AU651986B2 - Pyrazolo{1,5-a}pyrimidine derivative and anti-inflammatory containing the same - Google Patents

Pyrazolo{1,5-a}pyrimidine derivative and anti-inflammatory containing the same

Info

Publication number
AU651986B2
AU651986B2 AU82958/91A AU8295891A AU651986B2 AU 651986 B2 AU651986 B2 AU 651986B2 AU 82958/91 A AU82958/91 A AU 82958/91A AU 8295891 A AU8295891 A AU 8295891A AU 651986 B2 AU651986 B2 AU 651986B2
Authority
AU
Australia
Prior art keywords
lower alkyl
substituted
hydroxy
phenyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU82958/91A
Other languages
English (en)
Other versions
AU8295891A (en
Inventor
Toshiaki Funato
Kinji Hashimoto
Makoto Inoue
Toshiko Kuwahara
Yukio Sugimoto
Takuji Uesako
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd, Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Co Ltd
Publication of AU8295891A publication Critical patent/AU8295891A/en
Application granted granted Critical
Publication of AU651986B2 publication Critical patent/AU651986B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU82958/91A 1991-04-22 1991-08-06 Pyrazolo{1,5-a}pyrimidine derivative and anti-inflammatory containing the same Ceased AU651986B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3-90707 1991-04-22
JP9070791 1991-04-22
PCT/JP1991/001043 WO1992018504A1 (en) 1991-04-22 1991-08-06 PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME

Publications (2)

Publication Number Publication Date
AU8295891A AU8295891A (en) 1992-11-17
AU651986B2 true AU651986B2 (en) 1994-08-11

Family

ID=14006001

Family Applications (1)

Application Number Title Priority Date Filing Date
AU82958/91A Ceased AU651986B2 (en) 1991-04-22 1991-08-06 Pyrazolo{1,5-a}pyrimidine derivative and anti-inflammatory containing the same

Country Status (12)

