JPH06507628A - 新規ペルヒドロイソインドール誘導体及びその製造 - Google Patents

新規ペルヒドロイソインドール誘導体及びその製造

Info

Publication number
JPH06507628A
JPH06507628A JP4510463A JP51046392A JPH06507628A JP H06507628 A JPH06507628 A JP H06507628A JP 4510463 A JP4510463 A JP 4510463A JP 51046392 A JP51046392 A JP 51046392A JP H06507628 A JPH06507628 A JP H06507628A
Authority
JP
Japan
Prior art keywords
group
general formula
mixture
atom
diphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4510463A
Other languages
English (en)
Japanese (ja)
Inventor
アシヤール，ダニエル
グリゾニ，セルジユ
ハネシヤン，ステイーブン
ムートニエ，クロード
ペロネル，ジヤン−フランソワ
タバール，ミシエル
トリユシヨン，アラン
Original Assignee
ローン−プーラン・ロレ・ソシエテ・アノニム
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ローン−プーラン・ロレ・ソシエテ・アノニム filed Critical ローン−プーラン・ロレ・ソシエテ・アノニム
Publication of JPH06507628A publication Critical patent/JPH06507628A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP4510463A 1991-05-17 1992-05-15 新規ペルヒドロイソインドール誘導体及びその製造 Pending JPH06507628A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR91/06036 1991-05-17
FR9106036A FR2676443B1 (fr) 1991-05-17 1991-05-17 Nouveaux derives de perhydroisoindole et leur preparation.
PCT/FR1992/000430 WO1992020654A1 (fr) 1991-05-17 1992-05-15 Nouveaux derives de perhydroisoindole et leur preparation

Publications (1)

Publication Number Publication Date
JPH06507628A true JPH06507628A (ja) 1994-09-01

Family

ID=9412908

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4510463A Pending JPH06507628A (ja) 1991-05-17 1992-05-15 新規ペルヒドロイソインドール誘導体及びその製造

Country Status (23)

