JPH0532682A - ウイルスによる病気を治療するためのベンジルホスホン酸誘導体の使用 - Google Patents
ウイルスによる病気を治療するためのベンジルホスホン酸誘導体の使用Info
- Publication number
- JPH0532682A JPH0532682A JP3031339A JP3133991A JPH0532682A JP H0532682 A JPH0532682 A JP H0532682A JP 3031339 A JP3031339 A JP 3031339A JP 3133991 A JP3133991 A JP 3133991A JP H0532682 A JPH0532682 A JP H0532682A
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- group
- linear
- branched
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000010099 disease Diseases 0.000 title claims abstract description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 14
- 241000700605 Viruses Species 0.000 title claims description 8
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 51
- 150000001875 compounds Chemical class 0.000 claims abstract description 48
- -1 cyclic diester Chemical class 0.000 claims abstract description 30
- 229910052794 bromium Inorganic materials 0.000 claims abstract description 28
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 26
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 24
- 125000000304 alkynyl group Chemical group 0.000 claims abstract description 24
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 24
- 239000003814 drug Substances 0.000 claims abstract description 15
- 238000011282 treatment Methods 0.000 claims abstract description 13
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- 241000450599 DNA viruses Species 0.000 claims abstract description 5
- 125000001424 substituent group Chemical group 0.000 claims abstract description 5
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims abstract description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 128
- 229910052739 hydrogen Inorganic materials 0.000 claims description 35
- 239000001257 hydrogen Substances 0.000 claims description 32
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 27
- 239000000460 chlorine Substances 0.000 claims description 26
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 25
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- 239000011737 fluorine Substances 0.000 claims description 23
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 17
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 17
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- 150000002367 halogens Chemical class 0.000 claims description 16
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- 125000003710 aryl alkyl group Chemical group 0.000 claims description 8
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- 229910052708 sodium Inorganic materials 0.000 claims description 8
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- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- 125000004429 atom Chemical group 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
- 239000011593 sulfur Substances 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 125000001246 bromo group Chemical group Br* 0.000 claims description 2
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- 210000000952 spleen Anatomy 0.000 description 8
- BDZBKCUKTQZUTL-UHFFFAOYSA-N triethyl phosphite Chemical compound CCOP(OCC)OCC BDZBKCUKTQZUTL-UHFFFAOYSA-N 0.000 description 7
- WGVYCXYGPNNUQA-UHFFFAOYSA-N 1-(bromomethyl)-2-methylbenzene Chemical compound CC1=CC=CC=C1CBr WGVYCXYGPNNUQA-UHFFFAOYSA-N 0.000 description 6
- SAVIMLRIKAZZCZ-UHFFFAOYSA-N 1-(diethoxyphosphorylmethyl)-2-methylbenzene Chemical compound CCOP(=O)(OCC)CC1=CC=CC=C1C SAVIMLRIKAZZCZ-UHFFFAOYSA-N 0.000 description 6
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3882—Arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4003054.7 | 1990-02-02 | ||
| DE4003054A DE4003054A1 (de) | 1990-02-02 | 1990-02-02 | Verwendung von benzylphosphonsaeurederivaten zur behandlung von durch viren verursachte krankheiten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0532682A true JPH0532682A (ja) | 1993-02-09 |
Family
ID=6399265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3031339A Pending JPH0532682A (ja) | 1990-02-02 | 1991-02-01 | ウイルスによる病気を治療するためのベンジルホスホン酸誘導体の使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5242908A (de) |
| EP (1) | EP0440148A1 (de) |
| JP (1) | JPH0532682A (de) |
| KR (1) | KR910021407A (de) |
| CN (1) | CN1053793A (de) |
| AU (1) | AU639746B2 (de) |
| CA (1) | CA2035494A1 (de) |
| CS (1) | CS22891A2 (de) |
| DE (1) | DE4003054A1 (de) |
| HU (1) | HU208400B (de) |
| IE (1) | IE910363A1 (de) |
| IL (1) | IL97110A0 (de) |
| PT (1) | PT96626A (de) |
| TW (1) | TW207953B (de) |
