JPH05503722A - C型肝炎ウイルスに対する抗体を検出するための合成抗原 - Google Patents
C型肝炎ウイルスに対する抗体を検出するための合成抗原Info
- Publication number
- JPH05503722A JPH05503722A JP4500998A JP50099892A JPH05503722A JP H05503722 A JPH05503722 A JP H05503722A JP 4500998 A JP4500998 A JP 4500998A JP 50099892 A JP50099892 A JP 50099892A JP H05503722 A JPH05503722 A JP H05503722A
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- JP
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- Prior art keywords
- amino acids
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/82—Hepatitis associated antigens and antibodies
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1、式: (I)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 2.式: (II)【配列があります】 [YはXH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするたりに付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 3.式: (III)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 4.式: (IV)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 5.式: (V)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 6.式: (VI)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 7.式: (VII)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 8.式: (VIII)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 9.式: (IX)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 10.式: (X)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 11.式: (XI)【配列があります】 [YはNH2、1または複数のN−末端アミ/酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 12.式: (XII)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 13.式: (XIII)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 14.式: (XIV)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 15.式: (XV)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 16.式: (XVI)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 17.式: (XVII)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 18.式: (XVIII)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするたりに付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 19.式: (XIX)【配列があります】 [YはNH2、1または複数のN−末端アミノ酸、あるいはカップリングを容易 にするために付加された他の化学物質を表し、Zは結合、1または複数のアミノ 酸、あるいは連結に使用し得る1または複数の化学基を表し、XはOH、NH2 、あるいはこれらの基のいずれかを含有する結合を表す] で表されるペプチド。 20.第1項から第19項までのペプチドの少なくとも1つを含有する組成物。 21.担体に結合した第1項から第19項までのペプチドの少なくとも1つを含 有する組成物 22.血清または血漿などの生物学的液体中のC型肝炎ウイルスに対する抗体を 検出する方法であって、診断を受けるべき人の体液を第1項から第19項までの ペプチドあるいは第20項および第21項の組成物のいずれかと接触させ、該抗 体と1または複数の抗原との間に形成される免疫学的錯体を検出することを特徴 とする方法。 23.該免疫学的錯体の該検出が、抗ヒト免疫グロブリン抗体またはスタフィロ コッカルAプロテインまたはストレプトコッカルGプロテインまたはアビジンま たはストレプタピジンから選択される標識試薬と該免疫学的錯体を反応させ、該 複合体と該試薬の間で錯体形成した試薬を検出することによって達成されること を特徴とする第22項の方法。 24.第20項または第21項のいずれかに定義した組成物および生成する免疫 学的錯体を検出するための手段からなる、生物学的液体中の抗C型肝炎ウイルス 抗体の検出用キット。 25.該免疫学的錯体を検出するための該手段が1または複数の抗ヒト免疫グロ ブリンまたはプロテインAまたはプロテインGまたはアビジンまたはストレプタ ピジンと、検出される免疫学的複合体中に含まれる抗HCV抗体間に形成される 錯体を検出するための手段からなることを特徴とする第24項のキット。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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EP90124241A EP0489968B1 (en) | 1990-12-14 | 1990-12-14 | Synthetic antigens for the detection of antibodies to hepatitis C virus |
DE90124241.2 | 1990-12-14 | ||
EP90124241.2 | 1990-12-14 | ||
SG1996005024A SG47062A1 (en) | 1990-12-14 | 1990-12-14 | Synthetic antigens for the detection of antibodies to hepatitis virus |
Publications (2)
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JPH05503722A true JPH05503722A (ja) | 1993-06-17 |
JP2995216B2 JP2995216B2 (ja) | 1999-12-27 |
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JP4500998A Expired - Lifetime JP2995216B2 (ja) | 1990-12-14 | 1991-12-13 | C型肝炎ウイルスに対する抗体を検出するための合成抗原 |
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US (1) | US5922532A (ja) |