Country Link
US (1) US5508433A (enExample)
EP (2) EP0586471B1 (enExample)
JP (1) JPH06507628A (enExample)
AT (1) ATE116295T1 (enExample)
AU (1) AU1884092A (enExample)
CA (1) CA2109297A1 (enExample)
CZ (1) CZ244893A3 (enExample)
DE (1) DE69201058T2 (enExample)
DK (1) DK0586471T3 (enExample)
ES (1) ES2066620T3 (enExample)
FI (1) FI935072A7 (enExample)
FR (1) FR2676443B1 (enExample)
HU (1) HUT68913A (enExample)
IE (1) IE921579A1 (enExample)
IL (1) IL101867A0 (enExample)
MX (1) MX9202288A (enExample)
NO (1) NO933976L (enExample)
NZ (1) NZ242773A (enExample)
SK (1) SK126893A3 (enExample)
TW (1) TW226991B (enExample)
WO (1) WO1992020654A1 (enExample)
YU (1) YU51692A (enExample)
ZA (1) ZA923541B (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676442B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689889B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, et leur preparation.
US5508424A (en) * 1993-03-26 1996-04-16 Ortho Pharmaceutical Corporation 4-arylisoindole analgesics
FR2703679B1 (fr) * 1993-04-05 1995-06-23 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2709752B1 (fr) * 1993-07-30 1995-10-06 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2710913B1 (fr) * 1993-10-07 1995-11-24 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) * 1993-07-30 1999-08-01 Rhone Poulenc Rorer Sa Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
KR100885986B1 (ko) 1999-11-03 2009-03-03 에이엠알 테크놀로지, 인크. 노르에피네프린, 도파민 및 세로토닌의 재흡수를 방지하기위한 아릴 및 헤테로아릴 치환된테트라하이드로이소퀴놀린 및 이들의 용도
CA2415532C (en) 2000-07-11 2010-05-11 Albany Molecular Research, Inc. Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
US6709651B2 (en) 2001-07-03 2004-03-23 B.M.R.A. Corporation B.V. Treatment of substance P-related disorders
KR101389246B1 (ko) 2004-07-15 2014-04-24 브리스톨-마이어스스퀴브컴파니 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
EP1888050B1 (en) 2005-05-17 2012-03-21 Merck Sharp & Dohme Ltd. cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid for the treatment of cancer
ZA200800440B (en) 2005-07-15 2009-12-30 Amr Technology Inc Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EP2805945B1 (en) 2007-01-10 2019-04-03 MSD Italia S.r.l. Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
US8389553B2 (en) 2007-06-27 2013-03-05 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
KR101830447B1 (ko) 2009-05-12 2018-02-20 알바니 몰레큘라 리써치, 인크. 7-(［1,2,4］트리아졸로［1,5-α］피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린 및 이의 용도
EP2429295B1 (en) 2009-05-12 2013-12-25 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
CN102638982B (zh) 2009-05-12 2015-07-08 百时美施贵宝公司 (S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途
EP2488028B1 (en) 2009-10-14 2020-08-19 Merck Sharp & Dohme Corp. Substituted piperidines that increase p53 activity and the uses thereof
CN107090456B (zh) 2010-08-02 2022-01-18 瑟纳治疗公司 使用短干扰核酸的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1基因表达的抑制
JP2013537423A (ja) 2010-08-17 2013-10-03 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸（ｓｉＮＡ）を用いたＢ型肝炎ウイルス（ＨＢＶ）遺伝子発現のＲＮＡ干渉媒介性阻害
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
WO2012030685A2 (en) 2010-09-01 2012-03-08 Schering Corporation Indazole derivatives useful as erk inhibitors
EP2615916B1 (en) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel erk inhibitors
DK2632472T3 (en) 2010-10-29 2018-03-19 Sirna Therapeutics Inc RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
WO2012087772A1 (en) 2010-12-21 2012-06-28 Schering Corporation Indazole derivatives useful as erk inhibitors
EP2699568A1 (en) 2011-04-21 2014-02-26 Piramal Enterprises Limited A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
WO2013063214A1 (en) 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
EP2844261B1 (en) 2012-05-02 2018-10-17 Sirna Therapeutics, Inc. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
CN105050598B (zh) 2012-09-28 2018-04-27 默沙东公司 作为erk抑制剂的新型化合物
RS56680B1 (sr) 2012-11-28 2018-03-30 Merck Sharp & Dohme Kompozicije i postupci za lečenje kancera
US8846657B2 (en) 2012-12-20 2014-09-30 Merck Sharp & Dohme Corp. Substituted imidazopyridines as HDM2 inhibitors
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
EP3041938A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Circular polynucleotides
US10975084B2 (en) 2016-10-12 2021-04-13 Merck Sharp & Dohme Corp. KDM5 inhibitors
US11098059B2 (en) 2017-11-08 2021-08-24 Merck Sharp & Dohme Corp. PRMT5 inhibitors
EP3706742B1 (en) 2017-11-08 2023-03-15 Merck Sharp & Dohme LLC Prmt5 inhibitors
EP3833668B1 (en) 2018-08-07 2025-03-19 Merck Sharp & Dohme LLC Prmt5 inhibitors
EP3833667B1 (en) 2018-08-07 2024-03-13 Merck Sharp & Dohme LLC Prmt5 inhibitors
CA3108388A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042707A (en) * 1976-02-19 1977-08-16 E. I. Du Pont De Nemours And Company 3α-Arylhydroisoindoles
AU502760B2 (en) * 1977-02-28 1979-08-09 Science Union Et Cie, Societe Francaise De Recherche Medicale Azabicycloalkanes and their preparation
DE3276311D1 (en) * 1981-02-17 1987-06-19 Warner Lambert Co Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1h-isoindole-1-carboxylic acids and esters
US4439229A (en) * 1981-06-29 1984-03-27 Rohm And Haas Company Substituted phthalimides herbicides
JPH0278659A (ja) * 1988-09-12 1990-03-19 Shionogi & Co Ltd アザビシクロアルカン類化合物
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
DE69201058T2 (de) 1995-05-11
ES2066620T3 (es) 1995-03-01
FR2676443A1 (fr) 1992-11-20
ATE116295T1 (de) 1995-01-15
DK0586471T3 (da) 1995-06-06
IE921579A1 (en) 1992-11-18
FI935072A0 (fi) 1993-11-16
NZ242773A (en) 1994-06-27
CZ244893A3 (en) 1994-04-13
US5508433A (en) 1996-04-16
CA2109297A1 (fr) 1992-11-18
FR2676443B1 (fr) 1993-08-06
DE69201058D1 (de) 1995-02-09
ZA923541B (en) 1993-01-27
FI935072L (fi) 1993-11-16
AU1884092A (en) 1992-12-30
WO1992020654A1 (fr) 1992-11-26
EP0514274A1 (fr) 1992-11-19
NO933976D0 (no) 1993-11-03
YU51692A (sh) 1994-06-10
HUT68913A (en) 1995-08-28
EP0586471A1 (fr) 1994-03-16
NO933976L (no) 1993-11-03
IL101867A0 (en) 1992-12-30
EP0586471B1 (fr) 1994-12-28
FI935072A7 (fi) 1993-11-16
SK126893A3 (en) 1994-11-09
MX9202288A (es) 1992-11-01
HU9303250D0 (en) 1994-03-28
TW226991B (enExample) 1994-07-21

Similar Documents

Publication Publication Date Title
JPH06507628A (ja) 新規ペルヒドロイソインドール誘導体及びその製造
US5451601A (en) Perhydroisoindole derivatives and pharmaceutical compositions containing them
FI105023B (fi) Menetelmä terapeuttisesti käyttökelpoisten difenyyli-4-perhydroisoindolijohdannaisten valmistamiseksi
DE69010851T2 (de) Isoindolonderivate, ihre Herstellung und ihre Verwendung als Zwischenprodukte zur Herstellung von Substanz-P-Antagonisten.
JP2944402B2 (ja) インドリン誘導体
JPH06507895A (ja) 新規なチオピラノピロール誘導体類およびそれらの製造
JPS62273976A (ja) アミノ−チアゾ−ル及びオキサゾ−ル誘導体
AP192A (en) Carbamoyl derivatives.
JPH10237073A (ja) 新規な置換グアニジン誘導体およびその製法
US7776852B2 (en) Process for producing highly pure midazolam and salts thereof
DE69319902T2 (de) Neue perhydroisoindolderivate und ihre herstellung
JPH0517434A (ja) ベンズアミド誘導体
JPH09291076A (ja) 置換グアニジン誘導体およびその製法
JPH07258250A (ja) エステル誘導体
AU705431B2 (en) Indanylpiperidines as melatonergic agents
US3882119A (en) Tetracyclic substituted phthalazine compounds
JPS5833877B2 (ja) ユウキカゴウブツニカンスルカイリヨウ
CZ280931B6 (cs) Opticky aktivní karboxamidové deriváty, farmaceutický prostředek s analgetickým účinkem a prostředek s agonistickým účinkem vzhledem ke k-receptorům
JPH0357896B2 (enExample)
US3767670A (en) 1-r1-3-(3-phthalimido-alkyloxy)-5-or-6-r-1h-indazole compounds
Okada et al. A Facile and Convenient Synthetic Method for Fluorine-containing 1H-Pyrrolo (3, 2-h) quinolines
JPS6144854A (ja) Ｎ−ジクロロアルキル安息香酸アミド及びその製造方法
KR100228327B1 (ko) 3-알킬화 인돌의 제조방법
Barluenga et al. Synthesis of halogenated hydrazone derivatives and their applicability in the preparation of 4‐chloropyrazoles
US5792874A (en) Process for the manufacture of 8-chloro-6-(2-flourophenyl)-1-methyl-4H-imidazo 1,5A! 1,4!benzodiazepine (midazolam)