Country Link
US (1) US5688949A (OSRAM)
EP (1) EP0591528B1 (OSRAM)
JP (1) JPH0570353A (OSRAM)
KR (1) KR100191774B1 (OSRAM)
AT (1) ATE174917T1 (OSRAM)
AU (1) AU651986B2 (OSRAM)
CA (1) CA2107479C (OSRAM)
DE (1) DE69130683T2 (OSRAM)
DK (1) DK0591528T3 (OSRAM)
ES (1) ES2126573T3 (OSRAM)
TW (1) TW221434B (OSRAM)
WO (1) WO1992018504A1 (OSRAM)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0628559B1 (en) * 1993-06-10 2002-04-03 Beiersdorf-Lilly GmbH Pyrimidine compounds and their use as pharmaceuticals
AU680370B2 (en) * 1994-06-21 1997-07-24 Otsuka Pharmaceutical Factory, Inc. Pyrazolo(1,5-a)pyrimidine derivative
RU2147584C1 (ru) * 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US6664261B2 (en) * 1996-02-07 2003-12-16 Neurocrine Biosciences, Inc. Pyrazolopyrimidines as CRF receptor antagonists
CA2257222C (en) * 1996-06-06 2002-08-20 Otsuka Pharmaceutical Factory, Inc. Amide derivatives
EE04316B1 (et) * 1996-07-24 2004-06-15 Dupont Pharmaceuticals Company Asolotriasiinid ja -pürimidiinid, neid sisaldavadfarmatseutilised kompositsioonid ning nende kasutamine ravimite valmistamiseks
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
HU229024B1 (en) * 1996-07-24 2013-07-29 Bristol Myers Squibb Pharma Co Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
HUP9603001A3 (en) * 1996-10-30 1999-07-28 Richter Gedeon Vegyeszet Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
WO2000059908A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
AU4331500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
US20020061897A1 (en) * 2000-03-30 2002-05-23 Elliott Richard L. Neuropeptide Y antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
CA2441926A1 (en) 2001-03-27 2002-10-03 Neurogen Corporation (oxo-pyrazolo[1,5a]pyrimidin-2-yl)alkyl-carboxamides
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
WO2003101993A1 (en) * 2002-06-04 2003-12-11 Neogenesis Pharmaceuticals, Inc. Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents
KR20050057072A (ko) * 2002-09-04 2005-06-16 쉐링 코포레이션 사이클린 의존성 키나제 억제제로서의 피라졸로피리미딘
CA2497544C (en) 2002-09-04 2010-11-02 Schering Corporation Pyrazolo[1,5-a]pyrimidines compounds as cyclin dependent kinase inhibitors
US7161003B1 (en) * 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
JP4700344B2 (ja) * 2002-09-04 2011-06-15 シェーリング コーポレイション サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン
MY138201A (en) 2002-09-04 2009-05-29 Schering Corp Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
US8673924B2 (en) 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
CN1310918C (zh) 2002-09-04 2007-04-18 先灵公司 作为细胞周期蛋白依赖激酶抑制剂的吡唑并嘧啶
US7205308B2 (en) * 2002-09-04 2007-04-17 Schering Corporation Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US7119200B2 (en) 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
KR20050115252A (ko) 2003-02-28 2005-12-07 데이진 화-마 가부시키가이샤 피라졸로[1,5-ａ]피리미딘 유도체
WO2004087707A1 (en) * 2003-03-31 2004-10-14 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
US6949895B2 (en) * 2003-09-03 2005-09-27 Axcelis Technologies, Inc. Unipolar electrostatic quadrupole lens and switching methods for charged beam transport
AR049769A1 (es) * 2004-01-22 2006-09-06 Novartis Ag Derivados de pirazolo(1,5-a)pirimidin 7-il-amina para utilizarse en el tratamiento de enfermedades dependientes de la quinasa de proteina
CA2789097C (en) 2005-04-28 2017-02-21 Proteus Digital Health, Inc. Pharma-informatics system
WO2007032936A2 (en) * 2005-09-09 2007-03-22 Schering Corporation Azafused cyclin dependent kinase inhibitors
BRPI0617150A2 (pt) 2005-10-06 2011-07-12 Schering Corp pirazolopirimidinas como inibidores de protéina cinase
CA2624826A1 (en) * 2005-10-06 2007-04-19 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
GB0526419D0 (en) * 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
BRPI0719352A2 (pt) * 2006-11-29 2017-10-24 Abbott Lab inibidores de enzima diacilglicerol o-aciltransferase tipo 1
CL2008003810A1 (es) 2007-12-19 2009-05-22 Genentech Inc Compuestos derivados de 5-anilino imidazol[1,5-a]piridina o pirazina, inhibidores de la actividad mek quinasa; composiciones farmaceuticas que los contienen; y su uso para tratar trastornos hiperproliferativos y una enfermedad inflamatoria.
NZ616673A (en) 2009-02-20 2014-08-29 To Bbb Holding B V Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
EP2516008B1 (en) * 2009-12-23 2014-04-16 Katholieke Universiteit Leuven Novel antiviral compounds
EP2621925B1 (en) * 2010-09-28 2017-06-21 Merck Sharp & Dohme Corp. Fused tricyclic inhibitors of mammalian target of rapamycin
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
JP2013542243A (ja) 2010-11-15 2013-11-21 カトリーケ ウニヴェルシテイト ルーヴェン 新規な抗ウイルス性化合物
US8633198B1 (en) 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
EP3079693B1 (en) * 2013-12-11 2019-09-04 Nant Holdings IP, LLC Small molecule inhibitors of influenza a rna-dependent rna polymerase
AU2015208205B2 (en) 2014-01-22 2019-12-05 Curovir Ab Pyrazolo[1,5-a]pyrimidines as antiviral compounds
GB201410817D0 (en) 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R & D Therapeutic agents
CA3075751A1 (en) * 2017-09-15 2019-03-21 Aduro Biotech, Inc. Pyrazolopyrimidinone compounds and uses thereof
DE102018201598A1 (de) 2018-02-02 2019-08-08 Beiersdorf Ag Stabile Wundheilsalbe
TW202233620A (zh) 2020-10-23 2022-09-01 南韓商日東製藥股份有限公司 Cftr調節劑化合物、組合物及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60100381A (ja) * 1983-11-04 1985-06-04 Yuasa Battery Co Ltd 密閉形鉛蓄電池

