JPH0577981B2 - - Google Patents
Info
- Publication number
- JPH0577981B2 JPH0577981B2 JP58009599A JP959983A JPH0577981B2 JP H0577981 B2 JPH0577981 B2 JP H0577981B2 JP 58009599 A JP58009599 A JP 58009599A JP 959983 A JP959983 A JP 959983A JP H0577981 B2 JPH0577981 B2 JP H0577981B2
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- sample
- reagent
- reaction tube
- carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000006243 chemical reaction Methods 0.000 claims description 175
- 239000003153 chemical reaction reagent Substances 0.000 claims description 73
- 238000004458 analytical method Methods 0.000 claims description 44
- 238000000034 method Methods 0.000 claims description 41
- 239000000126 substance Substances 0.000 claims description 36
- 238000012360 testing method Methods 0.000 claims description 28
- 238000000926 separation method Methods 0.000 claims description 19
- 238000005406 washing Methods 0.000 claims description 19
- 239000000427 antigen Substances 0.000 claims description 18
- 102000036639 antigens Human genes 0.000 claims description 18
- 108091007433 antigens Proteins 0.000 claims description 18
- 230000001900 immune effect Effects 0.000 claims description 9
- 238000002372 labelling Methods 0.000 claims description 9
- 102000004190 Enzymes Human genes 0.000 description 43
- 108090000790 Enzymes Proteins 0.000 description 43
- 238000004140 cleaning Methods 0.000 description 33
- 238000003018 immunoassay Methods 0.000 description 21
- 238000005259 measurement Methods 0.000 description 14
- 238000010586 diagram Methods 0.000 description 12
- 239000011295 pitch Substances 0.000 description 11
- 239000000969 carrier Substances 0.000 description 9
- 238000004040 coloring Methods 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 230000002860 competitive effect Effects 0.000 description 7
- 238000007599 discharging Methods 0.000 description 7
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000000984 immunochemical effect Effects 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 238000005375 photometry Methods 0.000 description 5
- 239000012085 test solution Substances 0.000 description 5
- 239000007853 buffer solution Substances 0.000 description 4
- 239000003550 marker Substances 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 238000003127 radioimmunoassay Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 229920003002 synthetic resin Polymers 0.000 description 3
- 239000000057 synthetic resin Substances 0.000 description 3
- 230000004520 agglutination Effects 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 238000004879 turbidimetry Methods 0.000 description 2
- 101100441413 Caenorhabditis elegans cup-15 gene Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 1
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 1
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 102000013529 alpha-Fetoproteins Human genes 0.000 description 1
- 108010026331 alpha-Fetoproteins Proteins 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000012764 semi-quantitative analysis Methods 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
- G01N2035/00386—Holding samples at elevated temperature (incubation) using fluid heat transfer medium
- G01N2035/00396—Holding samples at elevated temperature (incubation) using fluid heat transfer medium where the fluid is a liquid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00564—Handling or washing solid phase elements, e.g. beads
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0441—Rotary sample carriers, i.e. carousels for samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/046—General conveyor features
- G01N2035/0465—Loading or unloading the conveyor
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP959983A JPS59135367A (ja) | 1983-01-24 | 1983-01-24 | 免疫学的自動分析方法 |
| DE19843402304 DE3402304C3 (de) | 1983-01-24 | 1984-01-24 | Verfahren für die automatische immunologische Analyse |
| DE19843448121 DE3448121C2 (fr) | 1983-01-24 | 1984-01-24 | |
| DE19843448210 DE3448210C2 (fr) | 1983-01-24 | 1984-01-24 | |
| DE19843448007 DE3448007C2 (en) | 1983-01-24 | 1984-01-24 | Reaction vessel for immunological analysis |
| US07/119,278 US5175086A (en) | 1983-01-24 | 1987-11-09 | Method for effecting heterogeneous immunological analysis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP959983A JPS59135367A (ja) | 1983-01-24 | 1983-01-24 | 免疫学的自動分析方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59135367A JPS59135367A (ja) | 1984-08-03 |
| JPH0577981B2 true JPH0577981B2 (fr) | 1993-10-27 |
Family
ID=11724775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP959983A Granted JPS59135367A (ja) | 1983-01-24 | 1983-01-24 | 免疫学的自動分析方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59135367A (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0664069B2 (ja) * | 1984-11-14 | 1994-08-22 | オリンパス光学工業株式会社 | 免疫学的自動分析方法 |
| JPH0656383B2 (ja) * | 1985-02-22 | 1994-07-27 | オリンパス光学工業株式会社 | 酵素免疫学的自動分析装置 |
| JPS62133355A (ja) * | 1985-12-06 | 1987-06-16 | Nitsuteku:Kk | Ｅｉａ自動分析装置 |
| JP2883347B2 (ja) * | 1989-03-15 | 1999-04-19 | 日本電子株式会社 | 自動免疫測定装置のカートリッジ洗浄装置 |
| JPH02245665A (ja) * | 1989-03-18 | 1990-10-01 | Jeol Ltd | 自動生化学分析装置 |
| JP3733432B2 (ja) * | 1996-07-26 | 2006-01-11 | 東ソー株式会社 | 免疫分析装置用反応装置 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56147067A (en) * | 1980-04-16 | 1981-11-14 | Olympus Optical Co Ltd | Automatic measuring instrument for enzyme immunity |
| JPS5774662A (en) * | 1980-10-28 | 1982-05-10 | Fujirebio Inc | Automatic measuring apparatus for enzyme immunity |
| JPS5984159A (ja) * | 1982-11-06 | 1984-05-15 | Kyoto Daiichi Kagaku:Kk | 酵素免疫自動測定方法及び装置 |
-
1983
- 1983-01-24 JP JP959983A patent/JPS59135367A/ja active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56147067A (en) * | 1980-04-16 | 1981-11-14 | Olympus Optical Co Ltd | Automatic measuring instrument for enzyme immunity |
| JPS5774662A (en) * | 1980-10-28 | 1982-05-10 | Fujirebio Inc | Automatic measuring apparatus for enzyme immunity |
| JPS5984159A (ja) * | 1982-11-06 | 1984-05-15 | Kyoto Daiichi Kagaku:Kk | 酵素免疫自動測定方法及び装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59135367A (ja) | 1984-08-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109142768B (zh) | 自动分析装置及样本分析方法 | |
| US5175086A (en) | Method for effecting heterogeneous immunological analysis | |
| US4837159A (en) | Method and apparatus for effecting immunological analysis | |
| EP0089346B1 (fr) | Systeme automatise d'analyse immunologique | |
| JP3372544B2 (ja) | 自動化学分析方法および装置 | |
| US5178834A (en) | Automatic immunoassay analyzer | |
| JP3673926B2 (ja) | 自動化学分析機においてサンプルを前処理するための方法および装置 | |
| US20050220670A1 (en) | Multipath access system for use in an automated immunoassay analyzer | |
| JP4374246B2 (ja) | タイプに従って分析を仕分けることによって臨床検査用自動分析装置の処理能力を向上させること | |
| JP2884604B2 (ja) | 自動免疫測定装置及びその使用方法 | |
| CN111033263A (zh) | 一种自动分析装置及其工作方法 | |
| US6103193A (en) | Automatic immunoassay method and apparatus | |
| JPS59147267A (ja) | 免疫学的自動分析方法およびこれに用いる反応容器 | |
| JPH0577981B2 (fr) | ||
| JPH0688828A (ja) | 免疫自動分析装置 | |
| JPH0656383B2 (ja) | 酵素免疫学的自動分析装置 | |
| JPS61117455A (ja) | 免疫学的自動分析方法 | |
| JP3733432B2 (ja) | 免疫分析装置用反応装置 | |
| JPH0619358B2 (ja) | 免疫学的自動分析方法 | |
| JPH0756490B2 (ja) | 免疫学的自動分析方法 | |
| JPS61258171A (ja) | 免疫学的自動分析方法および装置 | |
| JP3001994B2 (ja) | 自動分析装置 | |
| JPH061274B2 (ja) | 免疫学的自動分析方法 | |
| JPH0471182B2 (fr) | ||
| JPH01287465A (ja) | 液体を攪拌し得る分析装置および分析方法 |