JPH0570353A - 抗炎症剤 - Google Patents

抗炎症剤

Info

Publication number
JPH0570353A
JPH0570353A JP4055370A JP5537092A JPH0570353A JP H0570353 A JPH0570353 A JP H0570353A JP 4055370 A JP4055370 A JP 4055370A JP 5537092 A JP5537092 A JP 5537092A JP H0570353 A JPH0570353 A JP H0570353A
Authority
JP
Japan
Prior art keywords
compound
inflammatory agent
acid
present
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4055370A
Other languages
English (en)
Japanese (ja)
Inventor
Toshiko Kuwabara
登志子 桑原
Yukio Sugimoto
幸雄 杉本
Takuji Kamisako
卓司 上迫
Toshiaki Funato
利明 船戸
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Factory Inc
Priority to JP4055370A priority Critical patent/JPH0570353A/ja
Publication of JPH0570353A publication Critical patent/JPH0570353A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP4055370A 1991-04-22 1992-03-13 抗炎症剤 Pending JPH0570353A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4055370A JPH0570353A (ja) 1991-04-22 1992-03-13 抗炎症剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9070791 1991-04-22
JP3-90707 1991-04-22
JP4055370A JPH0570353A (ja) 1991-04-22 1992-03-13 抗炎症剤

Publications (1)

Publication Number Publication Date
JPH0570353A true JPH0570353A (ja) 1993-03-23

Family

ID=14006001

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4055370A Pending JPH0570353A (ja) 1991-04-22 1992-03-13 抗炎症剤

Country Status (12)

Country Link
US (1) US5688949A (OSRAM)
EP (1) EP0591528B1 (OSRAM)
JP (1) JPH0570353A (OSRAM)
KR (1) KR100191774B1 (OSRAM)
AT (1) ATE174917T1 (OSRAM)
AU (1) AU651986B2 (OSRAM)
CA (1) CA2107479C (OSRAM)
DE (1) DE69130683T2 (OSRAM)
DK (1) DK0591528T3 (OSRAM)
ES (1) ES2126573T3 (OSRAM)
TW (1) TW221434B (OSRAM)
WO (1) WO1992018504A1 (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006502184A (ja) * 2002-09-04 2006-01-19 シェーリング　コーポレイション サイクリン依存性キナーゼインヒビターとしての新規ピラゾロピリミジン
JP2017500314A (ja) * 2013-12-11 2017-01-05 ナント ホールディングス アイピー，エルエルシー Ａ型インフルエンザｒｎａ依存性ｒｎａポリメラーゼの低分子阻害剤
US9987282B2 (en) 2011-09-20 2018-06-05 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase

