 1999-06-08 National Jewish Center For Immunology And Respiratory Medicine Regulation of cytokine production in a hematopoietic cell
US7670767B1 (en) * 1997-01-16 2010-03-02 The Regents Of The University Of California Genetic alterations associated with cancer
EP1745797A3 (en) * 1998-03-24 2007-07-18 Chugai Seiyaku Kabushiki Kaisha Vascularization inhibitors
US6413773B1 (en) * 1998-06-01 2002-07-02 The Regents Of The University Of California Phosphatidylinositol 3-kinase inhibitors as stimulators of endocrine differentiation
BR9914465A (pt) * 1998-09-29 2001-10-09 Gamida Cell Ltd Métodos para controlar a proliferação e a diferenciação de células-tronco e células progenitoras e uma composição farmacêutica para induzir a diferenciação em uma população de células
ATE538794T1 (de) * 1999-01-13 2012-01-15 Bayer Healthcare Llc Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US6566081B1 (en) 1999-10-06 2003-05-20 The Brigham And Women's Hospital, Inc. Methods of identifying a compound which modulates the non-transcriptional non-map-kinase induced effects of steroid hormones
US6777439B2 (en) * 2000-05-30 2004-08-17 Advanced Research & Technology Institute, Inc. Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways
AU2002258798A1 (en) * 2001-04-13 2002-10-28 Children's Hospital Medical Center Methods for the treatment of hepatic disorders
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
US6703414B2 (en) * 2001-09-14 2004-03-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Device and method for treating restenosis
US20080108672A1 (en) * 2002-01-11 2008-05-08 Bernd Riedl Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors
IL152904A0 (en) * 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
WO2003062404A1 (en) * 2002-01-25 2003-07-31 Gamida-Cell Ltd. Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
US7838541B2 (en) 2002-02-11 2010-11-23 Bayer Healthcare, Llc Aryl ureas with angiogenesis inhibiting activity
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
AU2003248927A1 (en) * 2002-07-10 2004-01-23 Massachusetts Institute Of Technology Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans
US20050054097A1 (en) * 2002-11-17 2005-03-10 Tony Peled EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures
UY28213A1 (es) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
US20050054103A1 (en) * 2003-03-07 2005-03-10 Tony Peled Expansion of renewable stem cell populations using modulators of PI 3-kinase
WO2004093918A2 (en) * 2003-04-23 2004-11-04 Wyeth Holdings Corporation Peg-wortmannin conjugates
WO2004113274A2 (en) * 2003-05-20 2004-12-29 Bayer Pharmaceuticals Corporation Diaryl ureas with kinase inhibiting activity
IL161903A0 (en) * 2003-07-17 2005-11-20 Gamida Cell Ltd Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs
RS52625B (sr) * 2003-07-23 2013-06-28 Bayer Healthcare Llc Fluoro supstituisana omega-karboksiaril difenil urea za lečenje i prevenciju bolesti i stanja bolesti
DE602004026071D1 (de) 2003-08-13 2010-04-29 Kudos Pharm Ltd Aminopyrone und ihre verwendung als atm inhibitoren
WO2005016348A1 (en) * 2003-08-14 2005-02-24 Icos Corporation Method of inhibiting immune responses stimulated by an endogenous factor
WO2005016349A1 (en) * 2003-08-14 2005-02-24 Icos Corporation Methods of inhibiting leukocyte accumulation
PL1761540T3 (pl) 2004-05-13 2017-06-30 Icos Corporation Chinazolinony jako inhibitory ludzkiej kinazy 3-fosfatydyloinozytolu delta
JP2008500338A (ja) * 2004-05-25 2008-01-10 イコス・コーポレイション 造血細胞の異常増殖を治療及び／又は予防する方法
EP1799812A4 (en) * 2004-09-16 2009-09-09 Gamida Cell Ltd EX VIVO CULTIVATION METHODS OF STEM CELLS AND PRECURSOR BY CO-CULTURE WITH MESENCHYMAL CELLS
RU2408596C2 (ru) 2004-09-20 2011-01-10 Кудос Фармасьютикалс Лимитед Ингибиторы днк-пк
TW200626610A (en) * 2004-10-13 2006-08-01 Wyeth Corp Analogs of 17-hydroxywortmannin as PI3K inhibitors
CN1875959B (zh) * 2004-10-14 2010-05-12 孔庆忠 一种抗癌药物组合物
CN100369632C (zh) * 2004-10-14 2008-02-20 孔庆忠 抗癌药物组合物
WO2006085067A1 (en) 2005-02-09 2006-08-17 Kudos Pharmaceuticals Limited Atm inhibitors
EP1885356A2 (en) * 2005-02-17 2008-02-13 Icos Corporation Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation
AR053358A1 (es) 2005-04-15 2007-05-02 Cancer Rec Tech Ltd Inhibidores de adn - pk
JP2008543277A (ja) * 2005-05-11 2008-12-04 ジェネティック テクノロジーズ リミテッド 胎児細胞を富化する方法
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
WO2008056368A2 (en) * 2006-11-09 2008-05-15 Gamida-Cell Ltd. Use of ex-vivo cultured hematopoietic cells for treatment of peripheral vascular diseases
TW200845960A (en) * 2007-04-05 2008-12-01 Wyeth Corp Wortmannin-rapalog conjugate and uses thereof
US20100109416A1 (en) * 2008-11-03 2010-05-06 Jones Margaret L Adjustable safety harness
NZ631024A (en) 2008-11-13 2016-04-29 Gilead Calistoga Llc Therapies for hematologic malignancies
US9492449B2 (en) 2008-11-13 2016-11-15 Gilead Calistoga Llc Therapies for hematologic malignancies
US20100233733A1 (en) * 2009-02-10 2010-09-16 Nodality, Inc., A Delaware Corporation Multiple mechanisms for modulation of the pi3 kinase pathway
SG174529A1 (en) 2009-03-24 2011-10-28 Gilead Calistoga Llc Atropisomers of2-purinyl-3-tolyl-quinazolinone derivatives and methods of use
PT2421536E (pt) * 2009-04-20 2015-10-20 Gilead Calistoga Llc Métodos de tratamento para tumores sólidos
EP2456443A1 (en) 2009-07-21 2012-05-30 Gilead Calistoga LLC Treatment of liver disorders with pi3k inhibitors
BRPI1107182B1 (pt) * 2011-12-29 2022-03-08 Fundação De Amparo À Pesquisa Do Estado De Minas Gerais - Fapemig Composições farmacêuticas contendo ang-(1-7) ou outro agonista do receptor mas em combinação com inibidores de pi3k/akt para tratamento terapêutico anticâncer
BR112014020119A2 (pt) 2012-02-13 2020-10-27 Gamida-Cell Ltd cultura de células-tronco mesenquimais
AP2014007875A0 (en) 2012-03-05 2014-08-31 Gilead Calistoga Llc Polymorphic forms of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
WO2014203129A1 (en) 2013-06-19 2014-12-24 Olema Pharmaceuticals, Inc. Combinations of benzopyran compounds, compositions and uses thereof
EP3083623A1 (en) 2013-12-20 2016-10-26 Gilead Calistoga LLC Polymorphic forms of a hydrochloride salt of (s) -2-(9h-purin-6-ylamino) propyl) -5-fluoro-3-phenylquinazolin-4 (3h) -one
PT3083630T (pt) 2013-12-20 2019-11-15 Gilead Calistoga Llc Procedimentos para inibidores da fosfatidilinositol 3-quinase
JP6455995B2 (ja) 2014-06-13 2019-01-23 ギリアード サイエンシーズ， インコーポレイテッド ホスファチジルイノシトール３−キナーゼ阻害剤
CN104774239B (zh) * 2015-03-13 2017-01-04 暨南大学 多节孢绿胶霉素类化合物及其用途
CN107058137B (zh) * 2017-06-14 2020-02-07 海正药业(杭州)有限公司 一种渥曼青霉及其生产渥曼青霉素的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3668222A (en) * 1969-05-14 1972-06-06 Sandoz Ltd 11-desacetoxy-wortmannin
US4988682A (en) * 1989-02-03 1991-01-29 University Of Pittsburgh Myo-inositol analogs and method for their use
JPH0328948A (ja) * 1989-06-27 1991-02-07 Nec Corp 入出力制御装置の動作状態情報収集方式