EP (3) | EP0489968B1 (ja) |
JP (1) | JP2995216B2 (ja) |
KR (3) | KR0181344B1 (ja) |
AT (3) | ATE149522T1 (ja) |
AU (1) | AU652013B2 (ja) |
BR (1) | BR9106220A (ja) |
CY (2) | CY2043A (ja) |
DE (2) | DE69030124T2 (ja) |
DK (3) | DK0754704T3 (ja) |
ES (3) | ES2095852T3 (ja) |
GR (3) | GR3022089T3 (ja) |
HK (1) | HK57597A (ja) |
HU (1) | HU218357B (ja) |
IL (1) | IL100158A (ja) |
NZ (1) | NZ240964A (ja) |
SG (1) | SG47062A1 (ja) |
WO (1) | WO1992010514A2 (ja) |
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KR920703640A (ko) * | 1990-11-29 | 1992-12-18 | 테루카츄 아리마 | 비a비b형 간염 바이러스 항원 단백질 |
ES2066547T3 (es) * | 1991-03-01 | 1995-03-01 | Akzo Nobel Nv | Peptidos, inmunoquimicamente reactivos con anticuerpos dirigidos contra virus de hepatitis no-a, no-b. |
AU2068992A (en) * | 1991-08-02 | 1993-02-04 | Akzo N.V. | Non-a, non-b peptide |
ZA927243B (en) * | 1991-10-07 | 1994-01-26 | Akzo Nv | Non-A, Non-B peptides |
AU671623B2 (en) * | 1992-03-06 | 1996-09-05 | N.V. Innogenetics S.A. | Process for the determination of peptides corresponding to immunologically important epitopes and biotinylated peptides used therein |
-
1990
- 1990-12-14 DK DK96201157T patent/DK0754704T3/da active
- 1990-12-14 DK DK90124241.2T patent/DK0489968T3/da active
- 1990-12-14 EP EP90124241A patent/EP0489968B1/en not_active Revoked
- 1990-12-14 AT AT94108611T patent/ATE149522T1/de not_active IP Right Cessation
- 1990-12-14 ES ES90124241T patent/ES2095852T3/es not_active Expired - Lifetime
- 1990-12-14 EP EP96201157A patent/EP0754704B1/en not_active Expired - Lifetime
- 1990-12-14 EP EP94108611A patent/EP0644202B1/en not_active Revoked
- 1990-12-14 ES ES94108611T patent/ES2101388T3/es not_active Expired - Lifetime
- 1990-12-14 DK DK94108611.8T patent/DK0644202T3/da active
- 1990-12-14 DE DE69030124T patent/DE69030124T2/de not_active Expired - Fee Related
- 1990-12-14 SG SG1996005024A patent/SG47062A1/en unknown
- 1990-12-14 AT AT96201157T patent/ATE185350T1/de not_active IP Right Cessation
- 1990-12-14 ES ES96201157T patent/ES2138784T3/es not_active Expired - Lifetime
- 1990-12-14 AT AT90124241T patent/ATE144993T1/de not_active IP Right Cessation
- 1990-12-14 DE DE69029092T patent/DE69029092T2/de not_active Expired - Fee Related
-
1991
- 1991-11-26 IL IL100158A patent/IL100158A/en not_active IP Right Cessation
- 1991-12-12 NZ NZ240964A patent/NZ240964A/en not_active IP Right Cessation
- 1991-12-13 AU AU90689/91A patent/AU652013B2/en not_active Expired
- 1991-12-13 HU HU9202645A patent/HU218357B/hu not_active IP Right Cessation
- 1991-12-13 KR KR1019970708500A patent/KR0181344B1/ko not_active IP Right Cessation
- 1991-12-13 JP JP4500998A patent/JP2995216B2/ja not_active Expired - Lifetime
- 1991-12-13 KR KR1019920701932A patent/KR0181343B1/ko not_active IP Right Cessation
- 1991-12-13 WO PCT/EP1991/002409 patent/WO1992010514A2/en active Application Filing
- 1991-12-13 KR KR1019970708501A patent/KR0181345B1/ko not_active IP Right Cessation
- 1991-12-13 BR BR919106220A patent/BR9106220A/pt not_active IP Right Cessation
-
1995
- 1995-02-21 US US08/391,671 patent/US5922532A/en not_active Expired - Lifetime
-
1996
- 1996-12-18 GR GR960403535T patent/GR3022089T3/el unknown
-
1997
- 1997-05-01 HK HK57597A patent/HK57597A/xx not_active IP Right Cessation
- 1997-06-04 GR GR970401308T patent/GR3023664T3/el unknown
-
1998
- 1998-02-20 CY CY204398A patent/CY2043A/xx unknown
- 1998-04-30 CY CY9802053A patent/CY2053B1/xx unknown
-
1999
- 1999-12-15 GR GR990403236T patent/GR3032150T3/el unknown
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