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EP0628559B1 (en) * 1993-06-10 2002-04-03 Beiersdorf-Lilly GmbH Pyrimidine compounds and their use as pharmaceuticals
DK0714898T3 (da) * 1994-06-21 2002-03-18 Otsuka Pharma Co Ltd Pyrazolo[1,5-a]primidinderivat
RU2147584C1 (ru) * 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US6664261B2 (en) * 1996-02-07 2003-12-16 Neurocrine Biosciences, Inc. Pyrazolopyrimidines as CRF receptor antagonists
DE69717453T2 (de) * 1996-06-06 2003-07-10 Otsuka Pharmaceutical Factory, Inc. Amid derivate
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
PT915880E (pt) * 1996-07-24 2007-12-31 Bristol Myers Squibb Pharma Co Azol triazinas e pirimidinas
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
CZ299451B6 (cs) * 1996-07-24 2008-07-30 Bristol-Myers Squibb Pharma Company [1,5-a]-Pyrazolo-1,3,5- triaziny jejich použití afarmaceutické kompozice na jejich bázi
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
HUP9603001A3 (en) * 1996-10-30 1999-07-28 Richter Gedeon Vegyeszet Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
AU4331500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
AU4203500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
US20020061897A1 (en) * 2000-03-30 2002-05-23 Elliott Richard L. Neuropeptide Y antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
ATE345344T1 (de) * 2001-03-27 2006-12-15 Neurogen Corp (oxopyrazolo 1,5aöpyrimidin-2-yl) alkylcarbonsäureamide
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
JP4602076B2 (ja) * 2002-06-04 2010-12-22 ネオジェネシス ファーマシューティカルズ インコーポレイテッド 抗ウイルス剤としてのピラゾロ［１，５ａ］ピリミジン化合物
US7205308B2 (en) 2002-09-04 2007-04-17 Schering Corporation Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7119200B2 (en) 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
AR041136A1 (es) * 2002-09-04 2005-05-04 Pharmacopeia Drug Discovery Pirazolopirimidinas como inhibidores de cinasas dependientes de clclinas
US8673924B2 (en) 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US7161003B1 (en) * 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
WO2004022062A1 (en) * 2002-09-04 2004-03-18 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
EP2194058B1 (en) 2002-09-04 2013-11-27 Merck Sharp & Dohme Corp. Pyrazolopyrimidines suitable for the treatment of cancer diseases
NZ539162A (en) * 2002-09-04 2006-07-28 Schering Corp Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
EP1599482A4 (en) 2003-02-28 2008-10-01 Teijin Pharma Ltd PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES
WO2004087707A1 (en) * 2003-03-31 2004-10-14 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
US6949895B2 (en) * 2003-09-03 2005-09-27 Axcelis Technologies, Inc. Unipolar electrostatic quadrupole lens and switching methods for charged beam transport
PE20051089A1 (es) * 2004-01-22 2006-01-25 Novartis Ag Derivados de pirazolo [1,5-a] pirimidin-7-il-amina como inhibidores de quinasa de proteina
JP2008539047A (ja) 2005-04-28 2008-11-13 プロテウス バイオメディカル インコーポレイテッド ファーマインフォーマティックスシステム
DE602006016455D1 (de) * 2005-09-09 2010-10-07 Schering Corp Neue 4-cyano-, 4-amino-, und 4-aminomethylderivative von pyrazoloä1,5-aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h-indazolverbindungen und 5-cyano-, 5-amino- und 5-aminomethylderivative von imidazoä1,2-aüpyridinen, und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinase
AU2006299338A1 (en) 2005-10-06 2007-04-12 Merck Sharp & Dohme Corp. Pyrazolopyrimidines as protein kinase inhibitors
EP1940847A2 (en) * 2005-10-06 2008-07-09 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
GB0526419D0 (en) * 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
JP2010511058A (ja) * 2006-11-29 2010-04-08 アボット・ラボラトリーズ ジアシルグリセロールｏ−アシルトランスフェラーゼ１型酵素の阻害薬
EP2222675B1 (en) 2007-12-19 2013-09-11 Genentech, Inc. 5-anilinoimidazopyridines and methods of use
EP3395372B1 (en) 2009-02-20 2022-04-06 EnhanX Biopharm Inc. Glutathione-based drug delivery system
SG10201402069PA (en) 2009-05-06 2014-07-30 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
ES2475970T3 (es) * 2009-12-23 2014-07-11 Katholieke Universiteit Leuven Novedosos compuestos antivirales
US8927562B2 (en) * 2010-09-28 2015-01-06 Merck Sharp & Dohme Corp. Fused tricyclic inhibitors of mammalian target of rapamycin
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US9132129B2 (en) 2010-11-15 2015-09-15 Katholieke Universiteit Leuven Antiviral compounds
BR112016016798B1 (pt) * 2014-01-22 2022-06-28 Curovir Ab Composto, composição farmacêutica, e, uso de um composto
GB201410817D0 (en) 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R & D Therapeutic agents
BR112020003676A2 (pt) * 2017-09-15 2020-09-01 Aduro Biotech, Inc. compostos de pirazolopirimidinona e usos dos mesmos
DE102018201598A1 (de) * 2018-02-02 2019-08-08 Beiersdorf Ag Stabile Wundheilsalbe
AU2021363703A1 (en) 2020-10-23 2023-06-22 Ildong Pharmaceutical Co., Ltd. Cftr modulator compounds, compositions, and uses thereof

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BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
US3925385A (en) * 1972-04-20 1975-12-09 Icn Pharmaceuticals 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
US4026893A (en) * 1975-11-07 1977-05-31 Squibb & Sons Inc Pyrazolo{8 1,5-a{9 pyrido{8 3,2-e{9 pyrimidine-7-carboxylic acid derivatives
DE3338292A1 (de) * 1983-10-21 1985-05-02 Basf Ag, 6700 Ludwigshafen 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide
JPS60100381A (ja) * 1983-11-04 1985-06-04 Yuasa Battery Co Ltd 密閉形鉛蓄電池
JPS60100581A (ja) * 1983-11-07 1985-06-04 S D S Baiotetsuku:Kk ピラゾロ〔１，５−ａ〕ピリミジン誘導体，それらを含有する農園芸用殺菌剤及びそれらの製造方法
JPS6157587A (ja) * 1984-08-29 1986-03-24 Shionogi & Co Ltd 縮合複素環誘導体および抗潰瘍剤
JP2585462B2 (ja) * 1989-10-25 1997-02-26 株式会社大塚製薬工場 ピラゾロ［１，５―ａ］ピリミジン誘導体
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006502184A (ja) * 2002-09-04 2006-01-19 シェーリング　コーポレイション サイクリン依存性キナーゼインヒビターとしての新規ピラゾロピリミジン
JP4790265B2 (ja) * 2002-09-04 2011-10-12 シェーリング コーポレイション サイクリン依存性キナーゼインヒビターとしての新規ピラゾロピリミジン
US9987282B2 (en) 2011-09-20 2018-06-05 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
JP2017500314A (ja) * 2013-12-11 2017-01-05 ナント ホールディングス アイピー，エルエルシー Ａ型インフルエンザｒｎａ依存性ｒｎａポリメラーゼの低分子阻害剤

Also Published As

Publication number Publication date
DE69130683D1 (de) 1999-02-04
KR100191774B1 (ko) 1999-06-15
ES2126573T3 (es) 1999-04-01
EP0591528B1 (en) 1998-12-23
EP0591528A4 (en) 1995-02-15
WO1992018504A1 (en) 1992-10-29
DK0591528T3 (da) 1999-08-23
EP0591528A1 (en) 1994-04-13
DE69130683T2 (de) 1999-05-06
TW221434B (OSRAM) 1994-03-01
AU651986B2 (en) 1994-08-11
US5688949A (en) 1997-11-18
ATE174917T1 (de) 1999-01-15
AU8295891A (en) 1992-11-17
CA2107479C (en) 1997-12-16
CA2107479A1 (en) 1992-10-23

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