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005509635A (ja) * 2001-10-19 2005-04-14 アイコス コーポレイション 人間のホスファチジルイノシトール３−キナーゼデルタの阻害
JP4945060B2 (ja) * 2001-10-19 2012-06-06 イコス・コーポレイション 人間のホスファチジルイノシトール３−キナーゼデルタの阻害
WO2004077063A3 (en) * 2003-02-28 2004-10-07 Proxara Biotechnology Ltd Method involving plasma membrane localisation of oxysterol biding proteins
JP2008545670A (ja) * 2005-05-27 2008-12-18 バイエル・ヘルスケア・アクチェンゲゼルシャフト 疾患を処置するためのジアリールウレア類を含む組合せ治療
WO2007026928A1 (ja) * 2005-08-31 2007-03-08 Japan Science And Technology Agency 神経因性疼痛治療剤

Also Published As

Publication number Publication date
NO942641D0 (no) 1994-07-14
HU9402128D0 (en) 1994-09-28
EP0635268A1 (en) 1995-01-25
CZ283806B6 (cs) 1998-06-17
CN1111127A (zh) 1995-11-08
PL304317A1 (en) 1995-01-23
TW287102B (member.php) 1996-10-01
KR950002755A (ko) 1995-02-16
PH30794A (en) 1997-10-17
ZA945103B (en) 1996-03-27
NO942641L (no) 1995-01-20
CA2128046A1 (en) 1995-01-20
US5378725A (en) 1995-01-03
AU678831B2 (en) 1997-06-12
CZ169294A3 (en) 1995-02-15
AU6754094A (en) 1995-01-27
HUT67667A (en) 1995-04-28
RU94026082A (ru) 1996-05-20
IL110325A0 (en) 1994-10-21

Similar Documents

Publication Publication Date Title
JPH0753370A (ja) ワートマンニンおよびその類縁体によるホスファチジルイノシトール３−キナーゼの阻害
US5504103A (en) Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof
US5726167A (en) Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof
Hirano et al. Antiproliferative activity of mammalian lignan derivatives against the human breast carcinoma cell line, ZR-75-1
US5441947A (en) Methods of inhibiting vascular restenosis
US5468773A (en) Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs
EP0762879A1 (en) Stereochemical wortmannin derivatives
Chang et al. Isolation and partial characterization of a cholesterol-requiring mutant of Chinese hamster ovary cells.
JPH08176070A (ja) ジデプシド誘導体及びｐｉ３キナーゼ阻害剤
CN104892622B (zh) 嗜氮酮类化合物及其制备方法和用途
CN103860529B (zh) 金色灰绿曲霉素类化合物的用途
CA1232853A (en) Cl-1724 antibiotic/antitumor compounds, their production and use
US8586626B2 (en) Metabolites of wortmannin analogs and methods of using the same
CN117466903B (zh) 吲哚二萜生物碱类化合物及其制备方法和应用
US5218125A (en) Antihypertensive compound and method of use thereas
Holdsworth et al. A fraction derived from brewer's yeast inhibits cholesterol synthesis by rat liver preparations in vitro
MXPA02010297A (es) Ciclopostina, metodo para su produccion y su uso.
KR960005150B1 (ko) 신규한 nf-1616-904의 피라진옥사이드 화합물 및 이를 함유하는 약학 조성물
Silva et al. Cyclic nucleotide phosphodiesterase activity in bovine brain coated vesicles
JPH0256423A (ja) ナフトピラン誘導体およびその用途
KR0170065B1 (ko) 토요카마이신의 항암제로서의 용도 및 그의 제조방법
KR19990021882A (ko) 트로폴론 유도체의 효소 이노시톨 모노포스파타제 저해제로서의용도
JPH09295980A (ja) 新規マクロライド系化合物０４０６
IE914520A1 (en) Phenoxanes, process for the preparation thereof and¹compositions
KR19990075383A (ko) 스트렙토마이세츠 스피시즈 와이 비 401에서 생산되는 마크로락틴 에프를 이용한 콜레스테롤 생합성의억제 방법

Legal Events

Date Code Title Description
A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20030311