NO933976D0 - Nye perhydroisoindolderivater og deres fremstilling - Google Patents

Nye perhydroisoindolderivater og deres fremstilling

Info

Publication number
NO933976D0
NO933976D0 NO1993933976A NO933976A NO933976D0 NO 933976 D0 NO933976 D0 NO 933976D0 NO 1993933976 A NO1993933976 A NO 1993933976A NO 933976 A NO933976 A NO 933976A NO 933976 D0 NO933976 D0 NO 933976D0
Authority
NO
Norway
Prior art keywords
preparation
new
derivatives
halogen atom
perhydroiso
Prior art date
Application number
NO1993933976A
Other languages
English (en)
Norwegian (no)
Other versions
NO933976L (no
Inventor
Daniel Achard
Serge Grisoni
Stephen Hanessian
Claude Moutonnier
Jean-Francois Peyronel
Michel Tabart
Alain Truchon
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of NO933976L publication Critical patent/NO933976L/no
Publication of NO933976D0 publication Critical patent/NO933976D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO1993933976A 1991-05-17 1993-11-03 Nye perhydroisoindolderivater og deres fremstilling NO933976D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9106036A FR2676443B1 (fr) 1991-05-17 1991-05-17 Nouveaux derives de perhydroisoindole et leur preparation.
PCT/FR1992/000430 WO1992020654A1 (fr) 1991-05-17 1992-05-15 Nouveaux derives de perhydroisoindole et leur preparation

Publications (2)

Publication Number Publication Date
NO933976L NO933976L (no) 1993-11-03
NO933976D0 true NO933976D0 (no) 1993-11-03

Family

ID=9412908

Family Applications (1)

Application Number Title Priority Date Filing Date
NO1993933976A NO933976D0 (no) 1991-05-17 1993-11-03 Nye perhydroisoindolderivater og deres fremstilling

Country Status (23)

Country Link
US (1) US5508433A (enExample)
EP (2) EP0514274A1 (enExample)
JP (1) JPH06507628A (enExample)
AT (1) ATE116295T1 (enExample)
AU (1) AU1884092A (enExample)
CA (1) CA2109297A1 (enExample)
CZ (1) CZ244893A3 (enExample)
DE (1) DE69201058T2 (enExample)
DK (1) DK0586471T3 (enExample)
ES (1) ES2066620T3 (enExample)
FI (1) FI935072A7 (enExample)
FR (1) FR2676443B1 (enExample)
HU (1) HUT68913A (enExample)
IE (1) IE921579A1 (enExample)
IL (1) IL101867A0 (enExample)
MX (1) MX9202288A (enExample)
NO (1) NO933976D0 (enExample)
NZ (1) NZ242773A (enExample)
SK (1) SK126893A3 (enExample)
TW (1) TW226991B (enExample)
WO (1) WO1992020654A1 (enExample)
YU (1) YU51692A (enExample)
ZA (1) ZA923541B (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676442B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689889B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, et leur preparation.
US5508424A (en) * 1993-03-26 1996-04-16 Ortho Pharmaceutical Corporation 4-arylisoindole analgesics
FR2703679B1 (fr) * 1993-04-05 1995-06-23 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2709752B1 (fr) * 1993-07-30 1995-10-06 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2710913B1 (fr) * 1993-10-07 1995-11-24 Rhone Poulenc Rorer Sa Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) * 1993-07-30 1999-08-01 Rhone Poulenc Rorer Sa Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
ATE387429T1 (de) 1999-11-03 2008-03-15 Amr Technology Inc Arly- und heteroaryl-substituierte tetrahydroisoquinoline und ihre verwendung als hemmer der wiederaufnahme von norepinephrin, dopamin und serotonin
CN100430401C (zh) 2000-07-11 2008-11-05 Amr科技公司 新的4-苯基取代的四氢异喹啉类化合物及其治疗用途
US6709651B2 (en) 2001-07-03 2004-03-23 B.M.R.A. Corporation B.V. Treatment of substance P-related disorders
CN101119969B (zh) 2004-07-15 2014-04-09 阿尔巴尼分子研究公司 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用
WO2006123182A2 (en) 2005-05-17 2006-11-23 Merck Sharp & Dohme Limited Cyclohexyl sulphones for treatment of cancer
EA019115B1 (ru) 2005-07-15 2014-01-30 Олбани Молекьюлар Рисерч, Инк. Арил- и гетероарилзамещенные тетрагидробензазепины и их применение для блокировки обратного захвата норэпинефрина, допамина и серотонина
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
GEP20115337B (en) 2007-01-10 2011-11-25 St Di Ricerche Di Biologia Molecolare P Angeletti Spa Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
AU2008269154B2 (en) 2007-06-27 2014-06-12 Merck Sharp & Dohme Llc 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
MX2011011900A (es) 2009-05-12 2012-01-20 Squibb Bristol Myers Co Formas cristalinas de (s)-7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4 -(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y usos de las misma.
WO2010132437A1 (en) 2009-05-12 2010-11-18 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
CN102595902B (zh) 2009-05-12 2015-04-29 阿尔巴尼分子研究公司 7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途
MY174452A (en) 2009-10-14 2020-04-19 Schering Corp Substituted piperidines that increase p53 activity and the uses thereof
US8518907B2 (en) 2010-08-02 2013-08-27 Merck Sharp & Dohme Corp. RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
EP3587574B1 (en) 2010-08-17 2022-03-16 Sirna Therapeutics, Inc. Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
US8946216B2 (en) 2010-09-01 2015-02-03 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
US9260471B2 (en) 2010-10-29 2016-02-16 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
EP2654748B1 (en) 2010-12-21 2016-07-27 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
CA2833009A1 (en) 2011-04-21 2012-10-26 Merck Sharp & Dohme Corp. Insulin-like growth factor-1 receptor inhibitors
US9023865B2 (en) 2011-10-27 2015-05-05 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
EP3919620A1 (en) 2012-05-02 2021-12-08 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
JP6280554B2 (ja) 2012-09-28 2018-02-14 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｅｒｋ阻害剤である新規化合物
DK2925888T3 (en) 2012-11-28 2017-12-18 Merck Sharp & Dohme COMPOSITIONS AND METHODS OF CANCER TREATMENT
AR094116A1 (es) 2012-12-20 2015-07-08 Merck Sharp & Dohme Imidazopiridinas sustituidas como inhibidores de hdm2
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
EP3525785B1 (en) 2016-10-12 2025-08-27 Merck Sharp & Dohme LLC Kdm5 inhibitors
EP3706747B1 (en) 2017-11-08 2025-09-03 Merck Sharp & Dohme LLC Prmt5 inhibitors
US10947234B2 (en) 2017-11-08 2021-03-16 Merck Sharp & Dohme Corp. PRMT5 inhibitors
EP3833355A4 (en) 2018-08-07 2022-05-11 Merck Sharp & Dohme Corp. PRMT5 INHIBITORS
US11993602B2 (en) 2018-08-07 2024-05-28 Merck Sharp & Dohme Llc PRMT5 inhibitors
WO2020033284A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042707A (en) * 1976-02-19 1977-08-16 E. I. Du Pont De Nemours And Company 3α-Arylhydroisoindoles
AU502760B2 (en) * 1977-02-28 1979-08-09 Science Union Et Cie, Societe Francaise De Recherche Medicale Azabicycloalkanes and their preparation
EP0093805B1 (en) * 1981-02-17 1987-05-13 Warner-Lambert Company Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1h-isoindole-1-carboxylic acids and esters
US4439229A (en) * 1981-06-29 1984-03-27 Rohm And Haas Company Substituted phthalimides herbicides
JPH0278659A (ja) * 1988-09-12 1990-03-19 Shionogi & Co Ltd アザビシクロアルカン類化合物
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
EP0586471A1 (fr) 1994-03-16
HU9303250D0 (en) 1994-03-28
CZ244893A3 (en) 1994-04-13
NZ242773A (en) 1994-06-27
ZA923541B (en) 1993-01-27
YU51692A (sh) 1994-06-10
AU1884092A (en) 1992-12-30
US5508433A (en) 1996-04-16
ATE116295T1 (de) 1995-01-15
DE69201058D1 (de) 1995-02-09
FR2676443A1 (fr) 1992-11-20
ES2066620T3 (es) 1995-03-01
EP0514274A1 (fr) 1992-11-19
IE921579A1 (en) 1992-11-18
WO1992020654A1 (fr) 1992-11-26
NO933976L (no) 1993-11-03
TW226991B (enExample) 1994-07-21
JPH06507628A (ja) 1994-09-01
DK0586471T3 (da) 1995-06-06
CA2109297A1 (fr) 1992-11-18
HUT68913A (en) 1995-08-28
DE69201058T2 (de) 1995-05-11
FI935072A0 (fi) 1993-11-16
EP0586471B1 (fr) 1994-12-28
MX9202288A (es) 1992-11-01
SK126893A3 (en) 1994-11-09
FI935072L (fi) 1993-11-16
FI935072A7 (fi) 1993-11-16
FR2676443B1 (fr) 1993-08-06
IL101867A0 (en) 1992-12-30

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