| ZA (1) | ZA91762B (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011527345A (ja) * | 2008-07-07 | 2011-10-27 | ファスジェン， インコーポレイテッド | 新規な化合物、この化合物を含む医薬組成物、この化合物の使用方法、およびこの化合物の調製方法 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5300687A (en) * | 1991-07-18 | 1994-04-05 | Ortho Pharmaceutical Corporation | Trifluoromethylbenzylphosphonates useful in treating osteoporosis |
| AU4848193A (en) * | 1992-09-23 | 1994-04-26 | Upjohn Company, The | Arylmethylphosphonates and phosphonic acids useful as anti-inflammatory agents |
| US5508273A (en) * | 1993-12-30 | 1996-04-16 | Ortho Pharmaceutical Corporation | Substituted phosphonic acids and derivatives useful in treating bone wasting diseases |
| CN1302001C (zh) * | 2005-01-20 | 2007-02-28 | 申厚宝 | 邻氯苄基膦酸二甲酯生产工艺 |
| US20070004937A1 (en) * | 2005-06-29 | 2007-01-04 | Ferro Corporation | Methods for the preparation of phosphonic acid derivatives |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3161667A (en) * | 1960-01-04 | 1964-12-15 | Monsanto Co | Vinylidene aromatic phosphorus monomers |
| US3538196A (en) * | 1963-12-11 | 1970-11-03 | Hooker Chemical Corp | Bis(oxypropylated pentaerythritol) oxypropylated pentaerythritol phosphonate |
| US3346669A (en) * | 1964-04-06 | 1967-10-10 | Chemagro Corp | Halo-phosphorus compounds and process for their preparation |
| US3363032A (en) * | 1964-06-11 | 1968-01-09 | Monsanto Co | Long chain aliphatic benzylphosphonic acids, esters and salts |
| US3555123A (en) * | 1966-06-23 | 1971-01-12 | Milton H Fischer | Di-omega-alkynyl aryl(arylalkyl) phosphonates |
| CH506948A (de) * | 1969-04-02 | 1971-05-15 | Ciba Geigy Ag | Fungizides Mittel |
| FR2358882A2 (fr) * | 1976-07-22 | 1978-02-17 | Hoffmann La Roche | Nouveaux derives de peptides d'acides phosphonique et phosphinique |
| US4182759A (en) * | 1978-06-05 | 1980-01-08 | Sterling Drug Inc. | Arylalkyl and aryloxyalkyl phosphonates and use as antiviral agents |
| DK463679A (da) * | 1978-11-10 | 1980-06-06 | Sandoz Ag | Phosphonsyreesterderivater |
| DE3001065A1 (de) * | 1980-01-12 | 1981-07-16 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von optischen aufhellern |
| FR2512039B1 (fr) * | 1981-08-26 | 1985-10-11 | Ato Chimie | Composition de resine synthetique ayant une bonne resistance au feu renfermant un polycarbonate, un additif ignifugeant phosphore, et eventuellement d'autres additifs et/ou des charges et objets conformes |
| JPS602570A (ja) * | 1983-06-20 | 1985-01-08 | Dainippon Printing Co Ltd | 両面接着テ−プ自動貼着装置 |
| CH660305A5 (de) * | 1984-10-05 | 1987-04-15 | Schering Spa | Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren. |
| GB8501374D0 (en) * | 1985-01-18 | 1985-02-20 | Wellcome Found | Treatment of aids |
-
1990
- 1990-02-02 DE DE4003054A patent/DE4003054A1/de not_active Withdrawn
- 1990-10-12 TW TW077108577A patent/TW207953B/zh active
-
1991
- 1991-01-28 EP EP91101097A patent/EP0440148A1/de not_active Withdrawn
- 1991-01-31 CS CS91228A patent/CS22891A2/cs unknown
- 1991-01-31 IL IL97110A patent/IL97110A0/xx unknown
- 1991-01-31 PT PT96626A patent/PT96626A/pt unknown
- 1991-02-01 KR KR1019910001735A patent/KR910021407A/ko not_active Application Discontinuation
- 1991-02-01 ZA ZA91762A patent/ZA91762B/xx unknown
- 1991-02-01 AU AU70164/91A patent/AU639746B2/en not_active Ceased
- 1991-02-01 IE IE036391A patent/IE910363A1/en unknown
- 1991-02-01 JP JP3031339A patent/JPH0532682A/ja active Pending
- 1991-02-01 CA CA002035494A patent/CA2035494A1/en not_active Abandoned
- 1991-02-01 US US07/648,622 patent/US5242908A/en not_active Expired - Fee Related
- 1991-02-01 HU HU91365A patent/HU208400B/hu not_active IP Right Cessation
- 1991-02-01 CN CN91100604A patent/CN1053793A/zh active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011527345A (ja) * | 2008-07-07 | 2011-10-27 | ファスジェン， インコーポレイテッド | 新規な化合物、この化合物を含む医薬組成物、この化合物の使用方法、およびこの化合物の調製方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR910021407A (ko) | 1991-12-20 |
| US5242908A (en) | 1993-09-07 |
| CS22891A2 (en) | 1991-09-15 |
| ZA91762B (en) | 1991-10-30 |
| IL97110A0 (en) | 1992-03-29 |
| AU639746B2 (en) | 1993-08-05 |
| CA2035494A1 (en) | 1991-08-03 |
| DE4003054A1 (de) | 1991-08-08 |
| TW207953B (de) | 1993-06-21 |
| CN1053793A (zh) | 1991-08-14 |
| IE910363A1 (en) | 1991-08-28 |
| EP0440148A1 (de) | 1991-08-07 |
| HUT56498A (en) | 1991-09-30 |
| PT96626A (pt) | 1991-10-15 |
| AU7016491A (en) | 1991-08-08 |
| HU910365D0 (en) | 1991-08-28 |
| HU208400B (en) | 1993-10-28 |
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