JPH069560A - 新規なアリールカルボニルアミノアルキル−ジヒドロ−オキソ−ピリジン、その製法およびその使用 - Google Patents

新規なアリールカルボニルアミノアルキル−ジヒドロ−オキソ−ピリジン、その製法およびその使用

Info

Publication number
JPH069560A
JPH069560A JP5029515A JP2951593A JPH069560A JP H069560 A JPH069560 A JP H069560A JP 5029515 A JP5029515 A JP 5029515A JP 2951593 A JP2951593 A JP 2951593A JP H069560 A JPH069560 A JP H069560A
Authority
JP
Japan
Prior art keywords
oxo
compound
dihydro
lower alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5029515A
Other languages
English (en)
Japanese (ja)
Inventor
Heinrich Englert
ハインリヒ・エングラート
Dieter Mania
デイーター・マニア
David Wettlaufer
ダーフイツト・ヴエトラウフアー
Erik Klaus
エーリク・クラウス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of JPH069560A publication Critical patent/JPH069560A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
JP5029515A 1992-02-20 1993-02-19 新規なアリールカルボニルアミノアルキル−ジヒドロ−オキソ−ピリジン、その製法およびその使用 Pending JPH069560A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE92102828:8 1992-02-20
EP92102828 1992-02-20

Publications (1)

Publication Number Publication Date
JPH069560A true JPH069560A (ja) 1994-01-18

Family

ID=8209352

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5029515A Pending JPH069560A (ja) 1992-02-20 1993-02-19 新規なアリールカルボニルアミノアルキル−ジヒドロ−オキソ−ピリジン、その製法およびその使用

Country Status (17)

Country Link
US (1) US5360808A (en10)
EP (1) EP0556738B1 (en10)
JP (1) JPH069560A (en10)
KR (1) KR930017895A (en10)
CN (1) CN1075480A (en10)
AT (1) ATE122659T1 (en10)
AU (1) AU3375993A (en10)
CA (1) CA2089955A1 (en10)
CZ (1) CZ403592A3 (en10)
DE (1) DE69300152D1 (en10)
FI (1) FI930716A (en10)
HU (1) HU9300463D0 (en10)
IL (1) IL104781A0 (en10)
MA (1) MA22806A1 (en10)
MX (1) MX9300915A (en10)
NO (1) NO930594L (en10)
ZA (1) ZA931185B (en10)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010519204A (ja) * 2007-02-16 2010-06-03 アムジエン・インコーポレーテツド 窒素含有複素環ケトン類およびそれらのｃ−Ｍｅｔ阻害薬としての使用
JP2013503132A (ja) * 2009-08-26 2013-01-31 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング メチルピロロピリジンカルボキサミド

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1944801A (en) * 1999-12-21 2001-07-03 Monsanto Technology Llc Herbicidal diacyl derivatives of propylene diamine
DE10205219A1 (de) * 2002-02-08 2003-08-21 Bayer Ag Chinoxalinone und ihre Verwendung
US6869966B2 (en) * 2002-09-30 2005-03-22 Banyu Pharmaceutical Co., Ltd. N-substituted-2-oxodihydropyridine derivatives
US20040127129A1 (en) * 2002-12-31 2004-07-01 Shuiyuan Luo Grooved-shape monofilaments and the fabrics made thereof
WO2007008963A1 (en) * 2005-07-13 2007-01-18 Jenrin Discovery Mao-b inhibitors useful for treating obesity
JP2012513435A (ja) 2008-12-23 2012-06-14 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ７調節薬としてのジヒドロピリドンアミド
SG172336A1 (en) 2008-12-23 2011-07-28 Hoffmann La Roche Dihydropyridone amides as p2x7 modulators
SG172785A1 (en) 2008-12-23 2011-08-29 Hoffmann La Roche Dihydropyridone amides as p2x7 modulators
US8153808B2 (en) 2008-12-23 2012-04-10 Roche Palo Alto Llc Dihydropyridone amides as P2X7 modulators
BRPI0924059A2 (pt) 2008-12-23 2015-07-07 Hoffmann La Roche Didro piridona amidas como moduladores de p2x7

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2637477A1 (de) * 1976-08-20 1978-02-23 Hoechst Ag Dihydro-oxo-nicotinsaeuren und verfahren zu ihrer herstellung
IL61501A (en) * 1979-11-26 1984-06-29 Sterling Drug Inc 5-(pyridinyl)-2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them
US4297360A (en) * 1980-03-28 1981-10-27 Sterling Drug Inc. 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use
IT8367883A0 (it) * 1982-08-23 1983-08-22 Rorer Int Overseas Composti cardiotonici del 2 piridone 5 biciclico eteroaril sostituito e relative composizioni farmaceutiche
GB8809481D0 (en) * 1988-04-21 1988-05-25 Smith Kline French Lab Chemical compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010519204A (ja) * 2007-02-16 2010-06-03 アムジエン・インコーポレーテツド 窒素含有複素環ケトン類およびそれらのｃ−Ｍｅｔ阻害薬としての使用
JP2013503132A (ja) * 2009-08-26 2013-01-31 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング メチルピロロピリジンカルボキサミド

Also Published As

Publication number Publication date
HU9300463D0 (en) 1993-05-28
EP0556738A1 (en) 1993-08-25
US5360808A (en) 1994-11-01
KR930017895A (ko) 1993-09-20
EP0556738B1 (en) 1995-05-17
MX9300915A (es) 1993-09-01
FI930716A0 (fi) 1993-02-18
MA22806A1 (fr) 1993-10-01
CZ403592A3 (en) 1993-12-15
DE69300152D1 (de) 1995-06-22
CN1075480A (zh) 1993-08-25
ZA931185B (en) 1993-09-16
FI930716A (fi) 1993-08-21
NO930594L (no) 1993-08-23
AU3375993A (en) 1993-08-26
IL104781A0 (en) 1993-06-10
NO930594D0 (no) 1993-02-19
CA2089955A1 (en) 1993-08-21
ATE122659T1 (de) 1995-06-15

Similar Documents

Publication Publication Date Title
KR100202463B1 (ko) 아미노코우마란 유도체, 그들의 제조방법 및 용도
AU741173B2 (en) Substituted N-((aminoiminomethyl or aminomethyl)phenyl) propyl amides
JP3335362B2 (ja) キノレイン−２（１ｈ）−オン誘導体セロトニンアンタゴニスト
JP3176365B2 (ja) ベンゼンスルホンアミド誘導体
CZ174094A3 (en) Bicyclic compound having a core formed by two conjugated six-mebered rings and a pharmaceutical preparation containing thereof
JPH07188165A (ja) ５，６−双環性グリコプロテインＩＩｂ／ＩＩＩａ拮抗剤
KR100818060B1 (ko) 아미드 화합물 및 그의 용도
JP2005535702A (ja) 新規化合物
JPH09183766A (ja) 二環式複素環式化合物
JP2001500864A (ja) トロンビン阻害物質
JPH069560A (ja) 新規なアリールカルボニルアミノアルキル−ジヒドロ−オキソ−ピリジン、その製法およびその使用
JPH0466571A (ja) 脳及び心機能障害改善剤
JP3111321B2 (ja) 縮合チアゾール化合物
JPH08245593A (ja) ４−（キノリン−２−イル−メトキシ）−フエニル−酢酸誘導体
JPH07267954A (ja) 新規の３−フェニルスルホニル−３，７−ジアザビシクロ［３，３，１ノナン−化合物、その製法及び抗不整脈剤
JPS63295566A (ja) キノキサリノン誘導体
CA2140953A1 (en) Polyhydronorharman synthase inhibitors
CZ276092A3 (en) Heterocyclically substituted quinolylmethoxy-phenyl acetamides
EP0549598A1 (en) 2-METHYLIMIDAZO[4,5-c]PYRIDINE DERIVATIVES AND THERAPEUTIC AGENTS
JPH01132579A (ja) インドール誘導体
SE441746B (sv) Imidazo/4,5-h/isokinolin-dioner och forfarande for framstellning derav
US5356922A (en) Imidazole compounds, processes for their preparation, pharmaceuticals based on these compounds and some intermediates
US6660745B1 (en) Purine derivative dihydrate, drugs containing the same as the active ingredient and intermediate in the production thereof
WO1996013497A1 (fr) Derive de tetrahydroisoquinoleine et preparation medicinale contenant ce derive
JP3159995B2 (ja) トルイジン誘導体及びその製造方法