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3925385A (en) * 1972-04-20 1975-12-09 Icn Pharmaceuticals 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
US4026893A (en) * 1975-11-07 1977-05-31 Squibb & Sons Inc Pyrazolo{8 1,5-a{9 pyrido{8 3,2-e{9 pyrimidine-7-carboxylic acid derivatives
DE3338292A1 (de) * 1983-10-21 1985-05-02 Basf Ag, 6700 Ludwigshafen 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide
JPS60100581A (ja) * 1983-11-07 1985-06-04 S D S Baiotetsuku:Kk ピラゾロ〔１，５−ａ〕ピリミジン誘導体，それらを含有する農園芸用殺菌剤及びそれらの製造方法
JPS6157587A (ja) * 1984-08-29 1986-03-24 Shionogi & Co Ltd 縮合複素環誘導体および抗潰瘍剤
JP2585462B2 (ja) * 1989-10-25 1997-02-26 株式会社大塚製薬工場 ピラゾロ［１，５―ａ］ピリミジン誘導体
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60100381A (ja) * 1983-11-04 1985-06-04 Yuasa Battery Co Ltd 密閉形鉛蓄電池

Also Published As

Publication number Publication date
DE69130683D1 (de) 1999-02-04
AU8295891A (en) 1992-11-17
KR100191774B1 (ko) 1999-06-15
WO1992018504A1 (en) 1992-10-29
TW221434B (OSRAM) 1994-03-01
DK0591528T3 (da) 1999-08-23
EP0591528A1 (en) 1994-04-13
CA2107479C (en) 1997-12-16
ES2126573T3 (es) 1999-04-01
US5688949A (en) 1997-11-18
DE69130683T2 (de) 1999-05-06
EP0591528A4 (en) 1995-02-15
ATE174917T1 (de) 1999-01-15
JPH0570353A (ja) 1993-03-23
CA2107479A1 (en) 1992-10-23
EP0591528B1 (en) 1998-12-23

Similar Documents

Publication Publication Date Title
AU651986B2 (en) Pyrazolo{1,5-a}pyrimidine derivative and anti-inflammatory containing the same
CA2311742A1 (en) 6-amino-9-benzyl-8-hydroxypurine derivatives
GB2230527B (en) Aminopyrimidine derivatives useful for treating cardiovascular disorders
EP0638567A4 (en) ADENOSINE INHIBITORS.
ATE206412T1 (de) Heterocyclische verbindungen als bradykinin antagonisten
CA2111461A1 (en) 3-Aminopiperidine Derivatives and Related Nitrogen Containing Heterocycles
TW229140B (OSRAM)
ZA89986B (en) 3-alkenyl-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid compounds
DK0784054T3 (da) 1,2,3,4-tetrahydroquinoxalinderivater og deres anvendelse som glutamatreceptorantagonister
ATE79380T1 (de) 2-substituierte-e-kondensierte(1,2,4>triazolo(1,5-c>pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
HUT61004A (en) Process for producing quinoxaline derivatives and pharmaceutical compositions comprising such compounds as active ingredient
GB9318935D0 (en) Heterocyclic derivatives
TW221441B (OSRAM)
NZ330078A (en) Active oxygen carriers containing pterin derivatives and salts thereof for use as cosmetic agents and feed
DE69619259D1 (de) Amidin- und isothioharnstoffderivate als inhibitoren der stickstoffoxid-synthase
IT1147330B (it) Medicamento,o preparato farmaceutico,ad azione citostatica
NZ196018A (en) 6-(phenyl or heteroaryl)-2,3-dihydroimidazo(1,2-b)-pyridazines
CA2053705A1 (en) Piperazine derivatives
IL101032A0 (en) 1,2,4-triazolo(1,5-a)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
JO1631B1 (en) Derivatives of permidine

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired