JPH0678307B2 - インドール誘導体 - Google Patents

インドール誘導体

Info

Publication number
JPH0678307B2
JPH0678307B2 JP3229864A JP22986491A JPH0678307B2 JP H0678307 B2 JPH0678307 B2 JP H0678307B2 JP 3229864 A JP3229864 A JP 3229864A JP 22986491 A JP22986491 A JP 22986491A JP H0678307 B2 JPH0678307 B2 JP H0678307B2
Authority
JP
Japan
Prior art keywords
formula
alkyl
salt
nmr
isobutylphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP3229864A
Other languages
English (en)
Japanese (ja)
Other versions
JPH04244061A (ja
Inventor
達 岡田
弘造 澤田
奈津子 茅切
由紀 斉藤
洋和 田中
眞志 橋本
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPH04244061A publication Critical patent/JPH04244061A/ja
Publication of JPH0678307B2 publication Critical patent/JPH0678307B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP3229864A 1990-05-21 1991-05-21 インドール誘導体 Expired - Fee Related JPH0678307B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909011335A GB9011335D0 (en) 1990-05-21 1990-05-21 Indolebutyric acid derivatives and process for preparation thereof
GB9011335.8 1990-05-21

Publications (2)

Publication Number Publication Date
JPH04244061A JPH04244061A (ja) 1992-09-01
JPH0678307B2 true JPH0678307B2 (ja) 1994-10-05

Family

ID=10676312

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3229864A Expired - Fee Related JPH0678307B2 (ja) 1990-05-21 1991-05-21 インドール誘導体

Country Status (18)

Country Link
EP (1) EP0458207B1 (https=)
JP (1) JPH0678307B2 (https=)
KR (1) KR910019975A (https=)
CN (1) CN1030701C (https=)
AT (1) ATE150747T1 (https=)
AU (1) AU645560B2 (https=)
CA (1) CA2042905A1 (https=)
DE (1) DE69125308T2 (https=)
DK (1) DK0458207T3 (https=)
FI (1) FI912375A7 (https=)
GB (1) GB9011335D0 (https=)
GR (1) GR3022953T3 (https=)
HU (2) HUT60471A (https=)
IE (1) IE911641A1 (https=)
NO (1) NO175475C (https=)
PT (1) PT97717B (https=)
RU (1) RU2045518C1 (https=)
ZA (1) ZA913457B (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2120942C1 (ru) * 1991-06-17 1998-10-27 Фудзисава Фармасьютикал Ко., Лтд. ПРОИЗВОДНЫЕ ИНДОЛИЗИНА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ИНГИБИРОВАНИЯ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ
US5334716A (en) * 1991-06-17 1994-08-02 Fujisawa Pharmaceutical Co., Ltd. Heterocyclic derivatives
GB9115951D0 (en) * 1991-07-24 1991-09-11 Pfizer Ltd Indoles
WO1993005019A1 (en) * 1991-09-11 1993-03-18 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives as 5-alpha-reductase inhibitor
GB9127531D0 (en) * 1991-12-31 1992-02-19 Fujisawa Pharmaceutical Co Heterocyclic compound
GB9204024D0 (en) * 1992-02-25 1992-04-08 Fujisawa Pharmaceutical Co Indole derivatives
GB9204365D0 (en) * 1992-02-28 1992-04-08 Pfizer Ltd Indoles
JPH07506575A (ja) * 1992-05-21 1995-07-20 アンドルシェルシュ・インコーポレイテッド テストステロン５α−レダクターゼ活性の阻害剤
GB9302577D0 (en) * 1993-02-10 1993-03-24 Fujisawa Pharmaceutical Co Indole derivatives
EP0648208A1 (en) * 1993-04-05 1995-04-19 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives as testosterone 5 alpha-reductase inhibitors
GB9310092D0 (en) * 1993-05-17 1993-06-30 Fujisawa Pharmaceutical Co Indole derivatives
IL109728A0 (en) * 1993-05-28 1994-08-26 Pfizer Res & Dev Indoles
GB9317096D0 (en) * 1993-08-17 1993-09-29 Pfizer Ltd Indoles
ATE203012T1 (de) 1994-03-30 2001-07-15 Zeria Pharm Co Ltd 4-indol-1-yl-buttersäure derivate, deren herstellung und deren verwendung als inhibitoren für alpha1-adrenerge rezeptoren und testosteron 5alpha-reduktasen
GB9409583D0 (en) * 1994-05-13 1994-07-06 Pfizer Ltd Indoles
CA2383983C (en) * 1998-03-31 2009-09-29 The Institutes For Pharmaceutical Discovery, Llc Substituted indolealkanoic acids
WO2003020311A1 (fr) * 2001-08-28 2003-03-13 Fujisawa Pharmaceutical Co., Ltd. Remedes contre les maladies de la peau
KR100751163B1 (ko) 2003-05-09 2007-08-22 에프. 호프만-라 로슈 아게 알파-1 아드레날린 작용물질로서의 메틸 인돌 및 메틸피롤로피리딘
TW201329025A (zh) * 2011-11-01 2013-07-16 Astex Therapeutics Ltd 醫藥化合物
CA3095934A1 (en) 2018-04-05 2019-10-10 Beth Israel Deaconess Medical Center, Inc. Aryl hydrocarbon receptor modulators and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7337M (https=) * 1968-01-11 1969-10-13
PH23498A (en) * 1984-08-06 1989-08-16 Sterling Drug Inc 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof

Also Published As

Publication number Publication date
CA2042905A1 (en) 1991-11-22
DE69125308D1 (de) 1997-04-30
AU7711691A (en) 1991-11-21
HUT60471A (en) 1992-09-28
CN1056685A (zh) 1991-12-04
GR3022953T3 (en) 1997-06-30
FI912375A0 (fi) 1991-05-16
ZA913457B (en) 1992-02-26
EP0458207A2 (en) 1991-11-27
NO175475B (no) 1994-07-11
NO911938L (no) 1991-11-22
PT97717B (pt) 1998-08-31
NO911938D0 (no) 1991-05-16
RU2045518C1 (ru) 1995-10-10
AU645560B2 (en) 1994-01-20
EP0458207A3 (en) 1992-03-25
DK0458207T3 (https=) 1997-04-21
HU911681D0 (en) 1991-11-28
DE69125308T2 (de) 1997-07-10
ATE150747T1 (de) 1997-04-15
EP0458207B1 (en) 1997-03-26
HU211637A9 (en) 1995-12-28
GB9011335D0 (en) 1990-07-11
NO175475C (no) 1994-10-19
FI912375A7 (fi) 1991-11-22
JPH04244061A (ja) 1992-09-01
KR910019975A (ko) 1991-12-19
IE911641A1 (en) 1991-12-04
PT97717A (pt) 1992-02-28
CN1030701C (zh) 1996-01-17

Similar Documents

Publication Publication Date Title
JPH0678307B2 (ja) インドール誘導体
US5338756A (en) Benzimidazole compounds
US5804601A (en) Aromatic hydroxamic acid compounds, their production and use
EP0807105B1 (en) Pyridopyrimidones, quinolines and fused n-heretocycles as bradykinin antagonists
US4894386A (en) Aliphatic carboxamides
JPH09512795A (ja) 骨吸収抑制剤として有用なベンゾフラン誘導体
JPH11505524A (ja) イミダゾ１，２−ａピリジンおよびイミダゾ１，２−ａピリデジン誘導体、および骨吸収阻害剤としてのその用途
US20030130278A1 (en) Alkynylated fused ring pyrimidine compounds
NO874904L (no) Fremgangsmaate for fremstilling av nye imidazopyridin-forbindelser.
RU2119922C1 (ru) Производные пептидов или их фармацевтически приемлемые соли, способ их получения, фармацевтическая композиция и способ ингибирования действия тахикинина
JPH1087629A (ja) 新規イソキノリン誘導体、およびその医薬用途
JPH10114654A (ja) 新規用途
KR0130899B1 (ko) 인돌일피페리딘 화합물, 그 제조방법 및 그들을 함유하는 약학조성물
EP0290145B1 (en) Aliphatic carboxamides
JP3353301B2 (ja) Ｐｌａ▲下２▼阻害剤としてのエステル類およびアミド類
US5312829A (en) Indole derivatives
WO1993003012A1 (en) Indole derivatives
JP2663794B2 (ja) 複素環誘導体
US5212320A (en) Indole derivatives and their use for testosterone 5-alpha-reductase-mediated diseases
JPH05148233A (ja) アミン誘導体
WO1993005019A1 (en) Indole derivatives as 5-alpha-reductase inhibitor
JPH04244073A (ja) チアゾール化合物
RU2120942C1 (ru) ПРОИЗВОДНЫЕ ИНДОЛИЗИНА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ИНГИБИРОВАНИЯ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ
JP2000001486A (ja) グアニジン誘導体
JPWO2000039097A1 (ja) イミダゾール化合物およびその医薬用途

Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees