WO2003020311A1 - Remedes contre les maladies de la peau - Google Patents

Remedes contre les maladies de la peau Download PDF

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Publication number
WO2003020311A1
WO2003020311A1 PCT/JP2002/008235 JP0208235W WO03020311A1 WO 2003020311 A1 WO2003020311 A1 WO 2003020311A1 JP 0208235 W JP0208235 W JP 0208235W WO 03020311 A1 WO03020311 A1 WO 03020311A1
Authority
WO
WIPO (PCT)
Prior art keywords
testosterone
remedies
reductase inhibitor
skin diseases
effect
Prior art date
Application number
PCT/JP2002/008235
Other languages
English (en)
Japanese (ja)
Inventor
Shozo Sakuma
Yoshihiro Yokota
Shinichi Kishi
Hiroko Takeuchi
Original Assignee
Fujisawa Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co., Ltd. filed Critical Fujisawa Pharmaceutical Co., Ltd.
Publication of WO2003020311A1 publication Critical patent/WO2003020311A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La présente invention concerne des remèdes contre les maladies de la peau contenant un inhibiteur de la testostérone 5α-réductase comme principe actif. Il a en effet été confirmé qu'un inhibiteur de la testostérone 5α-réductase exerce une action inhibitrice sur la prolifération des kératinocytes et inhibe en outre les réactions inflammatoires et l'épaississement de l'épiderme chez plusieurs modèles animaux atteints de pathologies semblables au psoriasis. En particulier, il a été découvert que l'inhibiteur de la testostérone 5α-réductase exerce une action inhibitrice sur la prolifération des kératinocytes et possède un effet anti-inflammatoire.
PCT/JP2002/008235 2001-08-28 2002-08-12 Remedes contre les maladies de la peau WO2003020311A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001257554 2001-08-28
JP2001-257554 2001-08-28

Publications (1)

Publication Number Publication Date
WO2003020311A1 true WO2003020311A1 (fr) 2003-03-13

Family

ID=19085194

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008235 WO2003020311A1 (fr) 2001-08-28 2002-08-12 Remedes contre les maladies de la peau

Country Status (1)

Country Link
WO (1) WO2003020311A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155096A2 (fr) * 1984-02-27 1985-09-18 Merck & Co. Inc. 4-Aza-5 alpha androsténones substitués en 17 bêta et leur utilisation comme inhibiteurs de 5 alpha réductase
EP0291245A2 (fr) * 1987-05-11 1988-11-17 Ono Pharmaceutical Co., Ltd. Dérivés de l'acide benzoylaminophénoxybutanoique
EP0458207A2 (fr) * 1990-05-21 1991-11-27 Fujisawa Pharmaceutical Co., Ltd. Dérivés d'indole
EP0519353A2 (fr) * 1991-06-17 1992-12-23 Fujisawa Pharmaceutical Co., Ltd. Dérivés d'indolizine, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0715852A1 (fr) * 1994-12-05 1996-06-12 Denki Kagaku Kogyo Kabushiki Kaisha Utilisation de l'acide hyaluronique ou son sel pour le traitement des désordres de la peau
WO2000006144A1 (fr) * 1998-07-27 2000-02-10 Howard Murad Compositions pharmaceutiques et methodes de lutte contre des affections du cuir chevelu

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155096A2 (fr) * 1984-02-27 1985-09-18 Merck & Co. Inc. 4-Aza-5 alpha androsténones substitués en 17 bêta et leur utilisation comme inhibiteurs de 5 alpha réductase
EP0291245A2 (fr) * 1987-05-11 1988-11-17 Ono Pharmaceutical Co., Ltd. Dérivés de l'acide benzoylaminophénoxybutanoique
EP0458207A2 (fr) * 1990-05-21 1991-11-27 Fujisawa Pharmaceutical Co., Ltd. Dérivés d'indole
EP0519353A2 (fr) * 1991-06-17 1992-12-23 Fujisawa Pharmaceutical Co., Ltd. Dérivés d'indolizine, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0715852A1 (fr) * 1994-12-05 1996-06-12 Denki Kagaku Kogyo Kabushiki Kaisha Utilisation de l'acide hyaluronique ou son sel pour le traitement des désordres de la peau
WO2000006144A1 (fr) * 1998-07-27 2000-02-10 Howard Murad Compositions pharmaceutiques et methodes de lutte contre des affections du cuir chevelu

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NAZZARO-PORRO M. ET AL.: "L'acido azelaico nella terapia dell'acne", GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA, vol. 124, no. 4, 1989, pages 175 - 184, XP002959852 *
PASSI S. ET AL.: "Meccanismo di azione dell'acido azelaico nell'acne", GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA, vol. 124, no. 10, 1989, pages 455 - 463, XP002081116 *

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